Journal of Translational Autoimmunity最新文献

{"title":"COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature","authors":"Laura Camacho-Domínguez ,&nbsp;Yhojan Rodríguez ,&nbsp;Fernando Polo ,&nbsp;Juan Carlos Restrepo Gutierrez ,&nbsp;Elizabeth Zapata ,&nbsp;Manuel Rojas ,&nbsp;Juan-Manuel Anaya","doi":"10.1016/j.jtauto.2022.100140","DOIUrl":"10.1016/j.jtauto.2022.100140","url":null,"abstract":"<div><p>Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 vaccination is presented. Clinical manifestations rapidly remitted after the instauration of immunomodulatory management. This case, together with a comprehensive review of the literature, illustrates the association between COVID-19 vaccines and the development of autoimmune conditions.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/2a/main.PMC8730708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-dsDNA antibodies in the classification criteria of systemic lupus erythematosus","authors":"Maria Infantino ,&nbsp;Eszter Nagy ,&nbsp;Nicola Bizzaro ,&nbsp;Katarzyna Fischer ,&nbsp;Xavier Bossuyt ,&nbsp;Jan Damoiseaux","doi":"10.1016/j.jtauto.2021.100139","DOIUrl":"10.1016/j.jtauto.2021.100139","url":null,"abstract":"<div><p>Anti-double stranded DNA (dsDNA) antibodies play an important role in the diagnosis, classification and management of systemic lupus erythematosus (SLE), an autoimmune disease characterized by heterogeneous clinical manifestations and a wide range of autoantibodies, which makes the diagnosis quite challenging. In the absence of diagnostic criteria, classification criteria have been used for many decades. The first classification criteria for SLE were formulated in 1971 by the American College of Rheumatology (ACR), followed by two revisions in 1982 and 1997. In order to improve their clinical performance and to reflect new knowledge on autoantibodies, new classification criteria for SLE were issued in 2012 by the Systemic Lupus International Collaborating Clinics (SLICC). These criteria proposed to classify only patients that have at least one immunologic criterion, overcoming SLE classification based solely on clinical manifestations. In 2019, the European League Against Rheumatism (EULAR)/ACR proposed new criteria that aimed to maintain the high specificity of the ACR criteria with a sensitivity close to the SLICC 2012 criteria. These 2019 criteria reinforced the importance of autoantibodies in SLE diagnosis, assigning the highest score (6 points) to anti-dsDNA antibodies in the fully weighted scoring of the disease. The current criteria require the use of an anti-dsDNA assay with at least 90% specificity, such as the <em>Crithidia luciliae</em> immunofluorescence test (CLIFT) or FARR assay. However, the criteria do not comment on all the tests currently widely used in clinical laboratories. Neither do they consider the technological evolutions, nor standardization issues. Since strict adherence to any of the classification criteria, including the serological items, could lead to possible misclassification of SLE and/or delayed diagnosis, test characteristics of the distinct immunoassays should be taken into consideration.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/f1/main.PMC8741517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases","authors":"Suni Lee, Shoko Yamamoto, Yurika Shimizu, Bandaru Srinivas, N. Sada, N. Kumagai-takei, Tatsuo Ito, Y. Nishimura, M. Kusaka, K. Urakami, T. Otsuki","doi":"10.1016/b978-0-12-822564-6.00014-8","DOIUrl":"https://doi.org/10.1016/b978-0-12-822564-6.00014-8","url":null,"abstract":"","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80183225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Th17 cell in tissue inflammation and organ-specific autoimmunity","authors":"Rajdeep Dalal, Srikanth Sadhu, A. Awasthi","doi":"10.1016/b978-0-12-822564-6.00005-7","DOIUrl":"https://doi.org/10.1016/b978-0-12-822564-6.00005-7","url":null,"abstract":"","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90503143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributors","authors":"R. Ahmad, H. Ahsan, Miguel Álvaro-Benito, L. M. Amezcua-Guerra, A. Awasthi, E. Brunetta, Matthew C. Cook, Claudio Costantini, S. Daadaa, Rajdeep Dalal, M. Elfishawi, S. Elfishawi, M. Folci, Ting Gan, M Zahid Hasan, Tatsuo Ito, E. A. James, Trine N. Jorgensen, M. Kechida, E. Keller, N. Kumagai-takei, Vijay Kumar, M. Kusaka, Suni Lee, A. Lin, M. Mora-Ramírez, Y. Nishimura, Takemi Otsuki, Neeva B. Patel, V. Pucino, G. Ramponi, N. Rezaei, N. Sada, Srikanth Sadhu, Yurika Shimizu, Bandaru Srinivas, K. Urakami, Adrian Zelada Valdés, Hui-Hui Xu, Shoko Yamamoto, Wei-Hua Yan, Niloufar Yazdanpanah, Xuguang Zhou","doi":"10.1016/b978-0-12-822564-6.09989-4","DOIUrl":"https://doi.org/10.1016/b978-0-12-822564-6.09989-4","url":null,"abstract":"","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80691115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibodies in Sjögren's syndrome and its classification criteria","authors":"Sharon Veenbergen ,&nbsp;Ana Kozmar ,&nbsp;Paul L.A. van Daele ,&nbsp;Marco W.J. Schreurs","doi":"10.1016/j.jtauto.2021.100138","DOIUrl":"10.1016/j.jtauto.2021.100138","url":null,"abstract":"<div><p>Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by immune-mediated injury of exocrine glands. Extensive lymphocytic infiltrates may contribute to the destruction and loss of secretory function of glands. B-cell hyperactivity is a key feature of the disease resulting in the production of a diverse array of autoantibodies in these patients. Although not specific for SS, anti-Ro/SSA and anti-La/SSB antibodies have been useful biomarkers for disease classification and diagnosis. During recent years, novel autoantibodies have been discovered in SS. In this review, we summarize the historical role and clinical relevance that autoantibodies have played in the classification criteria of Sjögren's syndrome, discuss laboratory aspects in antibody detection and review the role of novel autoantibodies in predicting particular stages of the disease, clinical phenotypes and long-term complications.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/d8/main.PMC8728464.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of autoimmune serology test results on RA classification and diagnosis","authors":"Lieve Van Hoovels ,&nbsp;Paul Studenic ,&nbsp;Daniela Sieghart ,&nbsp;Günter Steiner ,&nbsp;Xavier Bossuyt ,&nbsp;Johan Rönnelid","doi":"10.1016/j.jtauto.2022.100142","DOIUrl":"10.1016/j.jtauto.2022.100142","url":null,"abstract":"<div><p>Rheumatoid arthritis (RA) is the most common systemic autoimmune disease and also the most severe arthritic disorder. The measurement of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) in serum supports the diagnosis of RA, which gained increasing significance over the last 65 years. However, a high variability between RF and ACPA methods has been described, impacting the diagnostic performance of the current ACR/EULAR RA classification criteria.</p><p>The great number of commercially available assays, often lacking traceability to an international standard, is a major factor attributing to this in-between assay variability. The adoption of an international standard for ACPA, as is since long available for rheumatoid factor, is therefore highly desirable.</p><p>Further harmonization in clinical interpretation of RF/ACPA assays could be obtained by harmonization of the cut-offs, for both the low and high antibody levels, based on predefined specificity in disease controls. Reporting test result specific likelihood ratios (LR) adds value in the interpretation of autoantibody tests. However, a good understanding of the control population used to define antibody test result interval-associated LRs is crucial in defining the diagnostic performance characteristics of antibody serology.</p><p>Finally, specificity in RA classification can be improved by refining serological weight scoring taking into account the nature of the antibody, the antibody level and double RF + ACPA positivity.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/4f/main.PMC8749172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39827864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycophenolate mofetil as second line treatment in autoimmune hepatitis – A retrospective single center analysis","authors":"Mirjam Kolev ,&nbsp;Stefan Diem ,&nbsp;Lara Diem ,&nbsp;Susana G. Rodrigues ,&nbsp;Annalisa Berzigotti ,&nbsp;Guido Stirnimann ,&nbsp;Nasser Semmo","doi":"10.1016/j.jtauto.2022.100172","DOIUrl":"10.1016/j.jtauto.2022.100172","url":null,"abstract":"<div><h3>Background</h3><p>Most patients with autoimmune hepatitis respond to standard treatment with steroids and azathioprine. While the disease is usually fatal if untreated, patients who respond well to therapy have an excellent prognosis. Nevertheless, second-line treatment is necessary in approximately 20% of patients, due to either intolerance or insufficient response to first line treatment.</p><p>While data for mycophenolate mofetil (MMF) in patients intolerant to azathioprine is encouraging, MMF seems of less benefit in patients with insufficient response to first line treatment, but analyzed data on this issue is limited.</p></div><div><h3>Aim</h3><p>To evaluate the efficacy and safety of MMF as a second-line therapy in patients with AIH.</p></div><div><h3>Methods</h3><p>Retrospective analysis of a monocentric database of AIH patients who received medical care from 2000 to 2022. Clinical, immunological and biochemical parameters were assessed at different time points including last follow-up.</p></div><div><h3>Results</h3><p>Overall, 144 patients with AIH were identified. Fifty out of 144 (35%) AIH patients received MMF. Forty (80%) received MMF due to first line treatment intolerance, while ten (20%) due to insufficient response to first line treatment.</p><p>Remission with MMF monotherapy was 81.5% in the intolerance group versus 30% in the insufficient response group. Patients switched to MMF because of an insufficient response, more often needed additional prednisolone doses higher than 5 mg/day, a switch to third-line treatment or combination regiments, to achieve disease control.</p></div><div><h3>Conclusions</h3><p>Patients treated with MMF because of intolerance to first line treatment show a good disease control under MMF in the majority of cases. Efficacy is considerably lower in the patients switched to MMF because of an insufficient response to first line treatment.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune response to vimentin and granuloma formation in a model of pulmonary sarcoidosis","authors":"Harini Bagavant ,&nbsp;Katarzyna Cizio ,&nbsp;Antonina M. Araszkiewicz ,&nbsp;Joanna A. Papinska ,&nbsp;Lori Garman ,&nbsp;Chuang Li ,&nbsp;Nathan Pezant ,&nbsp;Wonder P. Drake ,&nbsp;Courtney G. Montgomery ,&nbsp;Umesh S. Deshmukh","doi":"10.1016/j.jtauto.2022.100153","DOIUrl":"10.1016/j.jtauto.2022.100153","url":null,"abstract":"<div><p>A characteristic feature of sarcoidosis is a dysregulated immune response to persistent stimuli, often leading to the formation of non-necrotizing granulomas in various organs. Although genetic susceptibility is an essential factor in disease development, the etiology of sarcoidosis is not fully understood. Specifically, whether autoimmunity contributes to the initiation or progression of the disease is uncertain. In this study, we investigated systemic autoimmunity to vimentin in sarcoidosis. IgG antibodies to human vimentin were measured in sera from sarcoidosis patients and healthy controls. Mice immunized with recombinant murine vimentin were challenged intravenously with vimentin-coated beads to mimic pulmonary sarcoidosis. Lungs from treated mice were studied for cellular infiltration, granuloma formation, and gene expression. Immune cells in the bronchoalveolar lavage fluid were evaluated by flow cytometry. Compared to healthy controls, sarcoidosis patients had a higher frequency and levels of circulating anti-vimentin IgG. Vimentin-immunized mice developed lung granulomas following intravenous challenge with vimentin-coated beads. These sarcoidosis-like granulomas showed the presence of Langhans and foreign body multinucleated giant cells, CD4 T cells, and a heterogeneous collection of MHC II positive and arginase 1-expressing macrophages. The lungs showed upregulated pro-inflammatory gene expression, including <em>Ifng</em>, <em>Il17,</em> and <em>Tnfa,</em> reflecting TH1/TH17 responses typical of sarcoidosis. In addition, genes in the TH2 canonical pathway were also upregulated, congruent with increased numbers of ILC2 in the bronchoalveolar lavage. Overall, these results further validate vimentin as an autoantigen in sarcoidosis and provide evidence for an anti-vimentin immune response in disease pathogenesis. Our study also highlights the possible role of ILC2-driven TH2-like responses in the formation of lung granulomas in sarcoidosis.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909022000144/pdfft?md5=3e24074abe356b20c4ab9548e02bf283&pid=1-s2.0-S2589909022000144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47510273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational development and application of biomarkers in the field of autoimmunity: A conceptual framework guiding clinicians and researchers","authors":"Mirjam Kolev ,&nbsp;Michael P. Horn ,&nbsp;Nasser Semmo ,&nbsp;Michael Nagler","doi":"10.1016/j.jtauto.2022.100151","DOIUrl":"10.1016/j.jtauto.2022.100151","url":null,"abstract":"<div><p>Clear guidance is needed in the development and implementation of laboratory biomarkers in medicine. So far, no standardized phased approach is established that would pilot researchers and clinicians in this process. This leads to often incompletely validated biomarkers, which can bear the consequence of wrong applications, misinterpretation and inadequate management in the clinical context.</p><p>In this conceptual article, we describe a stepwise approach to develop and comprehensively validate laboratory biomarkers. We will delineate basic steps including technical performance, pre-analytical issues, and biological variation, as well as advanced aspects of biomarker utility comprising interpretability, diagnostic and prognostic accuracy, and health-care outcomes. These aspects will be illustrated by using well-known examples from the field of immunology.</p><p>The application of this conceptual framework will guide researchers in conducting meaningful projects to develop and evaluate biomarkers for the use in clinical practice. Furthermore, clinicians will be able to adequately interpret pre-clinical and clinical diagnostic literature and rationally apply biomarkers in clinical practice. Improvement in the implementation and application of biomarkers might relevantly change the management and outcomes of our patients for the better.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40309435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}