SCRIPTA SCORE Scientific Medical Journal最新文献

{"title":"Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia","authors":"Helena Azriz, Raihan Syah Ibrahim, Rafi Maulana, Rauza Sukma Rita","doi":"10.32734/scripta.v5i2.14678","DOIUrl":"https://doi.org/10.32734/scripta.v5i2.14678","url":null,"abstract":"Background: Human Immunodeficiency Virus (HIV) infection is an unresolved health problem in various countries. Indonesia is rich in various potential natural resources and is able to support the development of HIV therapy through the use of bioactive components from plants, one of which is flavonoid compounds which need to be investigated for their potential anti-HIV activity. Objective: To determine the anti-HIV potential of natural compound flavonoids. Method: The method used is a narrative literature review, with literature collection obtained from PubMed, ScienceDirect and Google Scholar. The selected articles are those published in the last ten years (2013-2022) and full text is available. Result and Discussion: 24 articles included related to flavonoid and HIV. Indonesia is in an emergency situation for HIV infection, antiretroviral drugs (ARV) can only inhibit the development of the virus, but do not kill the virus directly. The antiviral potential of flavonoid compounds makes this substance an opportunity to be studied in HIV infection. The flavonoid subclasses myricetin, herbacitrin, and chalcone have the best anti-HIV activity. The natural ingredient that has the highest flavonoid such as sea fern spores, dragon fruit with a content of 0.14 - 0.15 mg/g, Moringa leaves with a content of 7.79 mg/g, and cinnamon with a fairly high content. Conclusion: Flavonoids have anti-HIV potential with different mechanisms according to the type of flavonoid compounds contained. Flavonoids are mostly contained in sea fern spores, and are also found in dragon fruit, cinnamon and Moringa leaves, which are natural ingredients that are easily available every day.\u0000 \u0000Latar Belakang: Infeksi Human Immunodeficiency Virus (HIV) merupakan masalah kesehatan yang belum terselesaikan pada berbagai negara di dunia. Indonesia merupakan negara yang kaya akan berbagai sumber daya alam yang potensial dan mampu mendukung pengembangan terapi HIV melalui pemanfaatan komponen bioaktif dari tumbuhan, salah satunya adalah senyawa flavonoid yang perlu ditelitipotensi aktivitas anti-HIVnya. Tujuan: Mengetahui potensi anti-HIV dari senyawa flavonoid bahan alam Metode: Metode yang digunakan adalah tinjauan literatur naratif, dengan pengumpulan literatur dilakukan melalui database PubMed, ScienceDirect, dan Google Scholar. Artikel yang dipilih adalah yang terbit sepuluh tahun terakhir (2013-2022) dan tersedia full text. Pembahasan: 24 artikel didapatkan membahas flavonoid dan kaitannya pada HIV. Indonesia berada dalam kondisi darurat infeksi HIV, obat antiretroviral (ARV) hanya dapat menghambat perkembangan virus, namun tidak membunuh virus secara langsung. Adanya potensi antivirus dari senyawa flavonoid menjadikan zat ini berpeluang untuk diteliti pada penyakit infeksi HIV. Flavonoid subkelas myricetin, herbacitrin, dan kalkon memiliki aktivitas anti-HIV yang paling baik. Bahan alam yang mempunyai kandungan flavonoid tertinggi di antaranya spora paku laut, buah naga dengan kandun","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review: Oral Lumbrokinase as Potential Agent Prevents Myocardial Reinfarction Post-Reperfusion in ST-Elevation Myocardial Infarction (STEMI) Patients","authors":"Muhammad Mufaiduddin, Innelya, Alfi Rahmatika","doi":"10.32734/scripta.v5i2.15156","DOIUrl":"https://doi.org/10.32734/scripta.v5i2.15156","url":null,"abstract":"Background: Coronary Heart Disease (CHD) is a major cause of death and disability worldwide and its prevalence is expected to continue to increase in the coming years. Myocardial infarction is the largest and most dangerous manifestation of CHD, including in ST-Elevation Myocardial Infarction (STEMI). However, early therapy of STEMI cannot prevent the risk of myocardium reinfarction. Reinfarction post-STEMI reperfusion therapy has poor consequences and prognosis. Therefore, prevention of myocardial reinfarction is important. Objectives: The author has an innovation to use Lumbrokinase from Lumbricus rubellus extract in an oral dosage form as an alternative therapy to prevent reinfarction after reperfusion therapy in STEMI. Methods: Our article reviews the effect of lumbrokinase in preventing myocardial reinfarction using a non-systematic review method. Results and Discussion: Lumbrokinase can prevent myocardial reinfarction by several mechanisms, including its thrombolytic effect by activating plasminogen and degrading fibrin, its anti-inflammatory and antioxidant effects, and can prevent further myocardial apoptosis. Lumbrokinase can prevent apoptosis by increasing the activity of Silent Information Regulator 1 (Sirt1) and decreasing the pro-caspase-3 pathway. Lumbrokinase can prevent further inflammation by reducing levels of Nuclear Factor kappa-B (NF-kB) and the Toll-like Receptor 4 (TLR4) pathway, as well as preventing oxidative damage by deacetylating Forkhead Box-O (FoxO). The effect of Lumbrokinase plays an important role in preventing myocardial reinfarction. Oral lumbrokinase is made in capsule form. Conclusion: Oral lumbrokinase can potentially prevent myocardial reinfarction post-reperfusion in STEMI patients.\u0000Keyword: Lumbricus rubellus, Lumbrokinase, Myocardial reinfarction, Post-reperfusion STEMI\u0000Latar Belakang: Penyakit Jantung Koroner (PJK) merupakan penyebab utama kematian dan kecacatan di seluruh dunia dan prevalensinya diperkirakan akan terus meningkat di tahun mendatang. Tingginya angka mortalitas PJK, maka PJK menjadi penyakit yang patut diwaspadai, terutama untuk negara-negara berkembang. Infark miokardium adalah manifestasi terbesar dan paling berbahaya dari PJK, termasuk STEMI. Namun, terapi awal dari STEMI tidak dapat mencegah resiko reinfark. Reinfark yang terjadi setelah terapi reperfusi memiliki konsekuensi dan prognosis yang buruk. Oleh karena itu, pencegahan reinfark miokardium setelah terapi STEMI menjadi penting.  Tujuan: Penulis memiliki inovasi untuk menggunakan Lumbrokinase dari ekstrak Lumbricus rubellus dalam bentuk sediaan oral sebagai upaya terapi alternatif pencegahan reinfark setelah terapi reperfusi pada STEMI. Metode: Tinjauan pustaka ini bertujuan untuk meninjau efek dari lumbrokinase dalam mencegah reinfark miokardium setelah terapi STEMI dengan menggunakan metode non-systematic review. Pembahasan: Lumbrokinase dapat mencegah reinfark miokardium dengan beberapa mekanisme, termasuk efek trombolitiknya ","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of The Incidence of Acne Due to The Use of Masks During The COVID-19 Pandemic","authors":"Monica Syefi Febriyanti, Christanti Naomi Pramasanti Sitanggang, Ribka Liliana Zebua, Syahfori Widiyani","doi":"10.32734/scripta.v5i2.15061","DOIUrl":"https://doi.org/10.32734/scripta.v5i2.15061","url":null,"abstract":"Background: On March 11 2020, WHO declared COVID-19 as a pandemic. One of the efforts to prevent, control and break the chain of transmission of COVID-19 in the community is to use a mask. However, apart from feeling uncomfortable, many complaints about acne due to the use of masks are found in the community. During the COVID-19 pandemic, a popular phenomenon appeared on social media, namely \"Maskne\", a combination of the words mask and acne. Objective: The purpose of this study was to determine the incidence of acne due to the use of masks. Methods: The approach used in this research is quantitative, cross- sectional with data collection techniques through questionnaires. Data analysis using SPSS version 16.0 software. Results: The results showed that the longer use of masks, the higher incidence of acne; the more steps of cleaning the face, the smaller severity of acne. Conclusion: The incidence of acne due to wearing mask during the COVID-19 pandemic correlates with the length of time wearing a mask. The type of mask, the colour of the mask and the variety of beauty products used are not correlated with an increase in the incidence of acne during the use of masks.\u0000Keyword: acne, COVID-19, mask, maskne\u0000Latar Belakang: Pada tanggal 11 Maret 2020 WHO menyatakan COVID-19 sebagai pandemi. Salah satu upaya pencegahan dan pengendalian, serta pemutusan rantai penularan COVID-19 pada masyarakat adalah dengan menggunakan masker. Namun, selain rasa tidak nyaman, keluhan timbulnya jerawat akibat menggunakan masker banyak ditemukan di masyarakat. Selama pandemi COVID-19 muncul fenomena yang populer pada media sosial yaitu “Maskne” gabungan kata mask dan acne. Tujuan: Tujuan penelitian ini adalah mengetahui gambaran kejadian jerawat akibat menggunakan masker selama pandemi dan faktor yang menimbulkan jerawat akibat pemakaian masker. Metode: Pendekatan yang digunakan dalam penelitian ini yaitu kuantitatif, potong lintang dengan teknik pengumpulan data melalui kuesioner. Analisis data dengan menggunakan software SPSS versi 16.0. Hasil: Hasil penelitian didapatkan bahwa semakin lama pemakaian masker maka semakin tinggi angka kejadian jerawat; semakin banyak tahapan membersihkan wajah maka tingkat keparahan jerawat makin kecil. Kesimpulan: Insidensi jerawat akibat penggunaan masker pada pandemi COVID-19 berhubungan dengan lama penggunaan masker. Tipe masker, warna masker, dan jenis produk kecantikan digunakan tidak berhubungan dengan peningkatan insidensi jerawat pada penggunaan masker.\u0000Kata Kunci: COVID-19, jerawat, masker, maskne","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laporan Kasus Tinea Cruris et Corporis Menahun pada Pasien Usia 60 Tahun di RS Martha Friska Multatuli Medan","authors":"Viktoria Thanita","doi":"10.32734/scripta.v5i1.9736","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.9736","url":null,"abstract":"ABSTRAK Latar Belakang: Dermatofitosis adalah penyakit jamur superfisial, dengan penyebab Microsporusm, Trichopythonm, dan Epidermophyton. Tinea cruris adalah dermatofitosis superfisial pada lipat paha, pubis, daerah perineum, dan sekitar anus. Tinea korporis merupakan dermatofitosis superfisial pada kulit tidak berambut (glabrous skin). Pada tinea korporis yang menahun dapat terjadi bersama dengan tinea cruris yang disebut tinea corporis et cruris atau sebaliknya tinea cruris et corporis. Tujuan: Melaporkan satu kasus Tinea kruris et korporis pada pasien lansia di RS. Martha Friska Multatuli Medan. Ilustrasi Kasus: Seorang laki-laki lansia, usia 60 tahun datang dengan keluhan gatal dan bercak kemerahan. Didapati gambaran klinis berupa bercak kemerahan pada selangkangan kiri dan kanan, paha kiri dan kanan, daerah kelamin, daerah bokong kiri dan kanan, pinggul kanan dan perut. Pembahasan: Diagnosis ditegakkan berdasarkan anamnese dan pemeriksaan fisik dermatologi. Pengobatan diberikan Ketokonazol tablet, Krim Mikonazol 2%, dan cetirizin tablet. Edukasi yang diberikan menjaga higienitas. Kesimpulan: Terdapat perbaikan klinis pasien dengan pengobatan selama 14 hari. Kata Kunci: dermatofitosis, jamur superfisial, tinea corporis, tinea cruris, tinea cruris et corporis   ABSTRACT Background: Dermatofitosis is superficial fungal infection, caused by Microsporusm, Trichopythonm and Epidermophyton. Tinea cruris is superficial dermatofitosis in groin, pubic area, perineum, and perianal. Tinea corporis is superficial dermatofitosis on glaborus skin. Tinea corporis cronic can be coincidence with tinea cruris and called tinea corporis et cruris or tinea cruris et corporis. Objectives: Reported one case of tinea cruris et corporis of old man in Martha Friska Multatuli Medan. Case Illustration: A patience, 60 years old came with ithcy and reddish spot. The clinical featured reddish spot on right groin, left and right femur, pubic area, left and right gluteus, perianal, and stomach and right cruris. Discussion: Diagnose based on anamnese and dermatology phycal examination. Therapetic are Ketoconazol tablet 200mg 2x1, cream mikonazol 2% 2x1, and cetirizin tablet 1x1. Education keep hyginity. Conclusion: In this patience, there is clinical improvement in 14 days therapeutic. Keywords: dermatofitosis, superficial fungal, tinea corporis, tinea cruris, tinea cruris et corporis","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Stretch Mark pada Siswi SMA Global Prima National Plus School","authors":"R. Kamila, Imam Budi Putra, Dina Arwina Dalimunthe, Fauzan Azmi Hasti Habibi Samosir, Al Kadri","doi":"10.32734/scripta.v5i1.11035","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.11035","url":null,"abstract":"ABSTRAK Latar Belakang. Stretch mark merupakan jenis skar atrofi pada kulit yang disebabkan oleh peregangan kulit yang berlebihan. Karakteristik stretch mark bervariasi tahap awal yaitu striae rubrae yang berwarna kemerahan, hingga tahap kronis yaitu striae albae, stretch mark yang halus dan berwarna putih. Prevalensi stretch mark pada populasi remaja dilaporkan berkisar antara 6% hingga 86%. Hal ini dapat terjadi diakibatkan oleh beberapa faktor sehingga gambaran stretch mark pada remaja perempuan penting diketahui. Penelitian ini bertujuan untuk mengetahui gambaran stretch mark pada siswi SMA Global Prima National Plus School. Metode. Penelitian ini merupakan penelitian deskriptif dengan desain cross-sectional study. Subjek penelitian pada penelitian ini adalah siswi kelas XII SMA Global Prima National Plus School sebanyak 47 orang yang memenuhi kriteria inklusi dengan menggunakan metode purposive sampling. Pengumpulan data dilakukan dengan menggunakan lembar penelitian yang ditanyakan langsung kepada subjek penelitian lalu dilanjutkan dengan pemeriksaan fisik pada subjek penelitian secara langsung. Hasil. Stretch mark dijumpai pada 38 siswi dari 47 siswi dengan distribusi paling banyak pada usia 17 tahun (66%) dan reponden dengan usia menarche normal (51,1%) regio stretch mark terbanyak pada regio femur (25,4%) dan jenis stretch mark terbanyak yaitu striae albae (82,5%). Kesimpulan. Secara keseluruhan, sebagian besar subjek penelitian memiliki stretch mark, dimana paling banyak dijumpai pada subjek penelitian dengan IMT kategori normal dan pada subjek penelitian dengan riwayat keluarga memiliki stretch mark. Kata Kunci: Gambaran, stretch mark, striae albae, striae rubrae.   ABSTRACT Background. Stretch mark is a a type of atrophic scar that was caused by excessive stretching of the skin. Stretch mark vary in the early stages as striae rubrae, are characterized with redness and the chronic stage, striae albae which appears white and wrinkly. The prevalence of stretch marks in the adolescent population reportedly ranged from 6% to 86%. This can occur due to several factors so that the picture of stretch marks in adolescent girls is important to know. Aim of this study is to describing stretch mark in Global Prima National Plus School high school students. Methods.This is a descriptive study with cross-sectional study design. The sample in this study were 47 students of SMA Global Prima National Plus School who met the inclusion criteria by using the purposive sampling method. Data acquired by using a research sheet that was asked directly to the research subject followed by physical examination of the research subject directly. Results. Stretch marks were found in 38 students from 47 students with the most distribution at the age of 17 years (66%) and research subject with normal menarche (51.1%) the most common location of stretch marks are in the femur region (25.4%) and the most common types of stretch marks are striae albae (82.5%). Conclusi","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of Knowledge on Acne Vulgaris and Its Treatment Among Undergraduates Medical Students at Universitas Sumatera Utara","authors":"Lily Khalidatussofina, D. Dalimunthe","doi":"10.32734/scripta.v5i1.12494","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.12494","url":null,"abstract":"ABSTRACT Backgorund:  Acne vulgaris (AV) is a skin disorder commonly found on late teens, young adults and most patients are females. The classic pathophysiology circulates the relationship between inflammation, bacterial colonization, sebum excretion and follicular epidermal hyperproliferation. Other factors may include diet, stress level, self-hygiene, and hormones especially in female patients.  A proper diagnosis and the right treatment approach will help treat patient significantly. Sufficient knowledge on acne vulgaris and its treatment is important for a person to self-medicate or a visit to the dermatologist can be another option. Commonly used self-medication for acne are clindamycin and benzoyl peroxide (BPO). Treatment can either be single or combined therapy to achieve better results. Acne treatments might take some time to show its effects and it may also relapse. Objectives: The study aims to see the level of knowledge on acne vulgaris by the respondents. Methods: This cross-sectional study was conducted to medical undergraduates at Universitas Sumatera Utara. Results: 85.2% from total respondents have had acne before. 142 (55.5%) students chose to seek treatment with a dermatologist which majority of them are females (34.4%). Female students contribute the most with 160 responses. Most respondents are from age category of 16 to 21 (75.4%). Conclusion: Students do have the knowledge on acne vulgaris and its treatment hence almost half of them chose to self-medicate. Students are also aware that other treatment options are available. Keywords: acne vulgaris, behavior, Cutibacterium acnes, knowledge, treatment   ABSTRAK Latar Belakang: Akne vulgaris (AV) merupakan kelainan kulit yang sering ditemukan pada remaja akhir, dewasa muda dan kebanyakan penderitanya adalah wanita. Patofisiologi klasik mengedarkan hubungan antara peradangan, kolonisasi bakteri, ekskresi sebum dan hiperproliferasi epidermal folikel. Faktor lain mungkin termasuk diet, tingkat stres, kebersihan diri dan hormon terutama pada pasien wanita. Diagnosis yang tepat dan pendekatan pengobatan yang tepat akan membantu merawat pasien secara signifikan. Pengetahuan yang cukup tentang akne vulgaris dan pengobatannya penting bagi seseorang untuk mengobati sendiri atau kunjungan ke dokter kulit bisa menjadi pilihan lain. Pengobatan sendiri yang umum digunakan untuk jerawat adalah klindamisin dan benzoil peroksida (BPO). Perawatan dapat berupa terapi tunggal atau kombinasi untuk mencapai hasil yang lebih baik. Perawatan jerawat mungkin membutuhkan waktu untuk menunjukkan efeknya dan mungkin juga kambuh. Tujuan: Mengetahui gambaran pengetahuan dan pemilihan pengobatan akne pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara. Metode: Menggunakan metode desain penelitian potong lintang (cross sectional) dengan membagikan kuesioner kepada mahasiswa/i Fakultas Kedokteran Universitas Sumatera Utara. Hasil: 85,2% dari total responden pernah menderita akne sebelumnya. 142 (55","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Hasil Pemeriksaan Ekokardiografi Pasien Gagal Jantung di RSUP H. Adam Malik pada Tahun 2021","authors":"Trifena Aurelya Rimna Surbakti, Anggia Chairuddin Lubis","doi":"10.32734/scripta.v5i1.10867","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.10867","url":null,"abstract":"Pendahuluan. Angka kejadian penyakit gagal jantung masih terus meningkat di tingkat global. Dalam mendiagnosis dan mengevaluasi penyakit gagal jantung, terdapat beberapa modalitas yang dapat diandalkan, salah satunya adalah ekokardiografi. Metode pemeriksaan ekokardiografi berguna dalam banyak aspek termasuk penilaian fungsi dan diameter jantung, yang secara klinis menjadi landasan dalam pilihan pengobatan dan prognosis penderita gagal jantung. Tujuan. Tujuan penelitian ini adalah untuk mengetahui gambaran hasil pemeriksaan ekokardiografi pasien gagal jantung di RSUP H. Adam Malik Medan pada tahun 2021. Metode. Penelitian ini memiliki desain deskriptif retrospektif dengan pendekatan potong lintang (cross sectional). Hasil. Mayoritas penderita berasal dari kalangan usia produktif. 73,62% pasien berjenis kelamin laki-laki. Etiologi terbanyak pada penelitian ini adalah penyakit iskemik. Ditemukan 49,08% sampel mengalami hipertrofi eksentrik, 46,63% mengalami hipertrofi konsentrik, 1,84% mengalami remodelling konsentrik, dan 2,45% memiliki geometri LV yang normal. Rata rata LVEF adalah 44,70% dengan HFpEF yang paling mendominasi. 77,30% memiliki TAPSE normal dan dari 121 data yang tersedia, 46,63% mengalami disfungsi diastolik grade I, 14,72% mengalami disfungsi diastolik grade III, dan sisanya, 12,88% mengalami disfungsi diastolik grade II. Kesimpulan. Kebanyakan pasien gagal jantung di RSUP H. Adam Malik Medan pada tahun 2021 berasal dari kalangan usia produktif. Etiologi tersering adalah penyakit iskemik. Dimensi dan volume LV mayoritas pasien hipertrofi eksentrik. HFpEF mendominasi dan TAPSE kebanyakan normal. Dari 121 data mengenai disfungsi diastolik LV, disfungsi grade I merupakan yang terbanyak.   Kata Kunci: gagal jantung, ekokardiografi, LVEF, TAPSE, gambaran","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faktor yang Memengaruhi Penggunaan Pengobatan Herbal pada Pasien di Puskesmas Pekan Labuhan tahun 2023","authors":"Ahmad Razi, Rizki Fauzan Ghali Nasution, Abdul Hakim Nasution, Muhammad Rado Fauzi, D. Annisa, Cut Safira Alifa, Rina Amelia","doi":"10.32734/scripta.v5i1.13656","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.13656","url":null,"abstract":"ABSTRAK Latar Belakang. Indonesia kaya akan keanekaragaman hayati terutama di bidang pertanian, yang menyebabkan tingginya angka pemanfaatan herbal untuk pengobatan tradisional. Praktik tersebut dipengaruhi oleh banyak faktor terutama faktor sosio-demografis, ekonomi, pendidikan dan lainnya.Tujuan. Untuk menganalisis  jumlah dan tipe-tipe dari pengobatan herbal di Puskesmas Pekan labuhan dan juga faktor yang memengaruhi penggunaan obat-obatan herbal.Metode.Penelitian ini merupakan penelitian deskriptif dan analitik observasional dengan desain potong lintang, pada 119 pasien dewasa di Puskesmas Pekan Labuhan pada rentang waktu penelitian. Sampel diambil dengan metode purposive sampling pada pasien yang datang ke puskesmas. data dikumpulkan menggunakan kuesioner. Data di analisis secara univariat dan bivariat menggunakan tes pearson χ2  atau Fischer's Exact test menggunakan Statistical Package for Social Science (SPSS) versi ke-21 untuk windows pada interval kepercayaan 95%.Hasil. Penggunaan pengobatan herbal pada masyarakat sekitar Puskesmas Pekan Labuhan sebesar 49%. Umumnya pengobatan herbal digunakan sebagai obat komplementer, dengan jamu sebesar 39% dan pil ekstrak 23.7%. Penggunaan pengobatan herbal tersebar merata diantara kelompok demografis dan faktor pengobatan. Terdapat 2 faktor yang paling memengaruhi yaitu kepercayaan terhadap keamanan dari pengobatan herbal (PR 3.58, p<0.001) dan persepsi akan mahalnya pengobatan konvensional (PR 1.69, p=0.013). Kesimpulan : Penggunaan pengobatan herbal umum digunakan di lingkungan Puskesmas Pekan Labuhan, yang tersebar secara merata dalam berbagai factor latar belakang sosiodemografis. Oleh karena itu, dibutuhkan penelitian lebih lanjut yang lebih detail dan dengan cakupan yang lebih luas   Kata Kunci: Pusat Kesehatan Masyarakat, Pengobatan alternatif, Pengobatan herbal, Pengobatan komplementer, Pengobatan tradisional   ABSTRACT Background. Indonesia rich in biodiversity mainly in agriculture, causing high number of herbal utilization for medication among local traditional medication. The practice was affected by many factors mainly sociodemographic, economic, education, and other factors. Objectives. To analyze numbers and types of herbal medication in Pekan Labuhan Primary Health Centre and factors affecting the utilization.Methods. This is a descriptive and analytic observational study which is conducted in cross sectional design, on 119 selected adult in the Pekan Labuhan Primary Health Care Center visiting during research time range. Samples were obtained by purposive sampling on patient presenting to the PHC. Data were collected using questionnaires. Data were analyzed with univariate, bivariate analysis was using Pearson χ2 test or Fischer’s Exact test using Statistical Package for Social Science (SPSS) version 21 for windows on Confidence Interval of 95%.Results. Utilization of herbal medication among public around Pekan Labuhan PHC were approximately 49% of total. Most of herbal medication w","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Overview of Coronary Heart Disease Risk Factors in Perimenopausal and Postmenopausal Female Patients at Haji Adam Malik General Hospital in 2021","authors":"Elaine Faustine, Cut Aryfa Andra, D. Dalimunthe, T. B. Haykal, Yunilda Andriyani","doi":"10.32734/scripta.v5i1.12615","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.12615","url":null,"abstract":"ABSTRACT Background: Cardiovascular diseases are taking an estimated 17, 9 million lives each year, 85% were caused by coronary heart disease. After menopause, there are physiological changes that occurs in women’s body that increase the risk of coronary heart disease. Risk factors associated with the incidence of coronary heart disease are, family history, age, hypertension, diabetes, dyslipidemia, obesity, and smoking. Objectives: To examine the risk factors associated with the incidence of coronary heart disease in perimenopausal and postmenopausal women at RSUP Haji Adam Malik in 2021. Methods: This study is a descriptive study with cross sectional design and retrospective approach, carried out at RSUP Haji Adam Malik. The data were taken from 1 January-31 December 2021. Results: The results showed that out of 75 perimenopausal and postmenopausal women who suffered from CHD, 61 patients (81,3%) were >50 years old, 3 patients (4%) had a family history of CHD, 53 patients (70,7%) had hypertension, 45 patients (60%) had diabetes, 58 patients (77,3%) with dyslipidemia, 10 patients (13,3%) were obese, and 14 patients (18,7%) had a history of smoking. Conclusion: Risk factors for CHD in perimenopausal and postmenopausal women, are having a family history of CHD, age, hypertension, diabetes, dyslipidemia, obesity, and smoking. Keywords: coronary heart disease, risk factors, perimenopausal women, postmenopausal women, women with CHD   ABSTRAK Latar Belakang: Penyakit kardiovaskular menyebabkan kematian 17,9 juta penduduk dunia setiap tahunnya, dan 85% diantaranya disebabkan oleh penyakit jantung koroner. Pada wanita yang telah mengalami menopause, terjadi perubahan fisiologis pada tubuh wanita sehingga risiko penyakit jantung koroner meningkat. Faktor risiko yang meningkatkan kejadian penyakit jantung koroner antara lain, usia, riwayat keluarga, hipertensi, diabetes, dislipidemia, obesitas, dan merokok. Tujuan: Untuk mengetahui faktor risiko yang menyebabkan terjadinya penyakit jantung koroner pada pasien wanita perimenopause dan postmenopause di RSUP Haji Adam Malik Medan pada tahun 2021. Metode: Jenis penelitian yang dilakukan adalah penelitian deskriptif dengan desain penelitian cross sectional dengan pendekatan retrospektif, yang dilakukan di RSUP H. Adam Malik. Hasil: Hasil penelitian menunjukkan, dari 75 orang wanita perimenopause dan postmenopause yang menderita PJK, sebanyak 61 pasien (81,3%) berusia >50 tahun, 3 pasien (4%) memiliki riwayat keluarga dengan PJK, 53 pasien (70,7%) menderita hipertensi, 45 pasien (60%) menderita diabetes, 58 pasien (77,3%) mengalami dislipidemia, 10 pasien (13,3%) mengalami obesitas, dan 14 pasien (18,7%) memiliki riwayat merokok. Kesimpulan: Faktor risiko PJK pada wanita perimenopause dan postmenopause, meliputi riwayat keluarga, usia, hipertensi, diabetes, dislipidemia, obesitas, dan merokok. Kata Kunci: faktor risiko, penyakit jantung koroner, wanita dengan PJK, wanita perimenopause, wanita postmenopause","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Faktor Risiko Pasien Stroke Hemoragik di RSUP Haji Adam Medan Periode Januari 2021 s.d Desember 2021","authors":"Deak Bastian Sibagariang","doi":"10.32734/scripta.v5i1.10587","DOIUrl":"https://doi.org/10.32734/scripta.v5i1.10587","url":null,"abstract":"ABSTRAK Latar Belakang. Stroke merupakan penyebab utama kecacatan fisik pada usia produktif dan usia lanjut di dunia. Stroke hemoragik ditandai dengan perdarahan ke dalam jaringan otak yang mengakibatkan hematoma dan pergeseran jaringan otak. Dengan mengidentifikasi faktor risiko stroke dapat membantu penyedia layanan kesehatan untuk menetapkan strategi pencegahan. Tujuan. Penelitian ini bertujuan untuk mengetahui gambaran faktor risiko pasien stroke hemoragik di RSUP Haji Adam Malik Medan periode Januari 2021 s.d Desember 2021. Metode. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional retrospektif dan menggunakan metode total sampling dengan mengambil seluruh anggota populasi sebagai sampel. Subjek penelitian ini adalah pasien stroke hemoragik RSUP. H. Adam Malik Medan pada periode Januari 2021 s.d Desember 2021. Data yang digunakan adalah data sekunder yang diperoleh dari rekam medis pasien. Analisis yang digunakan adalah analisis univariat. Hasil. Penelitian ini melibatkan 93 pasien stroke hemoragik yang terdiri dari 51 orang (54,8%) laki-laki dan 42 orang (45,2%) perempuan, 10,7% diantaranya berusia ≤ 35 tahun; 14% berusia 36-45 tahun; 28% berusia 46-55 tahun; 24,7% berusia 56-65 tahun; dan 22,6% berusia >65 tahun. Terdapat 17 orang (18,3%) memiliki riwayat diabetes melitus, 74 orang (79,6%) memilki riwayat hipertensi, 27 orang (29%) memiliki riwayat dislipidemia, dan 28 orang (30,1%) memiliki riwayat merokok. Kesimpulan. Mayoritas penderita stroke hemoragik merupakan laki-laki (54,8%) dan kelompok usia di atas 45 tahun (75,3%). Faktor risiko yang paling banyak ditemukan adalah hipertensi (79,6%), diikuti oleh memiliki riwayat merokok (30,1%), lalu memiliki riwayat dislipidemia (29%), dan memiliki riwayat diabetes melitus (18,3%).   Kata Kunci: Faktor risiko, stroke, stroke hemoragik   ABSTRACT Background. Stroke is the main cause of physical disability in the productive age and the elderly in the world. Hemorrhagic stroke is characterized by bleeding into the brain tissue resulting in a hematoma and shift of brain tissue. Identifying stroke risk factors can help health care providers to establish prevention strategies. Objectives. This study aims to describe the risk factors for hemorrhagic stroke patients at Haji Adam Malik Hospital in Medan for the period January 2021 to December 2021. Methods. This research is descriptive study with a cross-sectional retrospective. This study used the total sampling method by taking all members of the population as a sample. Subjects in this study were hemorrhagic stroke patients at RSUP.H. Adam Malik Medan in the period January 2021 to December 2021. The data used is secondary data obtained from the patient's medical record. The analysis used is univariate analysis. Results. This study involved 93 hemorrhagic stroke patients consisting of 51 (54.8%) men and 42 (45.2%) women, 10.7% of whom were aged ≤ 35 years; 14% aged 36-45 years; 28% aged 46-55 years, 24.7% aged 56-65 yea","PeriodicalId":365874,"journal":{"name":"SCRIPTA SCORE Scientific Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}