Current Transplantation Reports最新文献

{"title":"Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature.","authors":"Vivek Kute, Hari Shankar Meshram, Vidya A Fleetwood, Sanshriti Chauhan, Krista L Lentine","doi":"10.1007/s40472-022-00362-5","DOIUrl":"10.1007/s40472-022-00362-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>As the coronavirus disease 2019 (COVID-19) pandemic continues to surge, determining the safety and timing of proceeding with solid organ transplantation (SOT) in transplant candidates who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and who are otherwise transplant eligible is an important concern. We reviewed the current status of protocols and the outcomes of SOT in SARS-CoV-2 recovered patients.</p><p><strong>Recent findings: </strong>We identified 44 published reports up through 7 September 2021, comprising 183 SOT [kidney = 115; lung = 27; liver = 36; heart = 3; simultaneous pancreas-kidney (SPK) = 1, small bowel = 1] transplants in SARS-CoV-2 recovered patients. The majority of these were living donor transplants. A positive SARS-CoV-2 antibody test, although not obligatory in most reports, was a useful tool to strengthen the decision to proceed with transplant. Two consecutive real-time polymerase chain test (RT-PCR) negative tests was one of the main prerequisites for transplant in many reports. However, some reports suggest that life-saving transplantation can proceed in select circumstances without waiting for a negative RT-PCR. In general, the standard immunosuppression regimen was not changed.</p><p><strong>Summary: </strong>In select cases, SOT in COVID-19 recovered patients appears successful in short-term follow-up. Emergency SOT can be performed with active SARS-CoV-2 infection in some cases. In general, continuing standard immunosuppression regimen may be reasonable, except in cases of inadvertent transplantation with active SARS-CoV-2. Available reports are predominantly in kidney transplant recipients, and more data for other organ transplants are needed.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"95-107"},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48812973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Alcohol-Associated Hepatitis in the COVID-19 Pandemic - a Structured Review.","authors":"Philipp Schulz,&nbsp;Rehma Shabbir,&nbsp;Sudha Ramakrishnan,&nbsp;Sumeet K Asrani","doi":"10.1007/s40472-022-00387-w","DOIUrl":"https://doi.org/10.1007/s40472-022-00387-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>The COVID-19 pandemic has been associated with a change in alcohol consumption, resulting in an increase in alcohol-related liver disease. In this study, we reviewed the literature on (acute) alcohol-associated hepatitis (AH) in the context of the COVID-19 pandemic.</p><p><strong>Methodology: </strong>PubMed, Ovid MEDLINE, Embase, Cochrane Library, and the pre-print servers medRxiv and bioRxiv were searched to retrieve 320 articles of which 15 abstracts, 7 full-text articles, 4 letters, 1 case report, and 1 poster were included for the final structured review.</p><p><strong>Recent findings: </strong>The pandemic resulted in an increase in healthcare utilization related to alcohol consumption. Admissions related to AH increased by 50% (range: 11-100%) during this time, which was disproportionally high in women, younger adults, African Americans, Hispanics, and patients living in rural areas. During this period, the number of new waiting list registrations and candidates with AH receiving liver transplantation (LT) simultaneously increased, which highlights the need for an approach to providing improvised healthcare services at the regional and individual levels.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":" ","pages":"227-239"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35253956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Vaccine Efficacy and Immunogenicity in End-Stage Renal Disease Patients and Kidney Transplant Recipients.","authors":"Nicolas F Moreno, Robert McAdams, John A Goss, N Thao N Galvan","doi":"10.1007/s40472-022-00366-1","DOIUrl":"10.1007/s40472-022-00366-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarize the current literature with respect to COVID-19 vaccine efficacy patients with end-stage renal disease on dialysis and kidney transplant recipients.</p><p><strong>Recent findings: </strong>Immunosuppressed patients are at greater risk of morbidity and mortality from COVID-19 infection. Patients with ESRD and KTR are immunosuppressed and mount a weaker antibody response to COVID-19 mRNA vaccination, and factors including immunosuppressant medications have been implicated for this weakened response. Third and fourth doses of vaccine doses have been shown to increase seropositivity and antibody production in kidney transplant recipients and patients on dialysis. Retrospective studies have demonstrated decreased mortality in vaccinated, immunosuppressed patients.</p><p><strong>Summary: </strong>ESRD and KTR patients have decreased antibody response to COVID-19 vaccines, but third and fourth doses have been shown to increase antibody production. Though a correlate of protection between antibody production and efficacy has yet to be fully established in this subset of the population, all US professional bodies who treat ESRD and KTR patients advocate for full vaccination against SARS-CoV-2 based on the data available. Studies demonstrating decreased mortality in vaccinated patients are promising on efficacy. Importantly, because KTR patients mount a weaker antibody response than ESRD patients, vaccination prior to kidney transplantation is critical.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"174-184"},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46696085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing the Costs of Routine Follow-up Care After Living Kidney Donation: a Review and Survey of Contemporary Experience, Practices, and Challenges.","authors":"Krista L Lentine,&nbsp;Nagaraju Sarabu,&nbsp;Gwen McNatt,&nbsp;Robert Howey,&nbsp;Rebecca Hays,&nbsp;Christie P Thomas,&nbsp;Ursula Lebron-Banks,&nbsp;Linda Ohler,&nbsp;Cody Wooley,&nbsp;Addie Wisniewski,&nbsp;Huiling Xiao,&nbsp;Andrea Tietjen","doi":"10.1007/s40472-022-00379-w","DOIUrl":"https://doi.org/10.1007/s40472-022-00379-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>While living organ donor follow-up is mandated for 2 years in the USA, formal guidance on recovering associated costs of follow-up care is lacking. In this review, we discuss current billing practices of transplant programs for living kidney donor follow-up, and propose future directions for managing follow-up costs and supporting cost neutrality in donor care.</p><p><strong>Recent findings: </strong>Living donors may incur costs and financial risks in the donation process, including travel, lost time from work, and dependent care. In addition, adherence to the Organ Procurement and Transplantation Network (OPTN) mandate for US transplant programs to submit 6-, 12-, and 24-month postdonation follow-up data to the national registry may incur out-of-pocket medical costs for donors. Notably, the Centers for Medicare and Medicaid Services (CMS) has explicitly disallowed transplant programs to bill routine, mandated follow-up costs to the organ acquisition cost center or to the recipient's Medicare insurance. We conducted a survey of transplant staff in the USA (distributed October 22, 2020-March 15, 2021), which identified that the mechanisms for recovering or covering the costs of mandated routine postdonation follow-up at responding programs commonly include billing recipients' private insurance (40%), while 41% bill recipients' Medicare insurance. Many programs reported utilizing institutional allowancing (up to 50%), and some programs billed the organ acquisition cost center (25%). A small percentage (11%) reported billing donors or donors' insurance.</p><p><strong>Summary: </strong>To maintain a high level of adherence to living donor follow-up without financially burdening donors, up-to-date resources are needed on handling routine donor follow-up costs in ways that are policy-compliant and effective for donors and programs. Development of a government-supported national living donor follow-up registry like the Living Donor Collective may provide solutions for aspects of postdonation follow-up, but requires transplant program commitment to register donors and donor candidates as well as donor engagement with follow-up outreach contacts after donation.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40472-022-00379-w.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":" ","pages":"328-335"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40391895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community Engagement to Improve Equity in Kidney Transplantation from the Ground Up: the Southeastern Kidney Transplant Coalition.","authors":"Rachel E Patzer,&nbsp;Samantha Retzloff,&nbsp;Jade Buford,&nbsp;Jennifer Gander,&nbsp;Teri Browne,&nbsp;Heather Jones,&nbsp;Matt Ellis,&nbsp;Kelley Canavan,&nbsp;Alexander Berlin,&nbsp;Laura Mulloy,&nbsp;Eric Gibney,&nbsp;Leighann Sauls,&nbsp;Dori Muench,&nbsp;Amber Reeves-Daniel,&nbsp;Carlos Zayas,&nbsp;Derek DuBay,&nbsp;Rich Mutell,&nbsp;Stephen O Pastan","doi":"10.1007/s40472-021-00346-x","DOIUrl":"https://doi.org/10.1007/s40472-021-00346-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to describe the Southeastern Kidney Transplant Coalition's mission, vision, goals, and Early Transplant Access registry as an example of a community/academic collaboration dedicated to improving access to transplantation and reducing inequities in transplant access.</p><p><strong>Recent findings: </strong>The barriers and facilitators to referral and evaluation for kidney transplantation are not necessarily the same as for waitlisting and transplantation. Recent findings suggest that inequities in transplant access are multilevel and multifactorial and require continued community engagement to improve access to kidney transplantation across patients, health systems, and populations.</p><p><strong>Summary: </strong>Community-engaged approaches are critical to ensuring that inequities in transplant access - which may vary across regions -- are not only described but are addressed in practice in a sustainable manner.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":" ","pages":"324-332"},"PeriodicalIF":2.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40348342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving Toward Continuous Organ Distribution","authors":"D. Stewart","doi":"10.1007/s40472-021-00352-z","DOIUrl":"https://doi.org/10.1007/s40472-021-00352-z","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"8 1","pages":"301 - 313"},"PeriodicalIF":2.1,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44099017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Transplant Program Performance Monitoring","authors":"Sharon Shepherd, R. Formica","doi":"10.1007/s40472-021-00344-z","DOIUrl":"https://doi.org/10.1007/s40472-021-00344-z","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"8 1","pages":"293 - 300"},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42860822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplantation for Chagas Heart Disease: a Comprehensive Review","authors":"F. Bacal, C. Murad, Carlos Aurélio dos Santos Aragão, I. W. de Campos, Luis Fernando Bernal da Costa Seguro, M. Avila, S. Mangini, F. Gaiotto, T. V. Strabelli, F. Marcondes-Braga","doi":"10.1007/s40472-021-00348-9","DOIUrl":"https://doi.org/10.1007/s40472-021-00348-9","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"8 1","pages":"344 - 350"},"PeriodicalIF":2.1,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41980776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support for Ex Vivo Organ Perfusion in Kidney and Liver Transplantation","authors":"A. Amin, Valeria Ripa, F. Paterno, J. Guarrera","doi":"10.1007/s40472-021-00347-w","DOIUrl":"https://doi.org/10.1007/s40472-021-00347-w","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"8 1","pages":"333 - 343"},"PeriodicalIF":2.1,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44336732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody-Mediated Rejection: the Role of Plasma Cells and Memory B Cells","authors":"S. S. Mujtahedi, Furkan Yiğitbilek, E. Ozdoğan, C. Schinstock, M. Stegall","doi":"10.1007/s40472-021-00342-1","DOIUrl":"https://doi.org/10.1007/s40472-021-00342-1","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"8 1","pages":"272 - 280"},"PeriodicalIF":2.1,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46421758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}