BDJ Open最新文献

{"title":"Establishing a postgraduate programme in orthodontics in the Caribbean: governance, collaborations and challenges, at the University of the West Indies.","authors":"Trudee Hoyte","doi":"10.1038/s41405-026-00424-1","DOIUrl":"10.1038/s41405-026-00424-1","url":null,"abstract":"<p><strong>Objective: </strong>To describe the development and implementation of the first postgraduate orthodontic training programme in the English-speaking Caribbean and situate its establishment within international outlines for postgraduate dental education and global health workforce development.</p><p><strong>Methods: </strong>A descriptive analysis was undertaken of the governance processes, curriculum development and institutional collaborations involved in establishing a postgraduate orthodontic programme at The University of the West Indies (UWI). Programme development incorporated regional workforce needs assessment, stakeholder consultation and benchmarking against internationally recognised competency frameworks, including those of the UK Specialist Advisory Committee and European postgraduate orthodontic education guidelines.</p><p><strong>Results: </strong>The programme was developed through a multi-stage governance pathway within UWI and in collaboration with the Royal College of Surgeons of Edinburgh. A competency-based curriculum was constructed through structured mapping of programme learning outcomes to international orthodontic training standards. The three-year full-time programme integrates supervised clinical training, theoretical instruction and a research dissertation. Clinical training comprises approximately 24-28 hours weekly with structured workplace-based assessments and competency-based progression. Hybrid teaching models and international faculty support were introduced to address regional staffing limitations.</p><p><strong>Conclusions: </strong>The establishment of this programme represents a significant milestone in specialist dental education in the Caribbean. By combining international educational standards with regional contextual adaptation, the initiative provides a model for developing sustainable specialist training programmes in small-island and resource-constrained settings.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental, mandibular and parotid gland radiation doses in curatively treated head and neck squamous cell carcinoma: a retrospective cohort study.","authors":"Veera Emilia Kärkkäinen, Henna Hietala, Petri Koivunen, Juha Nikkinen, Kaisa Lehtiö","doi":"10.1038/s41405-026-00416-1","DOIUrl":"10.1038/s41405-026-00416-1","url":null,"abstract":"<p><strong>Background and purpose: </strong>Radiation therapy (RT) is a cornerstone of head and neck squamous cell carcinoma (HNSCC) treatment, often used alongside surgical approaches, delivering curative doses between 50-70 Gy. Pre-RT dental screenings aim to prevent oral complications by extracting teeth with poor prognosis, particularly in high-dose areas exceeding 40 Gy. The aim of the present study was to measure the planned radiation doses received on dentition during definitive or postoperative radiation therapy for HNSCC.</p><p><strong>Material and methods: </strong>This retrospective study analyzed 91 HNSCC cases treated with RT at Oulu University Hospital (2018-2021), assessing radiation doses to dentition, mandible, and parotid glands across different tumor sites.</p><p><strong>Results: </strong>Results showed that ipsilateral RT spared contralateral and frontal dental regions more effectively than bilateral RT, particularly in oral cavity and oropharyngeal cancers. Conversely, hypopharyngeal and laryngeal cancers rarely exposed dentition to doses above 40 Gy. Bilateral RT often exceeded the 40 Gy threshold in mandibular and parotid regions, particularly in oral cavity cancers, underscoring the need for precise dose planning to balance tumor control with oral health preservation.</p><p><strong>Conclusion: </strong>The findings highlight that ipsilateral RT can reduce the need for pre-RT dental extractions in contralateral regions and provide a basis for optimizing dental care strategies. By understanding dose distributions, balance can be addressed between minimizing oral health impacts and ensuring effective HNSCC treatment.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between systemic immune-inflammation index and periodontitis in adults with and without hyperlipidemia: a population-based study.","authors":"Ying Xie, Shuangying Zhou","doi":"10.1038/s41405-026-00422-3","DOIUrl":"10.1038/s41405-026-00422-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between SII and periodontitis, and to determine whether this association differs by hyperlipidemia status in adults.</p><p><strong>Methods: </strong>21,283 U.S. adults aged ≥18 years were enrolled from NHANES 1999-2014. Multivariable logistic regression models were employed to assess the association between SII and periodontitis while controlling for potential confounding factors. We further explored non-linear dose-response relationships using two-piecewise regression model to identify any threshold effect of SII on periodontitis risk. Robustness of the findings was evaluated through sensitivity analyses.</p><p><strong>Results: </strong>Periodontitis was prevalent in 6,758 individuals (31.75%). In stratified analyses, this pattern was evident among individuals with hyperlipidemia: we identified an inflection point at SII ≈ 522. Within the lower SII range, a 500-unit increment demonstrated an inverse association with periodontitis susceptibility, yielding a significant 18% risk reduction (OR = 0.82, 95% CI 0.68-0.99, P = 0.036). Conversely, in the upper SII spectrum, identical 500-unit increments corresponded to a substantial 15% heightened periodontitis risk (OR = 1.15, 95% CI 1.05-1.25, P = 0.002). A significant non-linear dose-response was found in hyperlipidemic individuals (P for threshold effect = 0.005). In contrast, among individuals without hyperlipidemia, no significant association between SII and periodontitis was detected. Sensitivity analyses, including the exclusion of participants with malignancies, stratification by sex and using alternative periodontitis definitions, yielded consistent results, reinforcing the robustness of our findings.</p><p><strong>Conclusions: </strong>SII demonstrated a non-linear association with periodontitis that was restricted to individuals with hyperlipidemia. In hyperlipidemic adults, moderate increases in SII (within a lower range) were associated with reduced odds of periodontitis, whereas an SII beyond ~522 was significantly associated with higher disease prevalence.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the shared genetic architecture between periodontitis and cardiovascular disease.","authors":"Ting Jin, Jinfeng Lin, Peng Zhang, Yu Lu, Shenguo Chen, Haisheng Lin","doi":"10.1038/s41405-026-00421-4","DOIUrl":"10.1038/s41405-026-00421-4","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological evidence supports the association between periodontitis and cardiovascular diseases (CVD); however, their shared genetic mechanisms remain inadequately defined. This study elucidates their genetic architecture by identifying shared risk loci and associated genes.</p><p><strong>Methods: </strong>This study employs Mendelian randomization (MR) to investigate bidirectional causal relationships between periodontitis and five types of CVD based on genome-wide association study (GWAS) summary data. Cross-trait analyses were applied to examine genetic correlations across trait pairs, identifying pleiotropic loci and associated genes. Functional annotation and tissue-specificity analyses elucidate their biological functions.</p><p><strong>Results: </strong>Bidirectional and multivariable MR analyses confirmed that the association between CVD and periodontitis is not driven by a direct causal relationship. Additionally, the genetic correlation between these disorders underscores the importance of investigating their shared genomic architecture. Colocalization analysis identified significant shared causal variants at loci 4p14 and 15q25.1. At the gene level, seven unique pleiotropic genes (e.g., CD151, POLR2L, and HLA-DQA1) were annotated. Pathway analysis revealed that these genetic architectures likely mediate cross-disease interactions through an inflammation-metabolism regulatory axis (Inflammatory Response and Cholesterol Metabolism Pathway). Tissue enrichment analyses demonstrated that pleiotropic signals, from SNP to gene levels, were significantly enriched in immune-related tissues and disease-relevant sites like the heart.</p><p><strong>Conclusion: </strong>This study reveals a shared genetic basis between periodontitis and five types of CVD, suggesting potential underlying mechanisms. However, based on summary-level data, it remains unclear whether this association represents direct biological genetic determinants or indirect pathways mediated by shared environmental or behavioral risk factors. Future studies utilizing individual-level data with covariate adjustments are needed to further investigate these relationships.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Evaluation of an intermediate minor oral surgery service in Plymouth, England and implications for future commissioning.","authors":"Amirali Ziaebrahimi, Robert Witton","doi":"10.1038/s41405-026-00401-8","DOIUrl":"10.1038/s41405-026-00401-8","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tool to measure the influence of social media on health behaviors: an exploratory study.","authors":"Chloé Rethaber, Clément Mathieu, Gabriel Fernandez de Grado, Damien Offner","doi":"10.1038/s41405-026-00417-0","DOIUrl":"10.1038/s41405-026-00417-0","url":null,"abstract":"<p><strong>Objectives: </strong>Social media is deeply embedded in our daily lives, particularly among younger generations. In the field of health, these platforms are both promising tools for prevention and channels for misinformation. This study aimed to develop and validate an exploratory measurement tool to quantify the influence of social media on health-related behaviors across three dimensions: social, economic, physical.</p><p><strong>Study design: </strong>Cross-sectional survey using a self-administered 15-item questionnaire.</p><p><strong>Methods: </strong>Items of the questionnaire were developed from literature and refined through expert consensus to cover social, economic, and physical dimensions of influence. Participants were voluntarily recruited in hospital waiting rooms in France; a subset completed the tool twice for reliability (test/retest). Analyses included Pearson correlations, Cronbach's alpha, Intraclass Correlation Coefficients, and Multiple Correspondence Analysis to identify user profiles.</p><p><strong>Results: </strong>Data were collected from 110 participants aged 18 to 81. The instrument demonstrated excellent internal consistency (Cronbach's alpha = 0.9), strong test-retest reliability (ICC = 0.93), and high score fidelity (Pearson r = 0.87). MCA revealed three user clusters: non-influenced older adults using Facebook, moderately influenced youth using Snapchat, and highly influenced young adults under 35 using Instagram and TikTok. Women and younger participants were more influenced economically and physically.</p><p><strong>Conclusions: </strong>This study highlights the growing influence of social media on health behaviors and introduces a reliable exploratory instrument to identify the most receptive populations. The tool can support targeted public health strategies and ethical engagement on digital platforms, especially for younger audiences frequently exposed to health-related content.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.","authors":"Pascal Fandrich, Felix Justus Stammler, Joachim Enax, Erik Schulze Zur Wiesche, Bennett T Amaechi, Helge-Otto Fabritius, Thomas Hellweg","doi":"10.1038/s41405-026-00414-3","DOIUrl":"10.1038/s41405-026-00414-3","url":null,"abstract":"<p><strong>Objective: </strong>Hydroxyapatite (HAP; Ca₅(PO₄)₃(OH)) is used in oral care formulations as a remineralizing agent and acts as a reservoir for calcium and phosphate ions. Consequently, HAP can serve as a neutralizing agent during acidic attacks caused by erosive beverages or cariogenic processes. This in vitro study aims to investigate the neutralization potential of HAP particles, used in oral care products, with a focus on changes in pH value, Ca²⁺ release, and structural integrity.</p><p><strong>Materials and methods: </strong>5.0% (w/v) particulate HAP was added to hydrochloric acid, phosphoric acid, citric acid, and lactic acid (37 °C, 0.1 M), as well as to Sprite® and Coca-Cola®, all under continuous stirring. pH values were measured after equilibration. Neutralization kinetics of HAP were investigated in Sprite® and Coca-Cola® within the first 30 s after addition of 0.15% (w/v), 0.5% (w/v), and 5.0% (w/v) HAP. Scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) were employed to investigate crystallite morphology and composition. Atomic absorption spectroscopy (AAS) was conducted to analyze Ca²⁺ release.</p><p><strong>Results: </strong>The investigated HAP shows a significant increase in pH in all systems and neutralizes between 98.0% and 99.9% of the acidic protons in the equilibrium. Up to 2619 mg L^-1 ± 48 mg L^-1 of Ca²⁺ are released in hydrochloric acid, while the porous particle structure remains unaffected. Kinetic investigation in beverages shows that already 0.15% (w/v) HAP neutralizes most of the dissociated acid within 20 s (83.9% in Sprite®, 98.7% in Coca-Cola®).</p><p><strong>Conclusions: </strong>The study shows that HAP used in oral care formulations can efficiently counteract acids by increasing pH value and releasing Ca²⁺ ions, while retaining its functional morphology.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of postoperative pain after endodontic treatment in molars with and without foraminal enlargement: a prospective randomized clinical trial.","authors":"Fabiana Menezes Galdino de Aragão, Carlos Eduardo da Silveira Bueno, Rina Andrea Pelegrine, Daniel Guimarães Pedro Rocha, Carlos Eduardo Fontana, Vini Mehta, Wayne Martins Nascimento, Ana Grasiela da Silva Limoeiro, Marilia Fagury Videira Marceliano-Alves, Alexandre Sigrist De Martin","doi":"10.1038/s41405-026-00412-5","DOIUrl":"10.1038/s41405-026-00412-5","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pain following endodontic treatment is a significant and common issue in daily clinical practice, frequently studied, and a source of concern for both patients and clinicians.</p><p><strong>Aim: </strong>This study aimed to evaluate postoperative pain and analgesic use after single-visit endodontic treatment with a reciprocating system with or without foraminal enlargement in mandibular molars with necrosis and apical periodontitis.</p><p><strong>Methods: </strong>Sixty patients undergoing endodontic treatment on mandibular molars were divided into two groups (n = 30): with foraminal enlargement (FE), with the working length set at 0.0 mm from the apex, and the other group without foraminal enlargement (WFE) at 1.0 mm short of the apex. Instrumentation was performed with the Wave One Gold System in a single-visit, rinsed with 2.5% sodium hypochlorite, and filled with a single cone and AH -Plus sealer. The patients were requested to rate their pain at 24, 48, 72 h, and 1 week on a visual analog scale (VAS) as nonexistent, mild, moderate, or severe, as well as to indicate the need for oral analgesics. The number of participants reporting pain was similar at both 24 and 48 h (p > 0.05).</p><p><strong>Results: </strong>Mean VAS scores were low in both groups at all time points, with no clinically meaningful between-group differences. At 72 h and 7 days, no participant in either experimental group reported pain. There was no statistically significant difference in the painkiller tablets taken between the experimental groups at any evaluated period.</p><p><strong>Conclusion: </strong>The frequency of postoperative pain and the number of analgesics taken by the patients were similar in the two experimental groups.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental students' perception of objective structured clinical examination (OSCE): a cross-sectional study.","authors":"Nissaf Daouahi, Sarra Nasri, Yosra Gassara, Rim Kallala, Jilani Saafi","doi":"10.1038/s41405-026-00413-4","DOIUrl":"10.1038/s41405-026-00413-4","url":null,"abstract":"<p><strong>Background: </strong>The Objective Structured Clinical Examination (OSCE) is increasingly used to assess clinical competence in dental education. Understanding students' perceptions of this assessment method is essential for improving its design and educational impact, particularly in fixed prosthodontics.</p><p><strong>Objective: </strong>To assess dental students' perceptions of OSCEs in Fixed Prosthodontics.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted in May 2025 at the Department of Fixed Prosthodontics, Faculty of Dentistry, Tunisia. Final-year dental students (n = 144) who completed a fixed prosthodontics OSCE were invited to participate. Data were collected anonymously using a structured online questionnaire administered via Google Forms and QR code. The questionnaire assessed students' perceptions of the OSCE in terms of clarity of instructions, organization, and stress level. Participation was voluntary.</p><p><strong>Results: </strong>A total of 144 final-year dental students completed the questionnaire. The response rate was 100%. The majority of respondents (87%) reported that the OSCE content and instructions were clearly explained. Similarly, 87.5% indicated that they felt comfortable with the examiners before the examination. Regarding time allocation, 36.1% of students reported a neutral perception, while 11.8% indicated that the time available at certain stations was insufficient. In terms of stress, 65.9% of respondents described the OSCE as moderately stressful. With respect to perceived difficulty, most students reported greater difficulty in the cognitive station (43.1%), followed by the communication and behavioural station (33.3%). Finally, 93% of respondents reported that the competencies assessed during the OSCE were aligned with the objectives of their clinical training.</p><p><strong>Conclusion: </strong>This study shows that students perceived the OSCE as an appropriate assessment method for clinical skills in fixed prosthodontics. They were generally satisfied with its clarity and organisation. However, they reported that some aspects should be improved, such as the timing and stress management.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the dentine microhardness following the application of different intracanal medicaments. An in-vitro study.","authors":"Sara Gamal Elgamal, Kareem Hamdy Ahmed Aly, Nadia Saeed Hosny","doi":"10.1038/s41405-026-00408-1","DOIUrl":"10.1038/s41405-026-00408-1","url":null,"abstract":"<p><strong>Background: </strong>Intracanal medications used during routine endodontic treatment and regenerative endodontic procedures might cause undesirable effects on tooth properties, such as a reduction in dentine microhardness.</p><p><strong>Objectives: </strong>To compare the effect of five intracanal medicaments; Bio-C Temp (Angelus, Brazil), modified triple antibiotic electrospun nanofibers (m-TAP) (NanoEbers, Egypt), Levofloxacin (Memphis, Egypt), Calcium hydroxide (CH) (Meta biomed, Korea) and Simvastatin (Merck & Co., USA) on the microhardness of radicular dentine.</p><p><strong>Methods: </strong>Forty-five extracted single-rooted teeth were decoronated to a 15 mm root length then prepared. The specimens were assigned to five groups according to the used intracanal medicament: Bio-C Temp, m-TAP nanofibers, Levofloxacin, CH, and Simvastatin. After medicament application for two weeks, dentine microhardness was measured using a Vickers microhardness tester. Data were analyzed using the Kruskal-Wallis and Mann-Whitney U tests with a significance level set at p < 0.05.</p><p><strong>Results: </strong>Bio-C Temp, and m-TAP nanofibers recorded the highest overall dentine microhardness values, followed by Levofloxacin and Simvastatin, while CH showed the lowest. Significant differences were observed among the tested groups at the coronal and middle levels (p < 0.05), whereas no significant difference was found apically.</p><p><strong>Conclusions: </strong>Bio-C Temp, and m-TAP nanofibers demonstrated superior ability to preserve dentine microhardness, suggesting their promising potential advantage over conventional medicaments for strengthening root dentine.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}