Defence Life Science Journal最新文献_第8页

Panel of Regulatory miRNAs for Blood Coagulation under Normoxic and Hypoxic Conditions 常氧和低氧条件下血液凝固的调节mirna组

Defence Life Science Journal Pub Date : 2022-01-21 DOI: 10.14429/dlsj.7.17185

A. A. Hembrom, N. Ghosh, Vinay V. Kumar, I. Garg, L. Ganju, Swati Srivastava

{"title":"Panel of Regulatory miRNAs for Blood Coagulation under Normoxic and Hypoxic Conditions","authors":"A. A. Hembrom, N. Ghosh, Vinay V. Kumar, I. Garg, L. Ganju, Swati Srivastava","doi":"10.14429/dlsj.7.17185","DOIUrl":"https://doi.org/10.14429/dlsj.7.17185","url":null,"abstract":"Abnormal blood coagulation may lead to venous thromboembolism (VTE), a complex multifactorial disease. Hypoxia (oxygen deprivation) is a major factor disturbing the blood hemostasis and predisposing the body towards coagulation and VTE. Pathophysiology of VTE can be attributed to post-transcriptional gene regulation by microRNAs (miRNAs). The present study identified regulatory miRNAs involved in causing blood coagulation under normoxic and hypoxic conditions. Meta-analysis was performed, following PRISMA guidelines, for identifying miRNAs involved in blood coagulation pathway. Studies evaluating miRNAs from circulating blood as potential biomarkers of VTE were selected. A total of 16 studies met selection criteria and 8 having complete statistical information were selected for analysis. Study of blood coagulation mechanism under hypoxic conditions involved in-silico search within highly cited databases to identify miRNAs commonly regulating genes of hypoxia-inducible factor (HIF) family and coagulation pathway. Further bio-informatics approaches were employed to identify potential biomarker candidates. Meta-analysis revealed a panel of 12 miRNAs; two members of miR-27 family, hsa-miR-27a and hsa-miR-27b; two members of miR-320 family, hsa-miR-320a and hsa-miR-320b, hsa-miR-1233, hsa-miR-134, hsa-miR-424-5p, hsa-miR-221, hsa-miR-28-3p, hsa-miR-136-5p, hsa-miR-374-5p and hsa-miR-338-5p involved in blood coagulation under normoxic conditions. Besides these, present in-silico analysis identified a set of 5 miRNAs including hsa-miR-4667-5p, hsa-miR-6815-3, hsa-miR-4433a-3p, hsa-miR-6735-5p and hsa-miR-6777-3p which predominantly regulate genes that facilitate both coagulation and response to hypoxic stress. The present study generated a panel of regulatory miRNAs potentially involved in the process of blood coagulation under both normoxic and hypoxic conditions, which may serve as putative epigenetic biomarkers for coagulation.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46739851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raga Therapy An Effective Treatment for Stress Management 拉加疗法——一种有效的压力管理疗法

Defence Life Science Journal Pub Date : 2022-01-21 DOI: 10.14429/dlsj.7.17056

J. Tripathi, Seema Singh, Waheeda Khan

{"title":"Raga Therapy An Effective Treatment for Stress Management","authors":"J. Tripathi, Seema Singh, Waheeda Khan","doi":"10.14429/dlsj.7.17056","DOIUrl":"https://doi.org/10.14429/dlsj.7.17056","url":null,"abstract":"Delayed encounters with stress are identified with poor individual well-being and related to significant monetary expenses for the general public. Accordingly, the advancement of cost-effective stress prevention or stress management tactics has turned into a vital attempt at recent research endeavors. Music has been appeared to influence physiological, cognitive, and emotional stress-related procedures advantageously. Subsequently, the utilisation of tuning in to music as a financial, non-intrusive, and profoundly acknowledged mediation apparatus has gotten uncommon enthusiasm for the administration of stress and stress-related medical problems. “Raga is the grouping of chosen notes (swaras) that loan suitable ‘temperament’ or feeling in a specific blend. “Raga therapy means healing through the raga. It’s a yoga framework with the help of resonant sounds. Ragatherapy implies curing through the raga. It is the information on the most proficient method to utilise raga for curing [1]”. Symphonies of raga ensure a calming influence on the mind and body. Researchers have found the role of raga therapy in treating stress. In the present research, raga therapy was administered to 74 subjects suffering from stress as an intervention plan. The ISMA questionnaire was administered to them before and after the intervention. Different sequences of ragas were directed to them for 30 min. A significant effect of raga therapy established on stress management.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45412815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Performance Evaluation of Cabbage Cultivars under Open Field Cultivation in High Altitude of Tawang Arunachal Pradesh 印控"阿鲁纳恰尔邦"达旺高海拔露地栽培甘蓝品种性能评价

Defence Life Science Journal Pub Date : 2022-01-21 DOI: 10.14429/dlsj.7.17390

Ankit Tiwari, S. K. Singh, A. Bora, B. J. Gogoi, S. Dwivedi

{"title":"Performance Evaluation of Cabbage Cultivars under Open Field Cultivation in High Altitude of Tawang Arunachal Pradesh","authors":"Ankit Tiwari, S. K. Singh, A. Bora, B. J. Gogoi, S. Dwivedi","doi":"10.14429/dlsj.7.17390","DOIUrl":"https://doi.org/10.14429/dlsj.7.17390","url":null,"abstract":"The study has been undertaken to evaluate the performance of locally available commercial cultivars of cabbage in open field during summer season of 2019 at Defence Research Laboratory Research and Development Centre Tawang (Arunachal Pradesh). The commercial cultivars of these vegetables were evaluated based on the growth parameters and their yield performance under open field with paired row system of planting. It was found that the cultivar Green Express performance was outstanding among test edcultivars and it superseded cv. Royal Ball BC-51 and cv. Blue Jayes in terms of growth parameters as well as marketable yield (2.62 kg/m2) and biological yield (3.47 kg/m2). The cv. Royal Ball BC-86 was also found next best performing cultivar after cv. Green Express as former was at par with growth and yield parameter and harvest maturity of later. The head of cv. Green express attended harvest maturity (149.25 days) approximately one week earlier as compared to cv. Blue Jayes (155.0 days). However, the productivity of cultivars Green Express and Royal Ball BC-86 was found within the range of national average, therefore, these two cultivars could be recommended for the commercial cultivation with paired row system of planting under open field cultivation during summer season in high altitude areas of Tawang (Arunachal Pradesh).","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46941064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Anti Diabetic Potential of Loranthacean Hemi Parasite Helicantes elasticus Desv Danser Collected from Six Different Hosts 六种不同寄主的半寄生Loranthalean Helicantes elasticus Desv Danser的体外抗糖尿病作用

Defence Life Science Journal Pub Date : 2022-01-21 DOI: 10.14429/dlsj.7.17277

Ajit T.G, L. Mathew

引用次数: 0

Polyphenols as Therapeutic Approach to High Altitude Mediated Skeletal Muscle Impairments 多酚作为高海拔介导的骨骼肌损伤的治疗方法

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16344

Asha D Kushwaha, Varun Bhardwaj, Deepika Saraswat

{"title":"Polyphenols as Therapeutic Approach to High Altitude Mediated Skeletal Muscle Impairments","authors":"Asha D Kushwaha, Varun Bhardwaj, Deepika Saraswat","doi":"10.14429/dlsj.6.16344","DOIUrl":"https://doi.org/10.14429/dlsj.6.16344","url":null,"abstract":"Skeletal muscle impairments at high altitudes resulted into various consequences in un-acclimatised individuals thus hampering their physical activities by imposing severe oxidative stress, skeletal muscle atrophy, mitochondrial dysfunction/autophagy, and regeneration disability. Researchers have described many natural and synthetic supplements to alleviate oxidative stress-induced muscle impairments. In this review article we are focusing on the skeletal muscle impairments and their alleviation by using natural polyphenols. Polyphenols are plant-based compounds showing anti-oxidative and anti-inflammatory properties like Curcumin, Catechins, Resveratrol, Quercetin and Salidrosides appear to mainly act by reversing oxidative stress and mitochondrial dysfunction eventually ameliorate skeletal muscle impairments under various imposed pathological conditions. This review also drew attention on the molecular targets of polyphenols and their possible therapeutic effects in preventing HA induced muscle impairments. Unavailability of suitable intervention, there is a need to find a probable solution having highly protective anti-atrophic, anti-oxidative, anti-inflammatory properties with the tint of performance enhancer.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43889467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Probiotic Containing Foods in Military Dining 军用餐饮中的益生菌食品

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16046

Padmaj Kalgutkar, Riya Ashmin, D. Kumar, Venugopal Vasudevan, N. Gopalan, A. Semwal

{"title":"The Probiotic Containing Foods in Military Dining","authors":"Padmaj Kalgutkar, Riya Ashmin, D. Kumar, Venugopal Vasudevan, N. Gopalan, A. Semwal","doi":"10.14429/dlsj.6.16046","DOIUrl":"https://doi.org/10.14429/dlsj.6.16046","url":null,"abstract":"Probiotics are known to impact positively on one’s health, but this statement may have many concerns and challenges especially when it comes to military dining. The purpose of this review is to determine whether there is scientific research based justification to the recommend promotion of probiotic containing food(s) for service personal consumption. Several research findings have shown its beneficial effect on various conditions such as respiratory tract infections, gastro-intestinal diseases such as infectious diarrhoea, as well as for treating nosocomial infections when admitted to ICU. Peer reviewed literature was searched to identify original research related to the efficacy of pro/pre-biotic containing food(s) in prophylaxis or treatment of several service related ailments viz., acute infectious diarrhoea, depression, service related GI and liver diseases, irritable bowel syndrome, respiratory tract infections, Allergic rhinitis, dental health issues and female urogenital conditions. Available scientific evidence can be wisely used by the practitioners for different conditions keeping in mind the probiotic strain, dose, and method of delivery as the effect is not always the same in every person.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42725386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Thin Plate Spline Model for Estimation of Load Carriage at Varying Gradient and Speed 预测薄板样条模型在变坡度和速度下的承载能力估计

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16869

Susan Elias, L. Naganandhini

{"title":"Predictive Thin Plate Spline Model for Estimation of Load Carriage at Varying Gradient and Speed","authors":"Susan Elias, L. Naganandhini","doi":"10.14429/dlsj.6.16869","DOIUrl":"https://doi.org/10.14429/dlsj.6.16869","url":null,"abstract":"Laboratory-based experimental studies are being carried out for Indian soldiers to estimate optimal load carriage at different gradients and walking speeds. These experiments involve the recording of Cardio-respiratory responses such as Heart Rate (HR), Oxygen Consumption (VO2), Energy Expenditure (EE), Respiratory Frequency (RF), Minute Ventilation (VE), and Maximal Aerobic capacity (%VO2max). Due to limitations in the data sample size that can be obtained in laboratory-based experiments, there is a need for mathematical interpolation to obtain intermediate values in the study. Load carriage can be affected by factors that can be controlled, such as the speed of marching, and also by external factors that cannot be controlled like ambient temperature. Real-time interactions of all the factors also have an impact on the load-carrying capacity. Planning of the mission operations requires the specification of well-defined work-rest schedules and indication of total load limits, to ensure the operational effectiveness of the military personnel. In this paper, we present a Predictive 3-Dimensional Thin Plate Spline Model for efficient estimation of load. We developed a Multiple Linear Regression Model for predicting %VO2max for combinations of load and gradient. The accuracy of the model was 85 per cent and the maximum permissible loads were derived from the prediction model for the physiological limits of 50 per cent, 60 per cent, and 75 per cent of VO2max. A Thin Plate Spline based interpolation technique was used on this Multiple Linear Regression Model to generate optimal load at intermediate values for the experimental study. A similar predictive Interpolation Model was also developed for estimating load for varying walking speeds at level ground.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47965051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Antioxidant Potential and Phytochemical Contents of different Extracts of Wild Nasturtium Officinale W T Aiton Collected from Kumaun Region of Uttarakhand 北阿坎德邦库马恩地区野生牛蒡不同提取物抗氧化能力和植物化学成分的比较研究

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16281

P. Rawal, Nitisha Negi, A. Sah, Anchala Guglani

{"title":"A Comparative Study of Antioxidant Potential and Phytochemical Contents of different Extracts of Wild Nasturtium Officinale W T Aiton Collected from Kumaun Region of Uttarakhand","authors":"P. Rawal, Nitisha Negi, A. Sah, Anchala Guglani","doi":"10.14429/dlsj.6.16281","DOIUrl":"https://doi.org/10.14429/dlsj.6.16281","url":null,"abstract":"Nasturtium officinale W. T Aiton or “watercress” (Brassicaceae) is a nutritionally valuable plant that is the richest source of carotenoids, polyphenols, iron, calcium, iodine, folic acid, essential vitamins and minerals. It is traditionally used for their appetiser, anti-scorbutic, stimulant, diuretic and detoxifying properties. The present study was conducted to investigate the antioxidant potential, phytochemical contents (total phenolic, flavonoids and tannin contents) as well as a preliminary phytochemical screening of different extract of aerial parts of Nasturtium officinale collected from the Kumaun region. The different extracts showed significant antioxidant activity as well as total phenolic, flavonoids and tannin contents. The preliminary phytochemical screening showed the presence of several phytochemical constituents such as carbohydrates, proteins, amino acids, glycosides, alkaloids and others. The hydroalcoholic extract possess significantly (P<0.05) higher antioxidant potential with IC50 value (0.333 mg/ml, 0.509mg/ml)and EC50 value (3.537 mg/ml) by 2,2-diphenyl-1-picrylhydrazyl(DPPH), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)(ABTS), and ferric-reducing antioxidant power (FRAP) methods, respectively, as well as highest total tannin, flavonoid and phenolic contents among all the extracts. These results provide substantial evidence that the plant Nasturtium officinalehas antioxidant potential and valuable sources of phytochemicals.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45634934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Job Satisfaction on Psychological Well Being and Perceived Stress among Government and Private Employee 工作满意度对政府和私营部门员工心理健康和压力感知的影响

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16954

D. Bansal, Prachi Gulati, Dr Vijendra Nath Pathak

{"title":"Effect of Job Satisfaction on Psychological Well Being and Perceived Stress among Government and Private Employee","authors":"D. Bansal, Prachi Gulati, Dr Vijendra Nath Pathak","doi":"10.14429/dlsj.6.16954","DOIUrl":"https://doi.org/10.14429/dlsj.6.16954","url":null,"abstract":"The wellbeing and health of people are influenced by satisfaction about their job. The essence of job satisfaction is explained as mental gratification derived from one’s job. To know how the job satisfaction of an individual affects the other domains of an individual’s life like, psychological well-being and perceived stress in making an individual over-all healthy being. The study aims to investigate the Job satisfaction levels on psychological well-being and Perceived stress among government and private employees. Convenient sampling method was used in this study. In this study the sample consisted of 100 employees; 48 employees from the government sector and 52 employees from the private sector of the Delhi/ NCR region. For this study the behaviour tools used were job satisfaction scale, psychological well-being, and Perceived stress scale were taken for the study. These tools are used to measure government and private employee psycho social health issues. SPSS-18 software was used for data management. The results revealed significant negative correlation between Job satisfaction and Purpose in Life (r= -0.21) at p<0.05 level of significance. Perceived stress had a negative correlation between Autonomy (r= -.23) and Positive relation with others (r= -0.20) at p<0.05 level of significance. There was a significant difference between Government and Private sectors on Positive relations with others (p=0.003) at p<0.05 and Perceived stress (p=0.000) at p<0.05.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47823250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Data Mining Anthropometric Parameters for the Design and Sizing of Female Full Body Protector 女性全身保护器设计和尺寸的数据挖掘人体测量参数

Defence Life Science Journal Pub Date : 2021-10-05 DOI: 10.14429/dlsj.6.16602

L. R. Varte, Deepika Kakkar, S. Rawat, I. Singh, Yashmita Chaudhary, B. Kumar

{"title":"Data Mining Anthropometric Parameters for the Design and Sizing of Female Full Body Protector","authors":"L. R. Varte, Deepika Kakkar, S. Rawat, I. Singh, Yashmita Chaudhary, B. Kumar","doi":"10.14429/dlsj.6.16602","DOIUrl":"https://doi.org/10.14429/dlsj.6.16602","url":null,"abstract":"Since the entry of female troops in different paramilitary forces, there is a dearth of well-fitted personal protective gear for them to maximise operational safety and protection. A mismatch of anthropometry in design adversely affected the user’s performance during critical operation, compromising the safety and well-being of an individual. A detailed anthropometry-based sizing study was conducted by the research team, on the Indian female paramilitary troops for proper sizing of their protective gears and ensembles. An anthropometric survey of 325 female para-military troops, posted in two locations with age ranged from 21 to 54 years (mean ± SD) value: 37.14 ± 8.49 years was done. Each subject’s 28 different body dimensions were taken. The data was then investigated using the factor analysis method. Principal component analysis technique was used to reduce the variables to similar factor components where, two components with an Eigenvalue of more than 1 were selected. viz. Principal component 1 (girth dimensions) and Principal component 2 (abdomen or waist dimension). These two key variables were used to divide the population into three separate clusters using the K-means cluster method. These cluster groups were validated using a regression tree. Descriptive statistical analysis of data was conducted followed by Cluster analysis (of key components shortlisted) using Statistical Product and Service Solution (SPSS) version 21. The current study was the first complete anthropometric survey of Indian female paramilitary personnel for the development of a female-specific sizing system for a full-body protector (FBP) design resulting is an improved fit of full-body protector.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41744653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1