BDJ OpenPub Date : 2026-06-12DOI: 10.1038/s41405-026-00451-y
Megan Roberts, Rakhee Patel, Rebecca Ruth Wassall
{"title":"Domiciliary dental care: a scoping review of the literature.","authors":"Megan Roberts, Rakhee Patel, Rebecca Ruth Wassall","doi":"10.1038/s41405-026-00451-y","DOIUrl":"10.1038/s41405-026-00451-y","url":null,"abstract":"<p><strong>Aim: </strong>Domiciliary dental care is the provision of dental care for those patients who are unable to attend a clinic due to a disability or impairment. This scoping review aimed to identify developments in the literature regarding the provision of adult domiciliary dental care.</p><p><strong>Materials and methods: </strong>The Arksey and O'Malley framework was used and findings were reported in line with PRISMA-ScR. Subject specific library support was used to produce a search strategy using MeSH (Medical Subject Headings) terms and key words to identify studies published in English between January 2009 and October 2025 relevant to the topic area. Database searching of Medline, Embase, PsycINFO and CINAHL was conducted alongside hand searching.</p><p><strong>Results: </strong>In total, 45 primary research papers were included. Study types included qualitative research, observational studies and economic evaluations. Key themes identified included patient and staff reported barriers, facilitators to enable or improve domiciliary dental care and the role of dental team skill mix and education.</p><p><strong>Discussion: </strong>There is currently an absence of rigorous research into dental care in domiciliary settings, likely due to ethical, financial and logistical complexity of undertaking research in this area. Research that has currently been undertaken is mainly focused on older patients living in care facilities.</p><p><strong>Conclusions: </strong>Domiciliary dental care is an essential service for patients unable to attend a dental clinic due to a significant disability or impairment. Whilst a formal quality assessment of individual studies is not carried out in scoping review methodology, the results of this review identified a number of barriers to its provision. Appropriate risk assessment, education and the effective use of technology were identified as possible facilitators. Further research is needed to enable the provision of evidence-based care to this vulnerable population.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-06-10DOI: 10.1038/s41405-026-00450-z
Kanwalpreet Kaur, Syed Altafuddin Quadri, Ravinder S Saini, Mario Alberto Alarcón-Sánchez, Artak Heboyan
{"title":"Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic review and meta-analysis.","authors":"Kanwalpreet Kaur, Syed Altafuddin Quadri, Ravinder S Saini, Mario Alberto Alarcón-Sánchez, Artak Heboyan","doi":"10.1038/s41405-026-00450-z","DOIUrl":"10.1038/s41405-026-00450-z","url":null,"abstract":"<p><strong>Objective: </strong>Clear aligners have become a popular alternative to fixed appliances because they offer esthetic advantages and potential improvements in periodontal health and pain management while enhancing quality of life (QOL). This systematic review and meta-analysis investigated the effects of clear aligners versus fixed appliances on established outcomes.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in PubMed, Scopus, Cochrane Library, Embase, and ScienceDirect up to March 2025, along with gray literature and manual searching of key orthodontic journals. The eligible studies consisted of randomized controlled trials and observational studies that evaluated clear aligners against fixed appliances based on the plaque index (PI), gingival index (GI), probing depth (PD), pain intensity, and QOL. Researchers applied mean difference (MD) to PI, GI, and PD, while standardized mean difference (SMD) was used to evaluate pain intensity and QOL. Researchers evaluated heterogeneity using I² and publication bias while performing subgroup analyses centered on treatment duration.</p><p><strong>Results: </strong>Thirty-two studies were included in the systematic review, of which 28 were included in the meta-analysis. Clear aligners significantly improved periodontal outcomes compared to fixed appliances, as shown by lower PI scores (MD = -0.437, 95% CI: -0.507 to -0.367, p < 0.001), GI scores (MD = -0.233, 95% CI: -0.296 to -0.170, p < 0.001), and PD scores (MD = -0.332, 95% CI: -0.431 to -0.234, p < 0.001). Patients treated with clear aligners experienced less pain than those treated with fixed appliances, particularly during the early treatment phase (SMD = -0.419, p < 0.001). Clear aligners significantly improved the QOF of patients at 1 week (SMD = -0.985, p < 0.001), 1 month (SMD = -0.829, p < 0.001), and end of treatment (SMD = -0.970, p < 0.001) compared with fixed appliances. Low to moderate heterogeneity was observed between groups for pain outcomes, while high heterogeneity was observed for short-term QOF comparisons.</p><p><strong>Conclusion: </strong>Clear aligners resulted in favorable periodontal indices compared with those of fixed appliances. They also led to less early pain and better QOF than fixed appliances, although these differences were mostly observed at the beginning of treatment. Clinicians should interpret these results cautiously because of heterogeneity, the inclusion of observational evidence, potential publication bias, and small pooled effects.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-06-05DOI: 10.1038/s41405-026-00441-0
Shannu K Bhatia, Qabirul Abdullah
{"title":"Correlation between Grit score, academic achievement and learning approaches of dental students.","authors":"Shannu K Bhatia, Qabirul Abdullah","doi":"10.1038/s41405-026-00441-0","DOIUrl":"10.1038/s41405-026-00441-0","url":null,"abstract":"<p><strong>Background: </strong>Importance of non-cognitive skills such as Grit is being increasingly recognised. Grit is the perseverance and passion needed to achieve long-term goals in the face of challenges. This study examines the relationship between Grit scores, academic achievement and learning approaches of dental students METHODS: In this mixed method study, a validated Short Grit Scale was used to determine the Grit score of third year dental students (n = 62) and co-related to their assessment score. Relevant statistical analyses were done. Two focus groups were conducted of students with a higher Grit score (HG) and lower Grit score (LG). Thematic analysis was carried out to explore the differences in learning approaches.</p><p><strong>Results: </strong>Although there was no significant correlation between Grit and academic success, several differences between the higher and lower Grit groups were revealed in the qualitative phase. Major themes were motivation, personality characteristics that equip students to deal with challenges, self-directed learning, and role of peers.</p><p><strong>Conclusions: </strong>Dental students showed high Grit scores, but these were not associated with academic performance. Higher‑Grit students used deeper, more motivated learning strategies and coped better with pressures, whereas lower‑Grit students were more assessment‑driven. Grit appears to be a desirable construct to develop in students.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Awareness of oral health, hygiene practices, and chemotherapy-related oral manifestations among parents of pediatric oncology patients.","authors":"Vanshika Gandhi, Mansi Pal, Vathsala Patil, Radhika Garg, Deepak Kumar Singhal, Archana M V, Adarsh Kudva, Yogesh Chhaparwal, Nanditha Sujir","doi":"10.1038/s41405-026-00448-7","DOIUrl":"10.1038/s41405-026-00448-7","url":null,"abstract":"<p><strong>Background: </strong>Pediatric oncology patients are highly susceptible to oral complications during chemotherapy. Awareness amongst parents and oral hygiene practices play a crucial role in preventing and managing these issues.</p><p><strong>Aim: </strong>To assess parental knowledge and awareness about the oral hygiene practices and reported oral manifestations associated with chemotherapy in pediatric oncology patients.</p><p><strong>Materials and methods: </strong>This was a questionnaire-based cross-sectional study conducted in the Department of Pediatric Oncology over one year. Parents of 66 children aged 0-18 years completed a structured questionnaire covering dental care utilization, oral hygiene practices, awareness regarding oral health, pre-treatment dental status, and self-reported oral side effects after therapy.</p><p><strong>Results: </strong>Only 25.7% of children had ever visited a dentist, and 12.1% underwent dental evaluation before oncology treatment. While 57.6% brushed once daily, 51.5% required assistance, and 63.6% consumed snacks between meals. Parental awareness regarding the impact of diet and oral health on general health was low (30.3%). More than half of parents (57.6%) reported oral changes after the initiation of therapy, with oral ulcers (40.9%), difficulty eating (30.3%), and taste alteration (27.3%) being most common. Despite these symptoms, only 3% underwent dental treatment post-therapy initiation.</p><p><strong>Conclusion: </strong>The study reveals inadequate dental care utilization, suboptimal oral hygiene practices, and lack of awareness amongst parents of pediatric oncology patients. Routine dental screening, structured oral hygiene education, and multidisciplinary collaboration is essential to minimize oral complications and improve oral health during chemotherapy.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-27DOI: 10.1038/s41405-026-00449-6
K Julia Hurry, Tim Newton, Janet Davies, Vanessa Muirhead
{"title":"Comments on: \"The relationship between parental mental health and early childhood caries: a meta-analysis and systematic review\".","authors":"K Julia Hurry, Tim Newton, Janet Davies, Vanessa Muirhead","doi":"10.1038/s41405-026-00449-6","DOIUrl":"10.1038/s41405-026-00449-6","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-22DOI: 10.1038/s41405-026-00447-8
Shawn Ann Thomas, Supriya Nambiar, Mohammed Zuber, S M Abdul Khader, Athira V
{"title":"Correction: Understanding airflow dynamics: a computational study of nasal and oral breathers using patient-specific models.","authors":"Shawn Ann Thomas, Supriya Nambiar, Mohammed Zuber, S M Abdul Khader, Athira V","doi":"10.1038/s41405-026-00447-8","DOIUrl":"10.1038/s41405-026-00447-8","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-21DOI: 10.1038/s41405-026-00428-x
Pierre Alsayegh, Helen Rushdi Ayoubi, Yasser Alsayed Tolibah
{"title":"Impact of Triton solution irrigation protocol on root fracture resistance: a comparative in vitro study of different irrigation protocols.","authors":"Pierre Alsayegh, Helen Rushdi Ayoubi, Yasser Alsayed Tolibah","doi":"10.1038/s41405-026-00428-x","DOIUrl":"10.1038/s41405-026-00428-x","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of an irrigation protocol using Triton solution on the fracture resistance of treated root compared with other common irrigation protocols.</p><p><strong>Materials and methods: </strong>Sixty-four human mandibular premolars with single roots and single canals were decoronated to a length of 15 mm. The samples were prepared using the ProTaper system Universal Rotary System. The roots were randomly divided into four groups (n = 16 per group) according to the irrigation protocol used. In G1: (First experimental group), the canals were irrigated with Triton all-in-one irrigation during preparation and as a final irrigation. In G2: (Second experimental group), the canals were irrigated with 5.25% Sodium Hypochlorite (NaOCl) during preparation and 5.25% NaOCl + 17% Ethylenediaminetetraacetic acid (EDTA) + 2% Chlorhexidine (CHX) as a final irrigation. In G3: (Positive control group), the canals were irrigated with 5.25% NaOCl + distilled water. In G4: (Negative control group), the canals were irrigated with only distilled water. Each sample was tested for fracture on a universal testing machine at a crosshead speed of 1 mm/min. The fracture resistance of each sample was recorded, and the data were statistically analysed using a one-way ANOVA and Chi-square tests. The failure modes were observed and assessed. All data were analysed at a 95% confidence interval (α = 0.05).</p><p><strong>Results: </strong>The mean fracture resistance values ranged from 297.81 ± 61.39 N in G1 to 364.50 ± 84.38 N in G4, with no observed significant differences among the groups (p = 0.112). Regarding failure patterns, oblique fractures were the most frequently observed type, followed by vertical and comminuted fractures, with no significant differences in their distribution among the groups (p = 0.993).</p><p><strong>Conclusion: </strong>Roots treated with the Triton solution protocol demonstrated fracture resistance similar to those treated with common irrigation protocols.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-20DOI: 10.1038/s41405-026-00446-9
Romain Ceinos, Margaux Dubois, Jean-Pierre Attal, François Vigouroux, Yohann Flottes, Timothy Fasham, Elisabeth Dursun, Bruno Pelissier, Maria-Antonietta D'Agostino, Philippe François
{"title":"Light-curing units in restorative dentistry: a clinically oriented narrative review of performance, selection, and emerging optical functions.","authors":"Romain Ceinos, Margaux Dubois, Jean-Pierre Attal, François Vigouroux, Yohann Flottes, Timothy Fasham, Elisabeth Dursun, Bruno Pelissier, Maria-Antonietta D'Agostino, Philippe François","doi":"10.1038/s41405-026-00446-9","DOIUrl":"10.1038/s41405-026-00446-9","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize current evidence on dental light-curing units (LCUs), focusing on their radiometric performance, clinical selection criteria, and emerging optical functionalities.</p><p><strong>Methods: </strong>This narrative review was conducted in accordance with the SANRA recommendations. A structured search of PubMed/MEDLINE was performed to identify publications addressing the technological evolution of light-curing units, the parameters guiding device selection, clinical optimization and safety considerations, as well as the integration of fluorescence, transillumination and beam-shaping adjunctive features within contemporary systems.</p><p><strong>Results: </strong>LED LCUs have become the clinical standard, evolving from monowave to polywave devices to better match both Norrish type II and type I photoinitiators. Across technologies, the effectiveness of curing depends on the delivered radiant exposure, spectral compatibility, beam homogeneity and effective tip diameter rather than the manufacturer-reported irradiance. Clinical determinants (distance, angulation, maintenance, battery state and training) strongly modulate the delivered energy. Thermal and ocular hazards must be addressed through controlled protocols and protective measures. Multifunctional LCUs integrating fluorescence-aided identification and transillumination functions and interchangeable tips may support diagnosis and workflow optimization, but independent evidence remains limited.</p><p><strong>Conclusions: </strong>Curing should be approached as controlled energy delivery. Reliability depends on the radiant exposure, spectral compatibility and beam geometry rather than the nominal irradiance. Third-generation polywave LED LCUs appear to be the most versatile reference option for routine practice, particularly when the photoinitiator system of the material is unknown or includes Norrish type I initiators. The clinical value of integrated diagnostic and beam-shaping functions remains to be independently validated.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-19DOI: 10.1038/s41405-026-00445-w
Naji Ziad Arandi, Fatima Qtait
{"title":"Self-perception of dental aesthetics and social media influence among students at a Palestinian dental school.","authors":"Naji Ziad Arandi, Fatima Qtait","doi":"10.1038/s41405-026-00445-w","DOIUrl":"10.1038/s41405-026-00445-w","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate dental students' self-perception of dental aesthetics, aesthetic treatment preferences, and the perceived influence of social media and to examine whether these outcomes differed by sex and training stage.</p><p><strong>Methods: </strong>An online cross-sectional survey was conducted among undergraduate dental students at the Faculty of Dentistry, Arab American University, Palestine. A total of 246 students were selected via stratified random sampling by academic year and completed a structured questionnaire. Subgroup analyses were performed by sex and training stage.</p><p><strong>Results: </strong>Composite resin was the preferred restorative material (87.4%), and natural white (A1-A2) was the most preferred anterior shade (79.3%). Teeth whitening was the most common aesthetic treatment (40.2%). Instagram was the main platform for viewing aesthetic dental content (80.5%); 70.7% reported a moderate-to-very strong social media influence on their ideal smile, and 47.2% considered an aesthetic procedure after exposure to social media content. In subgroup analyses, female participants reported greater dissatisfaction with gingival display. Clinical-stage students more often notice gingival defects and are more likely to judge social media-driven aesthetic outcomes as not clinically achievable under routine practice conditions.</p><p><strong>Conclusion: </strong>Dental students reported generally positive self-perceptions and strong preferences for natural, tooth-coloured aesthetics, alongside high exposure to social media and substantial perceived influence. Differences by sex and training stage suggest that aesthetic awareness and expectations may evolve with clinical experience. These findings highlight the importance of supporting students in critically evaluating online aesthetic content and communicating clinically feasible outcomes.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BDJ OpenPub Date : 2026-05-15DOI: 10.1038/s41405-026-00442-z
Kanwalpreet Kaur, Ravinder S Saini, Mohamed Saheer Kuruniyan, Rayan Ibrahim H Binduhayyim, V N V Madhav, Sunil Kumar Vaddamanu, Mario Alberto Alarcón-Sánchez, Artak Heboyan
{"title":"Fluoride release and mechanical properties of S-PRG fillers in dental materials: a systematic review and meta-analysis.","authors":"Kanwalpreet Kaur, Ravinder S Saini, Mohamed Saheer Kuruniyan, Rayan Ibrahim H Binduhayyim, V N V Madhav, Sunil Kumar Vaddamanu, Mario Alberto Alarcón-Sánchez, Artak Heboyan","doi":"10.1038/s41405-026-00442-z","DOIUrl":"10.1038/s41405-026-00442-z","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aimed to assess the fluoride release and selected mechanical properties (direct tensile strength [DTS], flexural strength, and wear resistance) of S-PRG-containing dental materials.</p><p><strong>Method: </strong>A search was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar according to the PRISMA guidelines. Qualitative data were pooled narratively, and quantitative data were synthesized statistically in RevMan 5.4 using a random-effects meta-analysis. Subgroup analyses of DTS and flexural strength were conducted where appropriate. The risk of bias was assessed using the QUIN tool, and GRADE was used to assess the certainty of the evidence.</p><p><strong>Results: </strong>Of the 216 studies identified, 18 were deemed eligible. Seven studies provided quantitative fluoride-release data for the meta-analysis. The meta-analysis revealed an overall statistically significant difference between S-PRG-containing materials and comparators (mean difference: -3.21; 95% CI: -4.12 to -2.30; p < 0.01) with very high heterogeneity between studies (I² = 98%). Subgroup meta-analyses of mechanical property comparisons revealed pooled estimates of 6.50 and 11.20 for the DTS and flexural strength comparisons, respectively. Both comparisons showed extreme heterogeneity between studies. Most studies demonstrated a moderate risk of bias, and the certainty of evidence was low.</p><p><strong>Conclusion: </strong>Owing to their composition, S-PRG-containing materials might have the potential for fluoride release and may have different mechanical properties compared to comparator materials. Nevertheless, there is insufficient evidence owing to the extreme heterogeneity and high number of in vitro studies. Therefore, the interpretation of these findings should be made with caution, and future investigations should use standardized testing protocols and well-designed clinical trials.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}