Current Transplantation Reports最新文献

{"title":"The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.","authors":"Brittany Koons,&nbsp;Michaela R Anderson,&nbsp;Patrick J Smith,&nbsp;John R Greenland,&nbsp;Jonathan P Singer","doi":"10.1007/s40472-022-00365-2","DOIUrl":"https://doi.org/10.1007/s40472-022-00365-2","url":null,"abstract":"<p><strong>Purpose: </strong>Older adults (age ≥ 65 years) are the fastest growing age group undergoing lung transplantation. Further, international consensus document for the selection of lung transplant candidates no longer suggest a fixed upper age limit. Although carefully selected older adults can derive great benefit, understanding which older adults will do well after transplant with improved survival and health-related qualiy of life is key to informed decision-making. Herein, we review the epidemiology of aging in lung transplantation and its impact on outcomes, highlight selected physiological measures that may be informative when evaluating and managing older lung transplant patients, and identify directions for future research.</p><p><strong>Recent findings: </strong>In general, listing and transplanting older, sicker patients has contributed to worse clinical outcomes and greater healthcare use. Emerging evidence suggest that measures of physiological age, such as frailty, body composition, and neurocognitive and psychosocial function, may better identify risk for poor transplant outcomes than chronlogical age.</p><p><strong>Summary: </strong>The evidence base to inform transplant decision-making and improvements in care for older adults is small but growing. Multipronged efforts at the intersection of aging and lung transplantation are needed to improve the clinical and patient centered outcomes for this large and growing cohort of patients. Future research should focus on identifying novel and ideally modifiable risk factors for poor outcomes specific to older adults, better approaches to measuring physiological aging (e.g., frailty, body composition, neurocognitive and psychosocial function), and the underlying mechanisms of physiological aging. Finally, interventions that can improve clinical and patient centered outcomes for older adults are needed.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 3","pages":"149-159"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632682/pdf/nihms-1806931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xenotransplantation: The Contribution of CRISPR/Cas9 Gene Editing Technology","authors":"Z. Stewart","doi":"10.1007/s40472-022-00380-3","DOIUrl":"https://doi.org/10.1007/s40472-022-00380-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"268 - 275"},"PeriodicalIF":2.1,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48563434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic Machine Perfusion in Renal Transplantation","authors":"William G. Norton, R. Pearson, Joanne Devlin, M. Nicholson, S. Hosgood","doi":"10.1007/s40472-022-00378-x","DOIUrl":"https://doi.org/10.1007/s40472-022-00378-x","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"308 - 317"},"PeriodicalIF":2.1,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48704176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Where Are We Now With Liver Transplant for Colorectal Metastasis?","authors":"M. Chávez-Villa, L. Ruffolo, K. Tomiyama, R. Hernandez‐Alejandro","doi":"10.1007/s40472-022-00381-2","DOIUrl":"https://doi.org/10.1007/s40472-022-00381-2","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"267 - 267"},"PeriodicalIF":2.1,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43934774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding Donor Heart Utilization Through Machine Perfusion Technologies","authors":"J. Villanueva, Y. Joshi, S. Emmanuel, L. Gao, P. Macdonald","doi":"10.1007/s40472-022-00375-0","DOIUrl":"https://doi.org/10.1007/s40472-022-00375-0","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"219 - 226"},"PeriodicalIF":2.1,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46652608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy","authors":"Carolin Hermanns, Omar Paulino da Silva Filho, Vijayganapathy Vaithilingam, A. V. van Apeldoorn","doi":"10.1007/s40472-022-00371-4","DOIUrl":"https://doi.org/10.1007/s40472-022-00371-4","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"199 - 208"},"PeriodicalIF":2.1,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46149163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where Are We Now With Liver Transplant for Colorectal Metastasis?","authors":"M. Chávez-Villa, L. Ruffolo, K. Tomiyama, R. Hernandez‐Alejandro","doi":"10.1007/s40472-022-00373-2","DOIUrl":"https://doi.org/10.1007/s40472-022-00373-2","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"257 - 266"},"PeriodicalIF":2.1,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48546412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piloting Uncontrolled DCD Organ Donation in the UK; Overview, Lessons and Future Steps","authors":"Diana A. Wu, G. Oniscu","doi":"10.1007/s40472-022-00374-1","DOIUrl":"https://doi.org/10.1007/s40472-022-00374-1","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"250 - 256"},"PeriodicalIF":2.1,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46261147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Fabrication: Progress and Hurdles to Overcome","authors":"E. Kobayashi","doi":"10.1007/s40472-022-00372-3","DOIUrl":"https://doi.org/10.1007/s40472-022-00372-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"297 - 301"},"PeriodicalIF":2.1,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43938863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Transportation Innovations and Future Trends","authors":"Samuel J. Gavzy, J. Scalea","doi":"10.1007/s40472-021-00341-2","DOIUrl":"https://doi.org/10.1007/s40472-021-00341-2","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"143-147"},"PeriodicalIF":2.1,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49104020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}