HeeSeung Noh, Sun Geon Yoon, Kyunghak Choi, Kyu-Hyouck Kyung, Min Soo Kim
{"title":"Efficacy of Serum Antithrombin III Test in Patients With Severe Traumatic Brain Injury.","authors":"HeeSeung Noh, Sun Geon Yoon, Kyunghak Choi, Kyu-Hyouck Kyung, Min Soo Kim","doi":"10.13004/kjnt.2023.19.e29","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e29","url":null,"abstract":"<p><strong>Objective: </strong>Immune reactions following traumatic brain injury (TBI) cause many complications, including intravascular dissemination. Antithrombin III (AT-III) plays an important role in suppressing abnormal clot formation and ensuring hemostasis. Therefore, we investigated the efficacy of serum AT-III in patients with severe TBI.</p><p><strong>Methods: </strong>This retrospective study included 224 patients with severe TBI who visited a single regional trauma center between 2018 and 2020. AT-III levels were measured immediately after the TBI diagnosis. AT-III deficiency was defined as an AT-III serum level <70%. Patient characteristics, injury severity, and procedures were also investigated. Patient outcomes included Glasgow Outcome Scale scores at discharge and mortality.</p><p><strong>Results: </strong>AT-III levels were significantly lower in the AT-III deficient group (n=89; 48.27% ± 1.91%) than in the AT-III sufficient group (n = 135, 78.90% ± 1.52%) (p < 0.001). Mortality occurred in 72 of the 224 patients (33.04%), indicating that there were significantly more patients in the AT-III-deficient group (45/89, 50.6%) than in the AT-III-sufficient group (27/135, 20%). Significant risk factors for mortality included the Glasgow Coma Scale score (P = 0.003), pupil dilatation (P = 0.031), disseminated intravascular coagulopathy (P = 0.012), serum AT-III level (P = 0.033), and procedures including barbiturate coma therapy (P = 0.010). Serum AT-III levels were significantly correlated with Glasgow Outcome Scale scores at discharge (correlation coefficient = 0.455, p < 0.001).</p><p><strong>Conclusion: </strong>Patients with AT-III deficiency after severe TBI may require more intensive care during treatment, because AT-III levels reflect injury severity and correlate with mortality.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 2","pages":"234-241"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/73/kjn-19-234.PMC10329882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heewon Jeong, Jae Hyun Kim, Yoon-Hee Choo, Moinay Kim, Seungioo Lee, Eun Jin Ha, Jiwoong Oh
{"title":"Nutrition Therapy for Patients With Traumatic Brain Injury: A Narrative Review.","authors":"Heewon Jeong, Jae Hyun Kim, Yoon-Hee Choo, Moinay Kim, Seungioo Lee, Eun Jin Ha, Jiwoong Oh","doi":"10.13004/kjnt.2023.19.e31","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e31","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a global health and socio-economic problem, resulting in significant disability and mortality. Malnutrition is common in TBI patients and is associated with increased vulnerability to infection, higher morbidity and mortality rates, as well as longer stays in the intensive care unit and hospital. Following TBI, various pathophysiological mechanisms, such as hypermetabolism and hypercatabolism, affect patient outcomes. It is crucial to provide adequate nutrition therapy to prevent secondary brain damage and promote optimal recovery. This review includes a literature review and discusses the challenges encountered in clinical practice regarding nutrition in TBI patients. The focus is on determining energy requirements, timing and methods of nutrition delivery, promoting enteral tolerance, providing enteral nutrition to patients receiving vasopressors, and implementing trophic enteral nutrition. Enhancing our understanding of the current evidence regarding appropriate nutrition practices will contribute to improving overall outcomes for TBI patients.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 2","pages":"177-184"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/18/kjn-19-177.PMC10329886.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Clinical and Radiologic Outcomes of Single Burr Hole Drainage and Mini-craniotomy in the Treatment of Inhomogeneous Chronic Subdural Hematoma: A Retrospective Study (<i>Korean J Neurotrauma</i> 2022;18:208-220).","authors":"Joonho Byun","doi":"10.13004/kjnt.2023.19.e17","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e17","url":null,"abstract":"Multistage CSDH can be diagnosed by brain computed tomography (CT). However, diagnosing multistage and “multiseptated” CSDH using only a brain CT scan may be difficult. Magnetic resonance imaging (MRI) may provide helpful information for diagnosing multiseptated CSDH.2) Lee et al.4) reported that diffusion-weighted MRI provides better resolution of multiseptated CSDH and can predict post-treatment failure more accurately than brain CT.","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 2","pages":"266-267"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/78/kjn-19-266.PMC10329889.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancements in Neurointensive Care Medicine for the Treatment of Central Nervous System Injuries.","authors":"Byung-Jou Lee, Je Hoon Jeong, Hyuk-Jin Oh","doi":"10.13004/kjnt.2023.19.e30","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e30","url":null,"abstract":"","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 2","pages":"125"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/20/kjn-19-125.PMC10329890.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kummell's Disease is Becoming Increasingly Important in an Aging Society: A Review.","authors":"Myeong Jin Ko, Byung-Jou Lee","doi":"10.13004/kjnt.2023.19.e13","DOIUrl":"10.13004/kjnt.2023.19.e13","url":null,"abstract":"<p><p>Kummell's disease (KD) is referred to as delayed posttraumatic vertebral collapse, avascular necrosis of vertebrae, or ischemic vertebral collapse. KD is no longer rare in an aging society. It is mainly caused by minor trauma, and nonunion occurs secondary to avascular necrosis at the vertebral body fracture site, which can lead to vertebral kyphosis or intravertebral instability. Clinical symptoms of KD range from no symptoms to severe paralysis due to nerve injury. KD is considered a complication of osteoporotic vertebral compression fractures, and conservative treatment, including osteoporosis treatment, is important. Timely interventions such as vertebral augmentation or surgery, with active regular follow-up are necessary before the onset of neurological deficits due to osteonecrotic collapse in patients with suspected KD. In this study, we summarize the pathogenesis, diagnosis, and treatment of KD, which is showing increasing prevalence in an aging society. We have presented a literature review and discussed clinical guidelines and therapeutic strategies to reduce the morbidity and mortality associated with KD.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"32-41"},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/91/kjn-19-32.PMC10083447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of the Glucose Potassium Ratio in the Management of Traumatic Brain Injury.","authors":"Joaquín Ignacio Marini, Matías Emmanuel Sein","doi":"10.13004/kjnt.2023.19.e11","DOIUrl":"10.13004/kjnt.2023.19.e11","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic brain injury (TBI) has become a worldwide public health issue, raising concerns about which tool might be useful to guide initial management at hospital admission, especially to decide whether the patient would benefit from an opportune surgical intervention. Recently, the glucose-to-potassium ratio has more accurate predictive values than other biomarkers and is useful for its simplicity to obtain. To correlate each biomarker with the outcome for every patient with TBI.</p><p><strong>Methods: </strong>The analysis included patients treated in a single institution between 2020 and 2021, diagnosed with mild TBI that required neurosurgery, moderate or severe TBI. Blood samples were obtained at admission, and the glucose-to-potassium ratio was calculated retrospectively. Then, these values and other variables were compared with the outcome at 6 and 12 months. Extracranial lesions that directly contributed to the outcome, a Glasgow Coma Scale of 3 and below, hemodynamic instability, and cardiac arrest were exclusion criteria.</p><p><strong>Results: </strong>Forty-seven patients who reached the criteria were examined, 35 (74%) had a favorable outcome and 12 (26%) a poor one. The only biomarker significantly related to the outcome was the glucose-to-potassium ratio in both the bivariate and multivariate analysis (<i>p</i>=0.04; odds ratio, 8.61; 95% confidence interval, 1.07-69.6).</p><p><strong>Conclusion: </strong>An increase in the glucose-to-potassium ratio was the only biomarker associated with poor outcomes and increased mortality.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/b3/kjn-19-82.PMC10083449.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9303849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Importance of Prophylactic Ligation of the Bridging Vein in Acute Subdural Hematoma: A Case Report.","authors":"Jun Seok Park, Eui Gyu Sin","doi":"10.13004/kjnt.2023.19.e2","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e2","url":null,"abstract":"<p><p>Acute subdural hematoma (ASDH) induced by a bridging vein (BV) rupture is considered a catastrophic head injury, especially in the elderly. Epidemiological studies have shown a much higher incidence rate of BV-induced ASDH in the elderly compared to younger adults, along with elevated morbidity and mortality, and poor outcomes. Brain atrophy can be a risk factor contributing to the increased risk of ASDH in elderly trauma patients. Considering this, prophylactic ligation of the impending breakage in the BV may reduce the risk of rebleeding and treat the ASDH. Here, we report a relevant case.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"103-108"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/4c/kjn-19-103.PMC10083443.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9673778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Traumatic Migration of a Shunt Valve Into the Cyst.","authors":"El Kim","doi":"10.13004/kjnt.2023.19.e6","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e6","url":null,"abstract":"<p><p>Hardware migration is an unavoidable complication of intracranial shunt surgeries. Traumatic dislodgement of a valve into the skull occurred in a young boy with a cystoperitoneal shunt following a head injury. Shortly before admission, he fell off his wheelchair and hit his head on the floor. Medical treatment was initiated to manage the patient for traumatic intracranial hemorrhage, and he was subsequently discharged home. However, 2 weeks after discharge, computed tomography (CT) showed a migrating valve and associated meningitis. The CT scan showed that the shunt valve was deep in the temporal cyst. The dislodged shunt valve was left in situ because the parents did not want surgical intervention. The author demonstrates how this complication develops and suggests preventive measures through reviews on the migration of the shunt into the cranium.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/87/kjn-19-115.PMC10083450.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9673781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"History and Current Status of Regional Trauma Centers.","authors":"Min Soo Kim","doi":"10.13004/kjnt.2023.19.e7","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e7","url":null,"abstract":"https://kjnt.org Patients with severe trauma experience serious or significant complications, such as hemorrhagic shock or multiple organ dysfunction, resulting in major organ damage or extensive damage to other body parts, including edema or penetrating injuries.5,12) In these patients, the period of initial management after an accident has a great influence on prognosis, which is referred to as the ‘golden hour.’6,9) Although a single injury can occur, multiple injuries are more common and can negatively affect patient’s prognosis.2,4) Therefore, a multidisciplinary approach for managing multiple injuries in patients with severe trauma is needed.1)","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/b6/kjn-19-1.PMC10083451.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9303851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rehabilitation for Impaired Attention in the Acute and Post-Acute Phase After Traumatic Brain Injury: A Narrative Review.","authors":"Hoo Young Lee, Sung Eun Hyun, Byung-Mo Oh","doi":"10.13004/kjnt.2023.19.e1","DOIUrl":"https://doi.org/10.13004/kjnt.2023.19.e1","url":null,"abstract":"<p><p>Impaired attention is the most common and debilitating cognitive deficit following a traumatic brain injury (TBI). Attention is a fundamental function that profoundly influences the performance of other cognitive components such as memory and execution. Intriguingly, attention can be improved through cognitive rehabilitation. This narrative review summarizes the essential elements of rehabilitation for attention problems in acute and post-acute TBI. In the acute phase of mild TBI, investigations into the medical history and daily life performance, neurological examination, screening and management of concomitant sleep-wake disorders or neuropsychiatric disorders, and support and education on the natural course of concussion are covered. Rehabilitation for patients with moderate-to-severe TBI consists of serial assessment for patients with disorders of consciousness and a post-traumatic confusion state. In the post-acute phase after TBI, components of rehabilitation include investigating medical history; neurological, imaging, and electrophysiological tests; evaluation and treatment of factors that may impact attention, including sleep-wake, emotional, and behavioral disorders; evaluation of attention function; and cognitive rehabilitation as a matter of course. We summarized metacognitive strategy, direct attention training, computer-based cognitive interventions, medication, and environmental control as interventions to enhance attention.</p>","PeriodicalId":36879,"journal":{"name":"Korean Journal of Neurotrauma","volume":"19 1","pages":"20-31"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/2b/kjn-19-20.PMC10083445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9303847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}