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Inflammatory Mediators in Pericardial Fluid in Patients Undergoing Cardiac Surgery 心脏手术患者心包液中的炎症介质
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.001
Junsu Lee BSc , Nicole Travis BSc , Benjamin King BSc , Angel Luis Fernandez MD, PhD , Ali Fatehi Hassanabad MD, PhD , Paul W.M. Fedak MD, PhD , Marc Pelletier MD , Mohammad El-Diasty MD, PhD
{"title":"Inflammatory Mediators in Pericardial Fluid in Patients Undergoing Cardiac Surgery","authors":"Junsu Lee BSc ,&nbsp;Nicole Travis BSc ,&nbsp;Benjamin King BSc ,&nbsp;Angel Luis Fernandez MD, PhD ,&nbsp;Ali Fatehi Hassanabad MD, PhD ,&nbsp;Paul W.M. Fedak MD, PhD ,&nbsp;Marc Pelletier MD ,&nbsp;Mohammad El-Diasty MD, PhD","doi":"10.1016/j.cjco.2024.11.001","DOIUrl":"10.1016/j.cjco.2024.11.001","url":null,"abstract":"<div><div>The pericardial space provides a homeostatic environment that facilitates optimal cardiac function. The pericardial space contains pericardial fluid (PCF) and other tissue sources, including pericardial adipose tissue and the great vessels. Given its proximity to the heart, PCF has emerged as a potential diagnostic, prognostic, and therapeutic vehicle. As such, the biochemical and humoral characteristics of PCF have recently been the focus of several studies. Evidence shows that the PCF is a rich reservoir for various hormones, cytokines, adhesion molecules, and multiple other substances. This review aims to better understand the pericardial microenvironment, focusing on the kinetic and dynamic changes that govern different inflammatory molecules in the PCF in patients undergoing cardiac surgery. Our electronic search yielded 7 studies that reported the changes in PCF levels of interleukin (IL)-1, IL-6, IL-8, IL-10, tumour necrosis factor (TNF)α, interferon (IFN)γ, and vascular endothelial growth factor (VEGF) during or in the immediate postoperative period after cardiac surgery. Although it was not possible to make direct comparisons of inflammatory marker levels across studies because of inconsistencies in their reporting, we aimed to identify dynamic changes in pericardial levels of these inflammatory mediators, with a focus on their potential role in the development of postoperative inflammatory response.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 193-202"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Electrical Synchronization Achieved With Dynamic Atrioventricular Delays During Biventricular and Left Ventricular MultiPoint Pacing 双室和左室多点起搏时动态房室延迟实现急性电同步
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.003
Bernard Thibault MD , Peter Waddingham MD , Nima Badie PhD , Jan O. Mangual PhD , Luke C. McSpadden PhD , Tim R. Betts MD , Leonardo Calò MD , Domenico Grieco MD , Francisco Leyva MD , Anthony Chow MD
{"title":"Acute Electrical Synchronization Achieved With Dynamic Atrioventricular Delays During Biventricular and Left Ventricular MultiPoint Pacing","authors":"Bernard Thibault MD ,&nbsp;Peter Waddingham MD ,&nbsp;Nima Badie PhD ,&nbsp;Jan O. Mangual PhD ,&nbsp;Luke C. McSpadden PhD ,&nbsp;Tim R. Betts MD ,&nbsp;Leonardo Calò MD ,&nbsp;Domenico Grieco MD ,&nbsp;Francisco Leyva MD ,&nbsp;Anthony Chow MD","doi":"10.1016/j.cjco.2024.11.003","DOIUrl":"10.1016/j.cjco.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac resynchronization therapy (CRT) response relies on 2 factors: when and where to pace. These factors may be enhanced by dynamic atrioventricular delays (AVDs) (eg, SyncAV CRT, Abbott Cardiovascular, Abbott Park, IL) and multisite left ventricular (LV) pacing (eg, MultiPoint Pacing [MPP], Abbott). Their individual and combined synchronization contributions have not been evaluated across a comprehensive spectrum of pacing configurations. The objective is to distinguish the acute electrical synchrony achieved by static vs dynamic AVDs, single-site vs multisite LV pacing, and with vs without right ventricular (RV) pacing.</div></div><div><h3>Methods</h3><div>CRT-indicated patients with left bundle branch block (LBBB) and intact atrioventricular (AV) conduction (PR &lt; 250 ms) were enrolled and evaluated during implant. Acute changes in 12-lead electrocardiographic (ECG) QRS duration (QRSd) were evaluated during intrinsic conduction, biventricular pacing (BiV), biventricular MPP, LV-only single-site pacing (LVSS), and LV-only MPP (LVMPP). CRT modes were evaluated with static AVDs and optimized SyncAV AVDs.</div></div><div><h3>Results</h3><div>CRT implant and QRSd evaluation were completed in 85 patients (71% male, 34% ischemic, 179 ms PR). The median intrinsic QRSd of 165 ms was reduced by BiV, MPP, LVSS, and LVMPP without SyncAV to 144 ms (by 14%), 142 ms (16%), 155 ms (8%), and 149 ms (12%), respectively (<em>P</em> &lt; 0.01 vs intrinsic). BiV + SyncAV, MPP + SyncAV, LVSS + SyncAV, and LVMPP + SyncAV reduced the intrinsic QRSd significantly further to 128 ms (by 23%), 124 ms (26%), 131 ms (21%), and 129 ms (24%) (<em>P</em> &lt; 0.0001, each corresponding pair).</div></div><div><h3>Conclusions</h3><div>MPP combined with SyncAV achieved the narrowest QRSd, in the overall population and in the most patients, by delivering ventricular pacing from all available sites (RV + LV1 + LV2) while timed with dynamic AVDs.</div></div><div><h3>Clinical Registration Number</h3><div>NCT03567096.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 166-175"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midventricular Takotsubo Cardiomyopathy Following COVID-19 Infection: Diagnostic Role of Cardiac Magnetic Resonance Tissue Mapping COVID-19感染后中心室Takotsubo心肌病:心脏磁共振组织测绘的诊断作用
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.016
Yoshito Kadoya MD, PhD, Bethlehem Mengesha MD, Luc Michel Beauchesne MD, Aun Yeong Chong MD, Marino Labinaz MD, D. Ian Paterson MD
{"title":"Midventricular Takotsubo Cardiomyopathy Following COVID-19 Infection: Diagnostic Role of Cardiac Magnetic Resonance Tissue Mapping","authors":"Yoshito Kadoya MD, PhD,&nbsp;Bethlehem Mengesha MD,&nbsp;Luc Michel Beauchesne MD,&nbsp;Aun Yeong Chong MD,&nbsp;Marino Labinaz MD,&nbsp;D. Ian Paterson MD","doi":"10.1016/j.cjco.2024.11.016","DOIUrl":"10.1016/j.cjco.2024.11.016","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 141-144"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medial Dissection Following Balloon Angioplasty in Peripheral Pulmonary Artery Stenosis Harbouring Homozygous RNF213 p.Arg4810Lys Variant 含有纯合子RNF213 p.Arg4810Lys变异的外周肺动脉狭窄球囊成形术后内侧剥离
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.011
Takatoyo Kiko MD, PhD , Ryotaro Asano MD, PhD , Tomohiko Ishibashi MD, PhD , Jin Ueda MD , Akihiro Tsuji MD, PhD , Keiko Ohta-Ogo MD, PhD , Yoshikazu Nakaoka MD, PhD , Takeshi Ogo MD, PhD
{"title":"Medial Dissection Following Balloon Angioplasty in Peripheral Pulmonary Artery Stenosis Harbouring Homozygous RNF213 p.Arg4810Lys Variant","authors":"Takatoyo Kiko MD, PhD ,&nbsp;Ryotaro Asano MD, PhD ,&nbsp;Tomohiko Ishibashi MD, PhD ,&nbsp;Jin Ueda MD ,&nbsp;Akihiro Tsuji MD, PhD ,&nbsp;Keiko Ohta-Ogo MD, PhD ,&nbsp;Yoshikazu Nakaoka MD, PhD ,&nbsp;Takeshi Ogo MD, PhD","doi":"10.1016/j.cjco.2024.11.011","DOIUrl":"10.1016/j.cjco.2024.11.011","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 161-165"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of a Multidisciplinary Cardiogenic Shock Team in a Nonacademic Canadian Heart Centre: An Implementation Study 多学科心源性休克小组在加拿大非学术心脏中心的实施:一项实施研究
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.007
Dana El-Mughayyar MSc , Terrel Marshall BASc , Kenneth D’Souza PhD , Jeffrey B. MacLeod BSc , Amanda McCoy BNRN , Susan Morris BNRN Med , Meaghan Smith MNRN , Christopher W. White MD, PhD, FRCSC , Shreya Sarkar PhD , Keith R. Brunt PhD , Jean-François Légaré MD, FRCPSC, CIP
{"title":"Implementation of a Multidisciplinary Cardiogenic Shock Team in a Nonacademic Canadian Heart Centre: An Implementation Study","authors":"Dana El-Mughayyar MSc ,&nbsp;Terrel Marshall BASc ,&nbsp;Kenneth D’Souza PhD ,&nbsp;Jeffrey B. MacLeod BSc ,&nbsp;Amanda McCoy BNRN ,&nbsp;Susan Morris BNRN Med ,&nbsp;Meaghan Smith MNRN ,&nbsp;Christopher W. White MD, PhD, FRCSC ,&nbsp;Shreya Sarkar PhD ,&nbsp;Keith R. Brunt PhD ,&nbsp;Jean-François Légaré MD, FRCPSC, CIP","doi":"10.1016/j.cjco.2024.11.007","DOIUrl":"10.1016/j.cjco.2024.11.007","url":null,"abstract":"<div><h3>Background</h3><div>In this study we evaluated our ability to implement team-based cardiogenic shock (CS-Team), focussing on: 1) early screening; 2) CS-Team activation; and 3) use of invasive monitoring to guide therapy.</div></div><div><h3>Methods</h3><div>All patients admitted to the coronary care unit (CCU) over 12 months were screened for CS. A diagnosis of CS was made when both hypotension and hypoperfusion were present. The CS-Team was composed of the CCU attending, an interventional cardiologist, and a cardiac surgeon. Multivariate analysis was carried out with mortality as the outcome of interest.</div></div><div><h3>Results</h3><div>Screening was documented in 74% (1160 of 1562) of patients admitted to a critical care unit; of these, 1080 were not in CS. We identified 80 patients in CS (Society for Cardiovascular Angiography &amp; Interventions [SCAI] stages C-E), which represented 6.9% of all screened patients. Patients in CS had significantly higher in-hospital mortality (35% vs 2%, <em>P</em> &lt; 0.0001). CS-Team was activated in 35 of 80 patients (44%). CS-Team activation resulted in significantly greater use of invasive monitoring (pulmonary artery catheter [49% vs 7%, <em>P</em> &lt; 0.0001], cardiac catheterization [94% vs 76%, <em>P</em> &lt; 0.032], and mechanical circulatory support [51% vs 2%, <em>P</em> &lt; 0.001]). Independent predictors of mortality were severity of CS (SCAI grades D or E) (odds ratio [OR] 18.78, 95% confidence interval [CI] 4.89-96.65) and age, in years (OR 1.07, 95% CI 1.01-1.14), whereas CS-Team was not predictive of mortality (OR 0.66, 95% CI 0.16-2.41).</div></div><div><h3>Conclusions</h3><div>We found that: 1) early screening by frontline staff was feasible but had limitations (26% screening failure); 2) CS-Team activation appeared discretionary (limited activation to 45% of patients); and 3) CS-Team activation resulted in a significant increase in the use of invasive monitoring that helped guide therapy.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 231-238"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The COVID-19 Pandemic Did Not Negatively Impact Adherence to Cardiovascular Medications Among 548,601 Chronically Treated Patients in Alberta 在艾伯塔省548601名慢性治疗患者中,COVID-19大流行并未对心血管药物的依从性产生负面影响
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.10.014
Finlay A. McAlister MD, MSc , Anamaria Savu PhD , Luan Manh Chu PhD , Douglas C. Dover PhD , Padma Kaul PhD
{"title":"The COVID-19 Pandemic Did Not Negatively Impact Adherence to Cardiovascular Medications Among 548,601 Chronically Treated Patients in Alberta","authors":"Finlay A. McAlister MD, MSc ,&nbsp;Anamaria Savu PhD ,&nbsp;Luan Manh Chu PhD ,&nbsp;Douglas C. Dover PhD ,&nbsp;Padma Kaul PhD","doi":"10.1016/j.cjco.2024.10.014","DOIUrl":"10.1016/j.cjco.2024.10.014","url":null,"abstract":"<div><h3>Background</h3><div>Studies have suggested that the COVID-19 pandemic negatively impacted patient adherence with chronic medications. We explored whether adherence patterns changed in patients chronically treated with cardiovascular drugs after onset of the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study we examined drug dispensation data for all adult Albertans who were chronic users of at least 1 cardiovascular drug class between 2017 and 2023. We calculated each patient’s proportion of days covered (PDC) for each drug class in the prepandemic phase (March 15, 2018 to March 14, 2020) and the pandemic phase (March 15, 2020 to March 14, 2022), and used generalized estimating equation logistic regression to estimate the effect of time period on achievement of good adherence (PDC &gt;0.8) after adjusting for age, sex, socioeconomic status, and comorbidities.</div></div><div><h3>Results</h3><div>Of 548,601 chronic users of at least 1 cardiovascular drug class between March 15, 2018 and March 14, 2022, 47.2% were women, the mean age was 62.3 years, and 55.4% had Charlson Comorbidity Index (CCI) scores of 0. The most frequently dispensed cardiovascular drugs were angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (67.6%) and statins (53.8%); the most frequent diagnoses were hypertension (77.2%), diabetes mellitus (30.6%), and ischemic heart disease (19.6%). Chronic users of cardiovascular drugs were more likely to have PDC &gt;0.8 during the pandemic than in the prepandemic period: 75.4% vs 72.8%, with adjusted odds ratios ranging from 1.05 (95% confidence interval 1.00-1.11) for mineralocorticoid receptor antagonists to 1.16 (95% confidence interval 1.15-1.17) for statins.</div></div><div><h3>Conclusions</h3><div>Chronic users of cardiovascular drugs exhibited better adherence during the COVID-19 pandemic than before the pandemic.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 203-210"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Inaccurate Blood Pressure Measurement on Hypertension Prevalence 血压测量不准确对高血压患病率的影响
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.10.011
Alexander A. Leung MD, MPH , Swapnil Hiremath MD, MPH , Jeanne V.A. Williams MSc , Ross T. Tsuyuki BSc (Pharm), PharmD, MSc
{"title":"Implications of Inaccurate Blood Pressure Measurement on Hypertension Prevalence","authors":"Alexander A. Leung MD, MPH ,&nbsp;Swapnil Hiremath MD, MPH ,&nbsp;Jeanne V.A. Williams MSc ,&nbsp;Ross T. Tsuyuki BSc (Pharm), PharmD, MSc","doi":"10.1016/j.cjco.2024.10.011","DOIUrl":"10.1016/j.cjco.2024.10.011","url":null,"abstract":"<div><h3>Background</h3><div>The cornerstone of the management of hypertension is accurate measurement of blood pressure (BP). A recent study showed that more than one-half of home BP devices sold in Canada have no evidence of validation for accuracy. The purpose of this study was to model the implications of inaccurate BP measurements on diagnosis and control of hypertension.</div></div><div><h3>Methods</h3><div>We used data from the Canadian Health Measures Survey to model the effects of inaccurate BP devices by 5 or 10 mm Hg over or under the true BP value. Hypertension was defined as BP ≥ 140/90 mm Hg (or ≥130/80 mm Hg in those patients with diabetes).</div></div><div><h3>Results</h3><div>If both systolic and diastolic BP were overestimated by 10 mm Hg, the prevalence of hypertension would falsely increase by 50% to 63%, potentially leading to overtreatment of approximately 3.5 million Canadians. Conversely, the impact of underestimation of BP appeared minimal, but mostly because of design limitations of our study.</div></div><div><h3>Conclusions</h3><div>We found that overestimation of BP by only 10 mm Hg could lead to overtreatment of up to 3.5 million Canadians. Government should mandate the validation of BP devices before they can be sold; until then, clinicians and patients should be cautious in their selection of BP devices, using the Hypertension Canada Recommended Device Program to guide selection.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 239-246"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Femoral Vein Pulsatility and Neurocognitive Disorder in Cardiac Surgery 心脏手术中股静脉搏动与神经认知障碍
IF 2.5
CJC Open Pub Date : 2025-02-01 DOI: 10.1016/j.cjco.2024.11.002
Ali Hammoud RN, MSc , Tanya Mailhot RN, PhD , Melissa Parent MD , Karel Huard MD , Olivier Lachance MD , Patrick Tawil MD , Alexander Calderone MD , Sylvie Levesque MSc , Stéphanie Jarry RN, MSc , William Beaubien-Souligny MD, PhD , Étienne J. Couture MD , André Y. Denault MD, PhD
{"title":"Femoral Vein Pulsatility and Neurocognitive Disorder in Cardiac Surgery","authors":"Ali Hammoud RN, MSc ,&nbsp;Tanya Mailhot RN, PhD ,&nbsp;Melissa Parent MD ,&nbsp;Karel Huard MD ,&nbsp;Olivier Lachance MD ,&nbsp;Patrick Tawil MD ,&nbsp;Alexander Calderone MD ,&nbsp;Sylvie Levesque MSc ,&nbsp;Stéphanie Jarry RN, MSc ,&nbsp;William Beaubien-Souligny MD, PhD ,&nbsp;Étienne J. Couture MD ,&nbsp;André Y. Denault MD, PhD","doi":"10.1016/j.cjco.2024.11.002","DOIUrl":"10.1016/j.cjco.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Neurocognitive disorder and venous congestion are related in cardiac surgery. Femoral vein (FV) Doppler allows noninvasive assessment of venous congestion. This study aims to associate postoperative neurocognitive disorder in cardiac surgery with FV pulsatility.</div></div><div><h3>Method</h3><div>A secondary analysis was conducted using data from retrospective and prospective cohorts. FV Doppler and neurocognitive disorder were measured upon admission to the intensive care unit (ICU) after surgery. An index of FV pulsatility of ≥ 50% was considered abnormal. The presence of neurocognitive disorder was assessed using the Intensive Care Delirium Score Checklist (ICDSC). Descriptive statistical analyses and logistic regression were used to test the association between FV Doppler pulsatility and neurocognitive disorder.</div></div><div><h3>Results</h3><div>A total of 273 patients from both cohorts were analyzed, 155 (57%) patients had FV pulsatility indexes ≥ 50%. Abnormal pulsatile Doppler was associated with the presence of neurocognitive disorder compared with normal FV Doppler profile (57 vs 43%, odds ratio [OR], 1.73; 95% confidence interval [CI], 1.06-2.81). FV pulsatility was also associated with age, higher rate of stroke, prolongation of intubation duration and a longer ICU stay.</div></div><div><h3>Conclusions</h3><div>FV pulsatility is associated with the presence of neurocognitive disorder and postoperative complications in cardiac surgery. The FV Doppler technique is simple and fast, offering the potential to anticipate complications related to venous congestion, such as delirium. Future multicentre studies with larger samples will be necessary to consolidate these findings.</div></div><div><h3>Clinical Registration Number</h3><div><span><span>NCT04092855</span><svg><path></path></svg></span> and <span><span>NCT05038267</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 2","pages":"Pages 187-192"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Patients with Myocardial Injury After Noncardiac Surgery: A Retrospective Chart Review 非心脏手术后心肌损伤患者的处理:回顾性图表回顾。
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.004
Michael Ke Wang MD , Denise Sabac BHSc MSc , Roshan Sadhak MD , Amy Ajay MD , Myles Benayon MD , Flavia K. Borges MD, PhD , Yevin Cha MD , David Conen MD, MPH , Michael Coomber MD, CCFP , Katherine Fuller MD , Diljit Gill MD , Rahul Jayachandiran MD , Carol Koubaesh MD , Lekhini Latchupatula MD , Sabreena Moosa MD , Sandra Ofori MD, PhD , Keerthana Pasumarthi MD , Ameen Patel MD , Saif Samari MD , Steffen Blum MD, PhD , Maura Marcucci MD, MSc
{"title":"Management of Patients with Myocardial Injury After Noncardiac Surgery: A Retrospective Chart Review","authors":"Michael Ke Wang MD ,&nbsp;Denise Sabac BHSc MSc ,&nbsp;Roshan Sadhak MD ,&nbsp;Amy Ajay MD ,&nbsp;Myles Benayon MD ,&nbsp;Flavia K. Borges MD, PhD ,&nbsp;Yevin Cha MD ,&nbsp;David Conen MD, MPH ,&nbsp;Michael Coomber MD, CCFP ,&nbsp;Katherine Fuller MD ,&nbsp;Diljit Gill MD ,&nbsp;Rahul Jayachandiran MD ,&nbsp;Carol Koubaesh MD ,&nbsp;Lekhini Latchupatula MD ,&nbsp;Sabreena Moosa MD ,&nbsp;Sandra Ofori MD, PhD ,&nbsp;Keerthana Pasumarthi MD ,&nbsp;Ameen Patel MD ,&nbsp;Saif Samari MD ,&nbsp;Steffen Blum MD, PhD ,&nbsp;Maura Marcucci MD, MSc","doi":"10.1016/j.cjco.2024.10.004","DOIUrl":"10.1016/j.cjco.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial injury after noncardiac surgery (MINS) is associated with an increased incidence of cardiac morbidity and mortality. Little is known about how these patients are managed.</div></div><div><h3>Methods</h3><div>We performed a single-centre retrospective chart review of patients referred to a postoperative clinic with the diagnosis of MINS. Patients were included if they attended the clinic at least once between September 2018 and December 2019. We extracted preoperative, in-hospital, and postdischarge data on cardiac investigations and medication use.</div></div><div><h3>Results</h3><div>Of the 152 patients with MINS who were included, 34% had a history of coronary disease before MINS. The median peak high-sensitivity troponin I (hsTnI) level was 122 ng/L (interquartile range, 51–259), and 78% had no associated ischemic symptoms or electrocardiographic changes. Patients underwent echocardiography and nuclear stress imaging in 87% and 30% of cases, respectively. Of those who had cardiac investigations performed and no prior history of coronary artery disease, 23% (19 of 84) had ≥ 1 regional wall-motion abnormality on echocardiogram, and 39% (13 of 34) had evidence of ischemia on nuclear stress imaging. More patients were prescribed an antithrombotic and lipid-lowering drug at discharge (79%) and at their final clinic visit (86%), compared to the number before surgery (30%). A total of 57% of patients had changes made to ≥ 1 cardiovascular medication during clinic follow-up.</div></div><div><h3>Conclusions</h3><div>Patients with MINS followed in a postoperative clinic frequently had abnormal cardiac investigations and received medical optimization. Our findings suggest that postoperative clinics may represent an opportunity for risk mitigation after MINS, a possibility that deserves further evaluation.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 103-109"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Ambulatory Continuous Inotropes as a Bridge to Recovery in Advanced Heart Failure Secondary to Amphetamine-Induced Cardiomyopathy 探索动态持续肌力作为安非他明诱发心肌病继发晚期心力衰竭恢复的桥梁。
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.013
Asma Babar MD, MSc , Bastien Vallée-Marcotte PhD , Anton Savin MD , Mathieu Bernier MD , Kim O’Connor MD , Mario Sénéchal MD
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