Translational Medicine of Aging最新文献_第2页

Young and old animals “use” different strategies for adapting to the chronic effects of ethanol 年轻和年老的动物 "使用 "不同的策略来适应乙醇的慢性影响

Translational Medicine of Aging Pub Date : 2024-01-01 DOI: 10.1016/j.tma.2024.01.001

Anatoly I. Bozhkov, Nataliia I. Dobrianska, Rustam A. Akzhyhitov, Anna V. Novikova, Stanislav S. Haiovyi, Alona O. Pankratova, Olena O. Ivanova, Illia R. Onipko, Yuliia O. Komburlei

{"title":"Young and old animals “use” different strategies for adapting to the chronic effects of ethanol","authors":"Anatoly I. Bozhkov, Nataliia I. Dobrianska, Rustam A. Akzhyhitov, Anna V. Novikova, Stanislav S. Haiovyi, Alona O. Pankratova, Olena O. Ivanova, Illia R. Onipko, Yuliia O. Komburlei","doi":"10.1016/j.tma.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.tma.2024.01.001","url":null,"abstract":"<div><p>The study of the young and old animals’ adaptation characteristics to the chronic effect of ethyl alcohol provides a quick solution of problems in biomedicine and gerontology, such as the formation of age related dependencies on pathologies. We studied the chronic effect of 15 % ethanol on young and old rats (3 and 20 month) of the Wistar line, which require free access to alcohol, for 160 days (5.3 months). The time of death occurrence, the relative mass dynamics of the liver, spleen and kidneys, the activity of alcohol dehydrogenase in the post-mitochondrial supernatant of liver, the content of carbonylated proteins and the activity of aconitate hydrotase in the mitochondria of the liver, as well as the serum creatinine level after 10, 20 and 40 days from the start of taking ethyl alcohol were determined. It was shown that the “initial” functional state of the increased activity elements in the formation of ethanol tolerance in young and old animals was different, this is evidenced by changes in the ratios of such indicators as: the relative mass of the liver, kidneys and spleen, the activity of alcohol dehydrogenase, aconitate hydrotase, the content of carbonylated proteins in the liver. We came to a combination that in young rats a “compensatory delayed” adaptation to the chronic effect of alcohol is realized, while (about 50 %) have a “compensatory delayed”, and the rest have a “pathogenetic” strategy; the choice of an adaptation strategy depends on the “initial” functional state, an extremely probable participation in the exchange of ethanol.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"8 ","pages":"Pages 1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501124000014/pdfft?md5=956576db248c3289ece5a8e40bb2d0ba&pid=1-s2.0-S2468501124000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139493700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells 内质网在衰老和衰老细胞形成机制中的作用

Translational Medicine of Aging Pub Date : 2024-01-01 DOI: 10.1016/j.tma.2024.07.001

Lev Salnikov

{"title":"Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells","authors":"Lev Salnikov","doi":"10.1016/j.tma.2024.07.001","DOIUrl":"10.1016/j.tma.2024.07.001","url":null,"abstract":"<div><p>The role of the endoplasmic reticulum (ER) in aging processes has not attracted much attention of researchers, while this structure plays one of the central roles in the processes of intracellular synthesis. Summarizing the data presented in this review, we can conclude that the number of polysomes is directly related to the production of proteins required by the cell. In turn, polysomes responsible for the production of specialized proteins are associated with the ER of highly differentiated cells. At the same time, proteins necessary for the functioning of cellular infrastructure are translated on free polysomes, which are not associated with the ER. During aging, an increase in the quantity or surface area of ER was also observed in cells, especially in senescent cells. Summarizing these data we can conclude that cell aging is directly related to changes in their ER, which lead to inhibition of the production of proteins necessary for the operation of cellular infrastructure. Therefore, it is possible to distinguish two targets for reducing age-related processes. These should be actions aimed at changing the ratio between ER-bound and free polysomes in favor of the last ones. The second goal is to regulate the amount of ER by enhancing membrane exchange in the cell. Together, these effects will be aimed at preserving the infrastructural base of cells, at least delaying their age-related degradation. As research progresses, unraveling the complex interplay between intracellular membranes and aging holds great promise for developing novel therapeutic strategies to combat age-related diseases and promote longevity.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"8 ","pages":"Pages 29-32"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501124000063/pdfft?md5=abe4e6d8307b459d4cc3f4ea583209ba&pid=1-s2.0-S2468501124000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes 抗糖尿病双胍类药物的老年学传奇：从无知到谨慎，再到满怀希望

Translational Medicine of Aging Pub Date : 2024-01-01 DOI: 10.1016/j.tma.2024.05.001

Aleksei G. Golubev, Vladimin N. Anisimov

{"title":"The gerontological saga of antidiabetic biguanides: From ignorance to prudence via high hopes","authors":"Aleksei G. Golubev, Vladimin N. Anisimov","doi":"10.1016/j.tma.2024.05.001","DOIUrl":"10.1016/j.tma.2024.05.001","url":null,"abstract":"<div><p>The history of the discoveries that shaped the current attitudes to the use of antidiabetic biguanides, mainly metformin, as antiaging agents is reviewed. An emphasis is made on the mounting evidence that the diseases of aging including type II diabetes mellitus, the metabolic syndrome, neurodegenerative conditions and cancer that are featured in the clinical trials of metformin are increasingly recognized as those for which physical exercises are effective in risk reduction and therapy enhancement. The known primary molecular targets of metformin map to some of the signaling pathways by which the effects of the two most robust physiological antiaging interventions, i.e. energy consumption increase and calorie intake restriction, are transduced to the cellular and physiological systems implicated in regulating the balance between, on one hand, growth and proliferation and, on the other hand, maintenance and repair. However, metformin and other allegedly antiaging agents can reproduce but partly and in biased ways the effects of the physiological antiaging interventions. In particular, although metformin may help to maintain the current physical conditions, it hampers the gains in physical fitness that are afforded by exercises. These observations should be taken into account in advising metformin to healthy people engaged in increasing their physical fitness by exercises or to patients whose muscular mass is decreased during disease and should be restored thereafter.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"8 ","pages":"Pages 12-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501124000038/pdfft?md5=e190958743c898515b1a241f6eb07571&pid=1-s2.0-S2468501124000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erlec1 controls bone metabolism by affecting osteoblast type I collagen synthesis Erlec1 通过影响成骨细胞 I 型胶原蛋白的合成来控制骨代谢

Translational Medicine of Aging Pub Date : 2024-01-01 DOI: 10.1016/j.tma.2024.08.002

Chunbao Rao , Wenbo Cui , Zitian Lin , Yaozhong Zhang , Wei Lai , Qi Peng , Xiaomei Lu

引用次数: 0

Adrenergic innervation of thoracic lymphatic duct in postnatal ontogenesis 新生儿期胸腔淋巴管的肾上腺素能神经支配

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.10.003

Bayan Nurmakhanova , Georgii Demchenko , Serik Abdreshov , Sofiya Imankulova , Laura Koibasova

{"title":"Adrenergic innervation of thoracic lymphatic duct in postnatal ontogenesis","authors":"Bayan Nurmakhanova , Georgii Demchenko , Serik Abdreshov , Sofiya Imankulova , Laura Koibasova","doi":"10.1016/j.tma.2023.10.003","DOIUrl":"10.1016/j.tma.2023.10.003","url":null,"abstract":"<div><p>The adrenergic innervation of the thoracic lymphatic duct was studied in young, mature and old animals. Adrenergic innervation of lymphatic system in postnatal ontogenesis, especially in its late period, was not thoroughly studied. The purpose of this study was to determine the state of adrenergic innervation of TLD in young, mature, and senile animals. The study shows that the adrenergic apparatus in the TLD tissues of rats continues its formation and complication from the first days after birth and is entirely formed by Day 25–30 after birth. From the age of one month, the adrenergic innervation represents fully formed plexuses in all areas which function throughout life. These are brightly fluorescent nerve fibers that form plexuses with regularly located multiple sites of varicose dilation. In senile animals, the dilations remain frequent and numerous in all parts of the lymph node, but their brightness decreases; the fibers in the plexuses become discontinuous, the varicose thickenings become less frequent or disappear. The adrenergic vasomotor innervation in the walls of the TLD affects its function. The formed adrenergic innervation is presented across all periods of postnatal ontogenesis of the TLD and affects its functioning, and age-related changes in the course of development and aging of the organism can be considered as adaptation to new conditions. This study promotes understanding of the sympathetic regulation. The trial does not involve people and the trial registration is not required.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"7 ","pages":"Pages 133-136"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501123000147/pdfft?md5=0bc9b7b52274eff0050452a837f2b3f4&pid=1-s2.0-S2468501123000147-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment mechanism of immune triad from the repurposing drug against COVID-19 重组药物免疫三联体抗COVID-19的治疗机制

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.06.005

Jong hoon Lee

引用次数: 0

The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review 协作式同行评议框架作为培养生物医学研究生进行严格的、合乎道德的同行评议的模式

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.01.002

Jonathan An, Alex Mendenhall, Matt Kaeberlein

引用次数: 1

Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model 促卵泡激素受体单倍功能不全模型中缺乏加速卵巢衰老

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.01.001

Kristen Mehalko , Minhoo Kim , Sanjana Paye , Kelly Koh , Ryan J. Lu , Bérénice A. Benayoun

{"title":"Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model","authors":"Kristen Mehalko , Minhoo Kim , Sanjana Paye , Kelly Koh , Ryan J. Lu , Bérénice A. Benayoun","doi":"10.1016/j.tma.2023.01.001","DOIUrl":"10.1016/j.tma.2023.01.001","url":null,"abstract":"<div><p>Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that <em>Fshr</em> haploinsufficiency in female mice led to accelerated ovarian aging, including anticipated progressive fertility decline, irregular estrus cycles, increased follicular atresia and premature ovarian failure at 7–9 months of age. Interestingly, these phenotypes resemble key characteristics of human menopause and thus <em>Fshr</em> haploinsufficiency was proposed as a promising research mouse model of menopause. However, the <em>Fshr</em> haploinsufficiency model had not been fully explored, especially at the molecular level. In this study, we characterized the ovarian and endocrine functions of a <em>Fshr</em> heterozygous knockout allele that was generated on the C57BL/6 genetic background as part of the Knockout Mouse Project (KOMP). Based on our analyses of these mice using a breeding assay, ovarian tissue histology and serum hormone quantifications (<em>i.e.</em> FSH, AMH, INHA) analyses, the KOMP <em>Fshr</em> heterozygous knockout female mice do not show the anticipated phenotypes of ovarian aging in terms of fertility and endocrine function. We further confirmed that the expression of <em>Fshr</em> is unaltered in the ovaries of the KOMP <em>Fshr</em> heterozygous knockout animals compared to wild-type. Together, our data suggests that the KOMP <em>Fshr</em> heterozygous knockout strain does not recapitulate the previously reported ovarian aging phenotypes associated to another model of <em>Fshr</em> haploinsufficiency.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"7 ","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878709/pdf/nihms-1864462.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9142935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's disease DNA损伤反应作用的最新进展及其对阿尔茨海默病新治疗方法的理解

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.06.004

Rajesh Ranganathan, Georgy Sapozhnikov, Wang Ni, Siwen Li, Youqiang Song

引用次数: 1

Body composition, fear of falling and balance performance in community-dwelling older adults 社区居住老年人的身体成分、跌倒恐惧和平衡表现

Translational Medicine of Aging Pub Date : 2023-01-01 DOI: 10.1016/j.tma.2023.06.002

Ladda Thiamwong , Rui Xie , Norma E. Conner , Justine M. Renziehausen , Eunice Oladepe Ojo , Jeffrey R. Stout

{"title":"Body composition, fear of falling and balance performance in community-dwelling older adults","authors":"Ladda Thiamwong , Rui Xie , Norma E. Conner , Justine M. Renziehausen , Eunice Oladepe Ojo , Jeffrey R. Stout","doi":"10.1016/j.tma.2023.06.002","DOIUrl":"10.1016/j.tma.2023.06.002","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to 1) assess body composition using a portable technology, bioelectrical impedance analysis, (BIA) and 2) examine the associations between body composition and the discrepancy of fear of falling (FOF) and balance performance.</p></div><div><h3>Methods</h3><p>A cross-sectional study included 121 older adults 60 years and older, 78% were female, 41% lived alone, and 71% had no history of falls. The discrepancy between fear of falling and balance performance was categorized into four groups. We found 47% rational (low FOF and normal balance), 19% incongruent (low FOF despite poor balance), 18% irrational (high FOF despite normal balance), and 16% congruent (high FOF and poor balance).</p></div><div><h3>Results</h3><p>Body Fat Mass (BFM), Percent Body Fat (PBF), and Body Mass Index (BMI) were correlated with fear of falling and balance performance<em>.</em> BMI was significantly different in the rational group (p = 0.004) and incongruent group (p = 0.02) compared to the congruent group. PBF was significantly different between the incongruent (p = 0.002), irrational (p = 0.014), and rational (p < 0.001) groups, compared to the congruent group.</p></div><div><h3>Conclusions</h3><p>The study found that body BFM, PBF, and BMI were correlated with fear of falling and balance impairment. High Body Mass Index and Body Fat Mass were associated with a discrepancy between FOF and balance. Body composition analysis devices, such as BIA and other portable technologies, could be taken to underserved communities and may help identify community-dwelling older adults who are frail and may be at high risk of falling.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"7 ","pages":"Pages 80-86"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48073353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0