Korean Journal of Neurotrauma最新文献

Efficacy of Additional Surgical Decompression on Functional Outcome in Pyogenic Spinal Epidural Abscess With No Neurological Deficit. 附加手术减压对无神经功能缺损的化脓性脊髓硬膜外脓肿功能预后的影响。

Korean Journal of Neurotrauma Pub Date : 2024-12-27 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e48

Min Seok Kim, Atman Desai, Dongwoo Yu, Vivek Sanker, Sang Woo Kim, Ikchan Jeon

{"title":"Efficacy of Additional Surgical Decompression on Functional Outcome in Pyogenic Spinal Epidural Abscess With No Neurological Deficit.","authors":"Min Seok Kim, Atman Desai, Dongwoo Yu, Vivek Sanker, Sang Woo Kim, Ikchan Jeon","doi":"10.13004/kjnt.2024.20.e48","DOIUrl":"10.13004/kjnt.2024.20.e48","url":null,"abstract":"Objective: The aim of this study was to investigate the efficacy of additional surgical decompression with antibiotics to treat pyogenic spinal epidural abscess (SEA) with no neurological deficits.Methods: We retrospectively reviewed the data of patients diagnosed with spontaneous pyogenic SEA in the thoracolumbosacral area who presented with sciatica and no motor deficits in the lower extremities. The treatment took place in a single tertiary hospital. The effects of additional surgical decompression (decompressive laminectomy) and other clinical variables on functional outcome were assessed using the short form 36 (SF-36).Results: Fifty-nine patients (49 men and 10 women, mean age 65.73±12.29 [41-89] years) were included in the analysis. Surgical decompression had been performed in 31 patients (Group S, treated with additional surgical decompression and antibiotics). There were five (15.2%, 5/33) unplanned operations to control leg sciatica among the patients with initially non-surgical plans, and 28 patients were finally treated with only antibiotics (group N-S). Group S showed a statistically significant increased cost of hospitalization compared to group N-S (15,856.37±7,952.83 vs. 10,672.62±4,654.17 US dollars, p=0.004) with no superiority of 6-month functional outcome after the completion of antibiotic treatment (53.65±4.74 vs. 51.75±7.96 SF-36 scores, p=0.266).Conclusion: Although there is a possibility of requiring an unplanned operation to control leg sciatica during conservative antibiotic treatment, overall, additional surgical decompression in pyogenic SEA presenting with no motor deficit of the lower extremity showed increased medical burden and no greater benefit in terms of functional outcomes.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"276-288"},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induced Neural Stem Cell Transplantation in Spinal Cord Injury: Present Status and Next Steps. 诱导神经干细胞移植治疗脊髓损伤：现状和下一步。

Korean Journal of Neurotrauma Pub Date : 2024-12-26 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e45

Jae-Woo Jung, Je Hoon Jeong, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Subum Lee

{"title":"Induced Neural Stem Cell Transplantation in Spinal Cord Injury: Present Status and Next Steps.","authors":"Jae-Woo Jung, Je Hoon Jeong, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Subum Lee","doi":"10.13004/kjnt.2024.20.e45","DOIUrl":"10.13004/kjnt.2024.20.e45","url":null,"abstract":"Spinal cord injury (SCI) remains a significant clinical challenge, with no fully effective treatment available despite advancements in various therapeutic approaches. This review examines the emerging role of induced neural stem cells (iNSCs) as promising candidates for SCI treatment, highlighting their potential for direct neural regeneration and integration with host tissue. We explore the biology of iNSCs, their mechanisms of action, and their interactions with host tissue, including modulating inflammatory responses, promoting axonal growth, and reconstructing neural circuits. Additionally, the importance of administration route, optimal timing for transplantation, and potential adverse events are discussed to address key challenges in translating these therapies to clinical applications. The review also emphasizes recent innovations, such as combining iNSC transplantation with rehabilitative training and the integration of biomaterials and growth factors to enhance therapeutic efficacy. Although preclinical studies have demonstrated positive outcomes, larger, controlled trials and standardized protocols are essential for validating the safety and effectiveness of iNSC-based therapies for SCI patients.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"234-245"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical and Neurointensive Management for Acute Spinal Cord Injury: A Narrative Review. 急性脊髓损伤的外科和神经强化治疗：叙述性回顾。

Korean Journal of Neurotrauma Pub Date : 2024-12-26 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e44

Woo-Keun Kwon, Chang-Hwa Ham, Joonho Byun, Je Hoon Jeong, Myeong Jin Ko, Subum Lee, Byung-Jou Lee, Jong Hyun Kim

{"title":"Surgical and Neurointensive Management for Acute Spinal Cord Injury: A Narrative Review.","authors":"Woo-Keun Kwon, Chang-Hwa Ham, Joonho Byun, Je Hoon Jeong, Myeong Jin Ko, Subum Lee, Byung-Jou Lee, Jong Hyun Kim","doi":"10.13004/kjnt.2024.20.e44","DOIUrl":"10.13004/kjnt.2024.20.e44","url":null,"abstract":"Spinal cord injury (SCI) following high-energy trauma often leads to lasting neurologic deficits and severe socioeconomic impact. Effective neurointensive care, particularly in the early stages post-injury, is essential for optimizing outcomes. This review discusses the role of neurointensive care in managing SCI, emphasizing early assessment, stabilization, and intervention strategies based on recent evidence-based practices. SCI results from primary mechanical damage to the spinal cord, triggering secondary injuries involving vascular and cellular dysfunction. Early neurointensive care focuses on stabilizing airway, breathing, and circulation while preventing further spinal damage. Imaging and neurologic assessments, including the ASIA scale, guide the management plan. Early decompressive surgery within 24 hours is widely supported for patients with spinal instability or cord compression. Pharmacologic strategies aim to reduce secondary injury, though standardization remains limited. Prophylaxis for deep vein thrombosis and pulmonary embolism, intensive pulmonary support, and monitoring for pressure sores are critical in early-phase SCI. Early neurointensive care and surgical interventions play a pivotal role in mitigating SCI progression. Optimal care requires a multifaceted approach addressing both neurologic and systemic complications, significantly influencing recovery and long-term quality of life. Further research is needed to standardize pharmacologic treatments and optimize surgical timing.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Artificial Intelligence in the Comprehensive Management of Spinal Cord Injury. 人工智能在脊髓损伤综合治疗中的应用。

Korean Journal of Neurotrauma Pub Date : 2024-12-24 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e43

Kwang Hyeon Kim, Je Hoon Jeong, Myeong Jin Ko, Subum Lee, Woo-Keun Kwon, Byung-Jou Lee

{"title":"Using Artificial Intelligence in the Comprehensive Management of Spinal Cord Injury.","authors":"Kwang Hyeon Kim, Je Hoon Jeong, Myeong Jin Ko, Subum Lee, Woo-Keun Kwon, Byung-Jou Lee","doi":"10.13004/kjnt.2024.20.e43","DOIUrl":"10.13004/kjnt.2024.20.e43","url":null,"abstract":"Spinal cord injury (SCI) frequently results in persistent motor, sensory, or autonomic dysfunction, and the outcomes are largely determined by the location and severity of the injury. Despite significant technological progress, the intricate nature of the spinal cord anatomy and the difficulties associated with neuroregeneration make full recovery from SCI uncommon. This review explores the potential of artificial intelligence (AI), with a particular focus on machine learning, to enhance patient outcomes in SCI management. The application of AI, specifically machine learning, has revolutionized the diagnosis, treatment, prognosis, and rehabilitation of patients with SCI. By leveraging large datasets and identifying complex patterns, AI contributes to improved diagnostic accuracy, optimizes surgical procedures, and enables the personalization of therapeutic interventions. AI-driven prognostic models provide accurate predictions of recovery, facilitating improved planning and resource allocation. Additionally, AI-powered rehabilitation systems, including robotic devices and brain-computer interfaces, increase the effectiveness and accessibility of therapy. However, realizing the full potential of AI in SCI care requires ongoing research, interdisciplinary collaboration, and the development of comprehensive datasets. As AI continues to evolve, it is expected to play an increasingly vital role in enhancing the outcomes of patients with SCI.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Growing Skull Fracture That Developed Only 3 Weeks After Injury: A Case Report. 成功治疗创伤后仅3周发生的颅骨生长骨折1例。

Korean Journal of Neurotrauma Pub Date : 2024-12-19 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e42

Woo Hyeong Park, Sung Jin Kim, Jung-Ho Yun

引用次数: 0

Spinal Cord Injury From Tuberculous Spondylitis Misdiagnosed as Metastatic Spinal Tumor and Bacterial Spondylitis: A Case Report & Literature Review. 结核性脊柱炎所致脊髓损伤误诊为转移性脊柱炎及细菌性脊柱炎1例报告及文献复习。

Korean Journal of Neurotrauma Pub Date : 2024-12-17 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e41

Seong Hyun Wui, Myeong Jin Ko, Byung-Jou Lee, Subum Lee, Woo-Keun Kwon

{"title":"Spinal Cord Injury From Tuberculous Spondylitis Misdiagnosed as Metastatic Spinal Tumor and Bacterial Spondylitis: A Case Report & Literature Review.","authors":"Seong Hyun Wui, Myeong Jin Ko, Byung-Jou Lee, Subum Lee, Woo-Keun Kwon","doi":"10.13004/kjnt.2024.20.e41","DOIUrl":"10.13004/kjnt.2024.20.e41","url":null,"abstract":"Tuberculous (TB) spondylitis, also known as Pott's disease, was first described by Percivall Pott in 1779. The diagnosis of TB spondylitis is often delayed because of the non-specific nature of the infection, which can lead to severe consequences. Differential diagnosis is especially critical in cancer patients undergoing chemotherapy who present with lymph node or bone metastasis. We present the case of a 76-year-old female with advanced gastric cancer, who was initially suspected of having a metastatic spinal tumor and bacterial spondylitis. The patient presented with lower limb paralysis and was diagnosed with metastatic cancer, resulting in a loss of hope for recovery. However, following the subsequent diagnosis of TB spondylitis and multiple surgical interventions, the patient achieved complete remission and significant improvement, ultimately regaining the ability to walk independently. This case highlights the importance of accurate diagnosis and timely intervention in cases where the initial presentations may mimic metastatic disease.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"246-251"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelopathy Due to Hypertrophic Pachymeningitis Associated With ANCA Vasculitis: A 10-Year Follow-up Case Report. 与ANCA血管炎相关的肥厚性厚性脑膜炎所致脊髓病：10年随访病例报告。

Korean Journal of Neurotrauma Pub Date : 2024-12-16 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e39

JinWoo Jung, Eon Jeong Nam, Sangwoo Lee, Young San Ko, Dae-Chul Cho

引用次数: 0

Letter to the Editor: Commentary on Feasibility Study of Parkinson's Speech Disorder Evaluation With Pre-Trained Deep Learning Model for Speech-to-Text Analysis (Korean J Neurotrauma 2024;20:168-179). 给编辑的信：用预先训练的深度学习模型进行语音到文本分析的帕金森言语障碍评估的可行性研究评论（韩国神经创伤杂志2024；20:168-179）。

Korean Journal of Neurotrauma Pub Date : 2024-12-16 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e40

Kyung Hwan Kim

引用次数: 0

Letter to the Editor: Commentary on Factors Associated With Short-Term Outcomes of Burr-Hole Craniostomy Associated With Brain Re-Expansion and Subdural Hematoma Shrinkage for Chronic Subdural Hematoma (Korean J Neurotrauma 2023;19:324-332). 致编者的信：慢性硬膜下血肿的脑再扩张和硬膜下血肿缩小的脑洞开颅术短期预后相关因素的评论（韩国神经创伤杂志2023；19:24 24-332）。

Korean Journal of Neurotrauma Pub Date : 2024-12-13 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e38

Yong Gu, Xiaodong Long

引用次数: 0

Comparison of Outcomes of Hinge Craniotomy Versus Decompressive Craniectomy in Patients With Malignant Intracranial Hypertension: A Prospective, Randomized Controlled Study. 一项前瞻性、随机对照研究：铰链开颅术与减压开颅术治疗恶性颅内高压的疗效比较。

Korean Journal of Neurotrauma Pub Date : 2024-11-22 eCollection Date: 2024-12-01 DOI: 10.13004/kjnt.2024.20.e37

Mohammad Mostafa Harifi, Hesam Ghadirian, Koroush Karimi-Yarandi, Mohsen Nouri, Seyedsina Ahmadiabhari, Abolghasem Mortazavi

{"title":"Comparison of Outcomes of Hinge Craniotomy Versus Decompressive Craniectomy in Patients With Malignant Intracranial Hypertension: A Prospective, Randomized Controlled Study.","authors":"Mohammad Mostafa Harifi, Hesam Ghadirian, Koroush Karimi-Yarandi, Mohsen Nouri, Seyedsina Ahmadiabhari, Abolghasem Mortazavi","doi":"10.13004/kjnt.2024.20.e37","DOIUrl":"10.13004/kjnt.2024.20.e37","url":null,"abstract":"Objective: This randomized controlled trial (RCT) aimed to compare the short-, mid-, and long-term outcomes in patients with malignant intracranial hypertension undergoing either decompressive craniectomy (DC) or hinge craniotomy (HC).Methods: In this prospective RCT, 38 patients diagnosed with malignant intracranial hypertension due to ischemic infarction, traumatic brain injury, or non-lesional spontaneous intracerebral hemorrhage, who required cranial decompression, were randomly allocated to the DC and HC groups.Results: The need for reoperation, particularly cranioplasty, in the DC group was significantly different from that in the HC group. The percentage of brain expansion was higher in the DC group versus the HC group; however, the difference was not significant. There was no significant intergroup difference in the functional outcome according to the modified Rankin Scale or the Glasgow Outcome Scale. Additionally, no significant intergroup differences were observed in the rates of in-hospital complications.Conclusion: The HC and DC groups did not significantly differ in the rate of hospital complications such as infection, need for reoperation owing to the lack of intracranial pressure control, wound healing problems, or bone infection. Our results suggest that by performing HC, the probability of the need for major surgery (cranioplasty) is reduced, thereby removing financial burden from the patient and the health system.Trial registration: Iranian Registry of Clinical Trials Identifier: IRCT20180515039678N1.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"20 4","pages":"262-275"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0