Obstetrics, Gynecology and Reproduction最新文献

{"title":"Impact assessment of uterine artery embolization on reproductive","authors":"N. A. Kalinina, A. Sulima, Z. Rumyantseva, P. N. Baskakov, V. D. Kalinin","doi":"10.17749/2313-7347/ob.gyn.rep.2023.410","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.410","url":null,"abstract":"Introduction. Uterine artery embolization (UAE) is an effective minimally invasive manipulation that has been widely applied in obstetric and gynecological practice. The expediency of using this method of surgical treatment in patients with reproductive plans is still controversial. The main clinicians' concerns are the risk of developing local endometrial ischemia able to lead to habitual miscarriage, premature birth and pathological placentation as well as decreased ovarian reserve due to impaired adequate ovarian blood supply.Aim: to analyze the literature data regarding UAE effect on reproductive function.Materials and Methods. The search for literature was carried out in databases Web of Science, eLibrary, Scopus, PubMed/MEDLINE. We selected articles for the years 1995–2023 devoted to assessing UAE influence on reproductive function. The articles were searched by the keywords \"embolization\", \"uterine arteries\", \"reproductive function\", \"prognosis\", \"assessment\". No methodological filter was used to exclude the omission of suitable articles. The study included full-text sources and literary reviews on the subject under study. Articles that are not directly related to the subject UAE were excluded from the review. In order to avoid the inclusion of duplicate publications if two same author studies were found, the study period of each author was assessed, and if publication dates coincided, the most recent publication was selected.Results. Based on the review of domestic and foreign literature sources over recent years, it can be concluded that there are restrictions on the frequency and outcomes of pregnancy in such cohort of patients who underwent UAE. Many patients included in existing studies and case reports have variable factors complicating direct analysis or comparison such as age of patients, previous spontaneous abortions, previous uterine surgery, different techniques and professional training of X-ray endovascular surgeons, uncertainty of a woman regarding further reproductive plans and other forms of infertility, which can also distort research results. In addition, the most well-controlled studies often have small patients sample sizes not allowing to obtain meaningful clinical information from thereof.Conclusion. Pregnancy is possible in women after UAE, and many of these pregnancies proceed without complications and lead to successful childbirth. The actual fertility rate after UAE remains uncertain, but is approaching 38.3 % based on the available published results.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82297545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging in cervical cancer: current opportunities of radiomics analysis and prospects for its further developmen","authors":"A. Solopova, J. V. Nosova, B. B. Bendzhenova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.440","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.440","url":null,"abstract":"Introduction. Due to the dynamic development of modern imaging technologies in recent years, much attention has been paid to radiomics particularly texture analysis. The complexity of clinically evaluated tumor procession in cervical cancer (CC) accounts for a need to expand knowledge on applying medical imaging technologies in oncologic diagnostics spanning from predominantly qualitative analysis to a multiparametric approach, including a quantitative assessment of study parameters.Aim: to analyze the literature data on the use of radiomics and image texture analysis in diagnostics and prediction of aggressiveness of oncogynecological diseases including СС.Materials and Methods. A 2016–2023 systematic literature search was carried out in the PubМed/MEDLINE, eLibrary, Scopus databases, NCCN, ESUR, ACR resources. All publications on radiomics and image texture analysis used in CC diagnostics and prediction were investigated, with queries for key words and phrases in Russian and English: «cervical cancer», «radiomics»,«texture analysis», «oncology». The study included full-text sources and literature reviews on the study subject. Duplicate publications were excluded.Results. The features and advantages of using radiomics and image texture analysis in CC diagnostics were summarized. The introduction of the radiomic approach has expanded the views on interpretation of medical imaging data. The radiomics-based parameters extracted from digital images revealed high informativeness in some studies that contribute to improving diagnostic accuracy as well as expanding opportunities for predicting therapeutic effectiveness in CC patients.Conclusion. Radiomics used in diagnostics of oncogynecologic diseases including СС is one of the promising actively developing areas of analysis in radiology that requires to be further investigated.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74589218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What has changed over the year in the prevention of venous thromboembolic events in pregnant women and puerperas?","authors":"V. Bitsadze, M. S. Zainulina, J. Khizroeva, M. Nikolaeva, A. Makatsariya","doi":"10.17749/2313-7347/ob.gyn.rep.2023.439","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.439","url":null,"abstract":"An issue of venous thromboembolic events (VTEs) in pregnant women and puerperas in Russia as well as throughout the world remains relevant. Specialized events with expert’s participation could not be better to promote active discussion and constructive solution of complex problems, which refer to issues of VTEs prevention. Indeed, not disputable issues can be solved, but critical look and reasoned opinion leader presentations in the field undoubtedly improve our understanding and approaches to prevention of threatening complications in pregnant women and puerperas such as VTEs. In addition, actively discussed new data for dosing of low molecular weight heparins (LMWH) in pregnant women will allow to update current clinical guidelines, which would probably improve clinical outcomes of therapy.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85294389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of delivery in a COVID-19-convalescent woman with preeclampsia developing fetal distress during preterm labor","authors":"E. Iupatov, A. T. Khaertdinov, S. A. Osipov, E. E. Selivanova, R. R. Mukhametova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.396","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.396","url":null,"abstract":"The course of the pandemic revealed that despite the general populational risks for developing novel coronavirus infection (NCI) COVID-19, pregnant women are more susceptible to its severe course and unfavorable perinatal outcomes. Currently, NCI is associated with a high risk of spontaneous miscarriages, premature rupture of fetal membranes, preterm delivery, development of fetoplacental insufficiency, fetal growth retardation, fetal distress, exacerbation of chronic somatic pathology, and postpartum bleeding. A brief literature review and the described clinical case demonstrate a need to thoroughly examine puerperal women with preterm delivery.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81640673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding the prospects of using Lactobacillus-based probiotics, D-mannose and cranberry extracts in therapy of urinary tract infections","authors":"O. Gromova, I. Torshin","doi":"10.17749/2313-7347/ob.gyn.rep.2023.442","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.442","url":null,"abstract":"Antibiotics are most often used to combat urinary tract infections (UTIs). Taking into account the side effects related to antibiotic therapy, existing antibiotic-resistant strains of uropathogens, as well as the low effectiveness of the vast majority of antibiotics against bacterial agglomerations (biofilms), a search for alternative approaches to treat UTIs is highly relevant. One of the important in such search is presented by use of nutraceuticals – D-mannose (prevents interaction between pathogenic E. coli strains and the urothelium, destroys bacterial biofilms), Lactobacilli (prevents formation of bacterial pathogen biofilms, normalizes human microbiome, alleviates inflammation) and standardized cranberry extracts (inhibits uropathogen adhesion, exerts anti-inflammatory action). The results from basic and clinical studies suggest not only about high safety of such pharmaconutraceutical support of UTIs therapy, but also the effectiveness of separate and combined use of such nutraceuticals comparable to that of antibiotics, especially in treatment of uncomplicated UTIs forms","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78697501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps-associated markers in malignant neoplasms of the female reproductive system after surgical treatment and adjuvant chemotherapy","authors":"E. Slukhanchuk, V. Bitsadze, A. Solopova, J. Khizroeva, J.-K. Gris, I. Elalamy, N. Degtyareva, M. A. Gileva, N. Samburova, D. V. Shcherbakov, F. Yakubova, M. E. Zelepukhina, D. Blinov, A. Makatsariya","doi":"10.17749/2313-7347/ob.gyn.rep.2023.432","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.432","url":null,"abstract":"Introduction. Studies evidence about a relation between increased circulating free DNA (cfDNA) concentrations and chemotherapy, the majority of which have been focused on considering a tumor as a source of cfDNA. It has been suggested that neutrophils also contribute to this process, as cancer-related cfDNA characteristics resemble those of neutrophil extracellular traps (NETs). Therefore, the elevated concentration of cfDNA observed in chemotherapy patients may be associated with NETosis.Aim: assessment of NETosis markers in surgical treatment and adjuvant chemotherapy of patients with malignant neoplasms of the female reproductive system.Materials and Methods. A prospective non-randomized interventional controlled study was carried out by enrolling 111 patients with malignant breast diseases and female genital organs of various localizations and stages hospitalized for elective surgical treatment or chemotherapy course. The control group included 33 healthy women. 69 patients underwent surgical treatment. Adjuvant chemotherapy with paclitaxel and carboplatin was performed in 25 patients with ovarian cancer and 17 patients with breast cancer. In cancer patients, citrullinated histone H3 (citH3) and myeloperoxidase (MPO) were chosen as NETosis biomarkers allowing to distinguish NETs from other tumor-derived cfDNA thereby improving quality of research study. The concentration of NETosis markers was assessed before surgery or onset of chemotherapy upon admission to hospital and 14 days after surgery or 14 days after the second course of chemotherapy.Results. In all patients, the concentrations of NETosis markers before the start of therapy were significantly increased compared to the control group as well as 14 days after surgical treatment and 14 days after the second course of chemotherapy. However, in surgical patients, no significantly increased concentration of NETosis markers postvs. pre-surgery magnitude was observed. Upon that, patients underwent 2 courses of chemotherapy vs. baseline level were found to have significantly elevated magnitude of NETosis markers.Conclusion. The study revealed the relationship between administration of paclitaxel-containing chemotherapy in patients with ovarian cancer and breast cancer and a rise in NETs level. Chemotherapy is an essential component for management of patients with malignant neoplasms of the female reproductive system, therefore, development of new strategies to lower a risk of thrombosis and resistance to it is of crucial importance. ","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"287 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86415411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clitoromegaly: principles of diagnostics and treatment","authors":"N. V. Ivanov, I. P. Serebryakova, N. V. Khudyakova, A. I. Fedorova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.400","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.400","url":null,"abstract":"The literature review is dedicated to the topical subject in current endocrinology and gynecology – clitoromegaly. At present, clitoromegaly is considered as a symptom of an endocrinological disease associated with impaired testosterone or androgen production. However, in most cases, the cause of the disease cannot be determined. A condition described in the clitoromegaly classification as an \"idiopathic clitoromegaly\" holds a leading place. Despite an opportunity to perform a successful clitoroplasty in childhood, adult patients with clitoromegaly quite often seek specialists` help. Such girls and women often suffer from anxietydepressive disorders related to social maladjustment associated due to sexological and psychological problems, which requires a sexologist or psychotherapist` supervision and treatment. Here, we provide the data on genetic syndromes accompanied by clitoromegaly. Differential diagnostics algorithms for neonates, young and adult women are proposed.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"55 26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88485917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine, cancer and oncothrombosis","authors":"V. Bitsadze, E. Slukhanchuk, A. Solopova, J. Khizroeva, D. V. Shcherbakov, F. Yakubova, J. Gris, I. Elalamy, N. Degtyareva, A. V. Lazarchuk, M. A. Gileva, N. Samburova, Z. D. Aslanova, D. Blinov, A. Shkoda, A. Makatsariya","doi":"10.17749/2313-7347/ob.gyn.rep.2023.431","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.431","url":null,"abstract":"Introduction. Hyperhomocysteinemia (HHC) is one of the arms in the pathogenesis of thrombotic complications in female cancer patients.Aim: to assess an HHC-related impact to developing thrombotic complications in patients with malignant neoplasms of the female genital organs and breast cancer.Materials and Methods. There were retrospectively evaluated the data collected from 236 patients: with ovarian tumors (n = 63), cervical cancer (n = 51), breast tumors (n = 64), malignant neoplasms of the uterine body (n = 58). The control group consisted of 50 women without malignant neoplasms. The analysis of homocysteine (HC) concentration, the frequency of polymorphisms of the genes encoding folate cycle enzymes MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G as well as the rate of thrombotic complications was carried out. A risk of blood HC level-related thrombotic complications was assessed.Results. Plasma HC concentration comprised ≥ 22 μmol/l in 30.5 % of patients. Thrombotic complications within one year after discharge from the hospital were developed in 15.3 % cases. The risk of thrombotic complications turned out to be higher in patients with elevated plasma HC level (≥ 22 μmol/l) (odds ratio = 2.99; 95 % confidence interval = 1.11–8.08). No significantly increased prevalence of polymorphisms in the genes encoding folate cycle enzymes among female cancer patients was detected.Conclusion. Monitoring HC level in female cancer patients contributes separately to predict a likelihood of thrombotic complications. Prescribing drugs that reduce HC level (folic acid) and monitoring its concentration in female cancer patients during therapy, including chemotherapy, can potentially lower an incidence of thrombotic complications.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73058040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of GnRH agonist trigger followed by hCG add-back in normal responders for fresh embryo transfer: a case-control analysis from Vietnam","authors":"M. Le, N.S.V. Le, N.Q.T. Tran, Q. Nguyen, T. N. Cao","doi":"10.17749/2313-7347/ob.gyn.rep.2023.393","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.393","url":null,"abstract":"Aim: to assess the effects of a dual trigger by gonadotrophin-releasing hormone (GnRH) agonist and low-dose human chorionic gonadotropin (hCG) on in vitro fertilization (IVF) outcomes in women with normal ovarian response.Materials and Methods. This case-control analysis comprised 118 patients who responded normally to ovarian stimulation with a GnRH antagonist protocol at Hue Center for Reproductive Endocrinology and Infertility, Vietnam, between January 2018 and October 2019. Recruitment was achieved through case-control matching: a case (with Dual trigger – group A) was paired with control (with hCG trigger – group B) in a 1:1 ratio. The primary markers of success were the retrieval of oocytes and embryological data, the pregnancy rate, and the incidence of ovarian hyperstimulation syndrome (OHSS).Results. 59 patients in group A and 59 women in group B were recruited. Two groups had comparable patient characteristics and ovarian reserve. The initial dose, total dose, duration of gonadotropin administration, and peak of estradiol level were not statistically different across groups. The number of recovered oocytes (10.3 ± 4.2 vs. 10.0 ± 3.3; p = 0.663), mature oocytes (8.6 ± 3.7 vs.8.1 ± 2.8; p = 0.346), and high-quality embryos (56.2 ± 28.9 vs. 59.8 ± 35.9; p = 0.555) was equivalent. Fertilization, clinical pregnancy, and live birth rates were comparable between the dual trigger and hCG groups. In neither group were any occurrences of OHSS seen.Conclusion. Dual trigger may substitute hCG for final oocyte maturation and fresh embryo transfer in patients with normal responses to GnRH antagonist protocol-induced ovarian stimulation without compromising IVF outcomes.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73767148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic maladaptation of a pregnant woman as an early marker of preeclampsia","authors":"E. Timokhina, I. Ignatko, I. S. Grigoryan, I. A. Fedyunina, I. Bogomazova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.397","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.397","url":null,"abstract":"Prediction of a risk group and early diagnostics of preeclampsia (PE) are crucial for a comprehensive follow-up of women to improve maternal and fetal outcomes. This review presents current data regarding PE prognosis. We have substantially progressed in understanding PE pathogenesis and in the field of angiogenic markers, but not a single test meets the criteria to serve as an optimal biomarker. It has been increasingly emphasized that the role of maternal hemodynamics may be important in predicting PE risk. The cerebral and ophthalmic arteries, blood volume, potential echocardiographic markers to predict PE as well as a marker of heart failure, brain natriuretic peptide (BNP), are actively investigated. The analysis summarizes the data on contemporary markers for PE prognosis by focusing on impaired pregnancy-related maternal cardiovascular adaptation. Assessing hemodynamics represents a potential prognostic marker for impaired maternal cardiovascular adaptation.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73150125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}