接受实体器官(肾)移植的丙型肝炎患者的处理

Q3 Medicine
JAMMI Pub Date : 2018-12-01 DOI:10.3138/JAMMI.2017-0009
Parmvir Parmar, C. Cooper
{"title":"接受实体器官(肾)移植的丙型肝炎患者的处理","authors":"Parmvir Parmar, C. Cooper","doi":"10.3138/JAMMI.2017-0009","DOIUrl":null,"url":null,"abstract":"Many patients with hepatitis C (HCV) suffer from concurrent renal disease requiring dialysis and eventual renal transplant. HCV treatment with direct-acting antivirals (DAA) is safe and effective in the context of renal transplant, but the optimal timing of treatment in proximity to transplant remains a focus of debate. We present the case of a 60-year-old male with HCV genotype 3 infection. He failed two prior interferon-based treatments, underwent previous separate liver and kidney transplants, and is currently under evaluation for a second kidney transplant for end-stage renal disease (ESRD). Using this illustrative case, we discuss topics pertinent to the evaluation and clinical care of HCV-infected renal transplant candidates including evaluation for a simultaneous liver-kidney transplant in the context of HCV infection, optimal timing of HCV treatment with respect to transplantation, and the safety and monitoring requirements during DAA treatment in renal transplant candidates.","PeriodicalId":36782,"journal":{"name":"JAMMI","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3138/JAMMI.2017-0009","citationCount":"0","resultStr":"{\"title\":\"Management of hepatitis C in a patient undergoing solid organ (kidney) transplant\",\"authors\":\"Parmvir Parmar, C. Cooper\",\"doi\":\"10.3138/JAMMI.2017-0009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Many patients with hepatitis C (HCV) suffer from concurrent renal disease requiring dialysis and eventual renal transplant. HCV treatment with direct-acting antivirals (DAA) is safe and effective in the context of renal transplant, but the optimal timing of treatment in proximity to transplant remains a focus of debate. We present the case of a 60-year-old male with HCV genotype 3 infection. He failed two prior interferon-based treatments, underwent previous separate liver and kidney transplants, and is currently under evaluation for a second kidney transplant for end-stage renal disease (ESRD). Using this illustrative case, we discuss topics pertinent to the evaluation and clinical care of HCV-infected renal transplant candidates including evaluation for a simultaneous liver-kidney transplant in the context of HCV infection, optimal timing of HCV treatment with respect to transplantation, and the safety and monitoring requirements during DAA treatment in renal transplant candidates.\",\"PeriodicalId\":36782,\"journal\":{\"name\":\"JAMMI\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3138/JAMMI.2017-0009\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JAMMI\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3138/JAMMI.2017-0009\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAMMI","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3138/JAMMI.2017-0009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

许多丙型肝炎(HCV)患者同时患有肾脏疾病,需要透析和最终的肾移植。在肾移植的情况下,使用直接作用抗病毒药物(DAA)治疗丙型肝炎病毒是安全有效的,但在移植附近的最佳治疗时间仍然是争论的焦点。我们报告一例60岁男性丙型肝炎病毒基因型3感染。他之前两次以干扰素为基础的治疗都失败了,之前分别接受了肝脏和肾脏移植,目前正在评估第二次肾移植治疗终末期肾病(ESRD)。利用这个说明性案例,我们讨论了与HCV感染的候选肾移植的评估和临床护理相关的主题,包括在HCV感染的情况下同时进行肝肾移植的评估、与移植相关的HCV治疗的最佳时机,以及候选肾移植DAA治疗期间的安全性和监测要求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of hepatitis C in a patient undergoing solid organ (kidney) transplant
Many patients with hepatitis C (HCV) suffer from concurrent renal disease requiring dialysis and eventual renal transplant. HCV treatment with direct-acting antivirals (DAA) is safe and effective in the context of renal transplant, but the optimal timing of treatment in proximity to transplant remains a focus of debate. We present the case of a 60-year-old male with HCV genotype 3 infection. He failed two prior interferon-based treatments, underwent previous separate liver and kidney transplants, and is currently under evaluation for a second kidney transplant for end-stage renal disease (ESRD). Using this illustrative case, we discuss topics pertinent to the evaluation and clinical care of HCV-infected renal transplant candidates including evaluation for a simultaneous liver-kidney transplant in the context of HCV infection, optimal timing of HCV treatment with respect to transplantation, and the safety and monitoring requirements during DAA treatment in renal transplant candidates.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
JAMMI
JAMMI Medicine-Infectious Diseases
CiteScore
3.80
自引率
0.00%
发文量
48
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信