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Severe Coagulopathy Associated With Unintentional Salicylate Intoxication in a Postsurgical Patient
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.11.010
Yuji Kato MD , Naoto Fukunaga MD, PhD , Takuyo Misumi MD, PhD
{"title":"Severe Coagulopathy Associated With Unintentional Salicylate Intoxication in a Postsurgical Patient","authors":"Yuji Kato MD , Naoto Fukunaga MD, PhD , Takuyo Misumi MD, PhD","doi":"10.1016/j.cjco.2024.11.010","DOIUrl":"10.1016/j.cjco.2024.11.010","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 120-122"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous Closure of Ventricle Pseudoaneurysm—A Complication of Endomyocardial Biopsy in a Pediatric Heart Transplant Recipient: A Case Report
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.006
Michał Kapałka , Michał Gałeczka MD, PhD , Katarzyna Hajduk , Michał Krawiec , Małgorzata Szkutnik MD, PhD , Roland Fiszer MD, PhD
{"title":"Percutaneous Closure of Ventricle Pseudoaneurysm—A Complication of Endomyocardial Biopsy in a Pediatric Heart Transplant Recipient: A Case Report","authors":"Michał Kapałka , Michał Gałeczka MD, PhD , Katarzyna Hajduk , Michał Krawiec , Małgorzata Szkutnik MD, PhD , Roland Fiszer MD, PhD","doi":"10.1016/j.cjco.2024.10.006","DOIUrl":"10.1016/j.cjco.2024.10.006","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 100-102"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Impact of Insulin-Treated and Non–Insulin-Treated Diabetes in Patients with a Reduced Ejection Fraction After ST-Elevation Myocardial Infarction
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.001
Lidija Savic MD, PhD , Igor Mrdovic MD, PhD , Milika Asanin MD, PhD , Sanja Stankovic PhD , Ratko Lasica MD, PhD , Gordana Krljanac MD, PhD , Damjan Simic MD
{"title":"Prognostic Impact of Insulin-Treated and Non–Insulin-Treated Diabetes in Patients with a Reduced Ejection Fraction After ST-Elevation Myocardial Infarction","authors":"Lidija Savic MD, PhD ,&nbsp;Igor Mrdovic MD, PhD ,&nbsp;Milika Asanin MD, PhD ,&nbsp;Sanja Stankovic PhD ,&nbsp;Ratko Lasica MD, PhD ,&nbsp;Gordana Krljanac MD, PhD ,&nbsp;Damjan Simic MD","doi":"10.1016/j.cjco.2024.10.001","DOIUrl":"10.1016/j.cjco.2024.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Insulin- and non–insulin treated diabetes (ITDM and NITDM) have different prognostic impact in patients with myocardial infarction and/or heart failure. The aim of this study was to analyze the prognostic impact of ITDM and NTIDM on the incidence of all-cause mortality and major adverse cardiovascular events (MACE— cardiovascular death, nonfatal infarction, nonfatal stroke, and target vessel revascularization) in the 8-year follow-up of patients with ST-segment elevation myocardial infarction (STEMI) with a reduced ejection fraction (EF).</div></div><div><h3>Methods</h3><div>We analyzed 2230 consecutive STEMI patients treated with primary percutaneous coronary intervention and with EF &lt; 50%. Echocardiographic examination was performed after primary percutaneous coronary intervention . Patients were divided into 3three groups: those with ITDM, those with NITDM, and those with no DM. Patients presenting with cardiogenic shock were excluded.</div></div><div><h3>Results</h3><div>The incidence of DM was 20.7%; among the patients with DM, 103 (22.3%) had ITDM. Patients with ITDM and NITDM had a higher incidence of mortality and MACE, compared with patients without DM. Also, at 8-year follow-up, the incidences of all-cause mortality and MACE were significantly higher in patients with ITDM vs patients with NITDM (37.8% vs 13.1%, <em>P</em> &lt; 0.001 and 40.8% vs 18.9%, <em>P</em> &lt; 0.001, respectively). Multivariable analysis showed ITDM to be an independent predictor for long-term mortality (hazard ratio 1.76, 95% confidence interval 1.15-2.69), and MACE (hazard ratio 1.72, 95% confidence interval 1.15-2.62).</div></div><div><h3>Conclusions</h3><div>ITDM was an independent predictor of the occurrence of long-term mortality and MACE in patients with STEMI and reduced EF. NITDM was not an independent predictor for the occurrence of adverse events in analyzed patients.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 10-18"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing Rates of Exercise- and Sports-Related Cardiac Mortality
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.003
Carl J. Lavie MD , Nicholas Grubic MSc , Dermot M. Phelan MD, PhD , James H. O’Keefe MD
{"title":"Reducing Rates of Exercise- and Sports-Related Cardiac Mortality","authors":"Carl J. Lavie MD ,&nbsp;Nicholas Grubic MSc ,&nbsp;Dermot M. Phelan MD, PhD ,&nbsp;James H. O’Keefe MD","doi":"10.1016/j.cjco.2024.10.003","DOIUrl":"10.1016/j.cjco.2024.10.003","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 67-69"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterograde Retraction With Single Snare Catheter for Repositioning a Ventricularized Transcatheter Aortic Valve Guided With Heart-Navigator
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.11.004
Heberto Aquino-Bruno MD , Roberto Muratalla-González MD , Cesar A. Rojas-Sanchez MD , Kevin R. Hernández-Flores MD , Arnoldo S. Jiménez-Valverde MD , Antonio Vargas-Cruz MD , Jose A. Merino-Rajme MD , Juan F. García-García MD , Marco A. Alcántara-Meléndez MD
{"title":"Anterograde Retraction With Single Snare Catheter for Repositioning a Ventricularized Transcatheter Aortic Valve Guided With Heart-Navigator","authors":"Heberto Aquino-Bruno MD ,&nbsp;Roberto Muratalla-González MD ,&nbsp;Cesar A. Rojas-Sanchez MD ,&nbsp;Kevin R. Hernández-Flores MD ,&nbsp;Arnoldo S. Jiménez-Valverde MD ,&nbsp;Antonio Vargas-Cruz MD ,&nbsp;Jose A. Merino-Rajme MD ,&nbsp;Juan F. García-García MD ,&nbsp;Marco A. Alcántara-Meléndez MD","doi":"10.1016/j.cjco.2024.11.004","DOIUrl":"10.1016/j.cjco.2024.11.004","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 75-77"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Outcomes of Out-of-Hospital Cardiac Arrest Patients Admitted to the Hospital in Canada from 2013 to 2017
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.09.015
Nicholas Grubic MSc , Katherine S. Allan PhD, MASc , Ehsan Ghamarian MSc , Steve Lin MD, MSc , Gerald Lebovic PhD , Paul Dorian MD, MSc
{"title":"Incidence and Outcomes of Out-of-Hospital Cardiac Arrest Patients Admitted to the Hospital in Canada from 2013 to 2017","authors":"Nicholas Grubic MSc ,&nbsp;Katherine S. Allan PhD, MASc ,&nbsp;Ehsan Ghamarian MSc ,&nbsp;Steve Lin MD, MSc ,&nbsp;Gerald Lebovic PhD ,&nbsp;Paul Dorian MD, MSc","doi":"10.1016/j.cjco.2024.09.015","DOIUrl":"10.1016/j.cjco.2024.09.015","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital cardiac arrest (OHCA) remains a prominent medical concern worldwide. Epidemiologic metrics and trends over time for OHCA cases in Canada are not well defined. This study evaluated geographic differences in the incidence and outcomes of OHCA patients admitted to hospitals across Canada, during the period 2013-2017.</div></div><div><h3>Methods</h3><div>This population-based retrospective cohort study included 10,492 nontraumatic OHCA patients aged 2-85 years (66% male) who were admitted to an acute-care hospital in any Canadian province or territory (excluding Quebec) between 2013 and 2017. Overall age- and sex-standardized incidence measures (per 100,000 population per year) were calculated through direct standardization to the 2016 Canadian population. Temporal trends in incidence and survival to hospital discharge were evaluated.</div></div><div><h3>Results</h3><div>The overall age- and sex-standardized incidence of OHCA patients admitted to the hospital was 8.3 per 100,000 population per year, which did not change significantly from 2013 to 2017 (incidence rate ratio: 1.01, 95% confidence interval: 0.99-1.02). The incidence was highest in British Columbia (9.2 per 100,000 population per year), Manitoba (9.0 per 100,000 population per year), and Nova Scotia (9.0 per 100,000 population per year), and lowest in New Brunswick (6.5 per 100,000 population per year), Prince Edward Island (6.8 per 100,000 population per year), and Saskatchewan (7.5 per 100,000 population per year). The proportion of OHCA patients who survived to hospital discharge was highest in Prince Edward Island (57%) and lowest in Ontario (38%). No significant trend in rates of survival to hospital discharge was observed from 2013 (43%) to 2017 (42%; <em>P</em> = 0.86).</div></div><div><h3>Conclusions</h3><div>The age- and sex-standardized incidence of OHCA patients admitted to the hospital, and their survival outcomes, were stable in Canada from 2013 to 2017, with considerable variation noted across geographic regions.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 88-99"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.09.017
Tasuku Terada CEP, PhD , Matheus Hausen PhD , Hassan Mir MD , Jennifer L. Reed RKin, PhD , Thais D. Coutinho MD
{"title":"A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility","authors":"Tasuku Terada CEP, PhD ,&nbsp;Matheus Hausen PhD ,&nbsp;Hassan Mir MD ,&nbsp;Jennifer L. Reed RKin, PhD ,&nbsp;Thais D. Coutinho MD","doi":"10.1016/j.cjco.2024.09.017","DOIUrl":"10.1016/j.cjco.2024.09.017","url":null,"abstract":"<div><h3>Background</h3><div>Supervised exercise programs improve walking impairment and quality of life (QoL) in patients with peripheral artery disease (PAD). However, such programs are underutilized, due to their limited accessibility. A feasible and effective exercise program is needed. This study assessed the feasibility of a hybrid onsite and home-based exercise program (HY-PAD) and changes in walking capacity and PAD-specific QoL following HY-PAD.</div></div><div><h3>Methods</h3><div>Due to recruitment challenges imposed by the COVID-19 pandemic, this randomized controlled trial was modified to a pre–post intervention design that excluded the control group. Eligible patients with PAD were assigned to HY-PAD, consisting of 1-hour, supervised onsite exercise sessions 3 days per week for 4 weeks, followed by a home-based program with weekly 15-minute telephone calls to discuss exercise planning for 8 weeks. Feasibility was determined based on recruitment, adherence, and adverse events. Walking capacity was measured by a 6-minute walk test. PAD-specific QoL was assessed using the Walking Impairment Questionnaire.</div></div><div><h3>Results</h3><div>Of 24 patients enrolled (3 women, aged 70 ± 8 years), 21 (87.5%) completed HY-PAD. Twenty participants attended ≥ 87.5% of prescribed sessions. Two participants experienced adverse events (foot injury and limb ischemia). The 6-minute walk test distance (357 ± 105 vs 413 ± 53 meters, <em>P</em> = 0.021), and 2 domains of the questionnaires (walking speed: 38.4 ± 24.1 vs 60.6 ± 26.6 points and stair-climbing: 60.6 ± 29.4 vs 74.0 ± 23.1 points, both <em>P</em> &lt; 0.001) increased significantly.</div></div><div><h3>Conclusions</h3><div>High attendance and low dropout rates support the feasibility of using HY-PAD, which was associated with improved walking capacity and PAD-specific QoL. Future studies are warranted to confirm its efficacy.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 110-119"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Anti-Inflammatory Agents to Prevent Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Network Meta-Analysis
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.008
Alireza Malektojari MD , Zahra Javidfar , Sara Ghazizadeh MD , Shaghayegh Lahuti MD , Rahele Shokraei MD , Mohadeseh Zeinaee , Amirhosein Badele , Raziyeh Mirzadeh , Mitra Ashrafi MD , Fateme Afra , Mohammad Hamed Ersi , Marziyeh Heydari , Ava Ziaei MD , Zohreh Rezvani , Jasmine Mah MD, MSc , Dena Zeraatkar PhD , Shahin Abbaszadeh MD, AP , Tyler Pitre MD, MA
{"title":"Effectiveness of Anti-Inflammatory Agents to Prevent Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Network Meta-Analysis","authors":"Alireza Malektojari MD ,&nbsp;Zahra Javidfar ,&nbsp;Sara Ghazizadeh MD ,&nbsp;Shaghayegh Lahuti MD ,&nbsp;Rahele Shokraei MD ,&nbsp;Mohadeseh Zeinaee ,&nbsp;Amirhosein Badele ,&nbsp;Raziyeh Mirzadeh ,&nbsp;Mitra Ashrafi MD ,&nbsp;Fateme Afra ,&nbsp;Mohammad Hamed Ersi ,&nbsp;Marziyeh Heydari ,&nbsp;Ava Ziaei MD ,&nbsp;Zohreh Rezvani ,&nbsp;Jasmine Mah MD, MSc ,&nbsp;Dena Zeraatkar PhD ,&nbsp;Shahin Abbaszadeh MD, AP ,&nbsp;Tyler Pitre MD, MA","doi":"10.1016/j.cjco.2024.10.008","DOIUrl":"10.1016/j.cjco.2024.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Preventing postoperative atrial fibrillation (POAF) as one of the most significant complications of cardiovascular surgeries remains a major clinical challenge. We conducted a systematic review with network meta-analysis of randomized controlled trials, to identify the most effective and safe anti-inflammatory drugs to prevent new-onset POAF.</div></div><div><h3>Methods</h3><div>MEDLINE, Embase, Web of Science, and Cochrane Library were searched without language or publication-date restriction on August 8, 2022 (updated on August 8, 2023). We assessed the risk of bias of included trials using the Cochrane risk-of-bias 2.0 tool. We conducted a frequentist random-effects network meta-analysis in R, and we assessed the certainty of evidence using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.</div></div><div><h3>Results</h3><div>A total of 85 trials reported the incidence of new-onset POAF, including 18,981 patients. Use of nonsteroidal anti-inflammatory drugs (relative risk [RR] 0.37 [95% confidence interval [CI] 0.23-0.59]) and statins (RR 0.56 [95% CI 0.45-0.7]) potentially reduced the risk of POAF compared with placebo (both with a moderate certainty level). Use of fish oil in combination with vitamins C and E (RR 0.30 [95% CI 0.13-0.68]) may reduce the risk of POAF, compared with placebo (low level of certainty). Use of colchicine (RR 0.62 [95% CI 0.45- 0.85]), corticosteroids (RR 0.70 [95% CI 0.59-0.82]), and N-acetylcysteine (RR 0.69 [95% CI 0.49- 0.98]) may reduce the risk of POAF (all with a low level of certainty). None of the interventions had a significant effect on mortality rate or risk of serious adverse effects.</div></div><div><h3>Conclusions</h3><div>Use of nonsteroidal anti-inflammatory drugs and statins probably are effective in preventing new-onset POAF, with a moderate level of certainty, compared to placebo.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 35-45"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaco-Invasive Strategy Vs Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction in Latin America: A Meta-Analysis
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.10.005
Carlos Diaz-Arocutipa MD , Cynthia Vargas-Rivas MD , Daniel Mendoza-Quispe MD, MSc , Cesar Joel Benites-Moya MD , Javier Torres-Valencia MD , German Valenzuela-Rodriguez MD , Norma Nicole Gamarra-Valverde MS , Manuel Chacon-Diaz MD , Juan Pablo Costabel MD , Mamas A. Mamas MD, PhD , Lourdes Vicent MD, PhD
{"title":"Pharmaco-Invasive Strategy Vs Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction in Latin America: A Meta-Analysis","authors":"Carlos Diaz-Arocutipa MD ,&nbsp;Cynthia Vargas-Rivas MD ,&nbsp;Daniel Mendoza-Quispe MD, MSc ,&nbsp;Cesar Joel Benites-Moya MD ,&nbsp;Javier Torres-Valencia MD ,&nbsp;German Valenzuela-Rodriguez MD ,&nbsp;Norma Nicole Gamarra-Valverde MS ,&nbsp;Manuel Chacon-Diaz MD ,&nbsp;Juan Pablo Costabel MD ,&nbsp;Mamas A. Mamas MD, PhD ,&nbsp;Lourdes Vicent MD, PhD","doi":"10.1016/j.cjco.2024.10.005","DOIUrl":"10.1016/j.cjco.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Primary percutaneous coronary intervention (PCI) is the established treatment for ST-segment elevation myocardial infarction (STEMI), but often it is not readily available in low-resource settings. We assessed the safety and efficacy of the pharmaco-invasive strategy compared to primary PCI for STEMI in Latin America.</div></div><div><h3>Methods</h3><div>MEDLINE, Embase, and Latin American and Caribbean Health Sciences Literature (LILACS) were searched for the period from their inception to September 2023, for studies that compared a pharmaco-invasive strategy vs primary PCI in Latin America. Primary outcomes were major adverse cardiovascular events and bleeding. Secondary outcomes were all-cause mortality, cardiovascular mortality, recurrent myocardial infarction, and stroke. Risk of bias was assessed using the Risk Of Bias In Non-randomized Studies—of Interventions (ROBINS-I) tool. Risk ratios (RRs) and 95% confidence intervals (CIs) from random-effects meta-analyses were reported.</div></div><div><h3>Results</h3><div>Six cohort studies (n = 6621) were included; no clinical trials were found. The follow-up duration ranged from the in-hospital period to 1 year. Patients who underwent a pharmaco-invasive strategy (n = 841) vs a primary PCI (n = 5780) had similar rates of major adverse cardiovascular events (RR 0.82; 95% CI 0.59-1.16), major bleeding (RR 1.18; 95% CI 0.69-2.02), all-cause mortality (RR 0.70; 95% CI 0.47-1.05), cardiovascular mortality (RR 0.80; 95% CI 0.44-1.44), recurrent myocardial infarction (RR 0.54; 95% CI 0.18-1.61), and stroke (RR 1.27; 95% CI 0.17-9.73). Most studies had a serious (33%) or critical (50%) risk of bias.</div></div><div><h3>Conclusions</h3><div>Among patients with STEMI in Latin America, only low-quality observational evidence indicated that cardiovascular outcomes and major bleeding rates were similar for those treated with a pharmaco-invasive strategy vs primary PCI. Randomized studies are needed in Latin America with the development of STEMI networks for better care.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 78-87"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Arterial Hypertension Associated With Idiopathic Hypereosinophilic Syndrome: Importance of Eosinophilia Control With Steroid Therapy
IF 2.5
CJC Open Pub Date : 2025-01-01 DOI: 10.1016/j.cjco.2024.09.009
Yuzuki Mitsuyama , Ayumi Goda MD, PhD , Hanako Kikuchi MD , Kaori Takeuchi MD , Takumi Inami MD, PhD , Kyoko Soejima MD, PhD , Takashi Kohno MD, PhD
{"title":"Pulmonary Arterial Hypertension Associated With Idiopathic Hypereosinophilic Syndrome: Importance of Eosinophilia Control With Steroid Therapy","authors":"Yuzuki Mitsuyama ,&nbsp;Ayumi Goda MD, PhD ,&nbsp;Hanako Kikuchi MD ,&nbsp;Kaori Takeuchi MD ,&nbsp;Takumi Inami MD, PhD ,&nbsp;Kyoko Soejima MD, PhD ,&nbsp;Takashi Kohno MD, PhD","doi":"10.1016/j.cjco.2024.09.009","DOIUrl":"10.1016/j.cjco.2024.09.009","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 1","pages":"Pages 123-125"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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