JAMMI Pub Date : 2019-06-17 eCollection Date: 2019-06-01 DOI: 10.3138/jammi.2019.03.17.fr

引用次数: 0

Use of antiviral drugs for seasonal influenza: Foundation document for practitioners-Update 2019. 季节性流感抗病毒药物的使用：从业人员基础文件--2019 年更新。

JAMMI Pub Date : 2019-06-17 eCollection Date: 2019-06-01 DOI: 10.3138/jammi.2019.02.08

Fred Y Aoki, Upton D Allen, Samira Mubareka, Jesse Papenburg, H Grant Stiver, Gerald A Evans

引用次数: 0

Gonococcal meningitis: An unusual presentation of disseminated gonococcal infection. 淋球菌性脑膜炎:播散性淋球菌感染的一种不寻常的表现。

JAMMI Pub Date : 2019-06-17 eCollection Date: 2019-06-01 DOI: 10.3138/jammi.2018-0043

Salem Agabawi, Vanessa Tran, James McEachern, Andrew Walkty

{"title":"Gonococcal meningitis: An unusual presentation of disseminated gonococcal infection.","authors":"Salem Agabawi, Vanessa Tran, James McEachern, Andrew Walkty","doi":"10.3138/jammi.2018-0043","DOIUrl":"https://doi.org/10.3138/jammi.2018-0043","url":null,"abstract":"Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae. The rate of N. gonorrhoeae infections in Canada has increased from 2010 to 2015. Disseminated gonococcal infection typically results from bacteremic spread of N. gonorrhoeae from a preceding mucosal site of disease (e.g., urogenital). Common clinical manifestations of disseminated gonococcal infection include skin lesions, tenosynovitis, and septic arthritis. Bacterial meningitis as a manifestation of disseminated gonococcal infection has been rarely described. A case of bacterial meningitis due to N. gonorrheae, complicated by an ischemic stroke, is reported here. Clinical features that may point to N. gonorrhoeae as the pathogen in a patient with bacterial meningitis include a concomitant active urogenital infection, skin rash, arthritis, and/or tenosynovitis. Parenteral ceftriaxone for 10 to 14 days combined with a single oral dose of azithromycin is currently recommended as the treatment for gonococcal meningitis in recent guidelines. This case is presented to highlight a potential, albeit rare, complication of a preventable disease that has resurged in the last decade in our community.","PeriodicalId":36782,"journal":{"name":"JAMMI","volume":" ","pages":"116-120"},"PeriodicalIF":0.0,"publicationDate":"2019-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3138/jammi.2018-0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous cefazolin infusion versus cefazolin plus probenecid for the ambulatory treatment of uncomplicated cellulitis: A retrospective cohort study. 连续输注头孢唑林与头孢唑林加probenecid对非复杂性蜂窝织炎的动态治疗:一项回顾性队列研究。

JAMMI Pub Date : 2019-06-17 eCollection Date: 2019-06-01 DOI: 10.3138/jammi.2018-0039

Daniel L Landry, Sherif Eltonsy, Luc P Jalbert, Gabriel Girouard, Jonathan Couture, Mathieu Bélanger

{"title":"Continuous cefazolin infusion versus cefazolin plus probenecid for the ambulatory treatment of uncomplicated cellulitis: A retrospective cohort study.","authors":"Daniel L Landry, Sherif Eltonsy, Luc P Jalbert, Gabriel Girouard, Jonathan Couture, Mathieu Bélanger","doi":"10.3138/jammi.2018-0039","DOIUrl":"https://doi.org/10.3138/jammi.2018-0039","url":null,"abstract":"Background: The preferred ambulatory IV therapy for cellulitis is often once-daily cefazolin combined with once-daily oral probenecid (C+P). However, due to a national probenecid drug shortage in 2011, our centre developed a replacement protocol for the administration of cefazolin continuous infusion (CCI) using elastomeric infusers. Our goal was to compare treatment efficacy, duration of IV therapy, and recurrence associated with CCI and C+P using retrospective data from our centre.Methods: We conducted a non-inferiority single-centre retrospective cohort study of emergency department medical records. Patients received either C+P (cefazolin 2 g IV once daily plus probenecid 1 g PO once daily) or CCI (cefazolin 2 g IV loading dose, followed by cefazolin 6 g IV via continuous infusion over 24 hours, via an elastomeric infuser). We compared treatment efficacy, duration of IV therapy, and recurrence rates.Results: total of 203 patients were analyzed, with 107 included in the CCI arm and 96 in the C+P arm. Overall, CCI users and C+P users were comparable in their sociodemographic and clinical variables measured at admission. We observed increased odds of achieving successful treatment among the CCI group, however it did not reach statistical significance (odds ratio [OR] 2.25; 95% CI 0.84 to 6.07). Recurrence rates were similar between both groups (OR 1.91; 95% CI 0.32 to 11.31). The average duration of IV therapy was similar between groups (p = 0.6).Conclusions: ith results suggesting that CCI was non-inferior to C+P, and that both approaches required similar treatment durations, CCI could represent an acceptable alternative to C+P for the ambulatory IV treatment of cellulitis.","PeriodicalId":36782,"journal":{"name":"JAMMI","volume":" ","pages":"108-112"},"PeriodicalIF":0.0,"publicationDate":"2019-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3138/jammi.2018-0039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Measuring the impact of an HIV rotation on trainees' knowledge and confidence level: The importance of inviting recent graduates. 衡量艾滋病毒轮转对受训人员知识和信心水平的影响:邀请应届毕业生的重要性。

JAMMI Pub Date : 2019-06-17 eCollection Date: 2019-06-01 DOI: 10.3138/jammi.2018-0041

Jean-Michel Leduc, Claude Fortin, Danielle Rouleau, Valérie Martel-Laferrière

{"title":"Measuring the impact of an HIV rotation on trainees' knowledge and confidence level: The importance of inviting recent graduates.","authors":"Jean-Michel Leduc, Claude Fortin, Danielle Rouleau, Valérie Martel-Laferrière","doi":"10.3138/jammi.2018-0041","DOIUrl":"https://doi.org/10.3138/jammi.2018-0041","url":null,"abstract":"Background: The new Canadian Residency Accreditation Consortium (CanRAC) standards recommend surveying recently graduated trainees to target improvements in training programs. The goal of this study was to estimate the impact of a rotation in an HIV clinic on trainees' related knowledge, confidence, and practice profile at the Université de Montréal.Methods: An electronic survey was sent to practising physicians who completed the rotation between 2006 and 2016. Participants were asked to rate their agreement and level of confidence toward HIV- and HCV-related topics using 5-point Likert scales (0 to 4). Descriptive statistics and mean comparisons were calculated.Results: Among invited participants, 27 of 45 (60%) completed the questionnaire. The majority of respondents were infectious diseases physicians (48%) or family physicians (37%) and had an outpatient caseload of <10 HIV patients/year (80%). For 37% of the respondents, the rotation had a large or very large impact on their career path. They considered that the rotation had increased their knowledge on the overall management of HIV (mean 3.2/4 [95% CI 2.9 to 3.4]), but less on pre-exposure prophylaxis (PrEP) (mean 1.5/4 [95% CI 1.1 to 2.0]) or HCV care (mean 1.9/4 [95% CI 1.4 to 2.3]). Participants felt less confident with genotyping interpretation (mean 2.6/4 [95% CI 2.2 to 2.9]) and PrEP (mean 2.4/4 [95% CI 2.0 to 2.8]).Conclusions: These results suggest that a rotation in an HIV clinic improves knowledge related to HIV care. Feedback from past graduates helped us identify gaps in knowledge or level of confidence in PrEP and HCV care, which will feed curriculum improvement.","PeriodicalId":36782,"journal":{"name":"JAMMI","volume":" ","pages":"83-89"},"PeriodicalIF":0.0,"publicationDate":"2019-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602958/pdf/jammi.2018-0041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A walk through the tall grass: A case of transaminitis, thrombocytopenia, and leukopenia resulting from an emerging zoonotic infection in Nova Scotia 在高高的草丛中散步:一例由新斯科舍省出现的人畜共患感染引起的转氨炎、血小板减少症和白细胞减少症

JAMMI Pub Date : 2018-12-01 DOI: 10.3138/JAMMI.2018-08.07.2

B. Chase, P. Bonnar

引用次数: 2

Tuberculosis of the foot mimicking Charcot arthropathy 类似沙可关节病的足部结核

JAMMI Pub Date : 2018-12-01 DOI: 10.3138/JAMMI.2018-0023

Salem Agabawi, A. Walkty, B. Pilkey, Rick Bhullar, E. Trepman, J. Embil

引用次数: 1

Not so pretty in pink: A clinical vignette on invasive fungal sinusitis 粉红色不太漂亮:侵袭性真菌鼻窦炎的临床小品

JAMMI Pub Date : 2018-12-01 DOI: 10.3138/JAMMI.2018-08.07.1

Michaeline McGuinty, C. Buchan

引用次数: 0

Management of hepatitis C in a patient undergoing solid organ (kidney) transplant 接受实体器官(肾)移植的丙型肝炎患者的处理

JAMMI Pub Date : 2018-12-01 DOI: 10.3138/JAMMI.2017-0009

Parmvir Parmar, C. Cooper

引用次数: 0

Increased incidence, risk factors, and outcomes of Trichosporon spp bloodstream infections in immunocompromised hosts 免疫功能低下的宿主血液感染的发病率、危险因素和结局增加

JAMMI Pub Date : 2018-12-01 DOI: 10.3138/JAMMI.2018-0019

S. Herrera, Hussam Alobida, M. Bosaeed, S. Husain, C. Rotstein

{"title":"Increased incidence, risk factors, and outcomes of Trichosporon spp bloodstream infections in immunocompromised hosts","authors":"S. Herrera, Hussam Alobida, M. Bosaeed, S. Husain, C. Rotstein","doi":"10.3138/JAMMI.2018-0019","DOIUrl":"https://doi.org/10.3138/JAMMI.2018-0019","url":null,"abstract":"Objectives: To evaluate the incidence, risk factors, patient characteristics, and outcomes Trichosporon spp bloodstream infections in immunocompromised patients. Methods: This was a single centre retrospective study. Patients older than 18 years of age with Trichosporon spp bloodstream infections from 2004 to 2017 were reviewed. Data were extracted from the electronic medical records and the microbiology database and then analyzed. Results: Eight patients with Trichosporon spp bloodstream infections were included; 7 had hematological malignancies and 1 had ulcerative colitis but had undergone immunosuppressive therapy. A mean of 0.41 episodes per year were noted, but in 2017, 3 episodes were observed – more than a sevenfold increase over the mean. T. asahii was the most common isolate, seen in 7/9 isolates in 8 patients. Three episodes were labelled as primary fungemia (37.5%) and five (62.5%) were line-related. Previous use of steroids, broad-spectrum antibiotics, and neutropenia were found to be common co-existent factors in our patients. The mean treatment duration was 22.9 days and the response rate was 50% with a 30-day mortality rate of 50%. Conclusions: We observed a sixfold increase in the incidence of Trichosporon spp bloodstream infection in the final year of our study. These patients were predisposed to this infection due to their immunosuppressed state. Concerns about Trichosporon fungemia in such patients may impact the choice of antifungal therapy.","PeriodicalId":36782,"journal":{"name":"JAMMI","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3138/JAMMI.2018-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43907342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

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