Andrology and Genital Surgery最新文献

{"title":"Delayed reconstruction of the bladder and rectum after evisceration of the pelvic organs in patients with relapse of malignant neoplasms and radiation injuries (2 clinical observations)","authors":"V. Korotkov, L. Petrov, M. Kasymov, V. V. Pasov, V. Skoropad, L. V. Tivkova, A. Yamshchikova, I. Gunko, N. Naumov, A. Kaprin, S. A. Ivanov","doi":"10.17650/2070-9781-2022-23-2-83-91","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-83-91","url":null,"abstract":"The study presents two clinical observations of delayed reconstructive surgeries: 1) in a patient with recto-bladder fistula formed after a course of external beam therapy due to recurrent prostate cancer; 2) in a patient with progressing cervical carcinosarcoma, tumor invasion in the bladder wall, and metastases in the rectoperineal lymph nodes. Absence of standards of care, algorithms of diagnostic and surgical manipulations for this patient category creates a need for personalized approach to the stated problems. An interdisciplinary meeting allows to realize a plan of surgical help for these patients to address oncological process and complications of its treatment. At the reconstructive stage, we used techniques of formation of a new continent heterotopic reservoir from the ileocecal segment and coloanal anastomosis. The presented clinical observations are interesting due to delayed stage of reconstructive interventions which in the absence of progression of the main disease allows to perform correcting operations to improve patients’ quality of life.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129204183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral strictures in boys after hypospadias treatment: two-staged buccal urethroplasty","authors":"E. Ladygina, N. V. Demin, V. Nikolaev","doi":"10.17650/2070-9781-2022-23-2-68-77","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-68-77","url":null,"abstract":"Introduction. The most common cause of urethral strictures in boys is a complication of hypospadias treatment. Extended and complicated strictures represent the most difficult segment of the problem and the choice of the method of surgical correction.The study objective is to review the technique and results of replacement urethroplasty with buccal graft in urethral strictures that occurred after treatment of hypospadias in childhood.Materials and methods. A retrospective study conducted at the Clinical and Research Institute of Emergency Pediatric Surgery and Trauma from 2017 to 2020. Cases of 34 patients who underwent staged replacement buccal urethroplasty for complicated urethral stricture were studied. The examination revealed complications such as: Lichen sclerosus, short urethra, fistulas, diverticula, multiple (double) and extended strictures.Results. Complications occurred in 3 (8.8 %) patients: cutaneous urethral fistula developed in two, partial scarring of the free graft occurred in one child. Long-term results were assessed after an average of 16 months. Our experience of treating 34 pediatric and adolescent patients with p after-hypospadias strictures showed that the leading cause of stricture formation after hypospadias treatment is Lichen sclerosus, which occurred in 16 patients.Conclusion. During the last century, many donor tissues have been proposed for free urethroplasty, but it is the buccal graft that has won the largest number of supporters, and two-staged urethroplasty has become the method of choice for strictures of the anterior urethra. The surgeon’s considerable experience in performing buccal urethroplasty, adherence to the nuances of the technique and methodology of postoperative management, both at the first and second stages, allows you to obtain a good cosmetic and functional result even after a number of unsuccessful operations.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121061916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of penile length following radical prostatectomy","authors":"A. Osadchinskii, S. Kotov","doi":"10.17650/2070-9781-2022-23-2-54-60","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-54-60","url":null,"abstract":"Introduction. The majority of patients who undergo radical prostatectomy, apart from loss of sexual function, note a decrease in penis size which negatively affects their self-esteem. Penile rehabilitation is a set of measures aimed at recovery of sexual function to improve the quality of life.Objective. To analyze various options for penile rehabilitation in order to choose a method for preventing penis size reduction in patients undergoing nerve-sparing radical prostatectomy.Materials and methods. Patients who undergo radical prostatectomy (n = 83) at status flaccid and status erect were measured: length, circumference of the base, body and glans penis (mm) at different periods of penile rehabilitation. As a control, the tumescence coefficient was determined using pharmacodopplerography. All results were evaluated before, at the 6th and 12th months after radical prostatectomy.Results. Depending on the type of restoration of erectile function, the patients were divided into several groups: group 1 – men without penile rehabilitation; group 2 – patients treated with phosphodiesterase inhibitors of type 5; group 3 – using vacuum erection device (VED) and group 4 – taking combined penile rehabilitation. Medians of tumescence coefficient in group 1 on the 6th and 12th months was 2.7 (2.4; 3.1) and 2.6 (1.9; 2.9), in group 2 – 2.8 (2.2; 3.5) and 2.9 (2.2; 3.5), in group 3 – 2.7 (2.3; 3.3) and 2.8 (2.3; 3.3), in group 4 – 3.0 (2.2; 3.2) and 3.1 (2.1; 3.2), respectively (p <0.05).Conclusion. The determination of the tumescence coefficient in dynamics showed more significant results throughout the entire observation period. Combined penile rehabilitation is an effective method of restoring erectile function and also allows to maintain the size of the penis at all follow-up periods.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128293600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term complications after injuries of the male genitalia (results of a retrospective analysis)","authors":"M. A. Al-Vadzhikh, I. Vinogradov, A. Kapto","doi":"10.17650/2070-9781-2022-23-2-61-67","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-61-67","url":null,"abstract":"Genital injuries in men were most common among young people aged 18 to 45 (62.5 %). This is a group of able-bodied people and people who plan to have children. This makes this problem socially significant. Evaluation of the results and outcomes of treatment of injuries of the scrotum and penis should be carried out in a comprehensive manner. The assessment should assess the clinical component, radiation methods (ultrasound, ultrasound dopplerography, urethrocystography), disorders of spermatogenesis (spermogram), quality of life. The frequency of occurrence and severity of violations in all the designated groups of criteria for injuries of the scrotum organs correlate with the main assessment criteria – the degree of damage, the duration of the injury. The article presents the results of long-term consequences in patients after injuries of the genitals in men. The article also presents recommendations for the treatment of patients after injuries of the genitals in men, rehabilitation methods and recommendations for the medical examination of patients who have suffered injuries of the male genitals.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122522481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome of venous compression neuropathy in patients with pelvic varicose veins","authors":"A. Kapto","doi":"10.17650/2070-9781-2022-23-2-11-18","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-11-18","url":null,"abstract":"The study objective is to investigate the pathogenesis of the development of pelvic symptoms in patients with pelvic varicose veins.Materials and methods. From 2015 to 2022, 145 men with pelvic varicose veins were examined. The examination included questioning of patients using questionnaires (scales) and instrumental methods: 1) ultrasound examination of the scrotum with color Doppler mapping; 2) transrectal ultrasound examination of the prostate and veins of the periprostatic plexus; 3) magnetic resonance imaging of the inferior vena cava and pelvic vessels or computer (multispiral) tomography of the abdominal organs with contrast; 4) phlebography of the renocaval and ileocaval segments.Results. The variant anatomy of fibrous and fibro-osseous canals (tunnels) can explain the fact that with equally pronounced expansion of the pelvic veins, some patients have pelvic symptoms due to nerve compression, while the other part does not. This concept is supported by the fact that in those patients who had complaints of pain, dysuria and erectile dysfunction, after surgical treatment of pelvic varicose veins, in most cases they disappeared or decreased.Conclusion. Pain syndrome (56.6 % of cases), erectile dysfunction (51 % of cases) and dysuria (17.9 % of cases) were noted as clinical manifestations in patients with pelvic varicose veins. Analysis of data after examination and treatment of patients with pelvic varicose veins allowed us to identify “venous compression neuropathy syndrome” as a probable cause of the development of pelvic symptoms in patients with pelvic varicose veins. Depending on the level of localization of nerve compression by varicose veins, we proposed to distinguish three forms of this syndrome: 1) thoracic, 2) lumbar, and 3) sacral form.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115590442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of minimally invasive methods of treatment of localized prostate cancer","authors":"D. Chinenov, E. Shpot, Y. Chernov, Z. K. Tsukkiev, A. Votyakov, A. Kurbanov, H. M. Ismailov, Y. Lerner, L. Rapoport","doi":"10.17650/2070-9781-2022-23-2-34-46","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-34-46","url":null,"abstract":"The purpose of this work is to study the functional and oncological results of minimally invasive methods in patients with verified prostate cancer.Materials and methods. In our study, 160 patients with identified prostate cancer were presented, treatment was carried out with minimally invasive methods (methods of cryoablation (n = 53), brachytherapy (n = 52) and HIFU therapy (n = 55)). A qualitative assessment of the oncological outcome revealed high levels of prostate-specific antigen (PSA) and the results of repeated transrectal prostate biopsies. The evaluation of functional indicators and quality of life was carried out according to the results of the IIEF-5 (International Index of Erectile Function), IPSS (International Prostate Symptom Score), QoL (Quality of Life), Qmax (maximum urination rate of function).Results. The results of oncological control according to the data of positive repeated biopsies were worse in patients after cryoablation (7.54 %), the best indicators of oncological results were observed in patients after brachytherapy. Looking at the IPSS results, it is possible to detect statistical signs of higher scores in the brachytherapy group when various signs are found in the postoperative period, however, these differences do not reach statistical signs in the late period in patients of group brachytherapy and cryoablation. Patients of the cryoablation group showed higher levels of the IIEF-5 in the postoperative period, in the late period of observation of erectile function in patients  of the cryoablation group, the statistical data did not differ from those in patients after brachytherapy. Patients after HIFU therapy showed a decrease in de novo erectile dysfunction over a 3-year follow-up period, above average IIEF5 scores, below IPSS scores, and better QoL results.Conclusion. Long-term oncological results are, in general, revisions, however, the recurrence rate is slightly higher in patients after cryoablation. Prostate cancer recurrence was detected in patients of the ISUP 3 group. In patients after HIFU therapy, the quality of urination is higher than in patients of other groups, which can be associated with the laser enucleation of prostate hyperplasia performed by him. The advantage in patients after HIFU therapy was observed in the detection of IIEF-5, thus HIFU therapy had a better effect on the quality of life of patients with pathological prostate cancer.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128284666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of bovhyaluronidase azoximer in patients undergoing transurethral resection of the prostate","authors":"T. Shatylko, R. Safiullin, S. Gamidov, A. Popova, S. H. Izhbaev, A. F. Mazitova","doi":"10.17650/2070-9781-2022-23-2-47-53","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-47-53","url":null,"abstract":"Introduction. Inflammation and fibrosis may have a significant role in pathogenesis of benign prostatic hyperplasia and associated lower urinary tract symptoms. Moreover, those factors may compromise the outcomes of surgical interventions for bladder outlet obstructions, such as transurethral resection of the prostate (TURP). Additional measures, such as administration of anti-fibrotic agents, may decrease the incidence of certain complications (e.g. bladder neck stenosis, urethral stricture) and improve overall outcomes of TURP. Bovhyaluronidase azoximer is an enzyme combined with high molecular mass copolymer which may inhibit surgery-related tissue remodeling and prevent excessive fibrosis.Materials and methods. Sixty-five patients undergoing monopolar TURP were enrolled in this prospective randomized open-label study. Patients in Group 1 (n = 34) received 5 intramuscular injections of bovhyaluronidase azoximer (3000 IU) on days 3, 6, 9, 12 and 15 after TURP in addition to standard therapy. Patients in Group 2 (n = 31) received conventional peri-operative therapy. All patients routinely underwent uroflowmetry and post-void residual volume measurement on follow-up 3 months after TURP. Incidence of fibrosis-associated complications was compared using Fisher’s exact test. Uroflowmetric parameters were compared using Mann-Whitney U-test.Results. One patient in Group 1 was excluded from the study due to mild allergic reaction after second injection of bovhyaluronidase azoximer. There were three cases of clinically significant fibrosis-associated complications in Group 2 which were confirmed on imaging (9.7 %). One case of stricture in bulbar urethra was later successfully managed with anastomotic urethroplasty, and two cases of bladder neck stenosis were managed with transurethral incision. No such complications were observed in Group 1 (0 %). However, the difference was not statistically significant (p = 0.1079). Otherwise, there were no adverse events in both groups. Median Qmax in Groups 1 and 2 was 24 ml/s and 22 ml/s, respectively (p = 0.08). Median Qave in Groups 1 and 2 was 15 ml/s and 9 ml/s, respectively (p <0.00001). Median of post-void residual volume in Groups 1 and 2 was 25 ml and 40 ml, respectively (p = 0.00438).Conclusion. This study was underpowered to demonstrate significant difference in incidence of fibrosis-related complications of TURP, though there was a trend towards lower risk in patients treated with bovhyaluronidase azoximer. There was also a statistically significant difference in Qave and post-void residual volume in favor of Group 1, which may demonstrate lower rates of subclinical fibrosis. Overall, treatment with bovhyaluronidase azoximer was safe. Robust studies with longer follow-up are required to confirm efficacy of bovhyaluronidase preparations in post-TURP setting.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125916206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of semen analysis by quantitative kariological analysis of immature germ cells in azoospermic and cryptozoospermic patients","authors":"M. Shtaut, T. Sorokina, V. Chernykh, L. Kurilo","doi":"10.17650/2070-9781-2022-23-2-19-26","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-19-26","url":null,"abstract":"Introduction. Obtaining spermatozoa in azoospermic men is a relevant objective. Quantitative karyological analysis of immature germ cells (QKA IGCs) allows to characterize the progression of spermatogenesis through different meiotic stages, that present some advantages in comparison with standard semen analysis (SSA) examination and testicular biopsy.The study objective was to analyze SSA and QKA IGCs for detecting of germ cells in the ejaculate of patients with suspected azoospermia.Materials and methods. The ejaculate samples of 20 men with suspected azoospermia of various etiology (genetically determined and idiopathic male infertility) were studied. The ejaculate samples were processed in parallel by two methods, SSA performed according to the WHO laboratory manual for the examination and processing of human semen (2010) and QKA IGCs.Results. Using by the SSA, cryptozoospermia was detected in 1 (5 %) of 20 ejaculate samples. QKA IGCs revealed cryptozoospermia in 10 (50 %) samples, including 53 % of patients (with azoospermia according to SSA). The number of spermatozoa in the ejaculate sediment as a result of QKA IGСs (2.25 ± 4.22) is higher (p = 0.019; U = 113) than the number of spermatozoa as a result of the SSA – 0.25 ± 1.12.Conclusion. In patients with suspected azoospermia, the effectiveness of detecting cryptozoospermia using the QKA IGCs method is significantly (10 times) higher than the SSA. This method complements SSA and makes it possible to detect non-invasively the meiosis defects, including cases with an extremely low concentration of spermatozoa. The analysis is safe for the patient and can be performed repeatedly to track the dynamics of semen parameters.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129840834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of plastic surgery of the pyeloureteral junction with kidney transposition and nephropexy in hydronephrosis of a dystopic kidney","authors":"D. I. Laletin, M. A. Firsov, V. Y. Bodyagin, E. Bezrukov, P. A. Simonov","doi":"10.17650/2070-9781-2022-23-2-78-82","DOIUrl":"https://doi.org/10.17650/2070-9781-2022-23-2-78-82","url":null,"abstract":"Introduction. Obstruction of the pyeloureteral junction is the most common anomaly of the upper urinary tract. Irrespective of the causes, narrowing of the ureteropelvic junction leads to abnormal urine outflux, increased intrarenal pressure, gradual sclerosis of renal parenchyma, loss of kidney function. In some cases, obstruction of the ureteropelvic junction can be accompanied by dystopic kidney, nephroptosis, abnormal location of the main and accessory renal vessels which requires correction of the standard surgical treatment.The study objective is to evaluate the effectiveness of combination of laparoscopic pyeloplasty with kidney transposition and nephropexy in obstruction of the pyeloureteral junction of a dystopic kidney.Materials and methods. Medical records of 8 patients who underwent surgery in the Kracnoyarsk Regional Clinical Hospital between 2017 and 2021 were analyzed. Obstruction of the pyeloureteral junction was confirmed clinically by ultrasound of the kidneys, excretory retrograde pyelography, contrast-enhanced spiral computed tomography.Results. In all of the 8 patients, lumbar dystopia of the affected kidney was diagnosed, in 25 % pathology was accompanied by nephroptosis, in 50 % of cases by abnormal location of the main and accessory renal vessels. All patients underwent laparoscopic plastic surgery of the pyeloureteral junction per Anderson–Hynes with antegrade ureter stenting, kidney transposition, nephropexy. Mean operative time was 190 ± 39 min, no intraoperative blood loss was observed. Ureteral catheter was removed at day (6.3 ± 2.2). Hospital length of stay was 9.3 ± 3.7 days. In 1 patient, postoperative period was complicated by suture breakage in the posterior wall of the pyeloureteral anastomosis which required repeat laparoscopy to correct suture defect. Time of ureteral stent implantation was 34.6 ± 8.5 days. Control examination showed full remission of pain syndrome. Excretory urography showed full outflow of the contrast agent after examination with furosemide in 100 % of cases.Conclusion. Combination of laparoscopic plastic surgery of the pyeloureteral segment with kidney transposition and nephropexy is an effective minimally invasive operation for treatment of ureteropelvic junction stricture of a dystopic kidney.","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127728529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoprosin in the complex treatment of lower urinary tract symptoms in combination with prostatitis of category III","authors":"A. Polishchuk, S. Shkodkin, K. S. Shkodkin","doi":"10.17650/1726-9784-2022-23-1-76-81","DOIUrl":"https://doi.org/10.17650/1726-9784-2022-23-1-76-81","url":null,"abstract":"Introduction. The problem of effective and safe therapy of patients with benign prostatic hyperplasia and prostatitis of category III remains relevant, despite the numerosity of the drugs used in different groups. Under these conditions, the search for new pharmacological agents continues.The study objective was to evaluate the efficacy of Adenoprosin in the treatment of lower urinary tract symptoms and erectile dysfunction in patients with chronic pelvic pain syndrome and prostate hyperplasia.Materials and methods. The 90-day study included 60 patients aged 40 to 60 years with chronic pelvic pain syndrome and erectile dysfunction on the background of benign prostatic hyperplasia. Patients of the main group received alfa-1-adrenoreceptor blocker tamsulosin for 30 days in combination with the nonsteroidal anti-inflammatory drug nimesulide for 5 days and Adenoprosin suppositories. The men of the control group took tamsulosin for 30 days and nimesulide for 5 days. Over the next 60 days, the dynamics was evaluated based on the data from the NIH-CPSI (National Institutes Health Chronic Prostatitis Symptom Index), IPSS (International Prostate Symptom Score), QoL (Quality of Life Scale), AMS (Aging Male Symptoms), IIEF-5 (International Index of Erectile Function); urination diary analysis; general urine analysis; blood test for the level of prostate specific antigen, glucose; prostate secretion analysis; transrectal ultrasound examination of the prostate gland with measurement of residual urine; uroflowmetry.Results. Urinary frequency decreased at day 30 in the treatment group from 12.7 ± 1.4 to 7.3 ± 1.8 micturitions per day, in the control group from 13.1 ± 1.8 to 9.6 ± 1.1; subsequently (on days 60 and 90) positive effect persisted in the treatment group, while in the control group urinary frequency increased. Per the NIH-CPSI questionnaire, symptoms decreased at day 30: in the treatment group from 25.4 ± 2.1 to 12.3 ± 1.9 points, in the control group from 24.3 ± 1.7 to 17.6 ± 0.4 points; in the treatment group the trend towards symptom decrease remained, while in the control group symptoms increased at day 90. IPSS score at day 30 decreased in the treatment group from 12.9 ± 0.5 to 5.2 ± 1.4, in the control group from 14.1 ± 0.7 to 8.2 ± 0.9; further decrease was observed in both groups at day 60, but at day 90 the score increased (higher in the control group). Quality of life (QoL) improved in both groups at day 30 (in the treatment group 1.4 ± 0.6 points, in the control group 3.1 ± 0.8). Erectile function improved per the IIEF-5 questionnaire: in the treatment group from 11.5 ± 1.1 to 18.9 ± 1.4 points at day 30 with further positive tendency, in the control group from 10.7 ± 1.4 to 15.3 ± 1.1 points with subsequent negative dynamics. Uroflowmetry showed positive dynamics of Q max at the end of treatment in the treatment (from 8.3 ± 1.5 to 14.7 ± 1.1 mL/s) and control (from 8.8 ± 1.3 to 13.1 ± 1.6 mL/s) groups, with its further decrease. Prostate ","PeriodicalId":368206,"journal":{"name":"Andrology and Genital Surgery","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134159724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}