Obstetrics, Gynecology and Reproduction最新文献

{"title":"Iron deficiency in the practice of a gynecologist: therapeutic efficacy","authors":"E. M. Dzhobava, I. G. Knysheva, D. P. Artizanova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.402","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.402","url":null,"abstract":"Introduction. Iron deficiency (ID) of varying severity is the most common and rather serious extra-gynecological complication of adenomyosis resulting from meno/metrorrhagia of varying intensity, up to abnormal uterine bleeding requiring surgical hemostasis. Taking into account the chronic course of the disease, the complexity of radical therapy as well as a systemic effect ID also particularly affecting reproductive system, an issue of sufficient and timely ID correction in patients with adenomyosis of varying severity remains relevant.Aim: to study an efficacy of ID therapy with drug containing ferrous fumarate and folic acid in patients with adenomyosis.Materials and Methods. An observational study was conducted, which included 90 patients with isolated adenomyosis of varying severity: 30 patients with degree 1 adenomyosis (group 1), 30 patients with degree 2 adenomyosis (group 2), 30 women with degree 3–4 (group 3). All patients received ferrous fumarate plus folic acid for 30 days. To identify an ID variant, the level of serum ferritin, iron, transferrin, total iron-binding capacity of blood serum (TIBC), clinical blood test parameters such as hemoglobin level, erythrocyte count, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) were measured.Results. A significant increase in ferrokinetic parameters was found in all patient groups. The most significant and clinically important dynamics was noted for serum iron level and TIBC. For instance, after the therapy, the level of serum iron increased in group 1 from 11.0 ± 0.6 μmol/l up to 15.0 ± 1.1 μmol/l, in group 2 – from 9.0 ± 1.6 μmol/l up to 14 .0 ± 0.8 μmol/l, in group 3 from 7.0 ± 1.3 μmol/l up to 12.0 ± 1.3 μmol/l (p < 0.05). In addition, a decreased TIBC was found in group 3: from 68.0 ± 1.8 μmol/l down to 58.0 ± 1.7 μmol/l (p < 0.05); in groups 2 and 3 TIBC level tended to insignificantly decrease.Conclusion. The use of a preparation containing ferrous fumarate along with folic acid can effectively correct background ID of varying severity in patients with adenomyosis of varying intensity. An earlier and longer administration of iron preparations in patients with adenomyosis along with clinical and laboratory parameter monitoring is recommended to achieve more pronounced clinical effect.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79581351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression profile of plasma microRNAs and target genes in patients with complicated pregnancy","authors":"D. G. Pashkovsky, E. Solovieva, Ts. R. Rabadanova, P. T. Gorbunova, A. B. Dubovaya, E. R. Muslimova, E. E. Khoroz, Z. S. Karabash, L. E. Sorokina","doi":"10.17749/2313-7347/ob.gyn.rep.2023.413","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.413","url":null,"abstract":"Aim: comparative analysis of the expression profile of plasma microRNAs and target genes in patients with complicated pregnancy.Materials and Methods. A prospective observational comparative study in parallel groups was carried out. The study included 73 women divided into three groups: the main group – 42 patients with preeclampsia (PE), the comparison group – 12 pregnant women with fetal growth retardation (FGR), the control group – 19 clinically healthy women with uncomplicated pregnancy. An examination was performed, which included the analysis of clinical characteristics and the study of microRNA expression in blood plasma using the real-time polymerase chain reaction.Results. MicroRNA hsa-miR-210-5p and hsa-miR-1972 were not identified in any plasma sample. Analyzing plasma microRNAs in group of women with PE showed significant changes in the expression levels of hsa-miR-517a-3p (p = 0.025), hsa-miR-517c-3p (p = 0.036), hsa-miR-574-5p (p = 0.015), hsa-miR-517a-3p (p < 0.001) and an increase in miR-20a-5p (p = 0.046) compared to control group. No significant differences were found in the miRNA expression profile in group of women with FGR compared to control group. Assessing an influence of the studied microRNAs on regulatory signaling pathways allowed to establish that hsa-miR-miR-146a-5p, -181a-5p, -210-3p, -517a-3p, -517c-3p, -574-3p, -574-5p, -1304-5p are potential regulators of the reaction cascades involved in the PE pathogenesis.Conclusion. The changes revealed in the circulating blood plasma miRNA level indicate the presence of specific transcriptomic alterations during complicated course of pregnancy.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"72 s302","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72385914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing an ovarian reserve and risk factors for premature ovarian failure as part of pre-abortion counseling for women under 40 planning to terminate own first pregnancy","authors":"L. Tkachenko, I. A. Gritsenko, K. Tikhaeva, N. I. Sviridova, I. S. Gavrilova, V. A. Dolgova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.369","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.369","url":null,"abstract":"Introduction. The problem of artificial pregnancy termination is of global importance. Any woman faced with the problem of reproductive choice is vulnerable, needs both to be advised by an obstetrician-gynecologist and high-quality psychological support. At the stage of pre-abortion counseling, it seems possible to influence a decision to keep pregnancy by identifying risk factors for premature ovarian failure (РОF), laboratory and ultrasound criteria for reducing ovarian reserve (OR).Aim: optimization of the pre-abortion counseling algorithm by introducing an assessment of OR. Materials and Methods. A retrospective study was conducted, which included 58 women under 40 living in the Volgograd region and planning to terminate own first pregnancy. In order to identify factors of early decrease in OR, anamnestic data of patients were evaluated. A comprehensive assessment of the main OR parameters was performed by assessing blood serum level of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH) and inhibin B, ultrasound counting the number of antral follicles.Results. In the main group of patients, 8 (13.8 %) of the examined patients had a birth weight of about 2800 g, 6 (10.3 %) – with a history of ovarian surgery and ovarian cysts were found after menarche. A relationship was also found between OR laboratory parameters in primigravida and the age of menopause in paired mothers: 2 (3.4 %) – 45 years, 8 (13.8 %) – 48–50 years. According to the diagnostic results, 10 (17.2%) patients showed a decrease in ОR and 48 (82.8%) patients had a normal OR. Taking into account the data obtained, a modified project of pre-abortion counseling was developed for the first time devoted to РОF.Conclusion. The modified section of pre-abortion counseling takes into account the specifics of maternal OR and can improve quality of medical care for women planning to terminate own pregnancy due to more comprehensive information as well as affect the awareness of reproductive plans in the future.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82812149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal period affecting neuropsychic state of children in Arctic zone","authors":"N. L. Solovevskaya, N. K. Belisheva, S. Pryanichnikov","doi":"10.17749/2313-7347/ob.gyn.rep.2023.365","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.365","url":null,"abstract":"Aim: to identify potential causes accounting for development or predisposition to congenital neuropsychiatric disorders (NPD) in childhood and assessing an opportunity for conducting preventive interventions to lower a risk of childbirth coupled to congenital malformations.Materials and Methods. The pediatric medical records with NPD and psychomotor retardation were analyzed: data on the pattern of pregnancy and maternal delivery-related complications as well as delivery-associated complications and fetal developmental abnormalities, the maternal morbidity pattern before and during pregnancy; data on paternal health state as well as available social information about parents were also assessed.Results. It was revealed that potential causes for delivery of children with NPD and subsequent development of psychomotor retardation were due to complications during pregnancy such as infections of pregnant women, gestosis, anemia; among maternal complications in childbirth of special attention were long anhydrous period as well as surgical interventions.Conclusion. The course of pregnancy and childbirth as well as emerging neonatal pathology may be also influenced by the climatic and meteorological conditions of the Arctic zone causing Arctic hypoxia. Significant correlations between solar wind parameters and morbidity of pregnant women may indicate a need for more extensive studies regarding effects of geocosmic factors on course of pregnancy, childbirth and fetal gestation.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85435936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alexander D. Makatsariya is 2022 Best Author","authors":"A. Editorial","doi":"10.17749/2313-7347/ob.gyn.rep.2023.390","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.390","url":null,"abstract":"In 2022, A.D. Makatsariya, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, wasrecognized as the Best Author of the Sechenov University. The diploma and the award were solemnly presented by P.V. Glybochko,Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Rector of the Sechenov University.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79084662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen reproductive potential","authors":"A. A. Tagirova, A. Subkhankulova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.267","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.267","url":null,"abstract":"Reproductive behavior is a complex related to a system of actions and attitudes taken by a man and a woman regarding the process of conception, bearing and giving birth to children, including planning practices, as well as methods of control. Currently, there is a downward trend in the birth rate, with the percentage of infertile couples being increased, despite the development of reproductive medicine and demographic policy. National programs are aimed at increasing the spread of family planning methods and reducing the number of child marriages. In addition to deep behavioral changes predetermined by the historical, social, economic, cultural and moral situation of an individual and society as a whole, the changes in the birth rate are based on adaptive mechanisms during sexual selection. In particular, a substantial research has focused on identifying additional biomarkers of male fertility in seminal plasma. There have been proven to exist differences in their absolute and relative levels between fertile men and men classified as infertile, based on sperm parameters of the World Health Organization. Studies dating back to the 1920s suggested a multifaceted role for seminal fluid in the reproductive process. It has been established that the paternal biological contribution to pregnancy and related ability to influence the reproductive outcome goes beyond simple provision of male gametes at conception. A new paradigm is emerging detailing an importance of communication between father and mother during gestation as it is associated with maternal tolerance to fetal antigens and, ultimately, pregnancy success.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75678921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paul Morawitz","authors":"N. A. Makatsariya, I. S. Kalashnikova, F. E. Yakubova","doi":"10.17749/2313-7347/ob.gyn.rep.2023.380","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.380","url":null,"abstract":"Here, we describe the historical aspects of the life and scientific work of Paul Morawitz as well as his contribution to medicine.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135080123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stillbirth and fetal growth restriction","authors":"V. Volkov, M. Kastor","doi":"10.17749/2313-7347/ob.gyn.rep.2023.357","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.357","url":null,"abstract":"Aim: to estimate the rate of early-onset and late-onset fetal growth restriction (FGR) in stillbirth, identify features of placentaassociated complications and determine respective risk factors of stillbirth (especially at early gestational age).Materials and Methods. There were retrospectively studied 61 stillbirth cases in 2016–2019 that occurred in the III level obstetric hospitals: 32 early (23–31 weeks of gestation) and late (32–39 weeks) cases; 156 live births with 8–10 Apgar scores delivered at 36–41 weeks of gestation used as controls. Quantitative parameters were compared using the mean values and standard deviation; nominal parameters were analyzed using odds ratio (OR) and adjusted OR (aOR) with 95 % confidence interval (CI).Results. More than half of stillbirths are associated with FGR with almost 60 % of early-onset phenotype of this pathology. Both in stillbirths and live births, 2/3 of FGR have extremely low weight (OR = 1.8; 95 % CI = 0.6–6.9); 1/3 of growth restricted fetuses were detected shortly before delivery (OR = 1.3; 95 % CI = 0.7–2.4); 1/4 of pregnancies complicated by placental insufficiency are not associated with FGR (OR = 1.4; 95 % CI = 0.7–2.7). Risk factors of stillbirth in pregnancy complicated by FGR are the early-onset growth restriction phenotype (aOR = 3.2; 95 % CI = 1.0–10.3), maternal age over 28 years (aOR = 6.0; 95 % CI = 1.2–29.4), miscarriages and multiple induced abortions (aOR = 3.6; 95 % CI = 1.1–11.2), non-compliance in regular clinics visiting and correction of threatening conditions (aOR = 10.9; 95 % CI = 1.3–91.6), toxoplasma infection (aOR = 6.0; 95 % CI = 1.5–24.5). Early stillbirth with FGR is associated with an older mother's age (aOR = 5.8; 95 % CI = 1.0–34.4), greater parity (aOR = 3.3; 95 % CI = 1.0–10.4), uterine diseases including endometrial polyps, endometriosis, cervix cervicitis, cervix dysplasia (aOR = 4.0; 95 % CI = 0.9–17.2), diabetes mellitus (aOR = 3.1; 95 % CI = 0.8–13.2) and preeclampsia.Conclusion. The rate of early-onset FGR in stillbirth comprises almost 60 % that is twice higher than in live birth, with the rate of late-onset phenotype being less than 30 %. In late stillbirths the early-onset phenotype also prevails. There are no prominent features for stillbirths with FGR compared to previously known risk factors regardless of hypotrophy. Early vs. late stillbirth with FGR is more associated with gynecological pathologies as well as with diabetes mellitus and preeclampsia.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80385945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Course of pregnancy and childbirth in women with primary hypothyroidism","authors":"M. S. Medvedeva, A. Lyashenko, E. Lyashenko","doi":"10.17749/2313-7347/ob.gyn.rep.2023.366","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.366","url":null,"abstract":"Introduction. Primary hypothyroidism is observed in women of reproductive age in 2–3 % of cases. The most common thyroid pathology during pregnancy is subclinical hypothyroidism (SHT), which is caused by newly diagnosed autoimmune thyroiditis (AIT) or severe iodine deficiency. In some regions of the Russian Federation, the population has a mild iodine deficiency, the average concentration of iodine in the urine being found at 78 µg/L (the normal range is 100–200 µg/L). In women with primary hypothyroidism, complications of pregnancy and childbirth include: premature birth, weakness of labor, eclampsia, premature rupture of premature rupture of membranes (PROM), gestational diabetes mellitus (GDM), intrauterine growth retardation syndrome, fetal macrosomia, congenital hypothyroidism in the fetus, etc.Aim: to study the features of pregnancy and childbirth course in women with primary hypothyroidism.Materials and Methods. In a retrospective study, there were analyzed 62 birth histories, of which 37 were for patients with thyroid diseases. Two groups were formed: the main group – 25 patients with primary hypothyroidism, the comparison group – 25 patients without thyroid pathology. During the study, the next parameters were analyzed: age, number of pregnancies, number of births, term of delivery, body mass index, level of thyroid stimulating hormone (TSH), titer of thyroid peroxidase antibodies, newborn body weight, newborn assessment according to Apgar scale.Results. In the main group, the cause of primary hypothyroidism was as follows: newly diagnosed SHT – in 18 (48.6 %), AIT – in 7 (18.9 %) pregnant women. In the first trimester of pregnancy, TSH level in patients with hypothyroidism was 3.06 ± 0.36 mU/L. The following complications of pregnancy and childbirth course were identified: GDM (32.0 %), anemia of the first degree (12.0 %), large fetus (12.0 %), PROM (12.0 %), perineal rupture of the first degree (16.0 %), anomalies of labor activity with ineffective labor stimulation (8.0 %), pelvic-head disproportion (8.0 %).Conclusion. Timely diagnosis and compensation of hypothyroidism with hormone replacement therapy and iodine preparations, prediction of possible complications and correction of identified complications are the main ways to achieve a successful outcome of pregnancy and childbirth for mother and fetus.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91240575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An impact of neutrophil extracellular traps to the prothrombotic state and tumor progression in gynecological cancer patients","authors":"E. Slukhanchuk, V. Bitsadze, A. Solopova, J. Khizroeva, N. Degtyareva, D. V. Shcherbakov, J. Gris, I. Elalamy, A. Makatsariya","doi":"10.17749/2313-7347/ob.gyn.rep.2023.385","DOIUrl":"https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.385","url":null,"abstract":"Introduction. One of the leading causes in the mortality pattern of cancer patients is accounted for by thrombotic complications. Recent studies have shown that neutrophil extracellular traps (NETs) are involved in the activation of coagulation, contribute to the initiation and progression of thrombosis. In addition, NET-related effect on tumor progression and metastasis has been actively studied.Aim: to evaluate NET-related procoagulant activity in gynecological cancer patients.Materials and Methods. From April 2020 to October 2022, a prospective controlled interventional non-randomized study was conducted with 120 women. The main group included 87 patients aged 32 to 72 years with malignant neoplasms of the female genital organs and mammary glands who were hospitalized for elective surgical treatment or chemotherapy: uterine body cancer (subgroup 1; n = 18), ovarian cancer (subgroup 2; n = 26), cervical cancer – adenocarcinoma of the cervical canal (subgroup 3; n = 13), breast cancer (subgroup 4; n = 30). The control group consisted of 33 healthy women aged 32 to 68 years. In all women, plasma concentrations of citrullinated histone H3 (citH3), myeloperoxidase antigen (MPO:Ag), D-dimer, and thrombin–antithrombin (TAT) complexes were evaluated.Results. The magnitude of NETosis in cancer patients, assessed by level of citH3 (2.5 ± 0.7; 1.9 ± 0.8; 2.5 ± 0.7; 0.7 ± 0.5 ng/ml in four subgroups, respectively) and MPO:Ag (29.5 ± 13.1; 12.8 ± 3.7; 22.8 ± 8.7; 6.6 ± 2.5 ng/ml in four subgroups, respectively) was significantly higher compared to women in the control group (0.3 ± 0.1 ng/ml; p = 0.0001 and 2.5 ± 0.2 ng/ml; p = 0.0001). In parallel with increased NETosis markers in accordance with the disease stage, there was an increase in the concentration of hemostasis activation markers – D-dimer (1.7 ± 0.6; 2.0 ± 0.7; 1.4 ± 0.5; 1.5 ± 0.7 µg/ml in four subgroups, respectively) and TAT complexes (729.8 ± 43.9; 794.1 ± 164.8; 636.2 ± 149.5; 699.6 ± 165.7 pg/ml in four subgroups, respectively) exceeding their level in the control group (respectively, 0.4 ± 0.1 μg/ml; p = 0.0001 and 362.3 ± 0.1 pg/ml; p = 0.0001). The maximum values of parameters occurred at later stages according to the Classification of Malignant Tumours (tumor, nodus, metastasis, TNM). A significant correlation between TAT level and the concentrations of citH3 (r = 0.586; р = 0.04) and MPO:Ag was revealed (r = 0.631; р = 0.04).Conclusion. Tumor tissue creates milieu that stimulates NETs release, which, in turn, not only contribute to the creating a procoagulant state, but also might act as one of the factors that ensure tumor progression and metastasis. The development of targeted therapies acting on NETs has a potential to affect hemostasis in cancer patients and reduce rate of tumor growth and metastasis.","PeriodicalId":36521,"journal":{"name":"Obstetrics, Gynecology and Reproduction","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85190882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}