中华放射医学与防护杂志最新文献

{"title":"A CXCL12/CXCR4 axis in regulation of tumor behaviors by ionizing radiation","authors":"Qing Gu, Jianfeng Ji","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.015","url":null,"abstract":"In addition to induce cell death in tumor cells, ionizing radiation (IR) regulates many biological behaviors of malignant tumors, such as intrinsic radiosensitivity, invasion and metastasis, angiogenesis, as well as immune response of tumor cells. The C-X-C motif chemokine ligand 12 (CXCL12) and its receptor CXCR4 are highly expressed in a variety of malignant tumors, and are involved in the process of remote metastasis, blood vessel formation, immune regulation, and therapeutic resistance of malignant tumors. Recent studies have found that the CXCL12/CXCR4 signal axis plays critical roles in the IR-regulated biological behavior of malignant tumors. This paper reviews the roles of CXCL12/CXCR4 signal axis in the biological behavior changes of irradiated malignant tumors. \u0000 \u0000 \u0000Key words: \u0000CXCL12; CXCR4; Metastasis; Radiosensitivity; Immune reaction","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"6 1","pages":"955-960"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87357154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of epigallocatechin-3-gallate on radiation-induced esophagitis of rabbit","authors":"Zhu Wanqi, Jia Li, Chen Guanxuan, Li Xiaolin, Xing Ligang, Zhao Han-xi, Y. Jinming","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.004","url":null,"abstract":"Objective \u0000To analyze the effect of epigallocatechin-3-gallate (EGCG) in radiation induced esophagitis of model rabbit. \u0000 \u0000 \u0000Methods \u0000Thirty male New Zealand rabbits were randomly divided into EGCG group, saline group, blank group. The rabbits in EGCG and saline groups were irradiated with 6 MV X-rays. The blank group did not receive radiation. After irradiation, rabbits were given with 440 μmol/L EGCG or saline three times a day in continuous 5 days. The scores of pathological changes of esophagus were observed by optical microscope.The serum levels of interleukine-1 beta (IL-1β), interleukine-6 (IL-6), transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α) were detected by enzyme linked immunosorbent assay. The expression levels of 67KD laminin receptor (67LR) was detected by immunohistochemistry. \u0000 \u0000 \u0000Results \u0000After treatment, the scores of pathological changes of esophagus in blank group, saline group, EGCG group were 0, 3.9±1.10 and 2.80±0.92, respectively. At different time points after drug treatment, the levels of serum inflammatory factors among three groups were significantly different (F=23.66-236.32, P<0.05). The expressions of 67LR in esophageal tissue of 3 groups were also significantly different (F=585.38, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000EGCG reduced radiation-induced esophagitis in rabbits by decreasing the levels of serum inflammatory factors, which may be related to the expression of 67LR protein. \u0000 \u0000 \u0000Key words: \u0000Radiation injury; Epigallocatechin-3-gallate; Protection","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"103 1","pages":"899-903"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79457371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXO4 D-retro-inverso peptide increases radiosensitivity of non-small cell lung cancer cells","authors":"Yu Zhao, Junling Zhang, Xiaodan Han","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.001","url":null,"abstract":"Objective \u0000To explore the effects of FOXO4 D-retro-inverso peptide (FOXO4-DRI) on the radiosensitivity of non-small cell lung cancer (NSCLC) cells. \u0000 \u0000 \u0000Methods \u0000To detect the effect of FOXO4-DRI on NSCLC cells, H460 and A549 human lung cancer cells were divided into four groups, including untreated control, FOXO4-DRI, γ-ray irradiation and FOXO4-DRI + γ-ray groups. A sigle dose rate of 0.99 Gy γ-rays was used for radiation. H460 cells were administered with 6 μmol/L FOXO4-DRI and A549 cells were adiminstered with 30 μmol/L FOXO4-DRI at 10 min before radiation. Cell viability and survival were detected by CCK-8 assay and colony formation assay, respectively. Cell migration was detected by wound healing assay. Apoptosis and cell cycle arrest were detected with flow cytometry. \u0000 \u0000 \u0000Results \u0000FOXO4-DRI inhibited growth of H460 and A549 cells (t=1.06-50.75, P<0.05), and decreased cell mobility (t=33.37-139.10, P<0.05) and colony formation (t=5.20-93.48, P<0.05). FOXO4-DRI also increased apoptosis (t=2.95-42.00, P<0.05) and caused a cell cycle arrest at G0/G1 phase accompanied with a decreased proportion of G2/M phase (t=3.50-31.59, P<0.05). Furthermore, FOXO4-DRI increased radiosensitivity of both H460 cells and A549 cells (t=2.94-23.40, P<0.05), caused a Further Decrease of radiation-mediated mobility (t=5.25, 7.56, P<0.05) and colony formation (t=8.43-34.00, P<0.05) and a more increase of radiation-induced apoptosis (t=9.20-11.52, P<0.05). FOXO4-DRI also further decreased the proportion of G2/M phase cells but increased the proportion of S phase cells (t=3.85-17.62, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000FOXO4-DRI increases radiosensitivity of NSCLC cells by inducing apoptosis and suppressing cell proliferation. \u0000 \u0000 \u0000Key words: \u0000Cell apoptosis; Radiosensitivity; FOXO4-DRI; Lung cancer; Cell proliferation","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"54 1","pages":"881-886"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73566121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric comparison of two radiotherapy treatment planning approaches for multiple brain metastases from non-small cell lung cancer on CyberKnife","authors":"Xuyao Yu, Z. Yuan, Feng-tong Li, Yang Dong, Yongchun Song, Xiaoguang Wang","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.009","url":null,"abstract":"Objective \u0000To compare the dosimetrics of the plan target volume (PTV) and organs at risk (OARs) between two treatment planning approaches for patients with multiple brain metastases from non-small cell lung cancer on CyberKnife. \u0000 \u0000 \u0000Methods \u000020 patients with multiple metastases from lung carcinoma were reviewed and analyzed, who had been treated by CyberKnife from December 2017 to December 2018. The CyberKnife stereotactic radiotherapy plans of the 20 cases were re-planed with single plan for multiple lesions and multiple plans per lesion. The dosimetry differences of PTV and OARs isodose disribution, conformity index (CI), total beam counts and total monitor units (MUs) were compared in the two types of plans. \u0000 \u0000 \u0000Results \u0000The two types of plans could satisfy over 95% PTV coverage of the prescription dose. The maximum and mean dose of normal brain adjacent to the PTV were reduced in multiple plan approach effectively. Moreover, the maximum and mean dose of OARs (brainstem) dropped by 1.62% and 5.57% (t=1.09, P<0.01) respectively. The number of treatment nodes and total MU declined by 4.63% (t=1.87, P<0.01)and 1.06% in multiple plan approach, which could significantly shorten the clinical treatment time. The differences in CI index between these two types of plans was of no statistical significance. \u0000 \u0000 \u0000Conclusions \u0000For patients with multiple brain metastases of similar diameter and volume from non-small cell lung cancer to be treated on CyberKnife, multiple plans per lesion could not only reduce dose to normal brain tissue and OARs, but also improve the treatment efficiency. \u0000 \u0000 \u0000Key words: \u0000CyberKnife; Multiple brain metastases; Treatment Plan; Dosimetry distribution; Brain injury","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"39 1","pages":"926-930"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91344793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and bioinformatic analysis of target genes of lncRNA LOC102606465 induced by ionizing radiation","authors":"Chang Yu, Qi Wang, Ruixue Liu, Jinfeng Huang, Zhi-dong Wang, Meijuan Zhou","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.001","url":null,"abstract":"Objective \u0000To screen the target genes of long non-coding RNA LOC102606465, which was previously identified to be induced by ionizing radiation, in order to examine its potential biological role. \u0000 \u0000 \u0000Methods \u0000The downstream differentially expressed genes (DEGs) of LOC102606465 were detected by microarray and partially verified by qRT-PCR. GO and KEGG enrichment analysis was performed, and PPI protein interaction network was constructed to screen significant modules and hub genes. \u0000 \u0000 \u0000Results \u0000The expression of LOC102606465 targeted by siRNA-447 and siRNA-541 was significantly lower than that of siRNA-NC (t=29.095, 13.751, P<0.01). A total of 374 common DEGs were identified(112 up-regulated/262 down-regulated) in both siRNA-447 and siRNA-541. The qRT-PCR was used to validate the expression of DEGs, which was consistent with the microarray result. In GO enrichment analysis, down-regulated DEGs were significantly enriched in \" oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor\" (molecular function), \" basal lamina\" (cellular component), \" ammonium ion metabolic process\" (biological process). Up-regulated DEGs were mainly enriched in \" protein phosphatase inhibitor activity\" (molecular function), \" SNARE complex\" (cellular component), \" negative regulation of fibrinolysis\" (biological process). In addition, the KEGG enrichment analysis revealed that DEGs were significantly enriched in \" metabolism of xenobiotics by cytochrome P450\" , \" dorso-ventral axis formation\" , \" lysosome glycerophospholipid metabolism\" and \" p53 signaling pathway\" . Based on the STRING database, the PPI network was constructed (including 194 nodes and 268 edges), and one significant module and five key hub genes ACTRT3, CDKN1A, DPYD, TMP4, and PRKACB were identified. \u0000 \u0000 \u0000Conclusions \u0000LOC102606465 could be a potential biomarker for the regulation of ionizing radiation sensitivity, and the down-regulation of LOC102606465 plays an important role in the response to radiation, which would be an important target for regulating radiation sensitivity. \u0000 \u0000 \u0000Key words: \u0000Bioinformatic analysis; Microarray; LOC102606465; Ionizing radiation","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"150 1","pages":"801-806"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75390873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of acute radiation injury of right finger caused by 192Ir external irradiation","authors":"侯雨含, Hou Yuhan, 刘玉龙, L. Yulong, 王优优, Wang Youyou, 卞华慧, Bian Huahui, 陈炜博, Chen Weibo, 戴宏, D. Hong, 冯骏超, Feng Junchao, 崔冉, Cui Ran, 王睿昊, Wang Ruihao, 杜云, Duhwan Yun, 王敏, W. Min, 姚振, Y. Zhen","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.010","url":null,"abstract":"Objective \u0000To explore the treatment technique, occurrence and development patterns of such radiation injuries as in a major radiological accident in which a victim suffered mild bone marrow radiation sickness combined grade degree Ⅲ acute radiation induced skin injury, based on his dose estimation, clinical manifestations and disease treatments. \u0000 \u0000 \u0000Methods \u0000History inquiry in detail, earlier physical dose estimation and biological dose estimation were conducted in conjunction with analyzing the chromosome aberration of peripheral blood lymphocytes. The physical dose was estimated by Monte Carlo method.The systematic laboratory and imaging examination was performed to evaluate the condition. The comprehensive analysis was conducted to determine the diagnosis and treatment plan. \u0000 \u0000 \u0000Results \u0000At 3d after the exposure, \"Ren\" felt mild pain and discomfortable on the skin of the right index finger. The body of the right hand index finger was covered with blister at 21 d after exposure.The estimation of biological dose was 0.43 Gy (95%CI: 0.31-0.58 Gy), and the physical dose was estimated to be 36-164 Gy for each part of the right hand finger. The hematopoietic system, immune system and endocrine system were normal. The liver function index value was transiently increased. The liver damage resulted from the use of antibiotic-induced combined with the patient′s past medical history and admission examination result, and the relevant antibiotics were discontinued. The liver function returned to normal after liver protection treatment. At 22 d after irradiation, a right finger incision and decompression surgery were performed. The stem cells were extracted and implanted into the right index finger. After 59 days of hospitalization, there was no obvious discomfort in the body, and the right index finger recovered well, as well as the pain significantly relieved, and the knuckle activity was basically normal. \u0000 \u0000 \u0000Conclusions \u0000The patient with excessive radiation and grade Ⅲ acute radiation skin injury was successfully treated, and local application of autologous adipose-derived stem cell transplantation achieved good result . \u0000 \u0000 \u0000Key words: \u0000192Ir; Acute radiation induced skin iniury; Excessive external exposure","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"20 1","pages":"852-858"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73966725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term efficacy and adverse events of intensity-modulated radiotherapy combined with chronomodulated chemotherapy for locally advanced nasopharyngeal carcinoma","authors":"Hang Jiang, F. Jin, Wei-li Wu, Yuanyuan Li, Jinhua Long, X. Gong, Xiaoxiao Chen, J. Gan, Zhuolin Li","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.003","url":null,"abstract":"Objective \u0000To compare the adverse events, immune status, and short-term efficacy between chronomodulated chemotherapy (CCR) and routine chemotherapy (RCR) combined with intensity modulated radiotherapy (IMRT)in the treatment of patients with locally advanced nasopharyngeal carcinoma. \u0000 \u0000 \u0000Methods \u0000A total of 159 patients with newly diagnosed locally advanced nasopharyngeal carcinoma were randomized into the CCR group and the RCR group to evaluate the short-term efficacy and adverse events. \u0000 \u0000 \u0000Results \u0000No significant difference was found in CR, PR, SD, and PD between the CCR group and the RCR group (P>0.05), and no significant difference was observed in the response rate (CR+ PR) between the two groups (P>0.05). The incidence of leukopenia(Z=-2.222, P<0.05), neutropenia(Z=-1.999, P<0.05), vomiting(Z=-2.298, P<0.05), and oral mucositis(Z=-3.571, P<0.05)of the CCR group was lower than those of the RCR group with statistical significance. The CD16+ 56+ lymphocyte cell count was higher in the CCR group than that in the RCR group(Z=-2.332, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000As a novel invention, CCR combined with IMRT can reduce the incidence and severity of treatment-related adverse events and improve immune status without diminishing clinical efficacy, therefore deserving clinical application. \u0000 \u0000 \u0000Key words: \u0000Nasopharyngeal carcinoma; Chronomodulated chemotherapy; Intensity-modulated radiotherapy; Adverse events; Short-term efficacy","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"212 1","pages":"813-819"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76155722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological effects of carbon ion radiation combined with chemotherapy","authors":"Xumeng Fang, L. Kong","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.014","url":null,"abstract":"Carbon-ion beam (CIB) is a high-linear energy transfer (LET) radiation. CIB is featured with more superior physical dose distribution (i.e., Bragg Peak) as compared to photon beam. In addition, it induces more double-bond break thus has higher relative biological effectiveness (RBE) as compared to photon beam. The combined use of chemotherapy and conventional photon radiotherapy has been widely used in the treatment of tumors. Chemotherapy is used concurrently with photonradiotherapy due to its radiosensitization. However, the radiosensitization effect of chemotherapy used with carbon-ion radiotherapy is controversial. In this article, we reviewed the previous studies of biological effects of the combination of carbon ion radiotherapy and chemotherapy in basic biological studies (including cytological and animal experiments) and clinical outcomes, and elaborated the biological effects. \u0000 \u0000 \u0000Key words: \u0000Heavy ion; Radiotherapy; Chemotherapy","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"91 1","pages":"874-879"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83655188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical follow-up of exposed victims after the \" 5.7\" accident of radioactive source in Nanjing","authors":"王福如, Wang Furu, 王进, Wang Jin, 余宁乐, Yu Ningle, 张乙眉, Zhang Yimei, 杨小勇, Y. Xiaoyong, 秦永春, Qin Yongchun, 陈维, Chen Wei","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.011","url":null,"abstract":"Objective \u0000To explore the long-term effects of radiation injury and to provide scientific basis for the evaluation of the effects of ionizing radiation injury by carrying out medical follow-up of patients involved in the \" 5.7\" radiative source accident in Nanjing in 2014. \u0000 \u0000 \u0000Methods \u0000Through interviewing and investigating, we inquired about the new disease history of the exposed patients from rehabilitation treatment to medical follow-up peroid. Physical and laboratory examinations were carried out. According to relevant standards, physiological and biochemical indexes such as hematopoietic system, immune system, endocrine system, ophthalmology, circulatory system, digestive system, urinary system and bone mineral density were systematically evaluated, with the long-term effects being evaluated. \u0000 \u0000 \u0000Results \u0000The patient′s vital signs were good without new diseases. The indexes of hematopoietic system, immune system and endocrine system tended to be normal, the circulatory system, digestive system and urinary system showed degenerative changes, the ophthalmic examination showed visual acuity continue to decline, and bone mineral density examination indicated low bone mass. \u0000 \u0000 \u0000Conclusions \u0000Physiological and biochemical indicators of the patients gradually returned to normal without obvious symptoms of radiation damage. Further medical follow-up observation still needs to continue. \u0000 \u0000 \u0000Key words: \u0000Radiation emergency; Acute radiation sickness; Radiation damage; Long-term effect; Medical follow-up","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"64 4 1","pages":"859-863"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88461827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lipiodol on dose distribution of carbon ion therapy after transcatheter arterial chemoembolization","authors":"You Dan, Jingfang Zhao, Weiwei Wang, Y. Sheng, Z. Wang, Zhijie Huang, Shahnazi Kambiz, J. Lu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.11.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.11.012","url":null,"abstract":"Objective \u0000To investigate the effect of lipiodol as embolization agents in liver, after transcatheter arterial chemoembolization, on dose calculation under the carbon ion treatment plan. \u0000 \u0000 \u0000Methods \u0000The actual relative linear stopping powers(RLSP)in pure lipiodol, pure gel and lipiodol-gel mixture, together with the correctd RLSPs from their CT images, were compared.In seven typical cases with lipiodol deposition area, carbon ion treatment plan was performed for the original lipiodol images.Successively on the basis of analysis that has made, the RLSP in lipiodol deposition area was corrected to be as in normal liver tissue, for which the carbon ion treatment plan was again performed.A comparison was made of differences in water equivalent depth (WED) and dose distribution on different CT images. \u0000 \u0000 \u0000Results \u0000The RLSP value corrected according to CT image HU value, lipiodol, and lipiodol-gel mixture may increase by 4.6%-139.0% compared with the measured value. In seven typical cases, deposited lipiodol can cause WED to increase by (0.89±0.41) cm along the field track and RBE by(3.83±1.71)Gy within the 1 cm of distal area of target. \u0000 \u0000 \u0000Conclusions \u0000In order to improve the accuracy of dose distribution calculation, the HU value and/or RLSP in deposited lipiodol area in liver after transcatheter arterial chemoembolization should being corrected to be as in the normal liver tissue. \u0000 \u0000 \u0000Key words: \u0000Transcatheter arterial chemoembolization; Lipiodol; Carbon-ion; Relative stopping power","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"116 1","pages":"864-869"},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81715659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}