CJC Open最新文献_第4页

Predictive Value of Viable Myocardium of Papillary Muscle-Ventricular Wall Complex for Improvement in Moderate Ischemic Mitral Regurgitation

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.11.021

Zhiepng Wei MD , Enjun Zhu MD , Zhiyong Shi MD , Tong Tan MD , Ke Zhang MD , Zhihui Zhu MD , Shengwei Wang MD , Xiaoli Zhang MD , Yongqiang Lai MD

{"title":"Predictive Value of Viable Myocardium of Papillary Muscle-Ventricular Wall Complex for Improvement in Moderate Ischemic Mitral Regurgitation","authors":"Zhiepng Wei MD , Enjun Zhu MD , Zhiyong Shi MD , Tong Tan MD , Ke Zhang MD , Zhihui Zhu MD , Shengwei Wang MD , Xiaoli Zhang MD , Yongqiang Lai MD","doi":"10.1016/j.cjco.2024.11.021","DOIUrl":"10.1016/j.cjco.2024.11.021","url":null,"abstract":"<div><h3>Background</h3><div>Performing a mitral valve procedure during coronary artery bypass grafting (CABG) in patients with coronary artery disease complicated by moderate ischemic mitral regurgitation (IMR) remains controversial. This study aimed to assess the benefit of isolated CABG and to develop a new index of viable myocardium within the papillary muscle-ventricular wall complex (VM-PM-VWC) to predict the improvement of IMR by CABG alone.</div></div><div><h3>Methods</h3><div>In total, 122 patients (age, 62.34 ± 8.53 years; 78.70% male) with moderate IMR who underwent CABG alone at Beijing Anzhen Hospital were retrospectively analyzed. All patients underwent <sup>99m</sup>Tc-sestamibi single-photon emission computed tomography (SPECT) and <sup>18</sup>-fluorine fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) to evaluate the VM-PM-VWC. Based on the postoperative echocardiography results at 1-year follow-up, patients were divided into IMR-unimproved (moderate or severe IMR, n = 38) and IMR-improved (no or mild IMR, n = 84) groups. Factors associated with improvement were analyzed by multivariate logistic regression.</div></div><div><h3>Results</h3><div>The VM-PM-VWC was an independent factor for moderate IMR improvement (odds ratio, 1.16; 95% confidence interval [CI], 1.09-1.24; <em>P</em> < 0.001). The cutoff value for moderate IMR improvement was 12.50%, with a sensitivity and specificity of 76.32% and 80.95%, respectively (area under the curve [AUC] 0.830; 95% CI, 0.741-0.919; <em>P</em> < 0.001). During a median follow-up of 3.71 (interquartile range: 2.17-5.10) years, major cardiovascular and cerebrovascular event-free survival was higher in the improved group than in the unimproved group (<em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Most patients with moderate IMR improved from isolated CABG. The VM-PM-VWC was an independent predictor of IMR improvement, which could help surgical decision making.</div></div><div><h3>Clinical Trial Registration</h3><div>ChiCTR2100042454.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 351-361"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Case of Recurrent Takotsubo Cardiomyopathy Caused by Pheochromocytoma

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.12.004

Haitham Abu Khadija MD , Mohammad Alnees MD , Taiba Zornitzki MD , Jacob George MD , Sorel Goland MD

引用次数: 0

Trends in Global Burden and Socioeconomic Profiles of Atrial Fibrillation and Atrial Flutter: Insights from the Global Burden of Disease Study 2021

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.11.017

Samuel Chin Wei Tan MD , Mae-Ling Tang MD , Hongyuan Chu MD , Yun-Tao Zhao MD , Cuilian Weng MD

{"title":"Trends in Global Burden and Socioeconomic Profiles of Atrial Fibrillation and Atrial Flutter: Insights from the Global Burden of Disease Study 2021","authors":"Samuel Chin Wei Tan MD , Mae-Ling Tang MD , Hongyuan Chu MD , Yun-Tao Zhao MD , Cuilian Weng MD","doi":"10.1016/j.cjco.2024.11.017","DOIUrl":"10.1016/j.cjco.2024.11.017","url":null,"abstract":"<div><h3>Background</h3><div>Understanding trends in atrial fibrillation (AF) and atrial flutter (AFL) is crucial for effective prevention. This study quantifies the burden and identifies key risk factors for AF/AFL across 204 countries and territories from 1990 to 2021.</div></div><div><h3>Methods</h3><div>Using data from the Global Burden of Disease (GBD) study 2021, we employed average annual percentage change (AAPC) and Bayesian Age Period Cohort (BAPC) modelling to assess trends and future projections, with a focus on disparities across Socio-Demographic Index (SDI) levels.</div></div><div><h3>Results</h3><div>In 2021, AF/AFL remained the most common arrhythmia globally, with a prevalence of 52.55 million, 8.36 million disability-adjusted life years (DALYs), and 0.34 million deaths. For each 0.1 increase in SDI, age-standardized mortality rates increased by 4.94%, DALYs by 2.56%, and prevalence rates by 2.40%, highlighting the significant impact of socioeconomic development on AF/AFL burden. AAPC analysis indicated slight increases in deaths, prevalence, and DALYs, along with a decline in incidence, reflecting the impact of public health strategies. However, significant inequalities were observed across SDI levels, with a higher burden in high-SDI regions because of aging populations and improved detection, whereas lower SDI regions faced higher age-standardized mortality rates because of resource constraints.</div></div><div><h3>Conclusions</h3><div>By 2035, we project a 4.07% increase in incidence despite a 6.84% decrease in mortality. Nearly one-half of the AF/AFL burden is linked to modifiable risk factors, underscoring the importance of tailored prevention strategies and improved health care access, especially in lower SDI countries, to mitigate rising disease rates and reduce health care disparities.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 247-258"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrical Storm Potentially Associated With Ticagrelor: A Case Report and Literature Review

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.11.022

Vu Hoang Vu MD, PhD , Dung The Bui MD, PhD , Vinh Xuan Nguyen MD , Quang Dang Duy Pham MD, MSc , Bao Thien Duong MD, MSc , Binh Quang Truong MD PhD

引用次数: 0

Lyme Carditis Presenting As Idiopathic Myocarditis: Prompt Empirical Treatment Despite Negative Serology

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2025.01.003

Yohann Pilon MD , Tara Gédéon MD , Anne-Marie Claveau MD , Vartan Mardigyan MD

引用次数: 0

Septal Coronary Artery Injury After Left Bundle Branch Area Pacing

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.12.005

David Sánchez-Ortiz MD, Paula Vela-Martín MD, Daniel García-Rodríguez MD, Juan Francisco Oteo-Domínguez MD, PhD, Jorge Toquero-Ramos MD, PhD, Ignacio Fernández-Lozano MD, PhD, Víctor Castro-Urda MD, PhD

引用次数: 0

Managing Multivalvular Bioprosthetic Failure and a Hidden Aortic Root–Left Ventricular Outflow Tract Fistula With a Transcatheter Approach: Balancing Risk and Intervention

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.12.006

Julius Jelisejevas MD , Ali Husain MBBCh , Brian Chiang MD , Howard Paje RN , Hassan Ogran MD , Desiree Nadine Wussler MD , Stephanie L. Sellers MSc, PhD , Jonathon A. Leipsic MD , Philipp Blanke MD , Richard Cook MD , Janarthanan Sathananthan MBCHB, MPH , John G. Webb MD , David A. Wood MD

引用次数: 0

A Novel Nonsense Variant of FBN1 in Marfan Syndrome With Abdominal Aortic Aneurysm and Aortic Root Aneurysm

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2025.01.010

Chengkai Hu MD , Li Zhang MD , Anli Jin MD , Tong Yuan MD , Yuchong Zhang MD , Shouji Qiu MD , Wei Guo PhD , Lixin Wang PhD

引用次数: 0

Chemokine Ligands and Receptors Regulate Macrophage Polarization in Atherosclerosis: A Comprehensive Database Mining Study

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.11.018

Wanqian Yu MD , Linghua Fu MS , Guangtao Lei MD , Fan Luo MS , Peng Yu MD , Wen Shen MD , Qinghua Wu MS , Pingping Yang MD

{"title":"Chemokine Ligands and Receptors Regulate Macrophage Polarization in Atherosclerosis: A Comprehensive Database Mining Study","authors":"Wanqian Yu MD , Linghua Fu MS , Guangtao Lei MD , Fan Luo MS , Peng Yu MD , Wen Shen MD , Qinghua Wu MS , Pingping Yang MD","doi":"10.1016/j.cjco.2024.11.018","DOIUrl":"10.1016/j.cjco.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis is a systemic disease involving multiple blood vessels and a major cause of cardiovascular disease. Current treatment methods (eg, statins) for atherosclerosis can reduce the risk of cardiovascular diseases effectively, but they are insufficient to completely reverse existing atherosclerosis. Macrophages play a central role in development of atherosclerosis. Chemokines, the main mediators of macrophage chemotaxis, are important in immune and inflammatory responses. The effects of chemokines on mechanisms involved in atherosclerosis are unknown. This study preliminarily investigated these effects and mechanisms via bioinformatics methods.</div></div><div><h3>Methods</h3><div>In this study, data on chemokine ligands and receptors were obtained by mining public databases (the National Center of Biotechnology Information-Gene Expression Omnibus [NCBI-GEO] database, ArrayExpress database, and single-cell RNA sequencing [scRNA-seq] database), and an extensive literature search was performed. The expression levels of chemokines in mouse tissues were analyzed via Metascape software for signalling pathway enrichment, scRNA-seq data for chemokine expression in atherosclerotic plaque progression and regression, and GEO2R data for chemokine expression during macrophage polarization. Ingenuity Pathway Analysis (IPA) software was used to analyze regulatory factors such as transcription factors and microRNAs that are significantly differentially expressed upstream of chemokines in macrophage polarization. Finally, a model of the chemokine regulation of atherosclerosis was established on the basis of these results.</div></div><div><h3>Results</h3><div>There are 5 main findings: (1) In atherosclerosis, chemokines are regulated by transcription factors and microRNAs. (2) The transcription factor STAT1 promotes the polarization of dormant (M0) macrophages into classically activated (M1) macrophages and alternative activated (M2) macrophages by regulating chemokines. The transcription factors STAT1, IRF7 and IRF1 regulate the polarization of M0 macrophages into M2a and M2b macrophages via different chemokines. For example, some transcription factors promote M1 polarization of M0 macrophages through CCL4, but M2 macrophage polarization is regulated via CCL19, CCL5 and CCR7. (3) Transcription factors can promote and inhibit, whereas miRNAs can only inhibit atherosclerosis. (4) CCL4 existed in all 5 different chemokine-regulated macrophage models, whereas CXCL3 only existed in the M2b macrophage transcriptional regulation model, indicating that CXCL3 may promote the M2b type macrophages polarization of M0 macrophages. (5) CCL5 and CCR7 can promote the M2a macrophages and M2b macrophages polarization of M0 macrophages.</div></div><div><h3>Conclusions</h3><div>Atherosclerosis can be treated by regulating chemokines and regulating the polarization of macrophages. The chemokines CCL4, CCL5, CCL8, CCL19, CXCL3, CXCL10, CXCL13, an","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 310-324"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise Echocardiography of Left Ventricular Diastolic Function in Healthy Subjects: Insights From the RIGHT-NET

IF 2.5

CJC Open Pub Date : 2025-03-01 DOI: 10.1016/j.cjco.2024.11.015

Francesco Ferrara MD, PhD , Andreina Carbone MD , Luna Gargani MD, PhD , Rossana Castaldo PhD , Paola Argiento MD, PhD , Gergely Agoston MD , Rodolfo Citro MD, PhD , Anna D'Agostino PhD , Antonello D’Andrea MD, PhD , Michele D'Alto MD, PhD , Monica Franzese PhD , Stefano Ghio MD , Ekkehard Grünig MD, PhD , Marco Guazzi MD, PhD , Jarosław D. Kasprzak MD , Graziella Lacava MD , Giuseppe Limongelli MD, PhD , Alberto Marra MD, PhD , Matteo Mazzola MD , Emanuela Passaro MSc , Robert Naeije MD, PhD

{"title":"Exercise Echocardiography of Left Ventricular Diastolic Function in Healthy Subjects: Insights From the RIGHT-NET","authors":"Francesco Ferrara MD, PhD , Andreina Carbone MD , Luna Gargani MD, PhD , Rossana Castaldo PhD , Paola Argiento MD, PhD , Gergely Agoston MD , Rodolfo Citro MD, PhD , Anna D'Agostino PhD , Antonello D’Andrea MD, PhD , Michele D'Alto MD, PhD , Monica Franzese PhD , Stefano Ghio MD , Ekkehard Grünig MD, PhD , Marco Guazzi MD, PhD , Jarosław D. Kasprzak MD , Graziella Lacava MD , Giuseppe Limongelli MD, PhD , Alberto Marra MD, PhD , Matteo Mazzola MD , Emanuela Passaro MSc , Robert Naeije MD, PhD","doi":"10.1016/j.cjco.2024.11.015","DOIUrl":"10.1016/j.cjco.2024.11.015","url":null,"abstract":"<div><h3>Background</h3><div>Exercise transthoracic Doppler echocardiography (TTE) is considered suggestive of left ventricular (LV) diastolic dysfunction when the ratio of mitral Doppler E to tissue Doppler e′ waves is >15 with or without a peak tricuspid regurgitation velocity (TRV) >3.4 m/s. However, these measurements may be affected by exercise intensity. The aim of the study was to define the normal limits of LV diastolic function indices during exercise TTE.</div></div><div><h3>Methods</h3><div>One hundred ninety-two healthy adults (47% females, aged 16-76 years) underwent resting and exercise TTE on a semirecumbent cycle ergometer. LV diastolic measurements were acquired at baseline and midlevel exercise (heart rate ≤110 bpm) fusion of E and A waves. TRV was acquired at rest and at peak exercise. The E/e′ ratio was calculated with e′ as the average of septal and lateral measurements.</div></div><div><h3>Results</h3><div>At midlevel exercise, E/e′ increased modestly from 6.3 ± 1.9 to 7.3 ± 2.3 (<em>P</em> < 0.001) as a function of workload and cardiac output (CO), independently of sex and age. The 95th percentile of exercise E/e′ was 11.8. The slope of E/e′/CO was 0.4 ± 1.2/L/min. The slope of TRV/CO was 10.8 ± 11.5 cm/s/L/min. The upper 95% confidence interval of the E/e′/CO and TRV/CO slopes were 0.6/L/min and 13.1 cm/s/L/min, corresponding to an E/e′ of 13.2 and a TRV of 3.4 m/s at a CO of 15 L/min.</div></div><div><h3>Conclusions</h3><div>In healthy adult subjects, E/e′ slightly increased during midlevel exercise. Both E/e′ and TRV are exercise intensity-dependent and would therefore be better expressed as a function of CO for the diagnosis of normal vs abnormal LV diastolic response to exercise.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 325-333"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0