Current Drug Research Reviews最新文献

{"title":"Evaluation of Respirable Fraction by using Next Generation Impactor of Levosalbutamol Sulphate and Ipratropium bromide Metered Dose Inhaler.","authors":"Chirag Chilka, Jayesh Dhalani","doi":"10.2174/0125899775352741250309005146","DOIUrl":"10.2174/0125899775352741250309005146","url":null,"abstract":"<p><strong>Introduction: </strong>A lung condition in which the passage of air into the lungs is obstructed, is treated using a combination pharmaceutical aerosol (Pressurised Metered dosage Inhaler) dosage form, such as Levosalbutamol Sulphate (LS) and Ipratropium Bromide (IB) pressurized inhalation, which contains 50 μg and 20 μg, respectively. Aerodynamic particle size distribution (APSD) aids in comprehending the likelihood of particle deposition in the lungs. In addition to being crucial for the efficacy and safety of medications, the respirable fraction is a significant critical quality attribute (CQA) for nasal and orally inhaled medicinal formulations.</p><p><strong>Aims: </strong>The evaluation of in-vitro respirable fraction utilizing Next Generator Impactor (NGI) simulates drug particle deposition in the patient's lungs. The current study used a sensitive highpressure liquid chromatography technique to assess the deposited respirable fraction through APSD from NGI, as aerodynamic properties of the delivered dosage.</p><p><strong>Materials and methods: </strong>The samples are subjected to NGI and analyzed on an X-bridge C18 (50 x 4.6), 3.5 μm with 35°C column oven, volume of injection 100 μL, and 0.5 mL per min flow rate using a mobile phase that is a 75:25% v/v combination of Heptane sulphonic acid sodium salt buffer and Acetonitrile in high-pressure liquid chromatography. The designed approach was validated for its anticipated function and determined the respirable fraction of the delivered dose.</p><p><strong>Results and discussion: </strong>The respirable fraction (fine particle dose) in μg for Levosalbutamol sulfate and Ipratropium bromide were observed 27.644 ± 1.9 and 11.045 ± 1.8, respectively. The fine particle fraction in percentage for Levosalbutamol sulfate and Ipratropium bromide were observed 55 ± 1.8 and 56 ± 1.8, respectively. There is no method reported for the determination of Levosalbutamol sulphate and Ipratropium bromide from respirable fraction.</p><p><strong>Conclusion: </strong>The reliable results generated by novel combined in-vitro evaluation of LS and IB respirable fractions - correspond to lung deposition in a clinical study, which is about ≤ 5μm particle size in given doses of LS and IB inhalers.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":"137-146"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and Phytopharmacological Insights into <i>Argemone mexicana</i>: Integrative Approaches in Eastern Indian Region as Folk Medicine.","authors":"Omsatyam, Dharmendra Kumar, Laliteshwar Pratap Singh, Sandip Chatterjee","doi":"10.2174/0125899775362872250319082142","DOIUrl":"10.2174/0125899775362872250319082142","url":null,"abstract":"<p><strong>Introduction: </strong>Argemone mexicana, commonly known as the Mexican poppy, has earned significant recognition in the traditional healing systems of the Eastern Indian region, where it has been used for centuries as a folk remedy for a variety of diseases. The study was based on search or identified through Pubmed, Google Scholar, Science Direct, etc. Meta-analysis: Phytochemical analysis has demonstrated that the alkaloids present in A. mexicana exhibit potent antimicrobial properties, making the plant an effective natural remedy for treating infections caused by bacteria, fungi, and viruses. In addition, the plant's flavonoids and phenolic compounds are recognized for their strong anti-inflammatory and antioxidant activities, which play a crucial role in alleviating pain, reducing inflammation, and promoting tissue repair. Furthermore, A. mexicana has shown significant analgesic effects, which support its traditional use as a pain reliever. The integration of ethnobotanical knowledge with modern pharmacological research is essential for fully unlocking the therapeutic potential of A. mexicana. Future Scope: Future studies must focus on comprehensive clinical trials, toxicological evaluations, and in-depth mechanistic investigations to validate the efficacy and safety of A. mexicana in human populations.</p><p><strong>Conclusion: </strong>This review highlights the urgent need for further research to bridge the gap between traditional knowledge and contemporary scientific understanding. By advancing the study of A. mexicana, there is a significant opportunity to develop novel, cost-effective, and sustainable therapeutic agents that could serve as alternatives to synthetic drugs, particularly in regions where access to modern healthcare is limited.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":"121-136"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights.","authors":"Amulya Dhoddasomanahalli Prabhu, Prashant Tiwari, Sonal Dubey","doi":"10.2174/0125899775398736250911114640","DOIUrl":"https://doi.org/10.2174/0125899775398736250911114640","url":null,"abstract":"<p><strong>Introduction: </strong>Butrin, a flavonoid glycoside derived from Butea monosperma, has garnered attention for its neuroprotective effects attributed to its multifaceted pharmacological profile. It modulates dopamine and norepinephrine levels and exhibits antioxidant, antiinflammatory, and mitochondrial-protective actions. These properties position butrin as a promising candidate for therapeutic intervention in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. This review consolidates mechanistic insights, preclinical evidence, and therapeutic perspectives of butrin to assess its potential clinical applicability in managing neurodegenerative disorders.</p><p><strong>Methods: </strong>This review critically analyzes existing preclinical studies on the neuroprotective effects of butrin. Emphasis is placed on its mechanisms of action, including mitigation of oxidative stress, suppression of neuroinflammation, enhancement of neurotrophic factors, and preservation of mitochondrial integrity. Additionally, the review explores current limitations in clinical translation and evaluates emerging drug delivery strategies aimed at improving its therapeutic potential.</p><p><strong>Results: </strong>Preclinical evidence indicates that butrin effectively counters excitotoxicity and protein aggregation, key pathological features of neurodegenerative disorders. It attenuates neuropathological processes and demonstrates synergistic effects when combined with other neuroprotective and anti-inflammatory agents. Nonetheless, its poor bioavailability and limited ability to cross the blood-brain barrier remain significant barriers to clinical application.</p><p><strong>Discussion: </strong>Despite its promising pharmacological profile, the clinical translation of butrin is constrained by absorption challenges and suboptimal pharmacokinetics. Innovative strategies, such as nanocarrier-based delivery systems, drug repurposing, and combination therapies, may enhance its therapeutic efficacy. Addressing these limitations is crucial for advancing butrin from bench to bedside.</p><p><strong>Conclusion: </strong>Butrin exhibits compelling neuroprotective properties supported by robust preclinical data. However, large-scale clinical trials are essential to validate its efficacy. Integrating advanced drug delivery systems and personalized medicine approaches may unlock its full potential in managing neurodegenerative diseases.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Drug Delivery: The Promise of Self-emulsifying Systems in Overcoming Bioavailability Challenges.","authors":"Sonia Dhiman, Ashi Mannan, Maneesh Mohan, Thakur Gurjeet Singh","doi":"10.2174/0125899775386780250813111412","DOIUrl":"https://doi.org/10.2174/0125899775386780250813111412","url":null,"abstract":"<p><strong>Introduction: </strong>The oral route is a preferred method for drug administration; however, lipophilic drugs often suffer from poor water solubility, significantly limiting their therapeutic effectiveness. Traditional approaches like complexation, micronization, and solid dispersion have been explored, but each comes with inherent limitations.</p><p><strong>Methods: </strong>Self-Emulsifying Drug Delivery Systems (SEDDS) have emerged as a promising strategy to address solubility challenges. These systems incorporate drug molecules into a mixture of oils, surfactants, and cosolvents to enhance solubility. Ternary phase diagrams are frequently utilized to determine optimal component ratios for effective formulation.</p><p><strong>Results: </strong>SEDDS maintain drugs in a solubilized form within gastrointestinal fluids and protect peptide drugs from enzymatic degradation-a common issue in conventional formulations. They also facilitate the formation of stable emulsions at the target site, enhancing drug absorption. Additionally, the ability of SEDDS to traverse the blood-brain barrier (BBB) increases their applicability in treating neurological disorders.</p><p><strong>Discussion: </strong>The findings emphasize the utility of SEDDS in overcoming the solubility and stability challenges faced by poorly water-soluble drugs. Their capacity to enhance drug absorption and protect bioactive molecules from degradation aligns with current efforts to improve oral drug delivery systems. However, formulation complexities and variability in in vivo performance remain areas requiring further investigation.</p><p><strong>Conclusion: </strong>This review outlines the formulation strategies, characterization methods, and evaluation techniques for SEDDS, emphasizing their potential in enhancing the bioavailability of poorly soluble drugs, particularly those aimed at the central nervous system. SEDDS offer a promising platform for improving therapeutic outcomes across diverse clinical settings.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Therapeutic Potential of SGLT-2 Inhibitors in Managing Metabolic Syndrome: A Narrative Review.","authors":"Sulthan Al Rashid, Monisha Prasad, Inamul Hasan Madar, Kamalakanna Dhanabalan, Rajkapoor Balasubramanian, Naina Mohamed Pakkir Maideen","doi":"10.2174/0125899775382225250811111859","DOIUrl":"https://doi.org/10.2174/0125899775382225250811111859","url":null,"abstract":"<p><p>Metabolic syndrome, a cluster of interconnected metabolic risk factors such as central obesity, insulin resistance, hypertension, and dyslipidemia, significantly increases the risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Despite its rising prevalence and serious health consequences, metabolic syndrome remains underdiagnosed and undertreated. Sodium-glucose co-transporter-2 (SGLT-2) inhibitors, initially developed for T2DM management, have demonstrated promising therapeutic potential for addressing multiple components of metabolic syndrome. These drugs lower blood glucose levels by promoting glycosuria and exhibit additional benefits, including weight loss, reduced blood pressure, improved lipid profiles, and cardioprotective effects. The impact of SGLT-2 inhibitors on the five metabolic syndrome criteria listed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III)-central obesity, triglycerides, HDL cholesterol, blood pressure, and fasting glucose levels-is evaluated in this narrative review, which combines results from metaanalyses and clinical trials. Reduced waist circumference, better lipid profiles, lower blood pressure, and improved glycaemic management are some of the main outcomes. Diuresis, natriuresis, enhanced insulin sensitivity, and AMP-activated protein kinase (AMPK) activation are the processes that underlie these effects. Although SGLT-2 inhibitors have a good safety record, they can cause uncommon diabetic ketoacidosis and urinary tract infections, which can be avoided with careful management. The study highlights that more research is necessary to understand long-term effects, optimize dosing regimens, and assess real-world applicability. According to these findings, SGLT-2 inhibitors are essential therapies for managing metabolic syndrome holistically, and they hold great promise for lowering the disease's worldwide burden and related health hazards.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction.","authors":"Pranay Wal, Shaili Vadera, Namra Aziz, Prashant -, Rajesh K S, Chennu Mm Prasada Rao, Mukesh Chandra Sharma","doi":"10.2174/0125899775358899250726213130","DOIUrl":"https://doi.org/10.2174/0125899775358899250726213130","url":null,"abstract":"<p><p>Numerous therapeutic and culinary species produce scopoletin, a coumarin that is essential for treating a wide range of illnesses as a curative and chemopreventive agent. Globally, chronic illnesses are regarded as a major public health concern. Atypical regulation of various signalling pathways is the primary cause of most of these illnesses, which include cancer, as well as cardiovascular, metabolic, and neurological disorders. In Alzheimer's disease (AD), amyloid β (Aβ) peptide aggregates are deposited in the CNS, forming plaques. The investigation assessed the capacity of scopoletin to modify the disease to several AD-related factors. It activated the release of insulin in the β cell of the pancreas. Additionally, it has been noted that most currently approved treatments for these illnesses are mono-targeted and related to the development of chemoresistance, which limits their utility and prevents them from demonstrating prolonged efficacy. Conversely, the molecules originating from plants exhibit a multi-targeted nature, which has led to widespread interest in these phytochemicals due to their few adverse effects. The purpose of this review is to summarise the possible consequences of scopoletin. An outline of scopoletin pharmacology, pharmacokinetics, and toxicity is given in this review. In addition, this chemical is non-toxic and has good pharmacokinetic properties, so more research in clinical settings is necessary to develop it as a possible medication. The findings from the investigation could aid in the prevention and management of illnesses as well as the understanding of the benefits of plants containing scopoletin.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiopentone in Combination with Xylazine: An Experimental Investigation for Induction of Surgical Anesthesia and Safe Recovery in Experimental Rats.","authors":"Sagar More, Radhika Mundke, Awez Sikkalgar, Kalpesh Yeole, Ritesh S Tarwani, Sameer N Goyal, Yogeeta O Agrawal, Sumit S Rathod","doi":"10.2174/0125899775370000250728050535","DOIUrl":"https://doi.org/10.2174/0125899775370000250728050535","url":null,"abstract":"<p><strong>Introduction: </strong>Achieving reliable anesthesia induction and rapid postoperative recovery are crucial aspects of animal research, particularly in small experimental animals. Thiopentone is still a widely used anesthetic drug, but its safety is a primary concern in delivering a safe dose to experimental animals. However, the use of thiopentone in combination with xylazine for surgical procedures in small experimental animals remains underexplored. Therefore, this study assesses the efficacy and safety of combining thiopentone and xylazine for inducing anesthesia and facilitating recovery in Sprague-Dawley rats (n = 6).</p><p><strong>Methods: </strong>Several sedatives and anesthetic agents, with diazepam (A), thiopentone (B), and xylazine (C), were evaluated alone and in combinations (AB, AC, BC, ABC). Rectal temperature, pulse rate, onset of anesthesia, and sedation duration were recorded before and after the administration.</p><p><strong>Results: </strong>Thiopentone (45 mg/kg) alone caused significant declines in vital parameters and mortality. However, the BC combination (thiopentone 35 mg/kg + xylazine 7 mg/kg) induced rapid and prolonged anesthesia without mortality, mitigating thiopentone-induced hypothermia, bradycardia, and respiratory depression. This combination was further validated in 24 rats undergoing stereotaxic surgery, demonstrating its effectiveness and safety.</p><p><strong>Discussion: </strong>The results demonstrated that while thiopentone monotherapy led to significant adverse effects, including hypothermia, decreased pulse rate, and respiratory depression, the combination of thiopentone with xylazine, particularly at specific doses, showed promising outcomes in mitigating these side effects.</p><p><strong>Conclusion: </strong>The data obtained from the present study suggest that a combination of thiopentone (35 mg/kg) with xylazine (7 mg/kg) may represent the optimal surgical dose for inducing surgical anesthesia in rats.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation Mesoporous Silica Nanoparticles: Precision-engineered Platforms for Ovarian Cancer Therapy.","authors":"Shankar Lal Tolani, Shashank Soni","doi":"10.2174/0125899775385405250724152558","DOIUrl":"https://doi.org/10.2174/0125899775385405250724152558","url":null,"abstract":"<p><p>Silica nanoparticles (SiNPs) with antifouling properties offer a promising approach for enhancing ovarian cancer (OC) therapy. OC remains one of the deadliest gynecological malignancies due to late-stage diagnosis, high recurrence rates, and limited treatment efficacy. Conventional therapies, such as chemotherapy, often face challenges due to drug resistance and limited targeting ability. The development of SiNPs with antifouling capabilities aims to address these issues by improving drug delivery efficiency, reducing non-specific interactions, and enhancing biocompatibility. Functionalizing SiNPs with cancer-specific ligands or antibodies can further improve targeting and uptake by ovarian cancer cells while reducing the impact on healthy tissues. Additionally, the porous structure of SiNPs allows for the loading of multiple therapeutic agents, enabling combination therapies that can overcome drug resistance mechanisms. In order to overcome these constraints and enhance MSN efficacy in cancer theranostics, this study aims to highlight technical advancements, including tumor-specific, stimuli-responsive \"smart\" MSNs and multimodal MSN- based hybrid nanoplatforms. This review provides thorough knowledge about the role of mesoporous silica nanoparticles for the treatment of ovarian cancer, highlighting important areas for further study as well as the difficulties associated with this area. To possibly improve therapeutic results by offering more accurate and targeted theranostic methods, we want to highlight the vitality of MSN technology as well as the significance of recent research and developments in this area. Overall, antifouling SiNPs represent a versatile and effective platform for ovarian cancer treatment, with the potential to improve therapeutic outcomes and reduce side effects.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Compound Kushen Injection's Anticancer Properties in Hepatocellular Carcinoma: An Integrated Approach of Network Pharmacology, Bioinformatics, and Experimental Validation.","authors":"Changce Wei, Chunjuan Zhang, Shuyang Wang, Mingrui Yang, Jingxiao Wang, Miao Jiang, Cuiyan Ma","doi":"10.2174/0125899775387801250722064737","DOIUrl":"https://doi.org/10.2174/0125899775387801250722064737","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC), commonly referred to as primary liver cancer, is a malignant neoplasm that originates within the liver. Conventional treatment modalities frequently result in less than satisfactory outcomes, primarily attributed to the intricate physiological and pathological contexts. Compound Kushen Injection (CKI), formulated from the botanicals Sophora flavescens and Atractylodes macrocephala, is employed as a supplementary therapy in the treatment of advanced-stage malignant tumors, including HCC.</p><p><strong>Objective: </strong>Our study combined network pharmacology, bioinformatics, GeneMANIA-based functional association (GMFA), and experimental validation to elucidate CKI's therapeutic targets and mechanisms.</p><p><strong>Methods: </strong>STRING was used to build a protein-protein interaction network, and GO and KEGG analyses were performed with DAVID and ShinyGO on the overlapping targets of CKI and HCC. Hub targets were identified using CytoHubba and their clinical relevance was confirmed with GEPIA2. GMFA and TIMER assessed the functions of key hub genes. The findings were further verified through significant KEGG analysis, molecular docking, and experimental validation.</p><p><strong>Results: </strong>10 hub targets were identified for CKI against HCC and analyzed for their impact on HCC patient survival and gene expression. GMFA confirmed four key hub genes, and TIMER assessed the correlation between SRC expression and immune infiltration. Significant KEGG analysis highlighted SRC's role in cell proliferation and migration through the MMP/EGFRPI3K/ AKT pathway. Molecular docking showed interactions between SRC and desmethylanhydroicaritin or resokaempferol. Experiments in HepG2 cells confirmed CKI's inhibitory effect on tumor cells.</p><p><strong>Conclusion: </strong>CKI's anti-HCC effects may be exerted by regulating SRC via active compounds desmethylanhydroicaritin and resokaempferol.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Herbal Remedies in Menopause: Bridging Traditional Medicine and Modern Therapeutics.","authors":"Megha Chavda, Lata Mansukhbhai Manani, Chandni Chandarana","doi":"10.2174/0125899775387961250722040848","DOIUrl":"https://doi.org/10.2174/0125899775387961250722040848","url":null,"abstract":"<p><strong>Introduction: </strong>Menopause is a natural physiological transition marked by hormonal changes that can lead to a range of physical, emotional, and psychological symptoms, often impacting a woman's quality of life. This review aims to evaluate the effectiveness of herbal remedies as alternative or complementary options to conventional treatments, particularly hormone replacement therapy (HRT), in managing menopausal symptoms.</p><p><strong>Methods: </strong>An extensive literature review was conducted, focusing on commonly used herbs such as black cohosh, red clover, Dong Quai, and chaste tree berry. The review assessed the phytoestrogenic and adaptogenic properties of these herbs, exploring their mechanisms of action, clinical efficacy, safety profiles, and potential interactions. Comparisons were made with HRT and other conventional therapies. Non-hormonal pharmacological options and lifestyle interventions, including yoga and dietary changes, were also examined.</p><p><strong>Results: </strong>Herbal remedies, particularly black cohosh and red clover, demonstrated moderate effectiveness in alleviating menopausal symptoms, attributed to their phytoestrogenic and adaptogenic actions. Clinical evidence supports their safety, though individual responses and drug interactions vary. Additionally, non-hormonal treatments and lifestyle modifications, such as yoga and dietary adjustments, contribute to symptom relief.</p><p><strong>Discussion: </strong>The findings underscore the potential of herbal remedies as viable alternatives or adjuncts to HRT. While generally safe and moderately effective, the variability in individual response and the need for awareness of possible interactions are important considerations. Integrating herbal approaches with evidence-based medical practices may offer more personalized and holistic menopause care.</p><p><strong>Conclusion: </strong>Herbal therapies present a promising, well-tolerated option for managing menopausal symptoms. When combined with conventional or lifestyle-based interventions, they broaden the spectrum of therapeutic choices available to women, enabling individualized, integrative care during menopause.</p>","PeriodicalId":37008,"journal":{"name":"Current Drug Research Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}