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Micron-resolution Optical Coherence Tomography of the Human Eye 人眼的微米分辨率光学相干断层扫描
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.ci.235
M. Hee, J. Izatt, D. Huang, E. Swanson, Charles P. Lin, J. Schuman, C. Puliafito, J. Fujimoto
{"title":"Micron-resolution Optical Coherence Tomography of the Human Eye","authors":"M. Hee, J. Izatt, D. Huang, E. Swanson, Charles P. Lin, J. Schuman, C. Puliafito, J. Fujimoto","doi":"10.1364/aoipm.1994.ci.235","DOIUrl":"https://doi.org/10.1364/aoipm.1994.ci.235","url":null,"abstract":"We have developed a new technique for micron scale resolution cross-sectional imaging in biological systems called Optical Coherence Tomography (OCT)1,2 In OCT, low-coherence optical interferometry3,4 is used to resolve the position of reflective or optical backscattering sites within a sample. Two-dimensional tomographic images of a thin, optical slice of tissue may be obtained with 10 μm longitudinal and lateral resolution. Narrowband optical heterodyne detection achieves a sensitivity to reflected light as small as 10-10 of the incident optical power. OCT is non-contact, non-invasive, and has superior resolution to conventional clinical ultrasound. Unlike scanning laser ophthalmoscopy and scanning laser tomography, the optical sectioning capability of OCT is not restricted by the pupil-limited numerical aperture of the eye or ocular aberrations. OCT may be implemented in a compact, low-cost, fiber-optic based interferometer that is easily coupled to existing ophthalmic instrumentation. We demonstrate high-speed, in vivo OCT imaging in both the anterior and posterior eye.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"os-22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127766758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wave Dynamics and Spectral Correlation in Random Media 随机介质中的波动动力学和谱相关
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.wpl.43
A. Z. Genack, W. Polkosnik, A. Lisyansky, N. Garcı́a, P. Sebbah
{"title":"Wave Dynamics and Spectral Correlation in Random Media","authors":"A. Z. Genack, W. Polkosnik, A. Lisyansky, N. Garcı́a, P. Sebbah","doi":"10.1364/aoipm.1994.wpl.43","DOIUrl":"https://doi.org/10.1364/aoipm.1994.wpl.43","url":null,"abstract":"We present measurements of the microwave field transmitted through an ensemble of random dielectric samples. We compare the field correlation function with frequency shift with the intensity correlation function and relate it to the dynamic measurement of the time of flight distribution. Finally, we present measurements of the total phase accumulated by the wave in passing through random samples.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"8 Pt 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126269546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Scattering and Enhanced Backscattering Effects for Flat Substrates with Small Protuberances 小凸点平面基底的多重散射和增强后向散射效应
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.wpl.48
F. Moreno, J. Saiz, F. González
{"title":"Multiple Scattering and Enhanced Backscattering Effects for Flat Substrates with Small Protuberances","authors":"F. Moreno, J. Saiz, F. González","doi":"10.1364/aoipm.1994.wpl.48","DOIUrl":"https://doi.org/10.1364/aoipm.1994.wpl.48","url":null,"abstract":"Multiple scattering and enhanced backscattering effects are analyzed for a simple scattering system consisting on a flat substrate with two small spherical scatterers.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126334516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Locating Objects with Diffuse Light 用漫射光定位物体
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.dcwi.297
P. Outer, M. V. Rossum, T. Nieuwenhuizen, A. Lagendijk
{"title":"Locating Objects with Diffuse Light","authors":"P. Outer, M. V. Rossum, T. Nieuwenhuizen, A. Lagendijk","doi":"10.1364/aoipm.1994.dcwi.297","DOIUrl":"https://doi.org/10.1364/aoipm.1994.dcwi.297","url":null,"abstract":"A small object hidden in a multiple scattering medium is accurately located using a continuous light source. Good agreement between theory and experiment is found.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126379942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transillumination Imaging of Tissue by Phase Modulation Techniques 基于相位调制技术的组织透照成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.apmpdwi.88
M. Kaschke, H. Jess, G. Gaida, Johannes-Maria Kaltenbach, W. Wrobel
{"title":"Transillumination Imaging of Tissue by Phase Modulation Techniques","authors":"M. Kaschke, H. Jess, G. Gaida, Johannes-Maria Kaltenbach, W. Wrobel","doi":"10.1364/aoipm.1994.apmpdwi.88","DOIUrl":"https://doi.org/10.1364/aoipm.1994.apmpdwi.88","url":null,"abstract":"Optical imaging through human tissue to determine interior structure\u0000 and functional status has broad potential applications in many fields\u0000 of medicine, just to name early cancer diagnosis of breast and scrotum\u0000 or brain imaging. Images for medical diagnosis in these areas can be\u0000 obtained using a number of existing techniques1. However,\u0000 most of these techniques suffer from the fact that they are either\u0000 invasive by utilizing ionizing radiation or they are implemented\u0000 largely by non-portable, costly devices. Even more important, the\u0000 images obtained by these methods almost exclusively reveal static,\u0000 morphological information about the biological object, i.e. they give\u0000 no indication about the functional status or the functional dynamics\u0000 of the tissue under investigation.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134187498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time Resolved Diffusion Tomographic Image Reconstruction in Highly Scattering Turbid Media 高散射浑浊介质中时间分辨扩散层析成像的重建
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.ria269
W. Cai, B. Das, F. Liu, M. Zevallos, M. Lax, R. Alfano
{"title":"Time Resolved Diffusion Tomographic Image Reconstruction in Highly Scattering Turbid Media","authors":"W. Cai, B. Das, F. Liu, M. Zevallos, M. Lax, R. Alfano","doi":"10.1364/aoipm.1996.ria269","DOIUrl":"https://doi.org/10.1364/aoipm.1996.ria269","url":null,"abstract":"Image of objects hidden in highly scattering media was reconstructed using a new fast and noise-resistant algorithm applied to the optical diffusion tomography. Temporal intensities slices at multiple times of scattered profiles from multiple source-detector pairs are used as experimental input data to form an image.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130890613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Properties of Human Uterus at 630 nm 630nm人眼子宫的光学特性
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.opttm.262
S. Madsen, B. Tromberg, Y. Tadir, P. Wyss, L. O. Svaasand, R. Haskell
{"title":"Optical Properties of Human Uterus at 630 nm","authors":"S. Madsen, B. Tromberg, Y. Tadir, P. Wyss, L. O. Svaasand, R. Haskell","doi":"10.1364/aoipm.1994.opttm.262","DOIUrl":"https://doi.org/10.1364/aoipm.1994.opttm.262","url":null,"abstract":"The optical properties of normal and fibriotic human uteri were determined using frequency-domain and steady-state techniques.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131006577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Imaging through biological tissues by use of optical low-coherence heterodyne detection technique 利用光学低相干外差检测技术对生物组织进行成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.cit250
K. Chan, M. Yamada, H. Inaba
{"title":"Imaging through biological tissues by use of optical low-coherence heterodyne detection technique","authors":"K. Chan, M. Yamada, H. Inaba","doi":"10.1364/aoipm.1996.cit250","DOIUrl":"https://doi.org/10.1364/aoipm.1996.cit250","url":null,"abstract":"A coherent detection imaging system has been modified to employ a super-luminescent diode as low-coherence optical source for optical imaging through strongly scattering media such as biological tissues. By appropriately fixing the coherence gating, the system is able to selectively detect the coherent components of transmitted light. Using this system we have demonstrated the feasibility of optical heterodyne detection method in discriminating against the diffuse photons. The unique applications of low-coherence heterodyne detection in transillumination imaging that may potentially yield useful diagnostic information on tissue structures are also presented.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130745901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Back-Projection Reconstructions of Cylindrical Inhomogeneities from Frequency Domain Optical Measurements in Turbid Media 混浊介质中频域光学测量柱状非均匀性的反投影重建
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.mt137
S. Walker, S. Fantini, E. Gratton
{"title":"Back-Projection Reconstructions of Cylindrical Inhomogeneities from Frequency Domain Optical Measurements in Turbid Media","authors":"S. Walker, S. Fantini, E. Gratton","doi":"10.1364/aoipm.1996.mt137","DOIUrl":"https://doi.org/10.1364/aoipm.1996.mt137","url":null,"abstract":"We propose a fast, simple method of reconstruction, similar to x-ray ct, where the physical parameters are calculated from frequency domain data and back-projected to form an image of the region of interest. Images are shown for centimeter size inhomogeneities with optical properties similar the those of human tissue. Data is collected single and multiple inhomogeneities from linear scans with a source-detector separation of 5 cm (source λ=793 nm, frequency=120 MHz). While, objects are located correctly with this technique, optical properties are recovered only qualitatively.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132926270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Time-Resolved Imaging of Solid Tissue Phantoms Using a Perturbation Model 使用微扰模型的实体组织幻影的时间分辨成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.trit93
J. Hebden, S. Arridge
{"title":"Time-Resolved Imaging of Solid Tissue Phantoms Using a Perturbation Model","authors":"J. Hebden, S. Arridge","doi":"10.1364/aoipm.1996.trit93","DOIUrl":"https://doi.org/10.1364/aoipm.1996.trit93","url":null,"abstract":"Measurements of the time-dependent intensity of transmitted light through a highly scattering tissue phantom have been compared with an analytical model which describes the sensitivity of that intensity to localized changes in optical properties. A least-squares fitting procedure is employed to investigate the accuracy with which the model can predict the true displacement between a single embedded inhomogeneity and the line-of-sight across the phantom. The embedded object has twice the scatter and absorption coefficient of the surrounding medium. A further fitting procedure was used to derive the amplitudes of the measurement perturbations as the line-of-sight is translated towards the inhomogeneity. Results show that the diffusion perturbation amplitude provides inherently greater spatial resolution than the absorption perturbation amplitude.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114855066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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