CJC Open最新文献_第4页

β-Blockers in Patients With Spontaneous Coronary Artery Dissection (SCAD)—Easing Angina, But Not Anxiety 自发性冠状动脉夹层（SCAD）患者的β-受体阻滞剂-缓解心绞痛，但不能缓解焦虑

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.043

L.-M. Maukel, T. Coutinho, S. Mulvagh, D. So 1, M. Madan, K. Bouchard, C. Pacheco, J. Saw, J. Reed, S. Liu, L. Sun, G. Wells, H. Robert, N. Lappa, H. Tulloch

引用次数: 0

Cognitive Functioning and Biological Differences in Heart Failure: A Matter of Sex or Disease? 心力衰竭的认知功能和生物学差异：性别还是疾病的问题？

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.036

C.-A. Blanchette, F. Besnier, E.G. Dupuy, C. Gagnon, T. Vincent, J.-L. Rouleau, N. Bouabdallaoui, J. Iglesies-Grau, N. Racine, F. Tournoux, F.J. Apullan, P. Vitali, S. Belleville, L. Bherer

引用次数: 0

Women@Heart Inpatient Support Program: Bedside Support Initiative for Women With Heart Disease Women@Heart住院病人支持计划：心脏病妇女床边支持倡议

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.039

N. Elias, N. Parast, Z. Koopman, A. Charlebois, L. MacArthur, J. Harris, B. Quinlan

引用次数: 0

Sex-Specific Differences in Gestational Diabetes Mellitus-Induced Cardiac Hypertrophy and Altered Mitochondrial Protein Acetylation in the Offspring Heart and the Protective Role of SIRT3 妊娠糖尿病诱导子代心脏肥厚和线粒体蛋白乙酰化改变的性别差异及SIRT3的保护作用

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.026

C. Menzies, M. Tomczyk, B. Xiang, S. Kereliuk, R. Leduc, V. Dolinsky

引用次数: 0

Calls for Engaging Patient Partners Have Largely Gone Unheard in Cardiovascular Research 在心血管研究中，对患者伴侣参与的呼吁在很大程度上是闻所未闻的

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.054

K.D. Cobey, M.A. Albert, K. MacKinnon, S. Gariepy, H. Robert, A.-M. Julien, A.C. Vieira Armond, E. Xu, F. Almoli, B. Almoli, A. Gulati, N.Y. Barnes, S.G. Nicholls, S. Visintini, D. Moher

引用次数: 0

Microcirculation Function in Non-ST-Elevation Myocardial Infarction After the Index Event and at Follow-Up Assessment 指数事件后非st段抬高型心肌梗死的微循环功能及随访评价

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.005

Luis Paiva MD , Enrique Gutiérrez MD , Maria João Ferreira MD, PhD , Lino Gonçalves MD, PhD

{"title":"Microcirculation Function in Non-ST-Elevation Myocardial Infarction After the Index Event and at Follow-Up Assessment","authors":"Luis Paiva MD , Enrique Gutiérrez MD , Maria João Ferreira MD, PhD , Lino Gonçalves MD, PhD","doi":"10.1016/j.cjco.2025.04.005","DOIUrl":"10.1016/j.cjco.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>The assessment of coronary physiology is seldom considered in cases of non-ST-elevation myocardial infarction (NSTEMI). This study aimed to characterize coronary physiology and determine the incidence of microvascular dysfunction in the myocardial infarction (MI) culprit coronary artery during the acute phase of NSTEMI and subsequent follow-up evaluation.</div></div><div><h3>Methods</h3><div>This study included 30 patients hospitalized for NSTEMI. A physiological assessment of the MI culprit coronary artery was performed using fractional flow reserve, coronary flow reserve (CFR), and index of microcirculatory resistance (IMR). At a median of 7 months after MI, patients underwent repeated physiological assessment of the same coronary artery.</div></div><div><h3>Results</h3><div>Microvascular dysfunction identified using CFR (< 2.0) was frequently present (60%) during the acute phase of NSTEMI, whereas severe microcirculatory dysfunction (IMR > 40) was uncommon (17%). Over time, a significant reduction occurred in the prevalence of abnormal CFR values (< 2.0; 60% vs 26%, <em>P</em> = 0.013) and extensive microvascular resistance (IMR > 40; 17% vs 4%, <em>P</em> = 0.03) at the follow-up evaluation. Patients were categorized according to their CFR and IMR results. In patients with abnormal CFR (< 2.0) and normal IMR (< 25), reduced CFR is attributable to elevated resting coronary blood flow rather than diminished hyperemic flow.</div></div><div><h3>Conclusions</h3><div>In the acute phase of NSTEMI, reduced CFR was commonly observed in the MI culprit coronary artery, whereas severe microcirculatory dysfunction was infrequent.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 709-718"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse Changes in Social Ties Are a Risk of Developing Central Obesity Over 6 Years Among Aging Women and Men in Canada 在加拿大，社会关系的不利变化是6年以上老年女性和男性发生中心性肥胖的风险

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.066

G. Ceolin, G. Veenstra, N.A. Khan, R. Madani Civi, S. Mehranfar, A.I. Conklin

引用次数: 0

Getting to the Heart of the Matter—Social Determinants of Health, Behaviour Change, and Cardiovascular Disease: A Phenomenological Study 触及问题的核心——健康、行为改变和心血管疾病的社会决定因素：现象学研究

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.028

G. Crichlow, S.L. Sibbald

引用次数: 0

Incidence of Cardiometabolic-Associated Reproductive Events (CARE) Over 2010-2020 in Alberta, Canada 2010-2020年加拿大艾伯塔省心血管代谢相关生殖事件（CARE）发生率

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.04.055

K. Bali, B. Eckert, Z. Liu, E.A. Martin, C. Job-McIntosh, A. Metcalfe, J. Negre, K. Nix, A. Shahid, D. Southern, T.L.A. Hawkins, M. Vlasschaert, K.A. Nerenberg

引用次数: 0

Relationship Between Vascular Smooth Muscle Cell Phenotype and Degeneration of Elastin in the Aortic Media in Patients With Acute Aortic Dissection 急性主动脉夹层患者血管平滑肌细胞表型与主动脉介质弹性蛋白变性的关系

IF 2.5

CJC Open Pub Date : 2025-06-01 DOI: 10.1016/j.cjco.2025.03.020

Atsushi Harada MD, PhD , Yuya Denda MD, PhD , Yutaka Koyama MD, PhD , Sayaka Shimodai-Yamada MSc , Mayumi Suzuki BSc , Guillame van Eys PhD , Masashi Tanaka MD, PhD , Hiroyuki Hao MD, PhD

{"title":"Relationship Between Vascular Smooth Muscle Cell Phenotype and Degeneration of Elastin in the Aortic Media in Patients With Acute Aortic Dissection","authors":"Atsushi Harada MD, PhD , Yuya Denda MD, PhD , Yutaka Koyama MD, PhD , Sayaka Shimodai-Yamada MSc , Mayumi Suzuki BSc , Guillame van Eys PhD , Masashi Tanaka MD, PhD , Hiroyuki Hao MD, PhD","doi":"10.1016/j.cjco.2025.03.020","DOIUrl":"10.1016/j.cjco.2025.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Acute aortic dissection (AAD) is a life-threatening disease with no known detailed pathogenesis in a certain percentage of patients. Although phenotypic modulation of vascular smooth muscle cells (VSMCs) and degeneration of the extracellular matrix (ECM) are known to occur in AAD, the relationship between the VSMC phenotype and ECM degeneration is unclear. We designed this study to identify the relationship between the VSMC phenotype and ECM disorders in dissected aortic media.</div></div><div><h3>Methods</h3><div>The tunica media of the ascending aorta was collected from 24 patients with AAD and 17 control autopsy cases. Immunostaining and immunoblotting were performed using antibodies against the contractile phenotypic markers, smooth muscle myosin heavy chain (SM-MHC) and smoothelin, and the synthetic marker, S100A4.</div></div><div><h3>Results</h3><div>Immunostaining and immunoblotting demonstrated that the expression levels of both SM-MHC and smoothelin were significantly decreased, whereas S100A4 expression levels were elevated, in the tunica media from patients with AAD. The expression level of elastin, a major component of the ECM, was significantly decreased in patients with AAD. There were significant positive correlations between the expression levels of contractile markers, such as SM-MHC, smoothelin, and elastin.</div></div><div><h3>Conclusions</h3><div>Phenotypic modulation of VSMCs and matrix degeneration in the tunica media of patients with AAD may interact and this phenomenon may contribute to the pathogenesis of AAD.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 6","pages":"Pages 788-794"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0