CJC Open最新文献

{"title":"The Effect of Gender-Related Factors in the Association Between Hypertensive Disorders of Pregnancy and White Matter Hyperintensities","authors":"A. Angarita-Fonseca, M. Marcotte, A. Kaur, H. Behlouli, M. Rajah, L. Pilote","doi":"10.1016/j.cjco.2025.04.063","DOIUrl":"10.1016/j.cjco.2025.04.063","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Page S18"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Preliminary Validation of the Coronary Artery Disease Education Questionnaire for Postpartum Women With Pregnancy-Related Complications (CADE-Q-PP): A Modified Delphi Approach","authors":"G. Lima de Melo Ghisi, L. Cotie, K. Nerenberg, S. Gundy, G. Smith, C.L. Pollock, K. Fleming, T.J.F. Colella","doi":"10.1016/j.cjco.2025.04.030","DOIUrl":"10.1016/j.cjco.2025.04.030","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages S5-S6"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Diversity on Cardiac Magnetic Resonance in a Han Family With Fabry Disease","authors":"Jialin Li MSc , Jie Wang MD , Yucheng Chen MD","doi":"10.1016/j.cjco.2025.03.017","DOIUrl":"10.1016/j.cjco.2025.03.017","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 736-739"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Digital Tool to Improve Family Engagement in Acute Care: The NGAGE Randomized Pilot Feasibility Trial","authors":"Jean Pierre Abdallah BSc ,&nbsp;Sara B.A. Morel DEC ,&nbsp;Nataliya Soboleva BSc, MSc, NP ,&nbsp;Jessica Quan BSN ,&nbsp;Chella Price BSc ,&nbsp;Michael Goldfarb MD, MSc","doi":"10.1016/j.cjco.2025.03.007","DOIUrl":"10.1016/j.cjco.2025.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Engaging families in care is an important aspect of healthcare delivery. Our interdisciplinary team designed the NGAGE (for “family eNGAGEment”) tool to empower family members to increase their engagement in patient care. The objective of this study was to assess the feasibility of use of the NGAGE tool.</div></div><div><h3>Methods</h3><div>We conducted a single-centre, pilot, feasibility randomized controlled trial in the acute cardiac unit of a tertiary-care academic hospital. Family members of admitted patients were randomized in a 1:1 manner to the intervention (use of the NGAGE tool) or usual-care group. Intervention group participants could request engagement activities using the NGAGE tool and this request was transmitted to the treating healthcare team. At enrollment, demographics and family engagement scores were captured. At discharge, data on care satisfaction, mental health, and engagement were collected. Recruitment rate, intervention uptake, tool use, requests fulfilled, and follow-up rate were used to assess feasibility outcomes.</div></div><div><h3>Results</h3><div>A total of 88 participants (45 intervention, 43 control) were included in the analysis. The mean recruitment rate was 2.9 participants per week. In the intervention group, 69% of participants used the NGAGE tool (1.5 ± 0.9 uses per participant). Most engagement requests (39 of 47; 83.0%) were fulfilled. Follow-up data were available for 76% of participants (67 of 88). Family members who used the NGAGE tool improved their family engagement score. No between-group differences occurred in mental health or satisfaction at follow-up (all <em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>We found evidence to suggest that implementation of the NGAGE tool was feasible. The results will inform the design of a multicentre effectiveness trial of use of the NGAGE tool.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT05528185.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 743-749"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Risk-Prediction Tool for Emergency Department Patients with Symptoms of Coronary Artery Disease: A Research Study Protocol","authors":"Andrew D. McRae MD, PhD ,&nbsp;Aysha J. Macci BSc ,&nbsp;Jessalyn K. Holodinsky PhD ,&nbsp;Tolulope T. Sajobi PhD ,&nbsp;James E. Andruchow MD, MSc ,&nbsp;Bjug Borgundvaag MD, PhD ,&nbsp;Steven Brooks MD, MSc ,&nbsp;Ivy Cheng MD, PhD ,&nbsp;Saswata Deb MD, PhD ,&nbsp;Patrick Fok MD ,&nbsp;Peter A. Kavsak PhD ,&nbsp;Michelle M. Graham MD, MSc ,&nbsp;Jacques Lee MD, MSc ,&nbsp;Shelley L. McLeod PhD ,&nbsp;Frank Scheuermeyer MD, MHSc ,&nbsp;Venkatesh Thiruganasambandamoorthy MD, MSc ,&nbsp;Hana Wiemer MD ,&nbsp;Justin W. Yan MD, MSc ,&nbsp;Corinne M. Hohl MDCM, MHSc ,&nbsp;Canadian Emergency Department Research Network (CEDRN) and the Network of Canadian Emergency Researchers (NCER)","doi":"10.1016/j.cjco.2025.03.016","DOIUrl":"10.1016/j.cjco.2025.03.016","url":null,"abstract":"<div><div>Patients with chest pain and symptoms of acute coronary syndromes account for &gt; 600,000 emergency department (ED) visits annually in Canada. Of these patients, 85% do not have acute coronary syndromes, and most are discharged from the ED after a thorough evaluation. However, a large proportion of these patients are referred for outpatient cardiac testing after ED discharge, even though their short-term risk of major adverse cardiac events (MACE), including death, new myocardial infarction, and need for revascularization, is very small. These referrals contribute to substantial low-value healthcare utilization, and limit access for those patients who are more likely to benefit from objective testing.</div><div>Existing risk-prediction tools—developed prior to the advent of new high-sensitivity cardiac troponin assays—were derived in nonrepresentative populations, and when applied to ED patients with low cardiac troponin concentrations, systematically overestimate the short-term risk of MACE.</div><div>This multicentre prospective cohort study will enroll ED patients with chest pain to derive and validate a novel risk prediction tool that distinguishes patients at low risk of MACE who do not require further cardiac testing from those who may benefit from additional cardiac testing. We will enroll 6500 patients in 13 Canadian EDs and prospectively follow them to ascertain a primary outcome of MACE within 30 days after their index ED encounter. The risk-prediction tool developed in this project will guide the safe, efficient, and appropriate referral of ED patients with chest pain.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT06743672.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 777-783"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of The Left Subclavian Artery Originating Anomalously From the Main Pulmonary Artery","authors":"Qiaozhen Li MD,&nbsp;Weiqi Wang MD,&nbsp;Xiaoyuan Feng MD","doi":"10.1016/j.cjco.2025.03.010","DOIUrl":"10.1016/j.cjco.2025.03.010","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 807-808"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Location of Terminal Care in Pulmonary Hypertension","authors":"Ramzi Ibrahim MD ,&nbsp;Adam Habib MD ,&nbsp;April Olson MD ,&nbsp;Farah Shrourou ,&nbsp;Hoang Nhat Pham MD ,&nbsp;Mahmoud Abdelnabi MBBCh, MSc ,&nbsp;Maryam Emami Neyestanak PhD ,&nbsp;Sabrina Soin DO ,&nbsp;See-Wei Low MD ,&nbsp;Bhupinder Natt MD ,&nbsp;Mamas A. Mamas BMBCh, MA, DPhil, FRCP ,&nbsp;Timothy Barry BMBCh, BAO ,&nbsp;Chadi Ayoub MBBS, PhD ,&nbsp;Reza Arsanjani MD ,&nbsp;Franz P. Rischard MD ,&nbsp;Kwan Lee MD","doi":"10.1016/j.cjco.2025.03.026","DOIUrl":"10.1016/j.cjco.2025.03.026","url":null,"abstract":"<div><h3>Background</h3><div>Death locations for individuals in the US is influenced by social factors. Pulmonary hypertension (PH) is an uncommon condition, with a substantial impact on morbidity and mortality. We evaluated the patterns in and impact of demographics on PH death locations in the US.</div></div><div><h3>Methods</h3><div>From 2005 to 2020, our study identified PH-related deaths through the CDC repository. Patient-level demographic data for the year 2019 were directly queried from the CDC. Locations of death were categorized into 4 groups, as follows: inpatient; outpatient and/or emergency room (ER); home; and hospice and/or nursing facilities. Linear regression models were used to assess trends in proportion of deaths across these locations. Multivariable logistic regression models examined the influence of demographics on the likelihood of death occurring in each location.</div></div><div><h3>Results</h3><div>Between 2005 and 2020, a rise occurred in the proportion of deaths at home (β = 0.006, <em>P</em> &lt; 0.001) and in hospice and/or nursing facilities (β = 0.005, <em>P</em> &lt; 0.001). The odds of dying at home or in hospice and/or nursing facilities increased with age (<em>P</em> &lt; 0.001). Male decedents were more likely than female decedents to die in an outpatient and/or ER setting (odds ratio [OR] 1.22, <em>P</em> = 0.047) and at home (OR 1.16, <em>P</em> = 0.005). Compared to White decedents, Black decedents had higher odds of death in the inpatient (OR 1.99, <em>P</em> &lt; 0.001) and the outpatient and/or ER (OR 1.38, <em>P</em> = 0.007) settings, but lower odds of death at home (OR 0.63, <em>P</em> &lt; 0.001) or in hospice and/or nursing facilities (OR 0.46, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our analysis revealed a significant difference in the locations of death for patients with PH in recent years, as influenced by demographic factors.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 832-839"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes After Mitral Valve Replacement in Sex- and Age-Matched Patients With vs Without Mitral Annular Calcification","authors":"Rosalind Groenewoud MD ,&nbsp;Sorush Rokui MD ,&nbsp;Byron H. Gottschalk MD ,&nbsp;Defen Peng PhD ,&nbsp;Nicholas Sinclair MD ,&nbsp;Jian Ye MD","doi":"10.1016/j.cjco.2025.02.011","DOIUrl":"10.1016/j.cjco.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Mitral annular calcification (MAC) portends the need for a technically challenging mitral valve surgery and is associated with poor outcomes after mitral valve replacement (MVR). No study has compared long-term outcomes for patients with vs without MAC in age- and sex-matched cohorts.</div></div><div><h3>Methods</h3><div>Between 2000 and 2017, a total of 67 patients with MAC who underwent MVR were age- and sex-matched 1:3 with patients with other etiologies without MAC to create a study cohort of 268. An extended Cox regression model was used to investigate long-term outcomes of patients with MAC, compared to those with other mitral etiologies.</div></div><div><h3>Results</h3><div>The groups were matched for age (MAC, 70.5 years; non-MAC, 70.4 years) and sex (MAC, 61.2% male; non-MAC, 61.7% male). MAC was not a risk factor for 1-year mortality. After 1 year, MAC was an independent risk factor for reduced survival (hazard ratio 2.781, 95% confidence interval 1.642-4.709, <em>P</em> &lt; 0.001). The 5-year and 10-year survival rates were significantly lower in the MAC group than they were in the non-MAC group (5-year: 51.0% ± 6.9% vs 74.6% ± 3.1%; 10-year: 40.1% ± 8.0% vs 51.8% ± 4.1%, <em>P</em> &lt; 0.001). Peripheral vascular disease was the only independent risk factor for both early mortality and reduced long-term survival, and chronic renal failure was a strong independent risk factor for 1-year mortality.</div></div><div><h3>Conclusions</h3><div>In an age- and sex-matched cohort, patients with MAC have similar early outcomes, but poorer long-term survival following MVR, compared to those without MAC, suggesting that MVR can be performed safely in selected patients with MAC. MAC and PVD are independent risk factors for reduced long-term survival.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 5","pages":"Pages 649-656"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Ischemic Preconditioning for Electrical Cardioversion of Atrial Fibrillation—the Prospective Randomized PRECON-AF Study","authors":"Christoph Keim BSc ,&nbsp;Lilli Wiedenmann BSc ,&nbsp;Tim Schubert BSc ,&nbsp;Moritz Rothe MD ,&nbsp;Bianca C. Dobre MD ,&nbsp;Bernhard M. Kaess MD ,&nbsp;Joachim R. Ehrlich MD ,&nbsp;Andreas A. Boehmer MD","doi":"10.1016/j.cjco.2025.03.004","DOIUrl":"10.1016/j.cjco.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>Electrical cardioversion (ECV) is highly effective in restoring sinus rhythm in patients with atrial fibrillation (AF), but it does not influence long-term rhythm control. Remote ischemic preconditioning (RIPC) has demonstrated various cardioprotective effects. Combining ECV with RIPC could provide a promising approach to minimizing AF recurrences after successful ECV.</div></div><div><h3>Methods</h3><div>This prospective, randomized, single-blinded, single-centre study investigated the impact of RIPC on early AF recurrence following successful ECV (defined as sinus rhythm ≥ 30 seconds). Patients were randomized in a 1:1 ratio to receive either RIPC or sham preconditioning before ECV. RIPC was performed in a standardized manner, with 3 cycles of 5-minute forearm ischemia followed by 5 minutes of reperfusion. The primary efficacy endpoint was AF recurrence after 30 days. Safety endpoints included death, stroke, and procedure-related complications. Secondary endpoints were acute ECV success, mean energy, and number of shocks required to restore sinus rhythm.</div></div><div><h3>Results</h3><div>A total of 240 patients were enrolled. Of these, 214 (89%) had successful ECV. At follow-up, the RIPC group did not show a lower AF recurrence rate, compared to that in the sham group (39% vs 36%, <em>P</em> = 0.63), and no effect of RIPC on cardioversion parameters was seen. One stroke occurred in the RIPC group. The study was terminated before the number of prespecified follow-up visits was reached, due to determination of futility.</div></div><div><h3>Conclusions</h3><div>RIPC did not impact the short-term rhythm-control or cardioversion procedure in patients with AF undergoing ECV.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT05342220.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 5","pages":"Pages 571-578"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.1016/j.cjco.2025.03.005","DOIUrl":"10.1016/j.cjco.2025.03.005","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 5","pages":"Page 707"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}