Epilepsy and Behavior Reports最新文献_第8页

Chronic subthreshold cortical stimulation: A promising therapy for motor cortex seizures 慢性阈下皮层刺激：一种治疗运动皮层癫痫发作的有效疗法

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2023.100638

Sebastien Heyndrickx , Simon Lamquet , Joyce Oerlemans , Kristl Vonck , Paul Boon , Dirk Van Roost , Alfred Meurs

引用次数: 0

Metaphoric language in the differential diagnosis of epilepsy and psychogenic non-epileptic seizures: Time to move forward 癫痫和精神性非癫痫发作鉴别诊断中的隐喻语言：是时候向前迈进了

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2023.100639

Lina Urh , Daniele Piscitelli , Massimiliano Beghi , Silvia Diotti , Giuseppe Erba , Adriana Magaudda , Mikhail Zinchuk , Alla Guekht , Cesare Maria Cornaggia

{"title":"Metaphoric language in the differential diagnosis of epilepsy and psychogenic non-epileptic seizures: Time to move forward","authors":"Lina Urh , Daniele Piscitelli , Massimiliano Beghi , Silvia Diotti , Giuseppe Erba , Adriana Magaudda , Mikhail Zinchuk , Alla Guekht , Cesare Maria Cornaggia","doi":"10.1016/j.ebr.2023.100639","DOIUrl":"https://doi.org/10.1016/j.ebr.2023.100639","url":null,"abstract":"<div><p>Conversation analysis (CA) to identify metaphoric language (ML) has been proposed as a tool for the differential diagnosis of epileptic (ES) and psychogenic nonepileptic seizures (PNES). However, the clinical relevance of metaphoric conceptualizations is not clearly defined. The current study aims to investigate the ML utilized by individuals with ES and PNES in a pulled multi-country sample. Two blinded researchers examined the transcripts and videos of 54 interviews of individuals (n = 29, Italy; n = 11, USA; n = 14, Russia) with ES and PNES, identifying the patient-seizure relationship representative of the patient's internal experience. The diagnoses were based on video-EEG. Metaphors were classified as “Space/place”, “External force”, “Voluntary action”, and “Other”. A total of 175 metaphors were identified. No differences between individuals with ES and PNES were found in metaphoric occurrence (χ<sup>2</sup> (1, N = 54) = 0.07; p = 0.74). No differences were identified when comparing the types of metaphors utilized by participants with ES and those with PNES. Patients with PNES and ES did not demonstrate differences in terms of occurrence and categories in ML. Therefore, researchers and clinicians should carefully consider the use of metaphor conceptualizations for diagnostic purposes.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100639"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986423000576/pdfft?md5=411a649fa7d199bc1a8d75b113ac942d&pid=1-s2.0-S2589986423000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent super-refractory status epilepticus and stroke like episode in a patient with Behr syndrome secondary to biallelic variants in OPA1 gene 继发于 OPA1 基因双倍变异的贝洱综合征患者的复发性超难治性癫痫和中风样发作

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100652

Spoorthi Jagadish , Amy R.U.L. Calhoun , Sreenath Thati Ganganna

{"title":"Recurrent super-refractory status epilepticus and stroke like episode in a patient with Behr syndrome secondary to biallelic variants in OPA1 gene","authors":"Spoorthi Jagadish , Amy R.U.L. Calhoun , Sreenath Thati Ganganna","doi":"10.1016/j.ebr.2024.100652","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100652","url":null,"abstract":"<div><p>Behr syndrome is associated with compound heterozygous dysfunction in <em>OPA1</em> gene and typically presents with a constellation of visual impairment due to early onset optic atrophy, cerebellar ataxia, peripheral neuropathy, deafness, and gastrointestinal motility problems. Our patient with biallelic variants in <em>OPA1</em> gene had delayed motor milestones, cerebellar ataxia, and optic atrophy in infancy. At the age of 7 years, he presented with recurrent episodes of super-refractory status epilepticus and metabolic stroke due to underlying mitochondrial dysfunction associated with <em>OPA1</em> gene dysfunction. Besides the two rare prior case reports of focal and myoclonic seizures in patients with Behr syndrome, epilepsy in general is not well described in the typical phenotypic spectrum and to the best of our knowledge. Dramatic clinical presentation with recurrent super-refractory status epilepticus and metabolic stroke has not been reported previously. There is only one prior report of metabolic stroke in a patient with Behr syndrome due to <em>OPA1</em> gene dysfunction.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100652"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000091/pdfft?md5=6f81b5945abb8afdf92a0636809f6bc4&pid=1-s2.0-S2589986424000091-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localization of hypnopompic seizures – A stereo EEG study 催眠性癫痫发作的定位--立体脑电图研究

IF 1.8

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100729

Mohammad Alisali, Stuti Joshi, Chaitanya Ganne, Vladimir Vashin, Sandipan Pati

{"title":"Localization of hypnopompic seizures – A stereo EEG study","authors":"Mohammad Alisali, Stuti Joshi, Chaitanya Ganne, Vladimir Vashin, Sandipan Pati","doi":"10.1016/j.ebr.2024.100729","DOIUrl":"10.1016/j.ebr.2024.100729","url":null,"abstract":"<div><div>Hypnopompic seizures, characterized by arousal from sleep as the primary clinical manifestation, are a rare and challenging seizure type. Their exact localization has been elusive, often requiring stereotactic EEG (SEEG) for accurate identification. We present the case of a 23-year-old male with drug-resistant focal epilepsy, in whom hypnopompic seizures were localized to the mesial orbitofrontal cortex, with rapid recruitment of the middle temporal gyrus, fusiform gyrus, rostral cingulate, and amygdala. SEEG captured multiple seizures, with arousal occurring 4–5 s after EEG onset, followed by ictal central apnea. The patient underwent resection of the right orbitofrontal and mesial temporal lobe regions and has remained seizure-free for over seven months. This case provides new insights into the neuroanatomical origins of seizure-induced arousal, identifying the mesial orbitofrontal cortex as a potential site for hypnopompic seizures. The findings underscore the critical role of SEEG in accurately localizing seizure foci in complex epilepsy cases, enabling targeted surgical interventions. Additionally, we discuss the orbitofrontal cortex’s role as a site for extra-thalamic arousal pathways, offering new perspectives on the mechanisms underlying hypnopompic seizures.</div></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"28 ","pages":"Article 100729"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in health-related quality of life and somatic symptoms in employed and unemployed patients with epilepsy 就业和失业癫痫患者的健康相关生活质量和躯体症状差异

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100663

Hyun Jin Kang, Karen Torres, Michelle S. Kim

{"title":"Differences in health-related quality of life and somatic symptoms in employed and unemployed patients with epilepsy","authors":"Hyun Jin Kang, Karen Torres, Michelle S. Kim","doi":"10.1016/j.ebr.2024.100663","DOIUrl":"10.1016/j.ebr.2024.100663","url":null,"abstract":"<div><p>This study compared overall and specific aspects of health-related quality of life (HRQOL) and self-report of somatic, anxiety, and depressive symptoms between employed (n = 71) and unemployed (n = 48) patients with epilepsy (PWE). The Quality of Life in Epilepsy (QOLIE-89) and the Personality Assessment Inventory (PAI) were examined. The unemployed group reported significantly worse overall HRQOL including aspects of HRQOL related to epilepsy, physical health, mental health, and cognitive function. Among these four, physical health related HRQOL revealed the most difference between groups. While there were no differences between the groups in the level of social support and social isolation, the unemployed group reported worse social function with respect to work and driving. The unemployed group reported significantly greater somatic symptoms, but not anxiety and depressive symptoms. When specifically examining the subscales of the Somatic Concerns scale, conversion and health concerns, but not somatization, were greater in the unemployed group. Among the Depression subscales, the unemployed group reported greater physiologically manifested depressive symptoms. These findings suggest that along with optimizing seizure control, identifying and addressing presence of physical limitations, dysfunction, and somatic symptoms are also of importance in the care of PWE, particularly for those who are unemployed.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100663"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000200/pdfft?md5=485201708388ca2cc6968e7784d56820&pid=1-s2.0-S2589986424000200-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetoencephalographic detection of synchronized epileptic activity between the hippocampus and insular cortex 海马和岛叶皮层之间同步癫痫活动的脑磁图检测

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100669

Akitake Okamura , Akira Hashizume , Kota Kagawa , Go Seyama , Atsuo Yoshino , Shigeto Yamawaki , Nobutaka Horie , Koji Iida

{"title":"Magnetoencephalographic detection of synchronized epileptic activity between the hippocampus and insular cortex","authors":"Akitake Okamura , Akira Hashizume , Kota Kagawa , Go Seyama , Atsuo Yoshino , Shigeto Yamawaki , Nobutaka Horie , Koji Iida","doi":"10.1016/j.ebr.2024.100669","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100669","url":null,"abstract":"<div><p>Most magnetoencephalographic signals are derived from synchronized activity in the brain surface cortex. By contrast, the contribution of synchronized activity in the deep brain to magnetoencephalography (MEG) has remained unclear. We compared stereotactic electroencephalography (sEEG) with simultaneous MEG findings in a patient with temporal lobe epilepsy to determine the conditions under which MEG could also detect sEEG findings. The synchrony and similarity of the waves were evaluated using visual inspection and wavelet coherence. A 45-year-old woman with intractable temporal lobe epilepsy underwent sEEG and MEG simultaneously to determine the laterality and precise location of the epileptic focus. When spike-and-waves were seen in the right hippocampal head alone, no distinct spike-and-waves were observed visually in the right temporal MEG. The seizure then spread to the right insula on sEEG with a rhythmic theta frequency while synchronous activity was observed in the right temporal MEG channels. When polyspikes appeared in the right hippocampus, the right temporal MEG showed electrical activity with relatively high similarity to that of the right hippocampal head and insular cortex but less similarity to that of the right lateral temporal lobe cortex. MEG might detect epileptic activity synchronized between the hippocampus and insular cortex.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"26 ","pages":"Article 100669"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000261/pdfft?md5=e88a14adb2477781d637ecd8f5ecdfc5&pid=1-s2.0-S2589986424000261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A complex case with generalized epilepsy, probable focal seizures, and functional seizures 一个伴有全身性癫痫、可能的局灶性癫痫发作和功能性癫痫发作的复杂病例

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Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100684

Ahmed Elshetihy , Lema Nergiz , Thomas Cloppenborg , Friedrich G. Woermann , Birgitt Müffelmann , Christian G. Bien

{"title":"A complex case with generalized epilepsy, probable focal seizures, and functional seizures","authors":"Ahmed Elshetihy , Lema Nergiz , Thomas Cloppenborg , Friedrich G. Woermann , Birgitt Müffelmann , Christian G. Bien","doi":"10.1016/j.ebr.2024.100684","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100684","url":null,"abstract":"<div><p>In this patient, now 42 years old, genetic generalized epilepsy (juvenile myoclonic epilepsy) manifested itself at the age of 13. At the age of 39, she experienced a status episode with prolonged ICU treatment. She was left with a left-sided hippocampal sclerosis and probably focal seizures. In addition, since the age of 24, the patient also experiences functional seizures on the background of a borderline personality disorder. While generalized epileptic seizures could be controlled with antiseizure medication (ASM), the patient was multiple times admitted to Emergency Departments for her functional seizures with subsequent intensive care treatments, including intubation. As a complication, the patient developed critical illness polyneuropathy and myopathy, resulting in wheelchair dependence. Additionally, she acquired a complex regional pain syndrome after extravasation of ASM. The report demonstrates the uncommon development of hippocampal sclerosis after a generalized tonic-clonic status epilepticus and the poor treatability of functional seizures as compared to generalized and focal seizures.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100684"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000418/pdfft?md5=6f53a5bf98e4c0d858371db2452aa409&pid=1-s2.0-S2589986424000418-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye 睡惊和与睡眠相关的高运动性癫痫发作中的恐惧唤醒可能涉及显著性网络以及坎农和塞利的急性应激反应

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100650

Péter Halász , Péter Simor , Anna Szűcs

{"title":"Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye","authors":"Péter Halász , Péter Simor , Anna Szűcs","doi":"10.1016/j.ebr.2024.100650","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100650","url":null,"abstract":"<div><p>We consider the disorders of arousal and sleep-related hypermotor epilepsy as genetic twin-conditions, one without, one with epilepsy. They share an augmented arousal-activity during NREM sleep with sleep-wake dissociations, culminating in sleep terrors and sleep-related hypermotor seizures with similar symptoms. The known mutations underlying the two spectra are different, but there are multifold population-genetic-, family- and even individual (the two conditions occurring in the same person) overlaps supporting common genetic roots. In the episodes of disorders of arousal, the anterior cingulate, anterior insular and pre-frontal cortices (shown to be involved in fear- and emotion processing) are activated within a sleeping brain. These regions overlap with the seizure-onset zones of successfully operated sleep-related hypermotor seizures, and notably, belong to the salience network being consistent with its hubs. The arousal-relatedness and the similar fearful confusion occurring in sleep terrors and hypermotor seizures, make them alike acute stress-responses emerging from sleep; triggered by false alarms. The activation of the anterior cingulate, prefrontal and insular regions in the episodes of both conditions, can easily mobilize the hypothalamo-pituitary-adrenal axis (preparing fight-flight responses in wakefulness); through its direct pathways to and from the salience network. This hypothesis has never been studied.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100650"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000078/pdfft?md5=ed42c11f13fb4f68798e147a1d794103&pid=1-s2.0-S2589986424000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyses of patients who self-administered diazepam nasal spray for acute treatment of seizure clusters 对自行使用地西泮鼻喷雾剂急性治疗癫痫群发患者的分析

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100644

Sunita N Misra , Michael R. Sperling , Vikram R. Rao , Jurriaan M. Peters , Patricia Penovich , James Wheless , R. Edward Hogan , Charles S. Davis , Enrique Carrazana , Adrian L. Rabinowicz

{"title":"Analyses of patients who self-administered diazepam nasal spray for acute treatment of seizure clusters","authors":"Sunita N Misra , Michael R. Sperling , Vikram R. Rao , Jurriaan M. Peters , Patricia Penovich , James Wheless , R. Edward Hogan , Charles S. Davis , Enrique Carrazana , Adrian L. Rabinowicz","doi":"10.1016/j.ebr.2024.100644","DOIUrl":"https://doi.org/10.1016/j.ebr.2024.100644","url":null,"abstract":"<div><p>For acute treatment of seizure clusters in patients with epilepsy, intranasal administration of acute seizure therapies has been shown to provide accessibility and ease of use to care partners as well as the potential for self-administration by patients. Diazepam nasal spray (Valtoco®) was approved by the US Food and Drug Administration for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years. Self-administration consistent with the prescribing information is feasible and was reported by a subgroup of patients (n = 27 of 163) in a long-term phase 3 safety study. Data regarding self-administration among these patients with seizure clusters are examined here to explore the safety profiles and measures of effectiveness, as well as the quality of life of those who self-treated. In addition, this focused look at patients who self-administered diazepam nasal spray may offer some insights into the characteristics of patients who may be appropriate for self-administration.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"25 ","pages":"Article 100644"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000017/pdfft?md5=6b2780f004ef3bba4eea49011e27bd80&pid=1-s2.0-S2589986424000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep brain stimulation of the subiculum in the treatment for refractory temporal lobe epilepsy due to unilateral mesial temporal lobe sclerosis 在治疗单侧颞叶中叶硬化症引起的难治性颞叶癫痫时对枕下部进行深部脑刺激

IF 1.5

Epilepsy and Behavior Reports Pub Date : 2024-01-01 DOI: 10.1016/j.ebr.2024.100677

Michał Sobstyl , Magdalena Kowalska , Magdalena Konopko , Aleksandra Wierzbicka , Karol Karamon , Ewa Nagańska

{"title":"Deep brain stimulation of the subiculum in the treatment for refractory temporal lobe epilepsy due to unilateral mesial temporal lobe sclerosis","authors":"Michał Sobstyl , Magdalena Kowalska , Magdalena Konopko , Aleksandra Wierzbicka , Karol Karamon , Ewa Nagańska","doi":"10.1016/j.ebr.2024.100677","DOIUrl":"10.1016/j.ebr.2024.100677","url":null,"abstract":"<div><p>Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy. The main pathological changes primarily involve hippocampal sclerosis (HS). Early resective surgery of the sclerotic hippocampus is typically associated with favorable clinical outcomes. However, not all patients are suitable candidates for resective surgery of mesial temporal lobe structures. Therefore, alternative treatment modalities should be considered. We present the case of a 50-year-old right-handed woman with left HS who underwent unilateral subiculum stimulation for drug-resistant epilepsy (DRE). Since the age of 10, the patient had been experiencing focal to bilateral tonic-clonic seizures (FBTCS). Despite multiple antiseizure medications, she experienced 12 to 17 FBTCS per month in the last two years. Due to concerns about potential memory decline and personal preferences, she refused resective surgery. As an alternative, the patient underwent left unilateral subiculum stimulation. The stimulation resulted in a nearly 67 % reduction in seizure frequency at the last follow-up (20 months after surgery). This case highlights that drug-resistant epilepsy may be effectively treated with subicular stimulation in patients with HS.</p></div>","PeriodicalId":36558,"journal":{"name":"Epilepsy and Behavior Reports","volume":"27 ","pages":"Article 100677"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589986424000340/pdfft?md5=c413f7f2f9bc56741435194a0078aeab&pid=1-s2.0-S2589986424000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0