BDJ Open最新文献

{"title":"Oxidative balance score and periodontitis: nonlinear dose-response in NHANES 2009-2014.","authors":"Chong Gao, Miaoran Wang, Hairong He, Zhengchuan Zhu, Qiuyan Li, Zhuye Gao, Liqin Mei","doi":"10.1038/s41405-026-00410-7","DOIUrl":"10.1038/s41405-026-00410-7","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a chronic inflammatory disease associated with oxidative stress. The Oxidative Balance Score (OBS) is a composite measure of dietary and lifestyle factors that reflect the balance between pro-oxidants and antioxidants. Recently, there has been growing interest in research examining the connection between oxidative balance scores (OBS) and periodontitis. However, the nature of this relationship, particularly whether it follows a linear or non-linear pattern, remains unclear. This study aimed to explore association between OBS and periodontitis using data from the National Health and Nutrition Examination Survey (NHANES 2009-2014.).</p><p><strong>Methods: </strong>We conducted a cross-sectional study using data from NHANES 2009-2014. A total of 10,714 participants with a mean age of 32.60 years (SD = 24.91) were included in this study. Periodontitis was defined based on clinical periodontal examinations, and OBS was calculated using dietary and lifestyle factors. A generalized additive model was used to explore the nonlinear relationship between OBS and periodontitis. A two-piecewise linear regression model was employed to identify the threshold effect of OBS on periodontitis.</p><p><strong>Results: </strong>The study found a nonlinear relationship between OBS and periodontitis. When OBS was less than 16, the odds ratio (OR) for periodontitis was 0.74 (95% CI: 0.50-1.09, P = 0.13). However, when OBS was greater than 16, the OR for periodontitis significantly decreased to 0.14 (95% CI: 0.09-0.20, P < 0.001). The threshold effect of OBS on periodontitis was identified at 16.</p><p><strong>Conclusion: </strong>This study demonstrates a nonlinear relationship between OBS and periodontitis, with a significant reduction in the risk of periodontitis when OBS exceeds 16.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 980 nm diode laser irradiation in comparison with conventional irrigation on smear layer removal from radicular dentin-an in vitro experimental study.","authors":"Syeda Abeerah Tanveer, Robia Ghafoor, Adil Omerson","doi":"10.1038/s41405-026-00409-0","DOIUrl":"10.1038/s41405-026-00409-0","url":null,"abstract":"<p><strong>Introduction: </strong>The smear layer in radicular dentin reduces effective disinfection by occluding dentinal tubules and decreasing dentin permeability, contributing to persistent microbial infection and root canal treatment failures.</p><p><strong>Objective: </strong>To compare the effect of 980 nm Diode laser irradiation and conventional irrigation with Sodium hypochlorite and ethylenediaminetetraacetic acid (NaOCl +EDTA) on smear layer removal in radicular dentin through dye penetration test.</p><p><strong>Material and methods: </strong>Sixty-six extracted single-rooted permanent teeth were randomly allocated into two groups. Group I underwent 980 nm diode laser irradiation using a 200 µm fiber in helicoidal motion (2 W power, 200 Hz frequency, 1-4 ms pulse duration). Group II received conventional irrigation with 3% NaOCl followed by 17% EDTA. All specimens were immersed in 2% methylene blue dye for 48 h, after which cross-sections were obtained at 3, 5, and 8 mm from the anatomical apex. Dye penetration diameter (mm) and area (mm²) between the inner and outer circumferences were measured using ImageJ software under a stereomicroscope. Statistical analysis was performed using one-way ANOVA with Bonferroni post-hoc tests.</p><p><strong>Results: </strong>The diode laser irradiation demonstrated overall significantly greater dentinal tubule penetration (16.2 ± 1.91 mm) compared to the conventional irrigation (5.32 ± 0.70 mm; p = 0.001). The overall mean area of the laser group (12.61 ± 2.02 mm²) was greater as compared to the conventional group (1.67 ± 0.73 mm²; p = 0.001).</p><p><strong>Conclusion: </strong>Diode laser irradiation may serve as an effective adjunct for smear layer removal and improved root canal disinfection.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A two year randomized clinical trial comparing opposing enamel wear from milled resin-matrix ceramic and direct bulk-fill composite overlays.","authors":"Esraa Esmeail H Elhaddad, Aly Ayman M Elkady, Dina Fayez S Diab","doi":"10.1038/s41405-026-00400-9","DOIUrl":"10.1038/s41405-026-00400-9","url":null,"abstract":"<p><strong>Background: </strong>Tooth wear has become an increasingly prevalent clinical issue. It can lead to a reduction in the vertical dimension of occlusion (VDO), heightened tooth sensitivity, and alterations in both function and esthetics due to the progressive loss of dental hard tissues. As the incidence and severity of this multifactorial condition continue to rise, there is a growing need for dentists to adopt minimally invasive approaches for diagnosis, monitoring, and management. This clinical trial was designed to evaluate the amount of enamel wear on opposing enamel in response to either indirect milled resin matrix ceramic or direct bulk-fill resin composite overlays, using intraoral digital scanning technology.</p><p><strong>Methods: </strong>Eleven patients in each group received treatment for a total of 22 restorations. Participants were split into two groups, with R1 representing endodontically treated teeth restored with milled resin matrix ceramic overlays and R2 representing endodontically treated teeth restored with direct bulk-fill composite overlays. Using intraoral scanners and three-dimensional surface-based superimposition software, tooth enamel wear was assessed intraorally at baseline (T0), 12 months (T12), and 24 months (T24). The statistical analyses conducted included the Shapiro-Wilk test and the Mann-Whitney U test. The significance level was set at p < 0.05 across all tests.</p><p><strong>Results: </strong>The mean linear wear ( ± SD) for the indirect restorations was 0.41 ± 0.27 mm, compared to 0.20 ± 0.05 mm for the direct restorations; this difference was not statistically significant (p = 0.066). Similarly, the mean volumetric wear was 0.13 ± 0.06 mm³ for the indirect group and 0.12 ± 0.08 mm³ for the direct group, with no significant difference between them (p = 1).</p><p><strong>Conclusions: </strong>Within the limitations of this 2-year clinical evaluation, both direct bulk-fill resin composites and milled resin matrix ceramic overlays demonstrated comparable behavior with opposing enamel in posterior teeth, with no statistically significant differences between the tested materials.</p><p><strong>Trial registration: </strong>The study was registered at ClinicalTrials.gov on 29 Jan 2025 (#NCT06807125).</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between subclinical coronary artery atherosclerosis and oral health-a study on a Swedish population.","authors":"Jessica Berglundh Gottlieb, Göran Bergström, Cristiano Tomasi, Tord Berglundh, Jan Derks","doi":"10.1038/s41405-026-00406-3","DOIUrl":"10.1038/s41405-026-00406-3","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health has been linked to cardiovascular disease (CVD), but its relationship to subclinical coronary artery atherosclerosis (SCAA) remains unclear. Using coronary computed tomography angiography (CCTA), we explored this association in an asymptomatic population.</p><p><strong>Material and method: </strong>A total of 410 non-smokers (193 women, mean age: 64.6 years), comprising 204 individuals with SCAA and 206 without (non-SCAA), were assessed through clinical and radiographic oral evaluations. Self-reported oral symptoms were scored by questionnaire. We used sex-stratified regression analysis and compared model performance with and without the addition of data on oral health through area under the curve (AUC). The reference model included age and history of smoking.</p><p><strong>Results: </strong>Individuals with SCAA had more missing teeth, higher Decayed and Filled Teeth scores and greater prevalence of peri-apical lesions and marginal bone loss >33%. Missing teeth was an independent risk indicator for SCAA (OR 1.15 95%CI 1.04-1.27). Model performance improved with the addition of oral status and self-reported oral symptoms, most prominently in women (AUC 0.67 vs. 0.78, p = 0.010). Decision curve analyses confirmed a consistent net benefit when data on oral health were considered.</p><p><strong>Conclusions: </strong>The findings suggest that subclinical coronary artery atherosclerosis is associated with oral health. Oral health-related data may improve screening for risk of coronary events, especially in women.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"18"},"PeriodicalIF":3.1,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the barriers and facilitators of oral healthcare access for vulnerable migrants across high-income countries: a scoping review.","authors":"Zainab Lal, Luisa Silva, Nadia Alam, Mayuri Gogoi, Rebecca F Baggaley, Pip Divall, Holly Reilly, Harriet Walter, Manish Pareek","doi":"10.1038/s41405-026-00398-0","DOIUrl":"10.1038/s41405-026-00398-0","url":null,"abstract":"<p><strong>Background: </strong>According to the World Health Organisation, oral health (OH) diseases are a major global health issue and outcomes are consistently poorer among refugees and migrants than host populations in many high-income countries (HICs). In the UK, the Office for Health Improvement and Disparities recognises asylum seekers, refugees, undocumented migrants, low-wage migrants, unaccompanied minors, and victims of trafficking as vulnerable migrants. These groups face worse OH outcomes due to systemic, socio-economic, cultural, and lifestyle-related factors, alongside barriers to accessing dental services. This scoping review explores the barriers and facilitators to oral healthcare experienced by vulnerable migrants in HICs.</p><p><strong>Methods: </strong>We conducted a scoping review using the Arksey and O'Malley framework and reported findings in line with PRISMA-ScR. Embase and MEDLINE were searched from inception until April 30th 2024, for studies examining factors influencing access to oral healthcare services. Data were charted and thematically mapped onto the Dahlgren and Whitehead model of Social Determinants of Health (SDH).</p><p><strong>Results: </strong>Of 3894 identified records, 17 studies (10 qualitative, 5 quantitative, and 2 mixed-methods) were included, covering 2653 participants across 8 HICs (USA, UK, Australia, Austria, Germany, Finland, Saudi Arabia and Canada). Barriers and facilitators were present across all SDH layers. At the socio-economic, cultural, and environmental level, financial barriers were most commonly reported (12/17 studies). Language difficulties, low awareness of services, and mistrust of healthcare providers mapped to living and working conditions, while acculturation and social support aligned with the social and community networks layer. Limited knowledge of prevention was noted under lifestyle factors, and lastly, gender roles under personal characteristics. Cultural and religious norms also shaped care-seeking, with spirituality and religious traditions supporting positive OH practices.</p><p><strong>Conclusions: </strong>We identified barriers and facilitators to oral healthcare access across personal, behavioural, social, and structural levels, contextualised within the SDH framework. Addressing these requires policies and practices that address structural barriers, integrate OH into national public health strategies, and emphasise inclusive, culturally competent care to improve access to OH services for these groups.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"17"},"PeriodicalIF":3.1,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking lungs and gums: a meta-analysis of periodontitis prevalence and severity in chronic obstructive pulmonary disease.","authors":"Gowri Sivaramakrishnan, Kannan Sridharan","doi":"10.1038/s41405-026-00403-6","DOIUrl":"10.1038/s41405-026-00403-6","url":null,"abstract":"<p><strong>Aim: </strong>Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder associated with chronic inflammation and airflow limitation. Periodontitis shares common risk factors with COPD, such as smoking. This meta-analysis evaluates the prevalence and severity of periodontitis in COPD patients by assessing periodontal parameters, including probing depth (PD), clinical attachment loss (CAL), and bleeding on probing (BOP).</p><p><strong>Methods: </strong>A systematic search of electronic databases identified clinical studies reporting periodontitis in COPD patients. Studies with clear diagnostic criteria for both conditions were included. Data extraction was conducted using RAYYAN software, and study quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was performed in R Studio, with heterogeneity assessed using the I² statistic. To assess the robustness of the findings, a leave-one-out sensitivity analysis was conducted for CAL and PD. Publication bias was examined using the Trim and Fill method. Additionally, stratified subgroup analyses were performed based on smoking status and study design to explore potential sources of heterogeneity. Certainty of evidence was assessed using GRADE.</p><p><strong>Results: </strong>A total of 41 studies were included. Periodontitis prevalence in COPD patients was 35%, significantly higher than in non-COPD controls. COPD patients exhibited greater periodontal destruction, with increased CAL (0.68 [0.37;0.98]) deeper PD (0.72 [0.12; 1.31]), and BOP (1.49 [0.19;2.79]). However, the certainty of this evidence was rated as low to very low.</p><p><strong>Conclusion: </strong>COPD patients have a higher prevalence of periodontitis and worse periodontal parameters. While our meta-analysis suggests an association, the overall certainty of evidence is low. These findings should therefore be interpreted with caution. Future high-quality prospective studies are essential to confirm this relationship and inform clinical practice.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"16"},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 1.5-year randomized controlled trial comparing standard-sized implants and two diameters of mini-implants immediately loaded by mandibular overdenture: radiographic outcomes, short-term survival, and success rate.","authors":"Heba M Moftah, Mohannad H Al-Saadi, Khaldoun Darwich","doi":"10.1038/s41405-025-00369-x","DOIUrl":"10.1038/s41405-025-00369-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the marginal bone level changes (MBLC), survival, and success rate of 4 mini-implants (MIs) of two different diameters versus two standard-sized implants (SIs) that were loaded functionally and immediately by a complete mandibular denture.</p><p><strong>Materials and methods: </strong>The study comprised 29 participants with conventional complete dentures; they were randomly allocated into three groups. Group S included 11 participants who received two SIs of 3.75 mm diameter, group M3 included 8 participants who received four MIs of 3 mm diameter, and group M2.5 included 10 participants who received four MIs of 2.5 mm diameter. MBLC was evaluated on each implant's mesial and distal sides after 18 months of loading. A paired t-test and one-way ANOVA were used for intragroup and intergroup comparisons, respectively (P ≤ 0.05). The evaluation of survival and success rates adhered to the criteria established by the International Congress of Oral Implantologists in Pisa (2007).</p><p><strong>Results: </strong>Immediate loading was employed in all cases. No failure occurred in any case. The success rate after 18 months was 90.91% in the S group, 90.63% in the M3 group, and 90% in the M2.5 group. MBLC after 18 months of loading were 0.76 ± 0.62 mm mesially and 0.63 ± 0.90 mm distally in the S group, 1.04 ± 0.72 mm mesially and 1.05 ± 0.84 mm distally in the M3 group, and 1.37 ± 0.73 mm mesially and 1.11 ± 0.68 mm distally in the M2.5 group.</p><p><strong>Conclusion: </strong>The SIs group showed better radiographic results and success rates than the MIs groups. As the diameter of the implant decreases, the mean MBLC increases. However, the results of the MIs groups were within acceptable limits. The survival rate was 100% in the three groups.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"15"},"PeriodicalIF":2.5,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth-whitening treatment with potassium sodium tartrate: a non-invasive method that preserves enamel integrity.","authors":"Angelina Ivanova, Valeriia Buzova","doi":"10.1038/s41405-026-00405-4","DOIUrl":"10.1038/s41405-026-00405-4","url":null,"abstract":"<p><strong>Objectives: </strong>Tooth-whitening treatments in modern dentistry often led to enamel demineralization and sensitivity. This study explored potassium sodium tartrate, a piezoelectric material which employs a piezoelectricity effect to gently remove stains, as a non-invasive alternative to traditional peroxide-based whitening methods which chemically oxidize extrinsic stains causing enamel demineralization and sensitivity. Specifically, the research measured stain removal, enamel integrity, addressing common drawbacks of peroxide treatments.</p><p><strong>Materials and methods: </strong>The research was focused on two in vitro studies assessed sodium potassium tartrate efficacy for whitening and enamel preservation compared to carbamide peroxide. In the first experiment bovine enamel blocks (n = 10/group) were stained and treated with prototype toothpastes (2% potassium sodium tartrate, 2% carbamide peroxide, base-only control, deionized water) via simulated brushing followed by a cumulative 3.5-hour immersion to model extended action. Stain Removal Index (SRI%) and Surface Microhardness Recovery (%SMHR) were measured. In the second experiment Stained human enamel (n = 8-10/group) was treated with commercial-type toothpastes, including those containing 2% potassium sodium tartrate, over simulated 1-week and 1-month periods. Whitening was quantified as VITA® Bleachedguide shade changes. Instrument calibration and ethical sample sourcing were as per standardized protocols.</p><p><strong>Results: </strong>In the first experiment the potassium sodium tartrate and carbamide peroxide groups showed statistically equivalent stain removal (SRI%: 30.06 ± 7.08 vs. 30.02 ± 6.58). However, carbamide peroxide significantly reduced enamel microhardness (%SMHR: -15.80 ± 4.38), whereas potassium sodium tartrate preserved it (0.08 ± 4.06), similar to non-whitening controls. In the second experiment after one month, the potassium sodium tartrate formulation with fluoride achieved comparable shade improvement (4.76 ± 1.51 shades) to the peroxide-fluoride control (4.38 ± 0.58 shades).</p><p><strong>Conclusions: </strong>In vitro results indicate potassium sodium tartrate could provide an effective and enamel-safe alternative to peroxide-based whitening, meriting further clinical investigation.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"14"},"PeriodicalIF":2.5,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic pulpotomy for permanent teeth with irreversible pulpitis: comparative results from a practice-based quick poll in the USA and UK.","authors":"Thibault Ne Colloc, David Nj Ricketts, Janet E Clarkson, Ashraf F Fouad, Craig R Ramsay, Joana Cunha-Cruz","doi":"10.1038/s41405-026-00404-5","DOIUrl":"10.1038/s41405-026-00404-5","url":null,"abstract":"<p><strong>Background/aims: </strong>Treatment paradigms for teeth with signs and symptoms of irreversible pulpitis in permanent teeth are evolving, with increasing interest in conservative approaches such as therapeutic pulpotomy. Understanding the perspectives of both general dentists and endodontists is essential to defining current clinical practices and informing future research. This study explored dental practitioners' approaches to the diagnosis and management of irreversible pulpitis, with a focus on the use of pulpotomy as a definitive treatment.</p><p><strong>Methods: </strong>An online \"Quick Poll\" cross-sectional survey was distributed to dental practitioners in the United States via the National Dental Practice-Based Research Network and in the United Kingdom through open online channels, including local dental networks, practice-based research networks, and social media platforms.</p><p><strong>Results: </strong>A total of 750 practitioners responded (USA: 416; UK: 334), most of whom were general dental practitioners with over 10 years of experience. Irreversible pulpitis was most diagnosed in 1-5 patients per month. Root canal therapy was the predominant treatment in both countries (USA: 77%; UK: 90%), with extraction frequently selected in the UK (50%). Pulpotomy was reported as a treatment strategy by 20% of USA and 16% of UK respondents, though a larger proportion expressed willingness to consider it as a definitive option (USA: 47%; UK: 87%).</p><p><strong>Conclusion: </strong>This preliminary study highlights the growing interest in therapeutic pulpotomy as a definitive treatment for teeth with signs and symptoms of irreversible pulpitis in permanent teeth in primary care. Differences in clinical adoption and attitudes between the USA and UK suggest opportunities for further research, education, and implementation support to facilitate the integration of vital pulp therapies into routine practice.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"13"},"PeriodicalIF":3.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-associated tongue discoloration: a comprehensive assessment of USFDA adverse event reporting system using disproportionality analysis.","authors":"Kannan Sridharan, Gowri Sivaramakrishnan","doi":"10.1038/s41405-026-00402-7","DOIUrl":"10.1038/s41405-026-00402-7","url":null,"abstract":"<p><strong>Background: </strong>Drug-induced tongue discoloration can impact quality of life but remain under-recognized. While several antimicrobials are implicated, comprehensive signals across many drug classes remain poorly characterized.</p><p><strong>Methods: </strong>Reports of tongue discoloration, strawberry tongue, and black hairy tongue were extracted from the USFDA Adverse Event Reporting System from 2004 to 2024. Disproportionality analysis was conducted using reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker to detect associations between implicated drugs and tongue conditions.</p><p><strong>Results: </strong>A total of 2352 reports were analyzed. Drugs consistently associated with tongue discoloration by both frequentist and Bayesian analyses included clarithromycin, metronidazole, linezolid, amoxicillin, and fluticasone. Flucloxacillin and immunoglobulin G emerged as risks for strawberry tongue. Meclizine showed a signal for black hairy tongue across methods, whereas other drugs appeared risk factors using only frequentist tests. Demographic patterns varied by condition.</p><p><strong>Conclusion: </strong>This comprehensive signal detection revealed several high-priority drug-tongue condition associations using large-scale pharmacovigilance data. Findings carry implications for guiding clinical practice through enhancing adverse effect monitoring for high-risk medications. Priority signals merit validation through further research to optimize benefit-risk assessment and reduce preventable tongue disorders.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":"12"},"PeriodicalIF":2.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}