CXCL12/CXCR4轴通过电离辐射调节肿瘤行为

Q4 Medicine

中华放射医学与防护杂志 Pub Date : 2019-12-25 DOI:10.3760/CMA.J.ISSN.0254-5098.2019.12.015

Qing Gu, Jianfeng Ji

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引用次数: 0

摘要

除了诱导肿瘤细胞死亡外，电离辐射还调节了恶性肿瘤的许多生物学行为，如肿瘤细胞的固有放射敏感性、侵袭转移、血管生成以及免疫反应等。C-X-C基序趋化因子配体12 (CXCL12)及其受体CXCR4在多种恶性肿瘤中高表达，参与恶性肿瘤的远端转移、血管形成、免疫调节、治疗耐药等过程。近年来研究发现，CXCL12/CXCR4信号轴在红外调控的恶性肿瘤生物学行为中起着至关重要的作用。本文就CXCL12/CXCR4信号轴在辐照恶性肿瘤生物学行为改变中的作用进行综述。关键词:CXCL12;趋化因子受体CXCR4;转移;辐射敏感度;免疫反应

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A CXCL12/CXCR4 axis in regulation of tumor behaviors by ionizing radiation

In addition to induce cell death in tumor cells, ionizing radiation (IR) regulates many biological behaviors of malignant tumors, such as intrinsic radiosensitivity, invasion and metastasis, angiogenesis, as well as immune response of tumor cells. The C-X-C motif chemokine ligand 12 (CXCL12) and its receptor CXCR4 are highly expressed in a variety of malignant tumors, and are involved in the process of remote metastasis, blood vessel formation, immune regulation, and therapeutic resistance of malignant tumors. Recent studies have found that the CXCL12/CXCR4 signal axis plays critical roles in the IR-regulated biological behavior of malignant tumors. This paper reviews the roles of CXCL12/CXCR4 signal axis in the biological behavior changes of irradiated malignant tumors. Key words: CXCL12; CXCR4; Metastasis; Radiosensitivity; Immune reaction

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来源期刊

中华放射医学与防护杂志 Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.60

自引率

0.00%

发文量

6377

期刊介绍：