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Global Burden of Cardiovascular Diseases in Young Adults Aged 20-24 Years, from 1990-2021: An Analysis of the Global Burden of Disease Study 2021 1990-2021年20-24岁年轻人心血管疾病全球负担:2021年全球疾病负担研究分析
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-01-09 DOI: 10.1016/j.cjco.2025.12.016
Yixue Zhao PhD, Jianping Li MD
{"title":"Global Burden of Cardiovascular Diseases in Young Adults Aged 20-24 Years, from 1990-2021: An Analysis of the Global Burden of Disease Study 2021","authors":"Yixue Zhao PhD,&nbsp;Jianping Li MD","doi":"10.1016/j.cjco.2025.12.016","DOIUrl":"10.1016/j.cjco.2025.12.016","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular diseases (CVDs) remain a leading global health threat, with young adults (aged 20-24 years) increasingly affected, despite a historical research focus on older populations. This study investigates global, regional, and national CVD burden trends in this age group from 1990 to 2021 using the Global Burden of Disease Study 2021.</div></div><div><h3>Methods</h3><div>Age-standardized prevalence rate (ASPR), incidence rate (ASIR), death rate (ASDR), and disability-adjusted life years (DALYs) were analyzed for CVDs in those aged 20-24 years. Trends were stratified by sex, region, and sociodemographic index (SDI) levels.</div></div><div><h3>Results</h3><div>Globally, ASIR and ASPR have risen steadily since 1990, accelerating post-2000, whereas the ASDR and DALYs declined after 2006. Female patients exhibited a higher incidence and prevalence, whereas male patients bore greater mortality and DALY burdens. Low and low-middle SDI regions (eg, Oceania, Sub-Saharan Africa, North Africa and the Middle East) faced the highest burdens. Eritrea led in ASIR and ASPR; Nauru had the highest ASDR and DALYs. Ischemic heart disease dominated mortality and DALYs; rheumatic heart disease had the highest prevalence (greater in female patients); and stroke impacted male patients disproportionately.</div></div><div><h3>Conclusions</h3><div>Despite reduced mortality and DALYs, rising CVD incidence and prevalence in young adults—particularly in low-SDI settings—signals a growing public health crisis. Targeted preventive measures, early screening, and health promotion are critical to address this emerging challenge.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 882-893"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Unified Framework for Heart Failure with Nonreduced Ejection Fraction 非降低射血分数心力衰竭的统一框架
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-05-07 DOI: 10.1016/j.cjco.2026.04.016
Mena Gewarges MD, MA, FRCPC
{"title":"A Unified Framework for Heart Failure with Nonreduced Ejection Fraction","authors":"Mena Gewarges MD, MA, FRCPC","doi":"10.1016/j.cjco.2026.04.016","DOIUrl":"10.1016/j.cjco.2026.04.016","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 791-792"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incomplete Endothelialization, at 2 Years and 8 Months Postimplantation, of a WATCHMAN Left Atrial Appendage Closure Device WATCHMAN左心耳关闭装置植入后2年8个月不完全内皮化
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-02-28 DOI: 10.1016/j.cjco.2026.02.018
Satoko Ryuzaki MD, PhD, Yusuke Kondo MD, PhD, Takanori Aihara MD, Jun-ichiro Ikeda MD, PhD, Hironobu Nishiori MD, Goro Matsumiya MD, PhD, Yoshio Kobayashi MD, PhD
{"title":"Incomplete Endothelialization, at 2 Years and 8 Months Postimplantation, of a WATCHMAN Left Atrial Appendage Closure Device","authors":"Satoko Ryuzaki MD, PhD,&nbsp;Yusuke Kondo MD, PhD,&nbsp;Takanori Aihara MD,&nbsp;Jun-ichiro Ikeda MD, PhD,&nbsp;Hironobu Nishiori MD,&nbsp;Goro Matsumiya MD, PhD,&nbsp;Yoshio Kobayashi MD, PhD","doi":"10.1016/j.cjco.2026.02.018","DOIUrl":"10.1016/j.cjco.2026.02.018","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 894-896"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Nurse Practitioner–Led Care on Health-Related Quality of Life in Adult Patients with Atrial Fibrillation—A Randomized Controlled Trial 执业护士主导护理对成年房颤患者健康相关生活质量的影响——一项随机对照试验
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-04-08 DOI: 10.1016/j.cjco.2026.03.018
Marcie J. Smigorowsky BScN, MN, PhD, RN, NP, CCN(C), Ross T. Tsuyuki BSc(Pharm), PharmD, MSc, FCSHP, FACC, FCAHS, ISHF
{"title":"The Effect of Nurse Practitioner–Led Care on Health-Related Quality of Life in Adult Patients with Atrial Fibrillation—A Randomized Controlled Trial","authors":"Marcie J. Smigorowsky BScN, MN, PhD, RN, NP, CCN(C),&nbsp;Ross T. Tsuyuki BSc(Pharm), PharmD, MSc, FCSHP, FACC, FCAHS, ISHF","doi":"10.1016/j.cjco.2026.03.018","DOIUrl":"10.1016/j.cjco.2026.03.018","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is associated with significant morbidity, mortality, and healthcare resource utilization. Health system limitations can result in delays to specialty cardiovascular (CV) care. Nurse practitioner (NP)-led care may improve access and quality of care. The purpose of this study was to assess the effect of NP-led care compared to usual cardiologist care on quality of life in patients with AF.</div></div><div><h3>Methods</h3><div>Patients with AF referred to a specialized cardiac clinic were randomized to NP-led or usual cardiologist care for 6 months. Primary outcome was the difference in change in atrial fibrillation effect on quality of life (AFEQT) scores at 6 months between groups. Secondary outcomes were difference in change of EuroQOL EQ-5D-3L scores at 6 months between groups, composite outcome of death from CV causes, hospitalizations, emergency department visits, and patient satisfaction measured by the Consultant Satisfaction Questionnaire (CSQ) at 6 months.</div></div><div><h3>Results</h3><div>We enrolled 150 subjects<strong>,</strong> with 10% loss to follow-up. Study subjects were 62% male, with a mean age of 64 years, and an overall AFEQT baseline score of 66.45 ±4:86. No significant baseline differences between groups were present. AFEQT scores, EQ-5D-3L, and CV outcomes were not different at 6 months; NP-led care showed higher patient satisfaction in the CSQ domain of professional care (76.32 ± 11.32 vs 65.75 ± 15.45, <em>P</em> = 0.0006).</div></div><div><h3>Conclusions</h3><div>We found no difference in quality of life or CV outcomes at 6 months with NP-led care vs usual cardiologist care. NP-led care resulted in higher levels of patient satisfaction. Further research is needed to explore the effect of NP-led AF care in CV settings.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT02745236.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 808-816"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anabolic Steroids and the Silent Risk: Fulminant Heart Failure in a Woman After Therapeutic Nandrolone Use 合成代谢类固醇和无声风险:治疗性使用诺龙后女性暴发性心力衰竭
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2025-12-30 DOI: 10.1016/j.cjco.2025.12.007
Kaliana Maria Nascimento Dias de Almeida MD, Diandro Marinho Mota MD, Hugo Ribeiro Ramadan MD, Yasmin Erlichman Manganelli Junqueira MD, Thalita Oliveira Silvano Amaral MD, Paul Morales MD
{"title":"Anabolic Steroids and the Silent Risk: Fulminant Heart Failure in a Woman After Therapeutic Nandrolone Use","authors":"Kaliana Maria Nascimento Dias de Almeida MD,&nbsp;Diandro Marinho Mota MD,&nbsp;Hugo Ribeiro Ramadan MD,&nbsp;Yasmin Erlichman Manganelli Junqueira MD,&nbsp;Thalita Oliveira Silvano Amaral MD,&nbsp;Paul Morales MD","doi":"10.1016/j.cjco.2025.12.007","DOIUrl":"10.1016/j.cjco.2025.12.007","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 787-790"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Junctional Rhythms After Transcatheter Aortic Valve Implantation: Incidence, Temporal Patterns, and Clinical Outcomes 经导管主动脉瓣植入术后的神经节律:发生率、时间模式和临床结果
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-03-18 DOI: 10.1016/j.cjco.2026.03.005
Grégoire Massoullié MD, PhD, Margot Kachkach MD, Samuel Adelou MSc, Antoine Boudias MD, Frederic Jean MD, Pierre-Antoine Catalan MD, Saer Abu-Alrub MD, Nicolas Combaret MD, Bruno Pereira PhD, Géraud Souteyrand MD, Romain Eschalier MD, PhD
{"title":"Junctional Rhythms After Transcatheter Aortic Valve Implantation: Incidence, Temporal Patterns, and Clinical Outcomes","authors":"Grégoire Massoullié MD, PhD,&nbsp;Margot Kachkach MD,&nbsp;Samuel Adelou MSc,&nbsp;Antoine Boudias MD,&nbsp;Frederic Jean MD,&nbsp;Pierre-Antoine Catalan MD,&nbsp;Saer Abu-Alrub MD,&nbsp;Nicolas Combaret MD,&nbsp;Bruno Pereira PhD,&nbsp;Géraud Souteyrand MD,&nbsp;Romain Eschalier MD, PhD","doi":"10.1016/j.cjco.2026.03.005","DOIUrl":"10.1016/j.cjco.2026.03.005","url":null,"abstract":"<div><h3>Background</h3><div>Conduction disturbances are common after transcatheter aortic valve implantation (TAVI), yet the clinical implications of junctional rhythm (JR) remain poorly characterized. We aimed to assess the incidence, temporal characteristics, and clinical outcomes associated with JR occurring after TAVI.</div></div><div><h3>Methods</h3><div>We conducted a prospective study including all TAVI patients at Clermont-Ferrand University Hospital between December 2023 and April 2025. Patients who developed JR were identified, and a propensity score was used to match them in a 1:3 ratio with patients without JR.</div></div><div><h3>Results</h3><div>Among 616 TAVI procedures, JR was identified in 26 patients (4.2%). The mean time to onset was 41 ± 22 hours after TAVI, with a mean junctional rate of 71 ± 12 beats per minute. At baseline, no significant differences were present in clinical, electrocardiographic, or procedural characteristics between patients with vs without JR. The incidence of in-hospital high-grade atrioventricular block did not differ significantly between groups (11.5% vs 10.3%, <em>P</em> = 0.48). Permanent pacemaker implantation occurred in 38.5% of JR patients (10 of 26) vs 16.7% of controls (13 of 78; <em>P</em> = 0.02). JR was consistently asymptomatic and transient, and its morphology suggested either Hisian or infra-Hisian origin.</div></div><div><h3>Conclusions</h3><div>JR after TAVI appeared to be an infrequent and transient phenomenon. Although pacemaker implantation was more frequent among JR patients, no excess of documented high-grade atrioventricular block was observed. The higher pacemaker rate appeared to be related primarily to precautionary management decisions. These findings require confirmation in larger multicentre cohorts.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 842-850"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression As an Independent Predictor of Nonadherence to Cardiac Rehabilitation in a Latin American Country 在一个拉丁美洲国家,抑郁是心脏康复不依从性的独立预测因子
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-03-19 DOI: 10.1016/j.cjco.2026.02.023
Hernán G. Rincón-Hoyos MD, MPH, Juan Esteban Aponte-Arroyo MD, María Cardozo Rengifo MD, Roger Figueroa Paz MSc, Gabriela Caicedo Samboní Medical Student, MD, Valentina Calderón Sánchez Medical Student, MD, Salomé Cardona Giraldo MD, Ángela Murillo PT, Orlando Quintero Florez MD, Juan Carlos Rivas Nieto MD, PhD
{"title":"Depression As an Independent Predictor of Nonadherence to Cardiac Rehabilitation in a Latin American Country","authors":"Hernán G. Rincón-Hoyos MD, MPH,&nbsp;Juan Esteban Aponte-Arroyo MD,&nbsp;María Cardozo Rengifo MD,&nbsp;Roger Figueroa Paz MSc,&nbsp;Gabriela Caicedo Samboní Medical Student, MD,&nbsp;Valentina Calderón Sánchez Medical Student, MD,&nbsp;Salomé Cardona Giraldo MD,&nbsp;Ángela Murillo PT,&nbsp;Orlando Quintero Florez MD,&nbsp;Juan Carlos Rivas Nieto MD, PhD","doi":"10.1016/j.cjco.2026.02.023","DOIUrl":"10.1016/j.cjco.2026.02.023","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular diseases are the leading cause of mortality worldwide, and the primary cause of death from noncommunicable diseases in Colombia. Cardiac rehabilitation programs (CRPs) are effective strategies to reduce cardiovascular mortality, improve functional capacity, and decrease healthcare costs. However, their success depends on patient adherence, which remains suboptimal, particularly in low- and middle-income countries where CRPs are underutilized and understudied. The prognostic impact of anxiety and depression on adherence remains largely unexplored in such countries, where socioeconomic, cultural, and healthcare access barriers may amplify their impact.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study including patients aged ≥ 18 years who entered a CRP at a Colombian teaching hospital<u>,</u> between 2004 and 2014. Baseline anxiety and depression were measured using the Hospital Anxiety and Depression Scale. Adherence was defined as attending ≥ 30 of 36 sessions. Nested logistic regression models examined the prognostic association between anxiety, depression, and nonadherence, adjusting for demographic and clinical variables.</div></div><div><h3>Results</h3><div>Among 3659 patients (median age 62 years; 66.2% male), overall nonadherence reached 51.1%. Anxiety was present in 27.9% of patients, and depression in 16.5%. Depression independently predicted nonadherence (odds ratio 1.14; 95% confidence interval: 1.00-1.31), after adjustment for confounders. Anxiety lost its statistical significance in adjusted models (odds ratio 1.06; 95% confidence interval: 0.95-1.19).</div></div><div><h3>Conclusions</h3><div>Depression at program entry is a modifiable independent predictor of nonadherence in a Latin American CRP. Routine psychological screening and early management of depressive symptoms could enhance adherence and optimize CRPs' effectiveness in resource-limited settings.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 851-860"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic Characteristics Associated with PCSK9 Inhibitor Use in Individuals with Possible Familial Hypercholesterolemia in Alberta: A Cohort Study 艾伯塔省可能的家族性高胆固醇血症患者使用PCSK9抑制剂相关的社会人口学特征:一项队列研究
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-03-12 DOI: 10.1016/j.cjco.2026.03.002
Samuel E. Fineblit MD, FRCPC, David M. Vickers PhD, David J.T. Campbell MD, MSc, PhD, FRCPC
{"title":"Sociodemographic Characteristics Associated with PCSK9 Inhibitor Use in Individuals with Possible Familial Hypercholesterolemia in Alberta: A Cohort Study","authors":"Samuel E. Fineblit MD, FRCPC,&nbsp;David M. Vickers PhD,&nbsp;David J.T. Campbell MD, MSc, PhD, FRCPC","doi":"10.1016/j.cjco.2026.03.002","DOIUrl":"10.1016/j.cjco.2026.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Proprotein convertase subtilisin/kinase type 9 inhibitors (PCSK9is) significantly lower low-density lipoprotein cholesterol (LDL-c) level and improve cardiovascular outcomes, but they remain underutilized, potentially due to access-related barriers. This study examines clinical and sociodemographic factors associated with PCSK9i prescriptions in Alberta, Canada.</div></div><div><h3>Methods</h3><div>A population-based study was conducted using data from the Alberta Kidney Disease Network. Adults with possible familial hypercholesterolemia (LDL-c ≥ 5 mmol/L) and suboptimal LDL-c control despite high-intensity statin therapy were included. Individuals with ≥ 3 dispensations of PCSK9i formed the treatment cohort. Multivariable logistic regression analysis was performed based on the identified variables, including neighbourhood income, material and social deprivation, sex, age, urban vs rural residence, and specialist involvement.</div></div><div><h3>Results</h3><div>Among 15,286 eligible individuals, only 150 (0.98%) were prescribed PCSK9is. In multivariable analysis, those receiving PCSK9is were less likely to be female (adjusted odds ratio (OR) 0.50, 95% confidence interval (CI) [0.30, 0.81], <em>P</em> = 0.005), had higher baseline LDL-c levels (adjusted OR 1.47, CI [1.23, 1.74], <em>P</em> &lt; 0.001), had higher rates of atherosclerotic cardiovascular disease (adjusted OR 5.58, CI [1.63, 14.50], <em>P</em> = 0.003), and were more likely to have seen a specialist physician (adjusted OR 6.64, CI [2.69, 21.50], <em>P</em> &lt; 0.001). They were also more likely to reside in a higher-income neighbourhood.</div></div><div><h3>Conclusions</h3><div>PCSK9is are markedly under-prescribed in patients with severe hypercholesterolemia in Alberta. Prescription patterns have distinct differences by sex, specialist access, and neighbourhood income. Policy changes to improve equitable access, especially for disadvantaged populations, may help to reduce cardiovascular risk and improve outcomes.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 861-867"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality After Cardiovascular Surgery and Procedures During the COVID-19 Pandemic in Ontario, Canada: A Retrospective Cohort Study 加拿大安大略省COVID-19大流行期间心血管手术和手术后死亡率:一项回顾性队列研究
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-03-10 DOI: 10.1016/j.cjco.2026.03.001
Yuchen Dai MD, Anna Chu MHSc, J. Michael Paterson MSc, Xuesong Wang MSc, Maneesh Sud MD, PhD, Stephen Fremes MD, Joshua G. Lee BSc, Louise Y. Sun MD, SM
{"title":"Mortality After Cardiovascular Surgery and Procedures During the COVID-19 Pandemic in Ontario, Canada: A Retrospective Cohort Study","authors":"Yuchen Dai MD,&nbsp;Anna Chu MHSc,&nbsp;J. Michael Paterson MSc,&nbsp;Xuesong Wang MSc,&nbsp;Maneesh Sud MD, PhD,&nbsp;Stephen Fremes MD,&nbsp;Joshua G. Lee BSc,&nbsp;Louise Y. Sun MD, SM","doi":"10.1016/j.cjco.2026.03.001","DOIUrl":"10.1016/j.cjco.2026.03.001","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 disrupted global healthcare delivery, but its impact on cardiovascular procedure volumes and outcomes remains unclear. We compared rates and outcomes of coronary artery bypass grafting (CABG), isolated open valve (iValve) surgery, combined CABG and valve, other cardiac surgeries, transcatheter aortic valve implantation (TAVI), and percutaneous coronary intervention (PCI) before and during the pandemic.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used ICES health administrative data to identify all adults (aged ≥ 18 years) with Ontario Health Insurance Plan coverage who underwent cardiac surgery, TAVI, or PCI between April 2018 and March 2022. The primary outcomes—procedure rates and 30-day all-cause mortality—were compared between the pre-COVID period (April 1, 2018-March 31, 2020) and the COVID period (April 1, 2020-March 31, 2022), the latter using multivariable logistic regression. Secondary outcomes included hospital length of stay and 30-day readmission.</div></div><div><h3>Results</h3><div>A total of 41,511 cardiac surgeries, 7138 TAVIs, and 86,549 PCIs were analyzed. During the COVID period, procedure rates declined for CABG (−18.8%), iValve (−19.3%), and PCI (−14.7%), whereas TAVI rates increased by 21.4%. Adjusted 30-day mortality increased for CABG (1.92 [95% confidence interval [CI] 1.69-2.15] to 2.25 [95% CI 2.01-2.49] per 100 procedures; <em>P</em> = 0.043), iValve (2.25 [95% CI 1.78-2.71] to 3.29 [95% CI 2.76-3.82]; <em>P</em> = 0.016), and PCI (2.41 [95% CI 2.28-2.54] to 2.74 [95% CI 2.60-2.88]; <em>P</em> &lt; 0.001), but remained stable for TAVI. One excess death during the COVID period occurred per 303 CABGs, 96 iValves, and 303 PCIs.</div></div><div><h3>Conclusions</h3><div>Although CABG, iValve, and PCI volumes declined and 30-day mortality increased during the pandemic, the absolute number of additional deaths remained small.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"8 7","pages":"Pages 817-827"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148546785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medium to Long-Term Patient-Oriented Effectiveness of Surgical or Percutaneous Revascularization in Diabetes and Severe Coronary Artery Disease 手术或经皮血运重建术治疗糖尿病和严重冠状动脉疾病的中长期疗效观察
IF 2.1
CJC Open Pub Date : 2026-07-01 Epub Date: 2026-03-02 DOI: 10.1016/j.cjco.2026.02.017
Dominique Vervoort MD, MPH, MBA, Yuchen Dai MD, Anan Bader Eddeen MSc, Meltem Tuna PhD, Peter C. Austin PhD, Maral Ouzounian MD, PhD, Stephen Fremes MD, MSc, Douglas S. Lee MD, PhD, Harindra C. Wijeysundera MD, PhD, Louise Y. Sun MD, SM
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