{"title":"Brain Oxygenation and Metabolism Monitoring in Acute Brain Injury: Review on Current Trends and Clinical Implications.","authors":"In Sung Hwang, Yong-Won Shin, Eun Jin Ha","doi":"10.13004/kjnt.2025.21.e26","DOIUrl":"10.13004/kjnt.2025.21.e26","url":null,"abstract":"<p><p>Acute brain injury (ABI) remains a leading cause of morbidity and mortality worldwide. Secondary brain injury, a key modifiable determinant of neurological outcome, arises not only from elevated intracranial pressure but also from impaired cerebral oxygenation and metabolism. As a result, comprehensive monitoring strategies have gained increasing attention. This review outlines current trends in the monitoring of brain oxygenation and metabolism in ABI, covering both invasive and non-invasive modalities, and highlights key clinical milestones.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"163-171"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tailored Tissue Plasminogen Factor Injection via Subdural Catheter for Subacute Subdural Hematoma in an Elderly Patient: A Case Report and Literature Review.","authors":"Dongwook Seo","doi":"10.13004/kjnt.2025.21.e25","DOIUrl":"10.13004/kjnt.2025.21.e25","url":null,"abstract":"<p><p>This report presents an 89-year-old patient with subacute subdural hematoma (SDH) treated with local anesthesia via burr-hole trephination (BHT) and subdural drain placement, followed by liquefaction of the hematoma using the fibrinolytic agent, tissue plasminogen activator (tPA). Initially, the patient presented with acute post-trauma SDH without neurological symptoms, for which conservative treatment was administered. About a week later, the patient developed hemiplegia and progressed to a stuporous state. Radiographic evidence indicated that the subacute SDH had evolved into a chronic stage with an increased mass effect, causing new neurological deficits. Although craniotomy was considered, general anesthesia was not performed at the caregiver's request. After BHT, a subdural catheter was placed, but initial drainage was minimal. tPA was then administered to promote liquefaction and drainage. Follow-up computed tomography of the brain confirmed significant drainage of the hematoma. The patient subsequently recovered consciousness and motor function. This report discusses a less-invasive alternative for managing symptomatic subacute SDH. My approach of combining BHT with fibrinolytic therapy using tPA facilitated effective evacuation of the hematoma with minimal surgical intervention. Here, I present a case where tPA was used, detailing the methodology, imaging findings, and clinical outcomes of fibrinolytic therapy.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"208-215"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Injury Incidence and Radiological Outcomes in OLIF L5/S1: Iliac Bifurcation Versus Prepsoas Approach.","authors":"Yunhee Choi, Youngmin Kwon","doi":"10.13004/kjnt.2025.21.e24","DOIUrl":"10.13004/kjnt.2025.21.e24","url":null,"abstract":"<p><strong>Objective: </strong>The oblique lateral interbody fusion (OLIF) technique at the L5-S1 segment can be approached via iliac vessel bifurcation or prepsoas approaches, depending on vascular anatomy and iliac crest height. This study aims to compare clinical and radiological outcomes between these two surgical methods.</p><p><strong>Methods: </strong>This single-center retrospective study analyzed 58 patients undergoing OLIF surgery at L5-S1 from January 2020 to December 2023. Patients were divided into bifurcation (n=36) and prepsoas (n=22) approach groups. Outcomes measured included radiological parameters (anterior/posterior disc heights, foraminal height, disc angle), clinical parameters (Visual Analog Scale for leg/back pain, Oswestry Disability Index), and complications.</p><p><strong>Results: </strong>No significant differences were observed preoperatively between groups. Postoperatively, the prepsoas group showed significantly increased posterior disc and foraminal heights, whereas the bifurcation group had a significantly greater disc angle. Leg pain scores improved significantly more in the bifurcation group at four months. Complications were comparable, though the prepsoas approach was associated with higher incidences of contralateral root and endplate injuries.</p><p><strong>Conclusion: </strong>Both surgical approaches are safe and effective. The bifurcation corridor approach using an anterior lumbar interbody fusion cage optimizes segmental angulation, while the prepsoas corridor approach is more effective for increasing foraminal height. Careful preoperative anatomical evaluation is essential for selecting the optimal surgical approach.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"183-192"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun-Yong Cha, Sangsoo Choi, Sungbum Kim, Il-Tae Jang
{"title":"Vertebral Body Fracture During Manual Therapy in a Patient Following Spinal Surgery and Previous Instrumentation Removal.","authors":"Jun-Yong Cha, Sangsoo Choi, Sungbum Kim, Il-Tae Jang","doi":"10.13004/kjnt.2025.21.e23","DOIUrl":"10.13004/kjnt.2025.21.e23","url":null,"abstract":"<p><p>Spinal fusion with metallic implants is a widely used surgical approach to manage various spinal pathologies including instability and degenerative diseases. Although spinal instrumentations facilitate successful bone fusion by providing immediate rigid support and stability, their removal may be necessary because of pain, mechanical failure, or infection. However, implant removal, particularly in patients with low bone density, may lead to fractures of the fused vertebral bodies owing to stress-shielding effects. This case report describes a 70-year-old woman with a history of spinal fusion surgery at the L3-L4-L5 levels who underwent another spinal fusion surgery at the L5-S1 level and removal of previous implants owing to adjacent segment disease. During recovery, the patient developed sudden severe back pain due to vertebral body fractures at the L3 and L4 levels following manual therapy. Percutaneous vertebroplasty was performed to treat these fractures and allowed for recovery without any complication. This case highlights the importance of careful preoperative planning and postoperative management in preventing fractures associated with hardware removal.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"216-221"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing Spine Fracture Detection: The Role of Artificial Intelligence in Clinical Practice.","authors":"Seonghoon Jeong, Byung-Jou Lee","doi":"10.13004/kjnt.2025.21.e22","DOIUrl":"10.13004/kjnt.2025.21.e22","url":null,"abstract":"<p><p>Vertebral fractures are prevalent skeletal injuries commonly associated with osteoporosis, trauma, and degenerative diseases. Early and accurate diagnosis is crucial to prevent complications such as chronic pain and progressive spinal deformities. In recent years, artificial intelligence (AI) has emerged as a powerful tool in medical imaging to support automatic detection and classification of vertebral fractures. This review provides an overview of AI-based approaches for spinal fracture diagnosis and summarizes recent advances in deep learning (DL) and machine learning (ML) models. The performance of AI models, mainly evaluated by sensitivity, specificity, and accuracy metrics, varies with imaging modality and dataset size, with computed tomography-based models demonstrating superior diagnostic accuracy. In addition, AI-assisted workflows have been shown to improve diagnostic efficiency, reducing the time required for fracture detection. Despite these advances, challenges remain, such as dataset variability, the need for large-scale annotated datasets, and standardization of evaluation metrics. Future research should focus on improving model generalization, integrating multimodal imaging data, and validating AI applications in real-world clinical settings to further improve vertebral fracture diagnosis and patient management.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"172-182"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Commentary on Investigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model (<i>Korean J Neurotrauma</i> 2025;21:18-31).","authors":"Subum Lee","doi":"10.13004/kjnt.2025.21.e20","DOIUrl":"10.13004/kjnt.2025.21.e20","url":null,"abstract":"","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"224-225"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hidden Threat: A Delayed Diagnosis of an Intracranial Impacted Car Key Leading to Brain Abscess.","authors":"Ghassen Gader, Kerima Belhadj Ali, Houssem Hdhili, Ihsèn Zammel, Mouna Rkhami","doi":"10.13004/kjnt.2025.21.e21","DOIUrl":"10.13004/kjnt.2025.21.e21","url":null,"abstract":"<p><p>Penetrating cranial injuries involving retained foreign objects are rare but can lead to life-threatening complications including infections and neurological deficits. We report the case of a 38-year-old man with persistent headaches one week after sustaining a minor head injury during an assault. Initial evaluation by an independent practitioner revealed a small left temporal wound that was conservatively treated. However, a brain computed tomography revealed an intracranial foreign body, later identified as a car key, penetrating the left temporal bone and abscess formation. Surgical management included a craniotomy for foreign body removal, abscess evacuation, and postoperative antibiotic therapy. This case highlights the importance of thorough assessment and imaging in head trauma cases, even when the initial symptoms appear mild. Early detection and management of retained foreign objects are essential to prevent severe complications.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"202-207"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Commentary on Transcranial-Penetrating Craniocerebral Injury Inflicted by a Nail Gun: A Technical Case Report (<i>Korean J Neurotrauma</i> 2024;20:191-197).","authors":"Myoung Soo Kim","doi":"10.13004/kjnt.2025.21.e19","DOIUrl":"10.13004/kjnt.2025.21.e19","url":null,"abstract":"","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 3","pages":"222-223"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Future of Dedicated Neurosurgical Specialists in Regional Trauma Centers.","authors":"Mahnjeong Ha","doi":"10.13004/kjnt.2025.21.e18","DOIUrl":"https://doi.org/10.13004/kjnt.2025.21.e18","url":null,"abstract":"","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 2","pages":"63-64"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mu Seung Park, Jin Seo Yang, Suk-Hyung Kang, Hyuk Jai Choi, Jin Pyeong Jeon, Yong-Jun Cho
{"title":"Effect of Choline Alfoscerate on Cognitive Dysfunction After Mild Traumatic Brain Injury: A Single-Center Prospective Case-Control Study.","authors":"Mu Seung Park, Jin Seo Yang, Suk-Hyung Kang, Hyuk Jai Choi, Jin Pyeong Jeon, Yong-Jun Cho","doi":"10.13004/kjnt.2025.21.e17","DOIUrl":"https://doi.org/10.13004/kjnt.2025.21.e17","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to determine the effect of choline alfoscerate on the recovery of cognitive function in patients with mild traumatic brain injury.</p><p><strong>Methods: </strong>Patients with mild traumatic brain injuries were included. The Korean version of the Mini-Mental State Examination (K-MMSE) was used to evaluate cognitive function. The K-MMSE was performed on the 7th day post-trauma. The patients were divided into the choline and control groups (15 subjects). The choline group was administered choline alfoscerate (400 mg) twice daily for 8 weeks. After 8 weeks, the K-MMSE was administered to both groups, and the results were compared with those before treatment.</p><p><strong>Results: </strong>Thirty patients (15 each in the choline and control groups) were enrolled between November 2013 and March 2015. The mean ages were 64.2±12.1 and 63.7±16.8 years for the choline and control groups, respectively. The K-MMSE scores on the 7th day post-trauma were 21.7±6.2 and 25.1±4.3 for the choline and control groups, respectively. The K-MMSE scores at 9 weeks post-trauma were 24.1±5.1 and 25.7±4.4 for the choline and control groups, respectively. The change in cognitive function during the 8-weeks was 2.5±2.1 and 0.5±0.9 for the choline and control groups, respectively. The choline group showed greater cognitive improvement than the control group (<i>p</i>=0.004).</p><p><strong>Conclusion: </strong>Choline alfoscerate improves cognitive function in patients with mild traumatic brain injuries.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"21 2","pages":"114-123"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}