努那维克因纽特人的肥胖和心脏代谢健康：一项13年的随访研究

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CJC Open Pub Date : 2025-09-01 DOI:10.1016/j.cjco.2025.05.016

Fannie Lajeunesse-Trempe MD-PhD , Marie-Eve Piché MD-PhD , Paul Poirier MD-PhD , Sarah O’Connor PhD , André Tchernof PhD , Pierre Ayotte PhD

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引用次数: 0

摘要

背景：肥胖（身体质量指数[BMI]≥30 kg/m2）是心脏代谢健康的主要决定因素，但体重变化对加拿大因纽特人心脏代谢健康的临床影响尚不清楚。方法收集参加Qanuippitaa？2004年和Qanuilirpitaa？2017年努那维克因纽特人健康调查。测量人体测量指标（体重、BMI、腰围、腰高比、体脂百分比和无脂质量）、代谢生物标志物和血流动力学。采用配对t检验或χ2检验（经药物因素调整）比较2017年和2004年的人体测量特征和心脏代谢危险因素。使用调整后的多变量线性回归分析评估肥胖变化对心脏代谢危险因素（血压、血脂和葡萄糖稳态参数）的影响。结果：尽管2004年和2017年的BMI相似，但美国男性和女性（平均基线年龄分别为37.1岁和36.4岁）的年龄标准化体脂百分比显著增加。因纽特女性的年龄标准化腰围和腰高比显著上升（P < 0.05），而男性保持稳定。腹部脂肪增加与某些脂质（高密度脂蛋白胆固醇[HDL-C]、总胆固醇/HDL-C比值、载脂蛋白B）和葡萄糖稳态（胰岛素抵抗稳态模型评估）参数的不利变化有关（P < 0.05），但与低密度脂蛋白胆固醇、甘油三酯、非高密度脂蛋白c、空腹血糖或血压无关。结论努那维克因纽特人的肥胖表型和心脏代谢危险因素正在发生变化，但腹部脂肪增加与某些脂质参数、空腹血糖或血压无关。需要进一步的研究来了解种族特异性特征并改善体重相关并发症的管理。

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Adiposity and Cardiometabolic Health Among Inuit of Nunavik: A 13-Year Follow-Up Study

Background

Obesity (body mass index [BMI] ≥ 30 kg/m²) is a major determinant of cardiometabolic health, yet the clinical impact of weight changes on cardiometabolic health in the Canadian Inuit population remains unclear.

Methods

Data were collected from 302 individuals (107 men and 195 women) who participated in the Qanuippitaa? 2004 and Qanuilirpitaa? 2017 Nunavik Inuit health surveys. Anthropometric indices (weight, BMI, waist circumference, and waist-to-height ratio, percentage of body fat, and fat-freemass), metabolic biomarkers, and hemodynamics were measured. Anthropometric characteristics and cardiometabolic risk factors were compared between 2017 and 2004 using Student paired t tests or the χ² test, adjusted for medication. The impact of adiposity changes on cardiometabolic risk factors (blood pressure, lipid profile, and glucose homeostasis parameters) was assessed using adjusted multivariate linear regression analysis.

Results

Inuit men and women (mean baseline age: 37.1 and 36.4 years) showed a significant increase in age-standardized percentage of body fat, despite having similar BMI in 2004 and 2017. Inuit women had significant rises in age-standardized waist circumference and waist-to-height ratio (P < 0.05), whereas men’s remained stable. Increased abdominal fat was linked to adverse changes in some lipid (high-density lipoprotein cholesterol [HDL-C], total cholesterol/HDL-C ratio, apolipoprotein B) and glucose homeostasis (Homeostatic Model Assessment of Insulin Resistance) parameters (P < 0.05), but not low-density lipoprotein cholesterol, triglycerides, non-HDL-C, fasting glucose, or blood pressure.

Conclusions

Adiposity phenotypes and cardiometabolic risk factors are evolving among Nunavik Inuit, but increased abdominal fat is not linked to certain lipid parameters, fasting glucose, or blood pressure. Further research is needed to understand ethnicity-specific traits and improve management of weight-related complications.

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