多酚作为高海拔介导的骨骼肌损伤的治疗方法

Q3 Pharmacology, Toxicology and Pharmaceutics
Asha D Kushwaha, Varun Bhardwaj, Deepika Saraswat
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引用次数: 0

摘要

在高海拔地区,骨骼肌损伤会给不适应环境的个体带来各种后果,从而通过施加严重的氧化应激、骨骼肌萎缩、线粒体功能障碍/自噬和再生残疾来阻碍他们的身体活动。研究人员已经描述了许多天然和合成的补充剂,以减轻氧化应激引起的肌肉损伤。在这篇综述文章中,我们着重于骨骼肌损伤和他们的缓解使用天然多酚。多酚是一种基于植物的化合物,具有抗氧化和抗炎特性,如姜黄素、儿茶素、白藜芦醇、槲皮素和红柳苷,似乎主要通过逆转氧化应激和线粒体功能障碍起作用,最终在各种病理条件下改善骨骼肌损伤。本文还对多酚的分子靶点及其在预防透明质酸引起的肌肉损伤中的可能治疗作用进行了综述。由于没有适当的干预措施,需要找到一种可能的解决方案,具有高度保护性的抗萎缩、抗氧化、抗炎特性,并带有性能增强剂的色彩。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyphenols as Therapeutic Approach to High Altitude Mediated Skeletal Muscle Impairments
Skeletal muscle impairments at high altitudes resulted into various consequences in un-acclimatised individuals thus hampering their physical activities by imposing severe oxidative stress, skeletal muscle atrophy, mitochondrial dysfunction/autophagy, and regeneration disability. Researchers have described many natural and synthetic supplements to alleviate oxidative stress-induced muscle impairments. In this review article we are focusing on the skeletal muscle impairments and their alleviation by using natural polyphenols. Polyphenols are plant-based compounds showing anti-oxidative and anti-inflammatory properties like Curcumin, Catechins, Resveratrol, Quercetin and Salidrosides appear to mainly act by reversing oxidative stress and mitochondrial dysfunction eventually ameliorate skeletal muscle impairments under various imposed pathological conditions. This review also drew attention on the molecular targets of polyphenols and their possible therapeutic effects in preventing HA induced muscle impairments. Unavailability of suitable intervention, there is a need to find a probable solution having highly protective anti-atrophic, anti-oxidative, anti-inflammatory properties with the tint of performance enhancer.
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来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
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