SCRIPTA SCORE Scientific Medical Journal最新文献

{"title":"Penggunaan Heparin Dosis Tinggi pada Pasien COVID-19 dengan ARDS di Unit Perawatan Intensif (ICU) RS Darurat Wisma Atlit","authors":"Vien Hardiyanti","doi":"10.32734/scripta.v3i2.6293","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.6293","url":null,"abstract":"Background: An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. The severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) infection has been associated with significantly deranged coagulation parameters and increased incidence of thrombotic events.\u0000Case: Herein, we reported a 46-year-old morbidly obese man with acute respiratory distress syndrome (ARDS) of COVID who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharyngeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory and chest radiograph. The patient was referred to Intensive Care Unit (ICU) and received heparin therapy with therapeutic doses are based on the aPTT levels. After 20 days of intensive care, the patient showed a significant improvement.\u0000Discussion: A coagulopathy has been reported in up to 50% of patients with severe COVID-19 manifestations. COVID-19-induced hypercoagulability has been demonstrated to play a significant role in overall COVID-19 outcomes. Current literature shows promising evidence with the use of therapeutic anticoagulation in high-risk individuals.\u0000Conclusion: In patients who present with severe COVID-19 with respiratory failure, pharmacological prophylactic anticoagulants can help prevent venous thromboembolism and other thrombotic events.\u0000Keywords: ARDS, coagulopathy, COVID-19, heparin, thrombosis\u0000 \u0000Latar belakang: Penyebaran virus corona 2019 (COVID-19) yang disebabkan oleh  severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)  yang bermula di Wuhan, Cina menyebar dengan cepat ke berbagai negara di dunia dan menjadi sebuah pandemik. Infeksi virus corona diteliti berkaitan dengan adanya gangguan koagulasi dan peningkatan risiko trombosis. \u0000Kasus: Dalam laporan kasus ini, akan dipaparkan tentang kasus corona yang terjadi pada pria berusia 46 tahun terkonfirmasi COVID dengan Acute Respiratory Distress Syndrome (ARDS) berat yang sembuh dari penyakit tersebut. Uji real-time reverse transcriptase-polymerase chain reaction (RT-PCR) sampel nasofaring dan orofaring menunjukkan hasil positif SARS-CoV-2. Diagnosis ARDS juga sesuai dengan gejala klinis, laboatorium, dan fototoraks. Pasien kemudian dirawat di ruang rawat intensif (ICU) dan mendapat terapi heparin yang disesuaikan dengan level aPTT. Setelah 20 hari perawatan intensif, pasien menunjukkan perbaikan yang signifikan. \u0000Diskusi: Kasus koagulopati dilaporkan lebih dari 50% pasien dengan COVID-19 yang berat. Hiperkoagulopati yang dipengaruhi oleh COVID-19 memainkan pengaruh yang signifikan pada hasil akhir dari penyakit tersebut. Studi pustaka terbaru menunjukkan bukti yang menjanjikan tentang penggunaan antikoagulan pada individu yang berisiko tinggi. \u0000Kesimpulan: Pada pasien COVID-19 gejala ber","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117171420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Kebiasaan Menahan Buang Air Kecil, Jumlah Air Minum Harian dan Kebersihan Diri Saat Menstruasi dengan Kejadian Infeksi Saluran Kemih Non Komplikata pada Mahasiswi Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2017-2018","authors":"Habib Fachrurraji Nainggolan, Dhirajaya Dharma Kadar","doi":"10.32734/scripta.v3i2.5497","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.5497","url":null,"abstract":"Background: Urinary tract Infection (UTI) is an infection in the urinary tract that caused by the microorganism such as fungi, virus, and bacteria. UTI is one the infectious disease that often be found in the general practice. Number of the UTI patient in Indonesia has been recorded around 180,000 new cases in every year, with the most frequent in female. Urinary restriction, lack amount of daily water intake and poor menstrual hygiene are the most frequent events of the UTI in young age female.\u0000Objective: To find out the relationship between urinary restriction habit, amount of daily water intake, and menstrual hygiene with the event of uncomplicated UTI.\u0000Methods: This study is an analytic-observational study with cross-sectional design. Sample was taken by using simple random sampling technique. Sample was collected through a questionnaire and bivariate analyzing and then be processed with computer by using SPSS.\u0000Results: There are  no relationship between urinary retention habit (p=0,484) and menstrual hygiene (p=1,000) with the event of uncomplicated UTI. There is relationship between amount of daily water intake (p=0,000) with the event of uncomplicated UTI.\u0000Conclusion: There are no significant relationship between urinary retention habit and menstrual hygiene with the event of uncomplicated UTI. There is significant relationship between amount of daily water intake with the event of uncomplicated UTI.\u0000Keywords: menstruation, Urinary Tract Infection (UTI), urination, water intake\u0000 \u0000Latar belakang: Infeksi saluran kemih (ISK) merupakan infeksi pada saluran kemih yang disebabkan oleh mikroorganisme seperti jamur, virus, dan bakteri. ISK merupakan salah satu penyakit infeksi yang sering ditemukan di praktik umum. Jumlah pasien ISK di Indonesia tercatat sekitar 180.000 kasus baru pertahun, dengan kejadian tersering pada jenis kelamin perempuan. Kebiasaan menahan buang air kecil (BAK), kurangnya konsumsi air minum harian dan kebersihan diri saat menstruasi yang buruk merupakan penyebab tersering kejadian ISK pada wanita usia muda. \u0000Tujuan: Mengetahui hubungan antara kebiasaan menahan BAK, jumlah air minum harian, dan kebersihan diri saat menstruasi dengan kejadian ISK non komplikata. \u0000Metode: Penelitian ini merupakan penelitian analitik-observasional dengan desain cross-sectional. Pengambilan sampel dilakukan dengan teknik simple random sampling. Pengumpulan data dilakukan melalui kuesioner dan dilakukan analisa bivariat serta pengolahan data dengan komputerisasi menggunakan SPSS. \u0000Hasil: Tidak terdapat hubungan antara kebiasaan menahan BAK (p=0,484) dan kebersihan diri saat menstruasi (p=1,000) dengan kejadian ISK non komplikata. Terdapat hubungan antara jumlah air minum harian (p=0,000) dengan kejadian ISK non komplikata. \u0000Kesimpulan: Tidak terdapat hubungan antara kebiasaan menahan BAK dan kebersihaan diri saat mentruasi dengan kejadian ISK non komplikata. Terdapat hubungan antara jumlah air minum harian dengan kejadian ISK non komplikata.\u0000Kat","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122901392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Tomato (Solanum lycopersicum) in Management and Prevention of Four Most Common Cancer in Indonesia","authors":"Lathifah Dzakiyyah Zulfa, Dessyani Salim, Abigail Tirza Melia Silalahi","doi":"10.32734/scripta.v3i2.5522","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.5522","url":null,"abstract":"Introduction: The rate of new cancer cases in Indonesia is very high. With various risk factors, cancer becomes easier to attack individuals, but that does not mean these factors cannot be changed. One of the modifiable risk factors of cancer is diet from food.\u0000Objective: This review aims to investigate the role of chemical compound in tomato (S. lycopersicum) in management and prevention of breast, cervix uteri, lung, and liver cancer.\u0000Method: Method for writing this review is by searching for literature published in 2012 - 2020 was carried out to prove the effect of tomatoes on cancer incidence through in vitro, in vivo, and clinical studies.\u0000Results: Lycopene in tomatoes has been shown to withstand the cell cycle, inhibit NF-кB, and affect enzymes that produce toxic metabolites, thus preventing the development of various types of cancer. Other active compound such as carotenoid lutein can act as cytotoxic agents by increasing p53 phosphorylation and suppressing the expression of anti-apoptotic genes in breast cancer cells. Interaction between tomatine or tomatidine (another compound in tomatoes) with EGFR will prevent the development or metastasis of non-small cell lung carcinoma.\u0000Conclusion: These facts can be concluded that tomato (with various active compound in it) consumption potentially strong in preventing breast, cervix uteri, lung, and liver cancer. Further research should clarify the recommended tomato active compound level for daily consumption and its long-term side effect.\u0000Keywords: cancer, diet, Solanum lycopersicum\u0000 \u0000Pendahuluan: Tingkat kasus baru kanker di Indonesia sangatlah tinggi. Terdapat 65.858 kasus baru kanker payudara pada 2020. Dengan berbagai macam faktor risiko, kanker menjadi lebih mudah menyerang individu, namun bukan berarti faktor tersebut tidak dapat diubah. Salah satu faktor risiko yang dapat dimodifikasi adalah diet. \u0000Tujuan: Ulasan ini bertujuan untuk membahas bagaimana konsumsi tomat dapat mengurangi risiko terkena kanker maupun memperbaiki prognosis penderita kanker. \u0000Metode: Metode penulisan ulasan ini adalah mencari literatur yang dipublikasi selama 2016 – 2021 secara daring dilakukan untuk membuktikan pengaruh tomat terhadap kejadian kanker baik secara in vivo, in vitro, serta penelitian klinis. \u0000Hasil: Lycopene yang terkandung pada tomat terbukti menahan siklus sel, menginhibisi NF- B, dan menekan efek enzim yang memproduksi metabolit beracun sehingga bermanfaat dalam mencegah perkembangan berbagai jenis kanker. Bahan aktif lain seperti karotenoid lutein mampu bertindak sebagai agen sitotoksik yang meningkatkan fosforilasi p53 dan menekan ekspresi gen anti – apoptotic pada sel kanker payudara. Interaksi tomatine dan tomatidine (kandungan lain pada tomat) dengan EGFR akan mencegah perkembangan maupun metastasis non-small cell lung carcinoma. \u0000Kesimpulan: Beberapa fakta tersebut dapat disimpulkan bahwa konsumsi tomat berpotensi mencegah kanker payudara, serviks uteri, paru – paru, dan hepar. Penelitian s","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132767760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Adjuvant Administration of Macromolecules and Total Calories through Aggressive Parenteral Nutrition in Improvement of Neovascularisation of Infants with Retinopathy of Prematurity: A Literature Review","authors":"Stefany Tanto, G. Octavius, Alvita Suci Edgina","doi":"10.32734/scripta.v3i2.4471","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.4471","url":null,"abstract":"Introduction: Retinopathy of Prematurity (ROP) is almost exclusively in premature infants. With advanced care and technology, the prevalence of retinopathy of prematurity in babies is increasing, which means the incidence of preventable blindness in ROP is increasing.\u0000Objectives:  To evaluate the effects of protein, glucose, lipids, and total calories from Aggressive Parenteral Nutrition (APN) in improving neovascularisation of ROP in premature infants.\u0000Methods: We searched PubMed, Ophthalmology Advance, Scientific Reports, and Science Direct using the terms \"Retinopathy of Prematurity\", \"Aggressive Parenteral Nutrition\", \"Prevalence of Retinopathy of Prematurity in Indonesia\", \"Protein\", \"Lipid\", \"Carbohydrate\", \"Glucose\", \"Total Calories\", \"Neovascularization\", and \"Prematurity\" in various combinations.\u0000Results: We found three pieces of literature stating a positive association between APN and improvement of ROP, while one literature states that there is no significant change of prevalence of ROP by administering APN.\u0000Keywords: Aggressive Parenteral Nutrition, glucose, lipid, protein, Retinopathy of Prematurity\u0000 \u0000Pendahuluan: Retinopathy of Prematurity (ROP) adalah penyakit yang hampir secara eksklusif terjadi pada bayi prematur. Dengan perawatan dan teknologi yang canggih, prevalensi retinopati pada bayi prematur meningkat dan ini berarti kejadian kebutaan yang dapat dicegah pada ROP meningkat.\u0000Tujuan: Untuk mengevaluasi efek protein, glukosa, lipid, dan kalori total dari Nutrisi Parenteral Agresif (APN) dalam meningkatkan neovaskularisasi ROP pada bayi prematur.\u0000Metode: Kami mencari PubMed, Ophthalmology Advance, Scientific Reports dan Science Direct menggunakan istilah “Retinopathy of Prematurity”, “Aggressive Parenteral Nutrition”, “Prevalence of Retinopathy of Prematurity in Indonesia”, “Protein”, “Lipid”, “Carbohydrate” , \"Glukosa\", \"Kalori Total\", \"Neovaskularisasi\", dan \"Prematuritas\" dalam berbagai kombinasi.\u0000Hasil: Ditemukan tiga literatur yang menyatakan terdapat hubungan positif antara APN dengan peningkatan ROP sedangkan satu literatur menyatakan tidak ada perubahan signifikan prevalensi ROP dengan pemberian APN.\u0000Kata Kunci: Nutrisi Parenteral Agresif, glukosa, lipid, protein, Retinopati Prematuritas","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130749168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korelasi Aktivitas Fisik Dengan Memori Kerja Pada Mahasiswa Pendidikan Dokter Fakultas Kedokteran Universitas Sumatera Utara","authors":"Siti Raudhah Nadira, M. Daulay","doi":"10.32734/scripta.v3i2.6863","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.6863","url":null,"abstract":"Background: Physical activity is a contraction of the skeletal muscles which results in a core increase in caloric requirements compared to resting energy expenditure. Globally, around 23% of adults aged >18 years were not active enough in 2010. In Indonesia, low physical activity among people aged >10 years has increased, from 2013 to 26, 1% increased to 33.5% in 2018. Low levels of physical activity affect cognitive function, such as working memory, learning motivation, and concentration in addition to causing problems in physical and psychological health. Working memory plays an important role in learning process and is influenced by physical activity, low working memory will make it difficult to receive new information and decrease learning achievement.\u0000Objective: Finding the relationship between physical activity and working memory in medical students at the Universitas Sumatera Utara. \u0000Methods: This study used an analytical method using a cross-sectional design. The data will be analyzed with the Pearson or Spearman analysis test using a data processing program.\u0000Results: The mean physical activity was highest in the age of 22 years (3598.33 MET/week), class of 2018 (2389.83 MET-minutes/week), and male gender (3219.55 MET-minutes/week). While the mean working memory capacity was highest in the age of 22 years (43.67), class of 2017 (37.77), and male gender (38.1). The non-parametric correlation test had insignificant results (p=0.393), proving there was no relationship between physical activity and working memory in students.\u0000Conclusion: Physical activity doesn’t affect the working memory capacity of students at the Faculty of Medicine, Universitas Sumatera Utara.\u0000Keywords: cognitive function, physical activity, students, working memory\u0000 \u0000Latar Belakang: Aktivitas fisik adalah setiap kontraksi otot rangka yang menghasilkan peningkatan inti dalam kebutuhan kalori dibandingkan pengeluaran energi saat istirahat. Secara global, sekitar 23% orang dewasa yang berusia >18 tahun tidak cukup aktif pada tahun 2010. Di Indonesia, rendahnya aktivitas fisik pada penduduk usia >10 tahun mengalami peningkatan, dari tahun 2013 sebesar 26,1% meningkat menjadi 33,5% pada tahun 2018. Tingkat aktivitas fisik yang rendah berpengaruh pada fungsi kognitif, seperti memori kerja, motivasi belajar, dan konsentrasi selain menyebabkan masalah pada kesehatan fisik dan psikologis. Memori kerja berperan penting dalam proses pembelajaran dan dipengaruhi oleh aktivitas fisik, memori kerja yang rendah akan menimbulkan kesulitan untuk menerima informasi baru serta penurunan prestasi belajar. \u0000Tujuan: Menemukan korelasi antara aktivitas fisik dengan memori kerja pada mahasiswa fakultas kedokteran universitas sumatera utara. \u0000Metode: Penelitian ini menggunakan metode analitik dengan menggunakan desain cross sectional. Data akan dianalisis dengan uji analisis pearson atau spearman menggunakan program pengolahan data. \u0000Hasil: Rata-rata paling tinggi untuk aktivitas fisik pada usi","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131763852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitor Kanal Kv1.3: Ekstrak Racun Kalajengking spesies Heterometrus spinnifer (HsTX1) sebagai Terapi Potensial Lupus Eritematosus Sistemik (LES)","authors":"Yitzchak Millenard Sigilipu, Namira Assyfa Nurazizah, Nararian Padma Dewi","doi":"10.32734/scripta.v3i2.4538","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.4538","url":null,"abstract":"Background: Systemic Lupus Erythematosus (SLE) is one of the most complex and common autoimmune disease. Current therapy is limited to symptomatic treatment which lead to disease relapse. The use of corticosteroids as immunosuppressant has many side effects. Long-term use of this drug can cause the occurrence of osteoporosis, which confers more risk since most of SLE patients are women. Animal venom is a potential substance for development of therapeutic modalities. One of  the example of successful animal venom usage in therapy is captopril as anti-hypertensive agent.\u0000Objectives: exploring the potential of scorpion venom as therapeutic modality for LES.\u0000Methods: Analysis and synthesis of articles in the form of research paper and reviews relevant with the keywords Kv 1.3 channel, Systemic Lupus Erythematosus (SLE), dan Scorpion Venom.\u0000Discussion: Inhibition of Kv1.3 channel by the peptides of scorpion venom has given new hope for the treatment of autoimmune diseases one of which is SLE. The channel is involved in most of the lymphocyte activation.\u0000Conclusion: The utilization of scorpion toxins, especially the species of Heterometrus spinnifer (HsTX1), is expected to enlighten future developments of SLE treatment.\u0000Keywords: Heterometrus spinnifer, HsTX1, Kv1.3 channel, scorpion venom, Systemic Lupus Erythematosus (SLE)\u0000 \u0000Latar Belakang: Lupus Eritematosus Sistemik (LES) merupakan salah satu penyakit autoimun yang kompleks dan cukup sering ditemui. Terapi saat ini hanya sebatas pada pengobatan simtomatik dan bersifat sementara. Penggunaan kortikosteroid sebagai imunosupresan memiliki banyak efek samping. Penggunaan obat ini secara jangka panjang dapat menyebabkan terjadinya osteoporosis, terlebih LES umumnya diderita oleh wanita. Racun merupakan salah satu substansi yang potensial untuk digunakan sebagai modalitas terapi. Salah satu contoh keberhasilan pengolahannya adalah obat kaptopril yang berfungsi sebagai obat antihipertensi. \u0000Tujuan: menggali potensi penggunaan racun kalajengking sebagai terapi LES. \u0000Metode: Analisis dan sintesis dari artikel berupa research paper dan review yang relevan dengan kata kunci Kv 1.3 channel, Lupus Eritematosus Sistemik (LES), dan Scorpion Venom. \u0000Pembahasan: Inhibisi kanal Kv1.3 oleh peptida racun kalajengking memiliki potensi sebagai terapi penyakit autoimun salah satunya adalah LES. Kanal tersebut terlibat dalam sebagian besar aktivasi sel limfosit. \u0000Kesimpulan: Pemanfaatan kandungan racun kalajengking, khususnya spesies Heterometrus spinnifer (HsTX1), diharapkan dapat berkontribusi dalam pengembangan terapi LES di masa depan.\u0000Kata Kunci: Heterometrus spinnifer, HsTX1, kanal Kv1.3, Lupus Eritematosus Sistemik (LES), racun kalajengking","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115402846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Kombinasi Terapi Sel Punca Mesenkimal dengan Obat Antifibrotik sebagai Tata Laksana Fibrosis Paru Pasca COVID-19","authors":"Kelvin Kohar, Hubert Andrew, Arden Gabrian","doi":"10.32734/scripta.v3i2.5390","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.5390","url":null,"abstract":"Background: COVID-19 has infected more than 88 million people worldwide. Researchers found that over one-third of patients who survived showed lung abnormalities related to pulmonary fibrosis post COVID-19. PF is a progressive disease responsible for reducing pulmonary function which ultimately causes death. Moreover, there is no definitive cure for the disease. Available antifibrotic drugs (nintedanib and pirfenidone) only slow down PF progression while having adverse effects of its own.\u0000Objectives: In this review, we analyzed the potential of mesenchymal stem cells (MSCs) and antifibrotic drugs combination as therapy for PF and as reference for future research.\u0000Methods: We ran through PubMed, Scopus, and Wiley, searching for studies related to the topic.\u0000Discussions: From the literature review, we found that nintedanib and pirfenidone had finished phase III clinical trials with positive outcomes, but some significant adverse effects were discovered. We also found some preclinical MSCs studies conducted to show its efficacy. In addition, there were some phase I/IIa MSCs clinical trials that had established its safety. Outcomes of both types of MSCs studies were positive with minor adverse effects. Another preclinical research showed tremendously positive results while combining bone marrow-derived-MSCs and nintedanib to cure PF.\u0000Conclusions: To conclude, these results show high potential in combining antifibrotic drugs with MSCs therapy. However, due to the limitations we found, future studies are warranted to evaluate and investigate these promising results. If proven successful, its implementation would help achieve better outcomes in PF patients and reduce its mortality, especially considering the foreseen surge of IPF in COVID-19 survivors.)\u0000Keywords: post-covid pulmonary fibrosis, COVID-19, nintedanib, pirfenidone, mesenchymal stem cell\u0000 \u0000Latar Belakang: COVID-19 telah menginfeksi lebih dari 88 juta orang di seluruh dunia. Penelitian menemukan bahwa lebih dari sepertiga pasien yang sembuh menunjukkan abnormalitas paru terkait fibrosis paru pasca COVID-19 (FPPC). FPPC merupakan penyakit progresif yang menyebabkan penurunan fungsi paru dan pada akhirnya menyebabkan kematian. Selain itu, belum ada obat yang mampu menyembuhkan penyakit ini. Obat yang tersedia saat ini (nintedanib dan pirfenidone) hanya bersifat memperlambat FPPC dan tetap memiliki efek sampingnya tersendiri. \u0000Tujuan: Dalam tinjauan pustaka ini, penulis menganalisis potensi kombinasi sel punca mesenkimal (SPM) dan obat antifibrotik sebagai terapi FPPC serta sebagai referensi untuk penelitian ke depannya. \u0000Metode: Penulis mencari studi yang relevan dengan topik dari PubMed, Scopus, dan Wiley. \u0000Pembahasan: Dari tinjauan pustaka ini, penulis menemukan bahwa nintedanib dan pirfenidone telah menyelesaikan uji klinis fase III dengan hasil yang positif, tetapi juga ditemukan berbagai efek samping yang signifikan. Penulis juga menemukan studi praklinis SPM yang meneliti efikasinya. Sela","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123846519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbandingan Penutupan Ventricular Septal Defect secara Transkateter dengan Pembedahan pada Anak: Telaah Sistematis dan Meta Analisis","authors":"Alvin Ivander, R. Adriansyah, Ika Citra Dewi Tanjung, Abdul Halim Raynaldo","doi":"10.32734/scripta.v3i2.5412","DOIUrl":"https://doi.org/10.32734/scripta.v3i2.5412","url":null,"abstract":"Background: Ventricular Septal Defect is a Congenital Heart Defect characterized by an opening in interventricular septum or more that happen because of intraventricular septum’s failure to fuse during fetal development. Ventricular Septal Defect itself is the most prevalent type of CHD found on pediatric patient and decreased their quality of life thus corrective treatment become important to ensure child healthy growth. Transcatheter procedure is expected as one of the alternative for corrective treatment which is better and safer compared to surgical closure of VSD corrective treatment.\u0000Objectives: This research aimed to observe the comparison of VSD closure between transcatheter compared to surgical closure.\u0000Methods: This research is a systematic review and meta-analysis compliant with PRISMA guidelines and analyzed using Review Manager 5.3.\u0000Discussion: This research identifies 1.991 journals however, only 10 journals fulfilled the inclusion criteria. The review founded that there is no significant difference between either transcatheter or surgical closure outcome (RR = 0,99) however the analysis founded that transcatheter method are much safer in term of complication event (RR =0,54), residual shunt event (RR = 0,56), and blood transfusion (RR=0,03) while also provide a much cheaper cost with faster procedure time, and hospitalization.\u0000Conclusion: The results of data analysis found that transcatheter procedure is safer, cheaper, and have a much faster speed in term of operation duration and hospital stay compared to surgical closure of VSD. Transcatheter procedure is recommended as treatment choice for corrective treatment of patient diagnosed with VSD.\u0000Keywords: Ventricular Septal Defect, transcatheter, surgical closure, child\u0000 \u0000Latar Belakang: Ventricular Septal Defect adalah Penyakit Jantung Bawaan yang ditandai dengan adanya satu lubang pada septum interventrikular atau lebih yang terjadi akibat kegagalan fusi septum intraventrikular saat perkembangan janin. VSD sendiri adalah jenis PJB yang paling sering timbul pada anak dan mengakibatkan penurunan kualitas hidup anak sehingga terapi korektif menjadi penting agar anak dapat tumbuh dengan baik. Prosedur transkateter diharapkan menjadi salah satu alternatif terapi korektif yang lebih baik dibandingan dengan pembedahan dalam pengobatan korektif VSD. \u0000Tujuan: Tujuan dari penelitian ini adalah untuk melihat perbandingan penutupan VSD secara transkateter dibandingkan dengan pembedahan. \u0000Metode: Penelitian ini merupakan telaah sistematik dan meta analisis yang patuh pada kaidah pedoman PRISMA lalu dianalisis menggunakan Review Manager 5.3.\u0000Pembahasan: Penelitian ini menemukan 1.991 jurnal namun hanya 10 jurnal yang memenuhi kriteria inklusi. Telaah tersebut menemukan bahwa tidak ada perbedaan signifikan antara luaran prosedur transkateter atau pembedahan (RR = 0,99) namun analisis yang dilakukan menemukan bahwa transkateter lebih aman dalam segi kejadian komplikasi (R = 0,54), kejadian pirau ","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124119977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan antara Faktor Stres dan Siklus Menstruasi pada Mahasiswi Fakultas Kedokteran Universitas Sumatera Utara","authors":"Bahagia W.M. Nainggolan, Khairani Sukatendel","doi":"10.32734/scripta.v3i1.6585","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.6585","url":null,"abstract":"Background: Stressor is defined as the agent inducing the response of stress. Stress can give a negative impact on cognitives, physiological, and behavioral aspects. One of the effects of stress that can be occur is menstrual cycle disorder.\u0000Objectives: To know how is the relationship between stressors and menstrual cycle on medical students in Faculty of Medicine, University of Sumatera Utara.\u0000Method: This study used an analytic method with a cross sectional design. The study population was medical students in Faculty of Medicine, University of Sumatera Utara. The data was collected by filling The MSSQ questionnaire and the menstrual data that had been given to respondents if only the inclusion and exclusion criteria was met and used consecutive sampling for the methods.\u0000Results: From 80 respondents, the results obtained by Kendall’s Correlation p>0,05 for correlation each stressors with menstrual cycle which means that there is no significant relationship between stressors and menstrual cycle.\u0000Conclusion: From this study it can be concluded that there is no significant relationship between stressors and menstrual cycle on medical students in Faculty of Medicine, USU.\u0000Keywords: menstrual cycle, stress, stressor\u0000 \u0000Latar Belakang: Stresor adalah suatu hal yang dapat diidentifikasikan sebagai penyebab timbulnya stres. Stres dapat memberikan dampak negatif dalam aspek kognitif, fisiologi, dan perilaku. Salah satu dampak dari stres yang dapat terjadi adalah gangguan siklus menstruasi. \u0000Tujuan: Mengetahui pengaruh faktor stres terhadap siklus menstruasi pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara. \u0000Metode: Metode yang digunakan dalam penelitian ini adalah metode analitik dengan desain cross-sectional. Penelitian dilakukan pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara. Pengumpulan atau pengambilan data untuk diteliti dilakukan menggunakan kuesioner Medical Student Stressor Questionnaire (MSSQ) dan data siklus menstruasi yang diberikan kepada responden dengan syarat memenuhi kriteria inklusi maupun kriteria eksklusi yang telah ditetapkan serta menggunakan consecutive sampling sebagai metode yang digunakan. \u0000Hasil: Dari 80 responden, didapatkan hasil uji Kendall’s Correlation (p>0.05) untuk setiap hubungan faktor stres dengan siklus menstruasi yang berarti tidak ada hubungan yang signifikan antara faktor stres dengan siklus menstruasi. \u0000Kesimpulan: Dari penelitian ini disimpulkan bahwa tidak terdapat pengaruh yang signifikan antara faktor stres dengan siklus menstruasi pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara.\u0000Kata Kunci: siklus menstruasi, stres, stresor","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131396422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Posisi Menunduk saat Menggunakan Telepon Seluler dengan Nyeri Tengkuk","authors":"Ramadhani Dinda Salsalina Depari, A. S. Rambe","doi":"10.32734/scripta.v3i1.6364","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.6364","url":null,"abstract":"Background: Neck pain is pain that includes disorders of the nerves, tendons, muscles and ligaments around the neck. One of the causes of neck pain is the wrong position of the body which causes the neck in a certain position for a long time. In the use of cell phones there will be a process of changing the position of the neck, the position of the head will be bow to look at the cell phone screen and maintained for a long time, causing muscle problems which, if left unchecked, can become chronic muscle pain.\u0000Objectives: To find out relationship between the bow position when using a cell phone and neck pain.\u0000Methods: This study is an analytic-observational study with a cross-sectional design. The sampling technique used simple random sampling technique. The data will be analyze using chi-square statistical test. In which the p-value < 0.05 is significant.\u0000Results: There is a relationship between the bow position when using a cell phone to neck pain with p-value 0.045. On the other test, there is no relationship between the duration of cell phone use and neck pain, both in one use (p = 0.509) and in a day (p = 0.729).\u0000Conclusion: There is a significant relationship between the bow position when using a cell phone and neck pain.\u0000Keywords: neck pain, cell phone, bowing position\u0000 \u0000Latar Belakang: Nyeri tengkuk adalah rasa nyeri yang meliputi kelainan saraf, tendon, otot dan ligamen di sekitar leher. Salah satu penyebab dari nyeri tengkuk adalah posisi tubuh yang salah sehingga membuat leher berada dalam posisi tertentu dalam jangka waktu yang lama. Pada penggunaan telepon seluler akan terjadi proses perubahan posisi leher, yang mana posisi kepala akan menunduk untuk melihat ke arah layar telepon seluler dan dipertahankan dalam waktu yang relatif lama, sehingga menimbulkan masalah otot yang apabila dibiarkan dapat menjadi nyeri otot kronis. \u0000Tujuan: Untuk mengetahui hubungan posisi menunduk saat menggunakan telepon seluler dengan nyeri tengkuk. \u0000Metode: Penelitian ini merupakan penelitian analitik-observasional dengan desain cross-sectional. Pengambilan sampel dilakukan dengan teknik simple random sampling. Hasil pengukuran akan dianalisis menggunakan uji chi-square. Nilai p < 0,05 dianggap signifikan. \u0000Hasil: Terdapat hubungan antara posisi menunduk saat menggunakan telepon seluler terhadap nyeri tengkuk dengan nilai P = 0,045. Pada uji hubungan lainnya tidak ada hubungan antara durasi penggunaan telepon seluler terhadap nyeri tengkuk baik dalam sekali penggunaan (P = 0,509) maupun dalam sehari penggunaan (P = 0,729). \u0000Kesimpulan: Terdapat hubungan yang signifikan antara posisi menunduk saat menggunakan telepon seluler dengan nyeri tengkuk.\u0000Kata Kunci: nyeri tengkuk, telepon seluler, posisi menunduk","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114048815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}