Effect of Choline Alfoscerate on Cognitive Dysfunction After Mild Traumatic Brain Injury: A Single-Center Prospective Case-Control Study.

Q3 Medicine
Korean Journal of Neurotrauma Pub Date : 2025-04-25 eCollection Date: 2025-04-01 DOI:10.13004/kjnt.2025.21.e17
Mu Seung Park, Jin Seo Yang, Suk-Hyung Kang, Hyuk Jai Choi, Jin Pyeong Jeon, Yong-Jun Cho
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引用次数: 0

Abstract

Objective: The purpose of this study was to determine the effect of choline alfoscerate on the recovery of cognitive function in patients with mild traumatic brain injury.

Methods: Patients with mild traumatic brain injuries were included. The Korean version of the Mini-Mental State Examination (K-MMSE) was used to evaluate cognitive function. The K-MMSE was performed on the 7th day post-trauma. The patients were divided into the choline and control groups (15 subjects). The choline group was administered choline alfoscerate (400 mg) twice daily for 8 weeks. After 8 weeks, the K-MMSE was administered to both groups, and the results were compared with those before treatment.

Results: Thirty patients (15 each in the choline and control groups) were enrolled between November 2013 and March 2015. The mean ages were 64.2±12.1 and 63.7±16.8 years for the choline and control groups, respectively. The K-MMSE scores on the 7th day post-trauma were 21.7±6.2 and 25.1±4.3 for the choline and control groups, respectively. The K-MMSE scores at 9 weeks post-trauma were 24.1±5.1 and 25.7±4.4 for the choline and control groups, respectively. The change in cognitive function during the 8-weeks was 2.5±2.1 and 0.5±0.9 for the choline and control groups, respectively. The choline group showed greater cognitive improvement than the control group (p=0.004).

Conclusion: Choline alfoscerate improves cognitive function in patients with mild traumatic brain injuries.

胆碱对轻度创伤性脑损伤后认知功能障碍的影响:一项单中心前瞻性病例对照研究。
目的:探讨胆碱对轻度外伤性脑损伤患者认知功能恢复的影响。方法:选取轻度外伤性脑损伤患者。韩国版的简易精神状态测验(K-MMSE)用于评估认知功能。K-MMSE于创伤后第7天进行。将患者分为胆碱组和对照组(15例)。胆碱组给予高脂胆碱400 mg,每日2次,连用8周。8周后,两组均给予K-MMSE治疗,并与治疗前比较。结果:2013年11月至2015年3月共纳入30例患者,胆碱组和对照组各15例。胆碱组和对照组的平均年龄分别为64.2±12.1岁和63.7±16.8岁。胆碱组和对照组创伤后第7天K-MMSE评分分别为21.7±6.2和25.1±4.3。胆碱组和对照组创伤后9周K-MMSE评分分别为24.1±5.1和25.7±4.4。8周内,胆碱组和对照组的认知功能变化分别为2.5±2.1和0.5±0.9。胆碱组认知功能改善明显高于对照组(p=0.004)。结论:皂角化胆碱可改善轻度颅脑损伤患者的认知功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.10
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