CJC Open最新文献

{"title":"Outcomes of Surgical Myectomy and Mitral Valve Repair for Hypertrophic Cardiomyopathy With vs Without Marked Septal Hypertrophy","authors":"Kenza Rahmouni MDCM ,&nbsp;Hugo M.N. Issa MD ,&nbsp;Omar Toubar ,&nbsp;Andrew M. Crean MD, MPH ,&nbsp;Anne Williams MD ,&nbsp;Hanh Nguyen MD ,&nbsp;Menaka Ponnambalam RN(EC), NP ,&nbsp;Juan Grau MD ,&nbsp;Sean Dickie MD ,&nbsp;Gyaandeo Maharajh MDCM ,&nbsp;Marc Ruel MD, MPH","doi":"10.1016/j.cjco.2025.04.007","DOIUrl":"10.1016/j.cjco.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>This study reports a single institution’s clinical and echocardiographic outcomes for septal myectomy with vs without concomitant mitral valve interventions in patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction.</div></div><div><h3>Methods</h3><div>Consecutive patients who underwent transaortic septal myectomy with vs without subvalvular mitral apparatus intervention for HCM between October 2019 and March 2024 were included. All patients underwent transesophageal echocardiography and cardiac magnetic resonance imaging to confirm the pathology, measure intracavitary gradients, and assess mitral valve morphology. Patients were analyzed as an entire cohort and stratified by the presence of marked (&gt; 15 mm) or only mild (≤ 15 mm) septal hypertrophy.</div></div><div><h3>Results</h3><div>A total of 61 patients (32 male) were included, of whom 28 (45.9%) had mild septal hypertrophy. The follow-up assessment was 100% complete and averaged 26.9 ± 16.2 months. In addition to septal myectomy, 32 patients (52.5%) underwent concomitant papillary muscle realignment, and aberrant chordae were resected in 40 patients (65.6%). All patients with a septal thickness ≤ 15 mm had a mitral valve repair intervention. The 30-day and 2-year mortality were 1.6% and 3.3%, respectively. No postoperative ventricular septal defects occurred, including in the thin septum subgroup. Peak LVOT gradients were significantly reduced with surgery, both at rest (47.8 ± 34.7 mm Hg preoperatively vs 8.8 ± 12.3 mm Hg postoperatively, <em>P</em> &lt; 0.001) and under stress (114.2 ± 58.7 mm Hg preoperatively vs 17.6 ± 18.5 postoperatively, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In patients with symptomatic HCM, even in those without marked septal hypertrophy, septal myectomy with a concomitant mitral valve apparatus intervention is safe and provides excellent relief of LVOT obstruction.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 851-859"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Atrial Fibrillation Using Radiomic Features of Left Atrial Epicardial Adipose Tissue on Noncontrast Cardiac Computed Tomography","authors":"Shayna Cohen-Dor MD ,&nbsp;Moshe Rav-Acha MD, PhD ,&nbsp;Fauzi Shaheen MD ,&nbsp;Boris Chutko MD ,&nbsp;Hadas Labrisch-Kaye MD ,&nbsp;Zohar Ben-Haim MD ,&nbsp;Yoav Michowitz MD ,&nbsp;Hilla Gérard MD ,&nbsp;Naama Bogot MD ,&nbsp;Shemi Carraso MD ,&nbsp;Itzhak Vitkon-Barkay MD ,&nbsp;Laurian Copel MD ,&nbsp;Michael Glikson MD ,&nbsp;Arik Wolak MD","doi":"10.1016/j.cjco.2025.03.024","DOIUrl":"10.1016/j.cjco.2025.03.024","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of atrial fibrillation (AF) can prevent AF-related complications. Radiomic analysis of epicardial adipose tissue (EAT) was shown to predict AF recurrence postablation, but only limited data exist regarding left atrial EAT (LA-EAT) radiomic analysis for predicting AF in patients with yet unknown AF. Our aim was to develop prediction model for AF, based on the association of machine learning-based radiomic analysis of LA-EAT and AF.</div></div><div><h3>Methods</h3><div>Retrospective matched case-control study of patients with and without AF, undergoing noncontrast electrocardiographic (ECG)-gated cardiac computed tomography (CT). Segmentation of LA-EAT and extraction of LA-EAT radiomic features were performed using syngo.via Frontier (Siemens Healthineers, Forchheim, Germany). Univariate analysis identified radiomic features associated with AF. Predictive models for AF were developed via logistic regression and machine learning-based random forest analyses. Models were validated on external cohort of patients with 1:1 AF : control ratio and deployed in a real-world setting with an AF : control ratio of 15:85.</div></div><div><h3>Results</h3><div>The study included 280 patients, 120 with documented AF and 160 matched controls. Based on LA-EAT radiomic features, which were significantly associated with AF, logistic regression and random forest models were constructed and tested on separate internal cohort of patients, yielding area under the curve (AUC) of 0.88 and 0.86, respectively, for prediction of AF. External validation verified these results (AUC 0.84 and 0.78, respectively). Both models were further validated in a real-world setting cohort (AUC 0.85 and 0.81, respectively).</div></div><div><h3>Conclusions</h3><div>Models, based on LA-EAT radiomic features extracted from noncontrast ECG-gated cardiac CT, could accurately predict AF, suggesting a potential widespread noninvasive method for predicting the presence of AF.</div></div><div><h3>Clinical Registration Number</h3><div>0281-23-ASF.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 936-947"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Smoking Cessation in Patients with Coronary Artery Diseases According to Sex: Cohort of Smoking Cessation Services Data from France","authors":"Ingrid Allagbé PhD ,&nbsp;Marianne Zeller PhD ,&nbsp;Daniel Thomas MD, PhD ,&nbsp;Guillaume Airagnes MD, PhD ,&nbsp;Frédéric Limosin MD, PhD ,&nbsp;Abdelali Boussadi PhD ,&nbsp;Frédéric Chagué MD ,&nbsp;Anne-Laurence Le Faou MD, PhD","doi":"10.1016/j.cjco.2025.02.002","DOIUrl":"10.1016/j.cjco.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>In smokers with coronary artery diseases (CADs), smoking cessation (SC) is a major prevention goal. From the French national database of SC services (SCSs), CDTnet, we aimed to describe the social, medical, and smoking characteristics of smokers with CAD, as well as factors associated with their SC, according to sex.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted of smokers with CAD included in the CDTnet from January 2001 to December 2018. Endpoints were abstinence and reduction of daily cigarette consumption. Abstinence was defined as SC maintained for ≥ 28 consecutive days, confirmed by a carbon monoxide measure in exhaled breath testing &lt; 10 parties per million, and reduction was defined as at least a halving of consumption compared to consumption at the time of the first consultation. Sex stratification was performed.</div></div><div><h3>Results</h3><div>Among 4532 smokers included, 21% were women, and their mean age was 55 years in both sexes. Nearly half smoked ≥ 20 cigarettes daily, and most (80%) received nicotine replacement therapy. The 28-day abstinence rate (54%) and reduction rate (24%) were similar in both sexes. Factors positively associated with SC in women were having made ≥ 1 previous quit attempt, and dual use of conventional and electronic cigarettes at the time of the first consultation. In men, being employed, being overweight or obese, being confident in quitting, and being prescribed nicotine replacement therapy at the first consultation were factors associated with success. Other cardiovascular and respiratory diseases were associated negatively with SC in both sexes.</div></div><div><h3>Conclusions</h3><div>Abstinence rates were similar for both sexes, with different factors associated with quit attempt results, according to sex, highlighting the need for tailored interventions that address the specific needs of men and women who intend to quit.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 986-996"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Atrial Fibrillation Ablation in Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis","authors":"Emre Polat MD ,&nbsp;Rohit K. Kharbanda MD, PhD ,&nbsp;Moustafa Ghafar BSc ,&nbsp;Jan W. Schoones MA ,&nbsp;Robert J.M. Klautz MD, PhD ,&nbsp;Marta de Riva MD, PhD ,&nbsp;Meindert Palmen MD, PhD ,&nbsp;Evaldas Girdauskas MD ,&nbsp;Anton Tomšič MD, PhD","doi":"10.1016/j.cjco.2025.05.001","DOIUrl":"10.1016/j.cjco.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is common in patients undergoing surgical aortic valve replacement; however, surgical ablation remains underused due to limited data on its efficacy.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of the literature by searching PubMed, Embase, Web of Science, Emcare, and the Cochrane Library for studies reporting outcomes of concomitant surgical AF ablation in patients undergoing surgical aortic valve replacement. The primary outcomes included freedom from AF recurrence, overall survival, and complications. We analyzed outcomes using traditional meta-analysis at specific time points, alongside pooled Kaplan-Meier curves.</div></div><div><h3>Results</h3><div>Nine studies were included, encompassing a total of 12,683 patients. Concomitant ablation reduced the risk of postoperative AF but increased the risk of permanent pacemaker implantation (risk ratio 1.36, 95% confidence interval [CI] 1.16-1.60, <em>P</em> &lt; 0.01) and postoperative renal failure (RR 1.38, 95% CI 1.11-1.71, <em>P</em> &lt; 0.01). During follow-up, concomitant ablation effectively restored and maintained sinus rhythm, with up to 80% of patients remaining free from recurrent AF 2-4 years post-surgery. Moreover, improved late survival was observed with concomitant ablation (unadjusted hazard ratio 0.84, 95% CI 0.73-0.96, <em>P</em> = 0.013).</div></div><div><h3>Conclusions</h3><div>Surgical ablation during surgical aortic valve replacement was effective in restoring and maintaining sinus rhythm after surgery. Preoperative rhythm status may play an important role in guiding treatment plans, potentially enhancing the clinical outcomes for patients scheduled for aortic valve intervention.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 887-896"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Fibrillation Inducibility After Ablation of Paroxysmal Supraventricular Tachycardia","authors":"Ahmed AlTurki MD, MHPE ,&nbsp;Bruno Toscani MD ,&nbsp;Alejandro Vidal MD,&nbsp;Sergio Diaz MD,&nbsp;Pedro Y. Lima MD, MSc,&nbsp;Daniel Garcia MD,&nbsp;Marcio Neumann MD,&nbsp;Lucas Faganello MD,&nbsp;Rodrigo Silva Barbosa MD, MSc,&nbsp;Martin L. Bernier MD,&nbsp;Jacqueline Joza MD, MSc,&nbsp;Vidal Essebag MD, PhD","doi":"10.1016/j.cjco.2025.03.027","DOIUrl":"10.1016/j.cjco.2025.03.027","url":null,"abstract":"<div><h3>Background</h3><div>Data on the inducibility of atrial fibrillation (AF) following supraventricular tachycardia (SVT) ablation in patients without prior history of AF are limited. This study aims to identify features associated with inducible AF and the subsequent development of clinical AF in patients who undergo SVT ablation.</div></div><div><h3>Methods</h3><div>This prospective study enrolled patients who underwent electrophysiology study and SVT ablation. AF inducibility testing post ablation utilized decremental atrial burst pacing, employing the same protocol that previously had been demonstrated to have clinical significance following pulmonary vein isolation. AF was assessed clinically as well as through 12-lead electrocardiogram recordings and ambulatory Holter recordings.</div></div><div><h3>Results</h3><div>A total of 152 patients who underwent an SVT ablation were evaluated. The median age was 53 years (range: 18-90); 87 patients were female (57.2%). Atrioventricular nodal reentrant tachycardia was diagnosed in 112 of the patients (73.6%), and 40 patients (26.3%) exhibited arrhythmias related to an accessory pathway. AF was induced in 31 patients (20.4%) during the induction protocol. Among patients with inducible AF, 79% spontaneously converted to sinus rhythm, and the rest were managed with cardioversion. During a median follow-up period of 514 ± 287 days, 6 patients (3.9%) developed clinical AF. Inducible AF at the time of the SVT procedure was associated with the development of clinical AF (odds ratio = 8.81, 95% confidence interval 1.53-50.63; <em>P</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>A significant proportion of patients undergoing SVT ablation have inducible AF, but only a few have clinical AF in the first 2 years of follow-up. Inducible AF after SVT ablation predicts future AF.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 907-912"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Left Ventricular Rupture After Radiofrequency Catheter Ablation of Premature Ventricular Contractions Triggering Ventricular Fibrillation","authors":"Yuhei Kasai MD, FHRS ,&nbsp;Takayuki Kitai MD ,&nbsp;Junji Morita MD ,&nbsp;Ryo Horita MD ,&nbsp;Jungo Kasai PhD ,&nbsp;Tsutomu Fujita MD","doi":"10.1016/j.cjco.2025.04.013","DOIUrl":"10.1016/j.cjco.2025.04.013","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 952-954"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Sinus Origins of the Left Coronary Artery From the Right and Left Coronary Sinus","authors":"Federico Oliveri MD ,&nbsp;Martijn Van Oort Msc ,&nbsp;Frank Van der Kley MD, PhD ,&nbsp;J. Wouter Jukema MD, PhD ,&nbsp;José Montero-Cabezas MD, PhD","doi":"10.1016/j.cjco.2025.04.015","DOIUrl":"10.1016/j.cjco.2025.04.015","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 967-968"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular Ultrasound-Guided Stenting for Iatrogenic Aortocoronary Dissection: The Art of “Needlework”","authors":"Quentin Liabot MD ,&nbsp;Jérémie Macia MD ,&nbsp;Stéphane Fournier MD, PhD ,&nbsp;Guillaume Testu de Balincourt MD ,&nbsp;Aurelia Zimmerli MD ,&nbsp;Marion Dupré MD ,&nbsp;Victor Weerts MD ,&nbsp;Olivier Muller MD, PhD ,&nbsp;Adil Salihu MD ,&nbsp;Louis Viallard MD ,&nbsp;David Meier MD","doi":"10.1016/j.cjco.2025.04.009","DOIUrl":"10.1016/j.cjco.2025.04.009","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 964-966"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Is This Thing On?: Measuring Technology Self-Efficacy Influence on Cardiac Rehabilitation Patients’ Adoption of a Virtual Care Platform","authors":"Megan Graat MPH ,&nbsp;Peter L. Prior PhD ,&nbsp;Tim Hartley MSc ,&nbsp;Karen Unsworth MSc ,&nbsp;Robert S. McKelvie MD, PhD, FRCPC ,&nbsp;Ashlay A. Huitema MD, FRCPC ,&nbsp;Mahima K. Bijji BSc ,&nbsp;Neville G. Suskin MBChB, MSc, FRCPC","doi":"10.1016/j.cjco.2025.02.003","DOIUrl":"10.1016/j.cjco.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic accelerated the adoption of virtual cardiac rehabilitation (vCR) delivery models. Understanding patient-level factors, such as technology self-efficacy (SE), is crucial for enhancing vCR adoption and ensuring its long-term sustainability. However, no validated tool exists to assess technology SE specifically for vCR. This paper outlines the initial phase of a quality-improvement project focused on developing a survey to assess technology SE among patients with access to videoconferencing (VC) technology in a vCR program.</div></div><div><h3>Methods</h3><div>A 30-item technology SE survey was developed by adapting items from validated instruments to prospectively assess technology SE in vCR and was tested for internal consistency.</div></div><div><h3>Results</h3><div>Of the 413 eligible patients, 99 completed the technology SE survey (24% response rate); 86 attended vCR using VC, and 13 did not use VC. The VC attendees were significantly younger than the non-VC attendees (aged 64.1 vs 72.5 years, <em>P</em> = 0.009). Although no significant differences were found in overall self-reported technology skills, novel technology use SE, or healthcare technology-related attitudes, VC attendees scored significantly higher on a measure of healthcare technology SE and demonstrated greater confidence in tasks such as opening a Web browser, clicking hyperlinks, downloading apps, and using novel technologies.</div></div><div><h3>Conclusions</h3><div>This quality-improvement initiative highlights disparities in technology SE that may impact participation in vCR programs. Addressing these gaps through targeted screening and interventions could enhance vCR accessibility and equity. Future research should focus on validating SE tools modified for vCR settings and exploring associated interventions to improve technology SE and patient vCR adoption.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 955-959"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidisciplinary Aortopathy Clinic: The McGill Experience","authors":"Masaki Kodaira MD ,&nbsp;Kevin Lachapelle MD, FRSC(C), FACS ,&nbsp;Richard L. Leask PhD ,&nbsp;Kevin Bates MSc ,&nbsp;Yoni Grossman MD ,&nbsp;Carlos-Eduardo Guerrero-Chalela MD ,&nbsp;Lauren Kennedy MSc ,&nbsp;George Thanassoulis MD, MSc, FRCPC ,&nbsp;Oren K. Steinmetz MD, FRCS(C) ,&nbsp;Kent MacKenzie MD ,&nbsp;Josephine Pressacco MD, PhD ,&nbsp;James C. Engert PhD ,&nbsp;Judith Therrien MD, FRCPC","doi":"10.1016/j.cjco.2025.01.021","DOIUrl":"10.1016/j.cjco.2025.01.021","url":null,"abstract":"<div><h3>Background</h3><div>Guidelines recommend that patients with thoracic aortic disease (TAD) be seen in a multidisciplinary aortopathy clinic, because of their complex and high-risk profile. However, reports on such clinics are limited.</div></div><div><h3>Methods</h3><div>From September 2016 to May 2024, we evaluated 567 patients with TAD. They were seen by our multidisciplinary team, which is comprised of 1 cardiac surgeon, 2 vascular surgeons, 1 cardiologist, 1 cardiothoracic radiologist, a team of 4 engineering researchers, a dedicated member from the genetics department, and an administrative assistant. For patients who had computed tomography or magnetic resonance imaging performed outside our institution, image reanalysis was conducted by our cardiothoracic radiologist. Genetic testing was performed for patients with suspected hereditary TADs.</div></div><div><h3>Results</h3><div>Reanalysis of external computed tomography and/or magnetic resonance imaging by our radiologist altered clinical decision-making in 5 of 51 cases (9.8%). Genetic testing that examined 25 genes associated with Marfan syndrome and related aortopathies was conducted on 250 patients, revealing a positive TAD gene in 32 (12.8%), a variant of unknown significance in 99 (39.6%), and a negative result in 119 (47.6%). Forty patients (7%) had surgery within a median of 2.7 months (quartile 1–quartile 3: 1.1-4.9) from their initial clinic visit.</div></div><div><h3>Conclusions</h3><div>Our 8-year experience at the aortopathy clinic of McGill University demonstrates that a multidisciplinary approach to TAD can deliver complete, precise, and timely care to this complex patient population.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 7","pages":"Pages 921-927"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}