SCRIPTA SCORE Scientific Medical Journal最新文献

{"title":"Hubungan Kualitas Tidur dan Fungsi Kognitif Siswa MAN Binjai","authors":"Said Fachlefi, A. S. Rambe","doi":"10.32734/scripta.v3i1.5351","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.5351","url":null,"abstract":"Background: Sleep is a basic requirement of human beings. Sleeping brain is required to carry out adaptations to long-term structural and chemical needed to learn and remember. Rapid technological advances in recent times can reduce the duration of sleep especially in teenagers. A bad quality of sleep may affect cognitive function that will have an effect on students learning process.\u0000Objective: In general, this research aims to know the relationship between sleep quality with cognitive function of MAN Binjai student.\u0000Method: This research is a study of analytical method with cross sectional design. Data retrieval is performed only once for collecting primary data with the measuring instrument in the form of a questionnaire. Stratified random sampling technique was used to determine the number of samples.\u0000Results: on the analysis of correlation Sprearman obtained a value of 0.001 P (p< 0.05) indicating there is a relationship between sleep quality and cognitive  function. The correlation coefficient (r) is -0.764, which indicates medium relationship between sleep quality and cognitive function of MAN Binjai student.\u0000Conclusion:  There is a relationship that is directly proportional between the sleep quality with cognitive function in MAN Binjai students.\u0000Keywords: cognitive function, MoCA, PSQI, sleep quality, student\u0000 \u0000Latar Belakang: Tidur merupakan kebutuhan pokok manusia. Tidur diperlukan otak untuk melaksanakan penyesuaian-penyesuaian kimiawi dan struktural jangka panjang yang diperlukan untuk belajar dan mengingat. Kemajuan teknologi yang begitu pesat belakangan ini dapat mengurangi durasi tidur terutama pada remaja. Kualitas tidur yang buruk dapat memengaruhi fungsi kognitif yang akan berpengaruh terhadap proses belajar siswa. \u0000Tujuan: Secara  umum  penelitian  ini  bertujuan  untuk  mengetahui  hubungan kualitas tidur dengan fungsi kognitif siswa MAN Binjai. \u0000Metode: Penelitian  ini  merupakan  penelitian  dengan  metode  analitik  dengan desain penelitian potong lintang. Pengambilan data dilakukan hanya sekali untuk mengumpulkan data primer dengan alat ukur berupa kuesioner MoCA dan PSQI. Teknik stratified random sampling digunakan untuk menentukan jumlah sampel. Sampel berjumlah 60 orang. Korelasi spearman digunakan dalam analisis data. \u0000Hasil: Dari studi didapatkan r = -0.76(p<0.05) yang menunjukkan adanya korelasi sedang dan berbanding terbalik antara kuesioner M0CA dan PSQI. \u0000Kesimpulan:  Terdapat hubungan antara kualitas tidur dengan fungsi kognitif pada siswa MAN Binjai.\u0000Kata Kunci: fungsi kognitif, kualitas tidur, MoCA, PSQI, siswa","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124643958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memahami Kaitan Gaya Hidup dengan Kanker: Sebagai Langkah Awal Pencegahan Kanker","authors":"Ridwan Balatif, Alshafiera Azayyana Mawadhani Sukma","doi":"10.32734/scripta.v3i1.4506","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.4506","url":null,"abstract":"Background: Until now, cancer has become one of the main problem topics in the world of health. The incidence of this cancer is expected to continue to increase. One of the main risk factors that increase the risk of cancer is an unhealthy lifestyle in the form of alcohol consumption, unhealthy diet, smoking, and lack of physical activity.\u0000Objectives: This article provides an understanding of each unhealthy lifestyle pattern for the occurrence of cancer.\u0000Methods: The writing of this article uses the literature review method. Information is taken from e-book sources, websites, and search engines.\u0000Discussion: The initial process of cancer stems from genetic damage. If this genetic damage cannot be repaired, it can progress to cancer. Each pattern of unhealthy lifestyles has its own mechanism in triggering cancer.\u0000Conclusion: An unhealthy lifestyle can increase the risk of cancer.\u0000Keywords: cancer, life style, risk factor\u0000 \u0000Latar belakang: Sampai saat ini penyakit kanker menjadi salah satu topik permasalahan utama di dunia kesehatan.  Kejadian kanker ini diperkirakan akan terus mengalami peningkatan. Salah satu faktor risiko utama yang meningkatkan risiko terjadinya kanker adalah gaya hidup tidak sehat berupa konsumsi alkohol, diet tidak sehat, merokok, dan kurang aktivitas fisik. \u0000Tujuan: Artikel ini menjabarkan pemahaman mengenai masing-masing pola gaya hidup yang tidak sehat terhadap terjadinya kanker. \u0000Metode: Penulisan artikel ini menggunakan metode literature review. Informasi diambil dari sumber e-book, website, dan search engine. \u0000Pembahasan: Proses awal tercetusnya kanker bermula dari adanya kerusakan genetik. Apabila kerusakan genetik ini tidak dapat diperbaiki dapat berkembang menuju kanker. Setiap pola gaya hidup yang tidak sehat memiliki mekanismenya masing-masing dalam mencetuskan kanker. \u0000Kesimpulan: Gaya hidup tidak sehat dapat meningkatkan risiko terjadinya kanker.\u0000Kata Kunci: faktor risiko, gaya hidup, kanker","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126747565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tingkat Pengetahuan Tentang Infeksi Menular Seksual (IMS) Pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2019 Tahun 2020","authors":"A. Khairunnisa, Lidya Imelda Laksmi","doi":"10.32734/scripta.v3i1.5410","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.5410","url":null,"abstract":"Background: Sexually transmitted infection (STI) is an infection that can be passed from one person to another through sexual intercourse. Data from UNFPA and WHO lists 1 of 2 youths infected with sexually transmitted desease each year.\u0000Objectives: In general this study aims to determine the level of knowledge of FK USU batch 2019 student about sexually transmitted infections.\u0000Methods: This research is a study of descriptive method with cross sectional design. Simple random sampling technique was used to determine the number of samples. The research sample amounted to 155 people with an online questionnaire instreument that has been validated with Statistical Package for Social Science (SPSS).\u0000Results: In the calculation of the frequency and percentage of all respondents, 69 people (44.5%) were found to be in good categories, 83 people (53.5%) in moderate categories, and 3 people (2%) in bad categories. The description based on gender shows that there are 47 women with good knowledge (48.5%) with the proportion of women as many as 97 people and no one with bad knowledge, while 22 people with good knowledge and 3 people (5.2%) with poor knowledge with the proportion of men as many as 58 people. The description based on the age shows that the results with good knowledge are found at 17 years old with 100% good results, while those with poor knowledge are found at the age of 20 years old with a bad percentage of 4.2%.\u0000Conclusion: FK USU batch 2019 students are in the moderate category.\u0000Keywords: adolescence, HIV, Sexually Transmitted Infection (STI)\u0000 \u0000Latar Belakang: Infeksi menular seksual (IMS) adalah penyakit infeksi yang dapat menular dari satu orang ke orang lain melalui hubungan seksual. Data dari UNFPA dan WHO menyebutkan 1 dari 20 remaja tertular IMS setiap tahunnya. \u0000Tujuan: Tujuan penelitian ialah untuk mengetahui tingkat pengetahuan tentang infeksi menular seksual pada mahasiswa FK USU angkatan 2019. \u0000Metode: Penelitian ini merupakan penelitian dengan metode deskriptif dengan desain penelitian cross sectional, serta menggunakan teknik simple random sampling untuk menentukan jumlah sampel. Sampel penelitian berjumlah 155 orang dengan instrument kuesioner online yang telah di validasi dengan Statistic Package for Social Science (SPSS), kemudian hasilnya akan diolah dengan SPSS lalu dianalisis secara deskriptif dan disajikan dalam bentuk tabel. \u0000Hasil: Hasil dengan pengetahuan baik sebanyak 69 orang (44,5%), sedang sebanyak 83 orang (53,5%), dan buruk sebanyak 3 orang (2%) dari 155 responden. Pengetahuan berdasarkan jenis kelamin didapati hasil perempuan dengan pengetahuan baik sebanyak 47 orang (48,5%) dengan proporsi perempuan sebanyak 97 orang serta tidak ada yang berpengetahuan buruk., sedangkan laki-laki dengan berpengetahuan baik sebanyak 22 orang (37,9%) serta 3 orang (5,2%) dengan berpengetahuan buruk dengan proporsi laki-laki sebanyak 58 orang. Pengetahuan berdasarkan usia didapati hasil dengan berpengetahuan baik terdapat pada usia","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132754860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Madu terhadap Perbaikan Kerusakan Mukosa Gaster dan Penyembuhan Luka pada Penderita Ulkus Peptikum","authors":"Clarisa Rahmah","doi":"10.32734/scripta.v3i1.4531","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.4531","url":null,"abstract":"Background: Peptic ulcer is one of the diseases that many people experience in digestive tract disorders. Peptic ulcers occur due to excessive secretion of gastric acid (HCl) and pepsin by the gastric mucosa.\u0000Objectives: This discussion aims to determine the gastroprotector effect of honey on peptic ulcer healing.\u0000Methods: The method used is literature study from national and international journals by summarizing the discussion presented in the article.\u0000Discussion: The incidence of gastric ulcers commonly occurs due to because of Helicobacter pylori infection with increased mortality in older people with the use of Anti-Inflammatory Steroids (NSAIDs). Treatment and prevention of disease using traditional medicine that is widely reused, one of which is honey. Honey contains more than 200 compounds that are useful in the wound healing process such as anti-inflammatory, antibacterial, antioxidant, tissue stimulation, retaining moisture, and healing wound healing activities.\u0000Conclusion: Honey has a gastroprotective effect on the irritated stomach until the ulcer acts as an antibiotic, balancing gastric pH, and as an inducer of epithelialization of the gastric mucosa.\u0000Keywords: gastric, honey, mucosal repair, peptic ulcer, wound healing\u0000 \u0000Latar Belakang: Ulkus peptikum merupakan salah satu penyakit yang banyak dialami masyarakat dalam gangguan saluran pencernaan. Ulkus peptikum terjadi karena sekresi asam lambung (HCl) dan pepsin berlebih oleh mukosa lambung. \u0000Tujuan: Pembahasan ini bertujuan untuk mengetahui efek gastroprotektor pada madu terhadap penyembuhan ulkus peptikum. \u0000Metode: Metode yang digunakan studi literatur dari jurnal nasional dan internasional dengan merangkum pembahasan yang disajikan dalam artikel. \u0000Pembahasan: Insidensi tukak lambung banyak terjadi karena adanya infeksi Helicobacter pylori yang angka mortalitasnya meningkat pada orang tua dengan penggunaan Obat Anti Inflamasi Steroid (OAINS). Pengobatan dan pencegahan penyakit dengan obat tradisional/ herbal banyak digunakan kembali, salah satunya madu. Madu mengandung lebih dari 200 senyawa yang bermanfaat dalam proses penyembuhan luka seperti aktivitas antiinflamasi, antibakterial, antioksidan, stimulasi pengangkatan jaringan, mempertahankan kelembapan, dan mempercepat penyembuhan luka. \u0000Kesimpulan: Madu memiliki efek gastroprotektor pada mukosa gaster yang mengalami iritasi hingga ulkus berperan sebagai antibiotik, penyeimbang pH gaster, dan penginduksi epitelisasi mukosa gaster.\u0000Kata Kunci: gaster, madu, penyembuhan luka, perbaikan mukosa, ulkus peptikum","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130373475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refluks Laringofaring","authors":"Wita Aulia","doi":"10.32734/scripta.v2i1.3956","DOIUrl":"https://doi.org/10.32734/scripta.v2i1.3956","url":null,"abstract":"Laryngopharyngeal reflux (LPR) is a disease in which retrograde flow occurs from the contents of the stomach to the larynx and pharynx and then this material is in contact with the upper esophagus. This disease is different from gastroesophageal reflux disease (GERD). A man, 58 years old laborer, came with complaints of hoarseness since 3 months ago. Complaints are accompanied by swallowing pain and throat pain that has worsened since 1 month. The patient also complained that the sound had disappeared within 1 month. The patient has a history of smoking and claims that he has had a long-standing heartburn. Physical examination found blood pressure of 150/90 mmHg, pulse 102 x/minute, breathing 20 x/minute, temperature 37.9ºC. Investigations were done using the Fiber Optic Laryngoscope (LFO) and revealed a rigid epiglottis and bilateral hyperemic arytenoids and minimal edema. RSI score calculation results have been 18 and RFS score results have been 9. This pateint’s diagnosis is Laryngopharyngeal reflux (LPR). Pharmacological management for this patient is Omeprazole 40 mg 2x1 tablet, Sucralfate syrup 3x1 teaspoon, and N-acetylcysteine 3x1 tablet. Non-pharmacological management is by telling the patient to give 2 hours time between eating and lying down. The patient is also told to reduce the consumption of fatty foods, coffee, soda, alcohol, and low-acid diets, and position the head slightly higher when lying down.\u0000Keywords: Fiber Optic Laryngoscope, laryngopharyngeal reflux, Reflux Finding Score, Reflux Symptom Index\u0000 \u0000 \u0000Refluks laringofaring adalah penyakit dimana terjadi aliran retrograde dari isi lambung ke laring dan faring kemudian cairan ini bersentuhan dengan saluran esofagus bagian atas. Penyakit ini berbeda dengan gastroesophageal reflux disease (GERD). Seorang laki-laki, usia 58 tahun seorang buruh datang dengan keluhan suara serak sejak 3 bulan yang lalu. Keluhan disertai dengan nyeri menelan dan nyeri tenggorokan yang memberat sejak 1 bulan ini. Pasien juga mengeluhkan suara sempat hilang timbul dalam 1 bulan ini. Pasien memiliki riwayat merokok dan mengaku bahwa menderita sakit maag sejak lama. Pemeriksaan fisik didapatkan tekanan darah 150/90 mmHg, nadi 102 x/menit, pernapasan 20 x/menit, suhu 37,9ºC. Pada pemeriksaan penunjang Fiber Optic Laryngoscope (LFO), didapatkan epiglotis yang kaku serta aritenoid hiperemis bilateral dan edema minimal. Pada perhitungan skor RSI didapatkan hasil 18 dan skor RFS didapatkan hasil 9. Diagnosis pada pasien ini adalah refluks laringofaring. Penatalaksanaan pada pasien berupa medikamentosa yaitu Omeprazole tablet 40 mg 2x1 tablet, Sukralfat syrup 3x1 sendok teh, dan N-asetilsistein 3x1 tablet. Non-medikamentosa dengan memberitahukan kepada pasien untuk jarak makan dan berbaring kurang lebih 2 jam, mengurangi konsumsi makanan berlemak, kopi, soda, alkohol, dan diet rendah asam, serta memberitahukan kepada pasien untuk memposisikan kepala sedikit lebih tinggi saat berbaring\u0000Kata kunci: Fiber Optic L","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128867179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarettes and Its Effects on Health","authors":"R. Balatif","doi":"10.32734/scripta.v2i1.1246","DOIUrl":"https://doi.org/10.32734/scripta.v2i1.1246","url":null,"abstract":"Background: One of the biggest challenges in the world of health is the problem of smoking. In 2018, there was an increase in smokers at the age of 10-18 years by 9.1% compared to 2013, which was 7.2%. It is feared that the increasing number of smokers at a young age will increase the number of non-communicable diseases (NCD) at a young age.\u0000Methods: Writing this article uses the method of literature searching from various sources of information including e-books, websites and search engines. The e-books used contain cigarette information and its effects on health, the websites used are the website of the government and WHO to search for prevalence data and other information, and the search engines used are Google Scholar and Pubmed to search information on cigarette content research and its effects on health.\u0000Discussion: The content of cigarettes can cause various side effects in almost all organs of the body. Various studies have found that smoking is a risk factor for NCD.\u0000Conclusion: Cessation of smoking can save sufferers and also save people around smokers. When a smoker starts quitting smoking, the body will undergo the process of cleaning up toxic substances of cigarettes that have entered the body.\u0000Keywords: cigarette, literature searching, NCD\u0000 \u0000 \u0000Latar Belakang: Salah satu tantangan terbesar dalam dunia kesehatan ialah masalah rokok. Pada tahun 2018, terjadi peningkatan perokok pada usia 10-18 tahun sebesar 9,1% dibandingkan pada tahun 2013 sebesar 7,2%. Peningkatan jumlah perokok di usia muda ini dikhawatirkan akan meningkatkan jumlah Penyakit Tidak Menular (PTM) di usia muda.\u0000Metode: Penulisan artikel ini menggunakan metode pencarian literatur dari berbagai sumber informasi berupa e-book, website dan search engine. E-book yang dipakai memuat informasi rokok dan pengaruhnya kekesehatan, website yang dipakai adalah website pemerintah dan WHO untuk pencarian data prevalensi dan informasi lainnya, dan search engine yang dipakai adalah Google Scholar dan Pubmed untuk pencarian informasi penelitian kandungan rokok dan pengaruhnya kepada kesehatan.\u0000Pembahasan: Dari hasil pencarian, kandungan pada rokok dapat menimbulkan berbagai efek samping hampir di seluruh organ tubuh. Berbagai penelitian mendapatkan bahwa kebiasaan merokok merupakan faktor risiko terjadinya PTM.\u0000Kesimpulan: Penghentian kebiasaan merokok ini dapat menyelamatkan penderitanya dan juga menyelamatkan orang di sekitar perokok. Ketika seorang perokok mulai berhenti untuk merokok, maka tubuh akan melakukan proses pembersihan dari zat racun pada rokok yang sudah masuk ke dalam tubuh.\u0000Kata kunci: rokok, PTM, pencarian literatur","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116016630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemanfaatan Tanaman Kelor (Moringa oleifera Lam.) sebagai Sumber Terapi Preventif dan Kuratif pada Pasien Perlemakan Hepar dengan Sindrom Metabolik","authors":"Tiara Mahza Wardhani","doi":"10.32734/SCRIPTA.V1I2.3349","DOIUrl":"https://doi.org/10.32734/SCRIPTA.V1I2.3349","url":null,"abstract":"ABSTRAK \u0000Menurut The International Diabetes Federation (IDF) pada tahun 2015, sindrom metabolik ditemukan pada 25% populasi orang dewasa dunia dan diperkirakan akan terus meningkat. Sindrom metabolik menyebabkan peningkatan produk metabolik seperti trigliserida dan tetesan lemak hepatik yang berujung pada perlemakan hati. Tinjauan  pustaka ini bertujuan untuk mengetahui efek Moringa oleifera, Lam. sebagai sumber terapi preventif dan kuratif pada pasien perlemakan hati dengan sindrom metabolik. Tinjuan pustaka ini ditulis berdasarkan artikel yang dikumpulkan melalui beberapa mesin pencari ilmiah dengan kriteria inklusi dan ekslusi. Hasil studi didasarkan literatur yang telah teruji validitasnya dan  relevan dengan kajian analisis pembahasan. Setelah data yang diperlukan terkumpul, dilakukan pengolahan data dengan menyusun secara sistematis dan logis. Moringa oleifera, Lam.  menginhibisi TNF-α.,IL-1β, IL-6, dan IL-10 sehingga bersifat hepatoprotektif. Selain itu,  Moringa oleifera, Lam. menghambat lipogenesis melalui jalur Nf-kb yang ditandai turunnya LDL-R, SRB1c, DGAT2, PPARy dan peningkatan sensitivitas sekresi insulin sehingga menghambat  perlemakan hati. Moringa oleifera, Lam. Dapat digunakan sebagai sumber terapi preventif dan kuratif pada pasien perlemakan hati dengan sindrom metabolik. \u0000Kata Kunci: Moringa oleifera, Kelor, Trigliserida, Perlemakan hati, Sindrom Metabolik \u0000  \u0000ABSTRACT \u0000Based on The International Diabetes Federation research in 2015, metabolic syndrome found in 25% of the adult population in the world. Metabolic syndrome increases metabolic end products like triglyceride and steatosis which is causing non-alcoholic fatty liver.  This literature review aimed to determine the effect of Moringa oleifera, Lam.  as the source of preventive and curative therapy in the non-alcoholic fatty liver with metabolic syndrome. This literature review is based on journals and articles collected from search engines with some inclusion and exclusion criteria. Only valid and relevant works of literature consider as the preference. Moringa oleifera, Lam.  has hepatoprotective effect by inhibits TNF-α., IL-1β, IL-6, dan IL-10. Moringa oleifera, Lam. also inhibits fatty liver disease by inhibits lipogenesis through the Nf-kb pathway marked by decreasing LDL-R, SRB1c, DGAT2, PPARy, and increasing insulin sensitivity. Moringa oleifera, Lam. is useful for the natural source of preventive and curative therapy in the non-alcoholic fatty liver with metabolic syndrome. \u0000Keyword: Moringa oleifera, Triglyceride, Fatty Liver Disease, Metabolic Syndrome","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117312488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peran Reseptor IL-21 (IL-21R) sebagai Target Terapi Pada Penyakit Arteri Perifer","authors":"M. Adnan","doi":"10.32734/scripta.v3i1.4440","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.4440","url":null,"abstract":"Background: Peripheral Artery Disease (PAD) is caused due to the disruption of blood supply to the periphery caused by blockages in the arteries. PAD is a disease that is difficult to detect and the current therapy is still limited to pharmacological therapy to reduce the risk of PAP incidence and surgical therapy if complications of PAD arise. The interleukin-21 receptor (IL-21R) is a family of interleukins that has been widely studied for its role in many diseases.\u0000Objectives: The aim of this review is to discuss the effect of IL-21R on the pathogenesis of PAP.\u0000Methods: A literature search was performed with PubMed, Google Scholar, and ScienceDirect using the keywords “peripheral artery disease”, “interleukin-21 receptor”, “inflammation”, “angiogenesis”, and “therapy”.\u0000Discussion: PAD can arise due to the formation of atherosclerotic plaques that block arteries so that blood supply is impaired. In the case of PAD, activation of IL-21R has the ability to stimulate angiogenesis thereby modulating the perfusion of hypoxic tissues in cases of PAD. Further research is needed regarding IL-21R activity in the future to study the potential of IL-21R for the more effective treatment of PAD cases in the future.\u0000Conclusion: IL-21R can activate angiogenesis and avoid further tissue damage in PAP.\u0000Keywords: interleukin-21 receptors, peripheral artery disease, therapy\u0000 \u0000Latar Belakang: Penyakit Arteri Perifer (PAP) disebabkan karena gangguan suplai darah ke bagian perifer yang disebabkan karena sumbatan pada pembuluh darah arteri. PAP merupakan penyakit yang sulit terdeteksi dan terapi yang ada saat ini masih terbatas pada terapi farmakologis untuk menurunkan risiko kejadian PAP dan terapi pembedahan apabila timbul komplikasi PAP. Reseptor interleukin-21 (IL-21R) merupakan salah satu famili interleukin yang telah banyak dipelajari terkait perannya pada banyak penyakit. \u0000Tujuan: Tujuan dari tinjauan ini adalah untuk membahas pengaruh IL-21R terhadap perjalanan penyakit PAP. \u0000Metode: Pencarian literatur dilakukan dengan PubMed, Google Scholar, dan ScienceDirect menggunakan kata kunci “peripheral artery disease”, “reseptor interleukin-21”, “inflamasi”, ”angiogenesis”, dan “terapi”. \u0000Pembahasan: PAP dapat timbul karena pembentukan plak aterosklerosis yang menyumbat pembuluh darah arteri sehingga suplai darah terganggu. Pada kasus PAP, aktivasi IL-21R memiliki kemampuan untuk menstimulasi angiogenesis sehingga memodulasi perfusi jaringan yang mengalami hipoksia pada kasus PAP. Masih diperlukan penelitian lebih lanjut mengenai aktivitas IL-21R di masa depan untuk mempelajari potensi IL-21R untuk pengobatan kasus PAP yang lebih efektif di masa depan. \u0000Kesimpulan: IL-21R dapat mengaktivasi angiogenesis dan menghindari kerusakan jaringan lebih lanjut pada PAP.\u0000Kata Kunci: penyakit arteri perifer, reseptor interleukin-21, terapi","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131965060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotik sebagai Pengatur Komposisi Gut microbiota dalam Menghambat Progresivitas Parkinson’s Disease","authors":"Ahmad Taufik Fadillah Zainal, Andi Gunawan, A. Fitri Febrianty Fariadi","doi":"10.32734/scripta.v3i1.4410","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.4410","url":null,"abstract":"Background: Parkinson's Disease (PD) is one of the most common neurodegenerative diseases at the age of 40-70 years. Disorders of the Gut-Microbiota-Brain Axis have been linked to bacterial metabolite products that play a role in the occurrence of neuroinflammation. Understanding precisely the role of the neuroinflammatory process in PD can lead to an understanding of how PD occurs and its relation to gut microbiota (GM).\u0000Objectives: To determine the effectiveness of probiotics as a therapeutic target to inhibit the progression of PD.\u0000Methods: Literature study method by collecting valid references regarding GM and PD and the relationship between them.\u0000Discussion: Evidence from in vivo trials using Alpha-Synuclease-Overexpressing (αSyn) mice reported that Dysbiosis GM can cause inflammation by activating microglia cells and increasing proinflammatory cytokines modulated by metabolite products of Short Chain Fatty Acids (SCFAs)  which lead to the occurrence of alpha-Synuclein aggregation and leads to the progression of PD. One of the microbes that have decreased the number of Dysbiosis GM is Lactobacillus rhamnous GG, which has a neuroprotective role in inhibiting the progression of PD. Microbiota-targeted interventions using the probiotic L-GG method have shown a positive effect on inhibiting PD progression.\u0000Conclusion: GM dysbiosis caused by PD has a pathway that can increase the progression of PD. This can be used as a therapeutic target, microbial composition engineering with the method of giving L-GG probiotics to be a solution in inhibiting the progression of PD by restoring the neuroprotective effect of L-GG.\u0000Keywords: alpha-Synuclein (αSyn), Gut Microbiota (GM), Lactobacillus rhamnous GG (L-GG), Parkinson's Disease (PD), Short Chain Fatty Acids (SCFAs)\u0000 \u0000Latar Belakang: Penyakit Parkinson (Parkinson’s Disease/PD) adalah salah satu penyakit neurodegeneratif yang paling banyak terjadi pada usia 40-70 tahun. Dewasa kini, gangguan pada Gut-Microbiota-Brain Axis telah dihubungkan dengan produk metabolit bakteri yang berperan pada terjadinya neuroinflamasi. Memahami secara tepat peranan dari proses neuroinflamasi pada Parkinson Disease (PD) dapat membawa pemahaman terhadap bagaimana PD timbul dan kaitannya dengan mikroba usus (Gut Microbiota/GM). \u0000Tujuan: Untuk mengetahui efektivitas probiotik sebagai target terapi untuk menghambat progresivitas PD. \u0000Metode: Literature reviewini disusun menggunakan metode studi pustaka dengan mengumpulkan referensi yang valid mengenai GM dan PD serta hubungan antar keduanya. \u0000Pembahasan: Bukti uji coba in vivo menggunakan tikus Alpha-Synuclease-Overexpressing (ASO) dilaporkan bahwa Dysbiosis Gut Microbiota dapat menyebabkan terjadinya inflamasi dengan mekanisme pengaktifan sel mikroglia dan peningkatan sitokin proinflamasi yang dimodulasi oleh produk metabolit Short Chain Fatty Acids (SCFAs) yang mengarahkan pada terjadinya agregasi alpha-Synuclein (αSyn) dan berujung pada progresivitas PD. Salah satu mikroba yan","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125036824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laporan Kasus: Pemeriksaan Tes PCR untuk SARS-CoV-2 Tetap Positif dengan Gejala Klinis Minimal di RSUD.Undata Palu, Sulawesi Tengah","authors":"Indah Fitriyani, Rosa Dwi Wahyuni, Reny Arniwaty Lamadjido","doi":"10.32734/scripta.v3i1.6363","DOIUrl":"https://doi.org/10.32734/scripta.v3i1.6363","url":null,"abstract":"Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is a new type of corona virus that has never been previously identified in humans. There are at least two types of coronavirus that are known to cause diseases that can cause severe symptoms, such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). WHO recommends molecular testing for all patients suspected of being infected with COVID-19. The recommended method is the molecular detection method / NAAT (Nucleic Acid Amplification Test) such as the RT-PCR examination.\u0000Objectives: To report a case of Covid 19 which focuses on laboratory examination problems.\u0000Case Illustration: A 27-year-old woman has a persistent high fever accompanied by pain in the joints, coughing, and also a rash on the face and all over the body. On the fourth day of fever, the sufferer loses his sense of smell and taste. Work history as a volunteer for medical personnel in the Covid (+) room.\u0000Discussion: Laboratory tests for the diagnosis of Covid 19 consist of a complete hematology examination, clinical chemical examination, immunological examination, molecular examination (RT-PCR), examination of SARS CoV-2 antibodies.\u0000Conclusion: In this patient, the results of the swab were still reactive even though the patient was no longer showing clinical symptoms. This indicates that the virus can still be detected through RT-PCR examination.\u0000Keywords: clinical symptoms, Covid 19 PCR test, SARS-CoV-2\u0000 \u0000Latar Belakang: Coronavirus Disease 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 merupakan corona virus jenis baru yang belum pernah diidentifikasi sebelumnya pada manusia. Ada setidaknya dua jenis corona virus yang diketahui menyebabkan penyakit yang dapat menimbulkan gejala berat seperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). WHO  merekomendasikan  pemeriksaan molekuler untuk seluruh pasien yang terduga terinfeksi COVID-19. Metode yang dianjurkan adalah  metode deteksi molekuler/NAAT (Nucleic Acid Amplification Test) seperti pemeriksaan RT-PCR.\u0000Tujuan: Melaporkan satu kasus Covid 19 yang menitikberatkan pada masalah pemeriksaan laboratorium. \u0000Ilustrasi Kasus: Seorang wanita usia 27 tahun  mengalami demam tinggi terus menerus disertai nyeri pada persendian, batuk, dan juga timbul ruam di wajah dan seluruh badan. Hari ke empat demam, penderita mengalami kehilangan indra penciuman dan indra perasa. Riwayat kerja sebagai sukarela tenaga medis di ruangan Covid (+).  \u0000Pembahasan: Pemeriksaan laboratorium untuk diagnosis Covid 19  terdiri dari pemeriksaan hematologi lengkap, pemeriksaan kimia klinik, pemeriksaan immunologi, pemeriksaan molekular (RT-PCR), pemeriksaan antibody SARS CoV-2. \u0000Kesimpulan: Pada pasien ini didapatkan hasil swab yang masih terus reaktif walau","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131492776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}