Irene K Kim, Paulo N. Martins, M. Pavlakis, N. Eneanya, R. Patzer
{"title":"Past and Present Policy Efforts in Achieving Racial Equity in Kidney Transplantation","authors":"Irene K Kim, Paulo N. Martins, M. Pavlakis, N. Eneanya, R. Patzer","doi":"10.1007/s40472-022-00369-y","DOIUrl":"https://doi.org/10.1007/s40472-022-00369-y","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"114 - 118"},"PeriodicalIF":2.1,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44422641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychosocial Evaluation for Lung Transplantation: an Empirically Informed Update","authors":"L. Christon, Patrick J. Smith","doi":"10.1007/s40472-022-00360-7","DOIUrl":"https://doi.org/10.1007/s40472-022-00360-7","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"76 - 94"},"PeriodicalIF":2.1,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47025500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Bioethical Issues in Geriatric Organ Transplantation","authors":"Mariam Fazal, E. Gordon, C. Humbyrd","doi":"10.1007/s40472-022-00364-3","DOIUrl":"https://doi.org/10.1007/s40472-022-00364-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"55 - 62"},"PeriodicalIF":2.1,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49308409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Removal of DSA from KP/Pancreas Allocation","authors":"Laura A. Rausch, S. Niederhaus, R. Forbes","doi":"10.1007/s40472-022-00356-3","DOIUrl":"https://doi.org/10.1007/s40472-022-00356-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"19 - 25"},"PeriodicalIF":2.1,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42360047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Behind the Curtain — the Do’s and Do Not’s of the OPTN and the Final Rule","authors":"Yolanda Becker","doi":"10.1007/s40472-022-00353-6","DOIUrl":"https://doi.org/10.1007/s40472-022-00353-6","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"1 - 4"},"PeriodicalIF":2.1,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49411112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COVID-19 and Solid Organ Transplantation: Role of Anti-SARS-CoV-2 Monoclonal Antibodies.","authors":"Abhay Dhand, Raymund R Razonable","doi":"10.1007/s40472-022-00357-2","DOIUrl":"10.1007/s40472-022-00357-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Solid organ transplant recipients (SOTRs) are ideal candidates for early treatment or prevention of coronavirus disease 2019 (COVID-19) using anti-SARS-CoV-2 monoclonal antibodies because of multiple underlying medical conditions, chronic immune-suppression, sub-optimal immunogenic response to vaccination, and evolving epidemiological risks. In this article, we review pertinent challenges regarding the management of COVID-19 in SOTRs, describe the role of active and passive immunity in the treatment and prevention of COVID-19, and review real-world data regarding the use of anti-SARS-CoV-2 monoclonal antibodies in SOTRs.</p><p><strong>Recent findings: </strong>The use of an anti-SARS-CoV-2 monoclonal antibody in high-risk solid organ transplant recipients is associated with a reduction in the risk of hospitalization, need for intensive care, and death related to COVID-19. Overall, the early experiences from a diverse population of solid organ transplant recipients who were treated with anti-spike monoclonal antibodies are encouraging with no reported acute graft injury, severe adverse events, or deaths related to COVID-19.</p><p><strong>Summary: </strong>Anti-SARS-CoV-2 antibodies are currently authorized for treatment of mild-moderate COVID-19 and post-exposure prophylaxis, including in SOTRs. Potential future uses include pre-exposure prophylaxis in certain high-risk persons and synergistic use along with emerging oral treatment options. Successful timely administration of anti-SARS-CoV-2 monoclonal antibodies requires a multidisciplinary team approach, effective communication between patients and providers, awareness of circulating viral variants, acknowledgement of various biases affecting treatment, and close monitoring for efficacy and tolerability.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"26-34"},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SARS-CoV-2 Vaccines: Safety and Immunogenicity in Solid Organ Transplant Recipients and Strategies for Improving Vaccine Responses.","authors":"Ayelet Grupper, Helena Katchman","doi":"10.1007/s40472-022-00359-0","DOIUrl":"https://doi.org/10.1007/s40472-022-00359-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>While solid organ transplant (SOT) recipients are at the highest risk for severe complications and increased mortality from COVID19 disease, their vaccination against SARS-CoV-2 remains challenging due to fear of immune-mediated adverse events and suboptimal immune response. Our current review is aimed to summarize current knowledge about the safety and efficacy of SARS-CoV-2 vaccines, describe factors that are correlated with immune response, and discuss strategies to improve vaccine immunogenicity in SOT recipients.</p><p><strong>Recent findings: </strong>SARS-CoV-2 vaccines are safe in SOT recipients and not related to rejection or other major adverse events. The immune response to two doses of vaccine is suboptimal and correlated to age and magnitude of immunosuppression. Administration of a third vaccine dose brings to significant amplification of immune response.</p><p><strong>Summary: </strong>This review strengthens the existing recommendation of vaccination by three doses of vaccine in all SOT recipients and completion of vaccination before transplantation if possible.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"35-47"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39872575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}