Current Transplantation Reports最新文献

{"title":"Digital Slide and Simulation-Based Learning in Pre-Implantation Kidney Biopsies","authors":"A. Eccher, P. Antonini, A. Barreca, B. Fabbrizio, U. Boggi, Paola Chiara Rizzo, Ilaria Girolami","doi":"10.1007/s40472-023-00392-7","DOIUrl":"https://doi.org/10.1007/s40472-023-00392-7","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"40 - 50"},"PeriodicalIF":2.1,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47304033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium in Liver Transplantation","authors":"J. Ruck, E. King, Nadia M. Chu, D. Segev, M. McAdams‐DeMarco","doi":"10.1007/s40472-023-00391-8","DOIUrl":"https://doi.org/10.1007/s40472-023-00391-8","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"83-88"},"PeriodicalIF":2.1,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43716166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Frailty into the Kidney Transplant Evaluation","authors":"Valerie L. Thompson, D. Segev, M. McAdams‐DeMarco","doi":"10.1007/s40472-023-00389-2","DOIUrl":"https://doi.org/10.1007/s40472-023-00389-2","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"12-20"},"PeriodicalIF":2.1,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47462295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothermic Machine Perfusion of Extended Donor Criteria Renal Allografts Before Kidney Transplantation: a Systematic Review","authors":"M. Moein, Joseph F. Toth, Jonathan Capelin, R. Saidi","doi":"10.1007/s40472-023-00388-3","DOIUrl":"https://doi.org/10.1007/s40472-023-00388-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43130677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Dysfunction in Liver Disease and Its Implications for Transplant Candidates","authors":"J. Ruck, E. King, Nadia M. Chu, D. Segev, M. McAdams‐DeMarco","doi":"10.1007/s40472-023-00390-9","DOIUrl":"https://doi.org/10.1007/s40472-023-00390-9","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"21-27"},"PeriodicalIF":2.1,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46130209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehabilitation in Adult Solid Organ Transplant Candidates.","authors":"Evelien E Quint,&nbsp;Manoela Ferreira,&nbsp;Barbara C van Munster,&nbsp;Gertrude Nieuwenhuijs-Moeke,&nbsp;Charlotte Te Velde-Keyzer,&nbsp;Stephan J L Bakker,&nbsp;Coby Annema,&nbsp;Sunita Mathur,&nbsp;Robert A Pol","doi":"10.1007/s40472-023-00395-4","DOIUrl":"https://doi.org/10.1007/s40472-023-00395-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>To highlight the importance of biological age in the context of prehabilitation and to present relevant research regarding prehabilitation prior to solid organ transplantation.</p><p><strong>Recent findings: </strong>Studies on the effect of prehabilitation have been performed in kidney-, lung-, liver-, and heart transplant patient populations. Prior to kidney transplantation, exercise interventions have been shown to improve cardiopulmonary- and physical fitness and result in a decreased length of hospital stay postoperatively. Among lung transplant candidates, various methods of prehabilitation have been studied including home-based, outpatient and in-patient programs, consisting of physical training, psychological support, education, and nutritional interventions. Overall, prehabilitation seems to improve or maintain quality of life and exercise capacity in this patient population. Patients undergoing liver transplantation seem to benefit from prehabilitation as well. Not only does it seem safe and feasible, but significant improvements in aerobic and functional capacity have also been found. Regarding heart transplant candidates, both inpatient and outpatient, supervised prehabilitation programs show promising results with improvements in exercise capacities and quality of life.</p><p><strong>Summary: </strong>Prehabilitation is an effective and safe intervention for improving functional outcomes of solid organ transplant patients. Future studies should evaluate whether prehabilitation translates into improved pre- and post-transplant clinical outcomes.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 2","pages":"70-82"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engraftment of Kidney Organoids In Vivo.","authors":"Benjamin S Freedman, Benjamin Dekel","doi":"10.1007/s40472-023-00397-2","DOIUrl":"10.1007/s40472-023-00397-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Kidney organoids are heterocellular structures grown in vitro that resemble nephrons. Organoids contain diverse cell types, including podocytes, proximal tubules, and distal tubules in contiguous segments, patterned along a proximal-to-distal axis. Human organoids are being explored for their potential as regenerative grafts, as an alternative to allograft transplants and hemodialysis. Earlier work, analyzing grafts of developing human kidney tissue and whole human embryonic kidney rudiments, serves as a baseline for organoid implantation experiments.</p><p><strong>Recent findings: </strong>When transplanted into immunodeficient mice beneath the kidney capsule, kidney organoid xenografts can form vascularized, glomerulus-like structures, which exhibit a degree of filtration function. However, the absence of an appropriate collecting duct outlet and the presence of abundant stromal-like cells limits the functionality of such grafts and raises safety concerns. Recently, ureteric-like organoids have also been generated, which extend projections that resemble collecting ducts.</p><p><strong>Summary: </strong>Combining nephron-like and ureteric-like organoids, along with renal stromal cells, may provide a path towards more functional grafts.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 2","pages":"29-39"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right vs Left Hepatectomy for LDLT, Safety and Regional Preference","authors":"P. Vargas, N. Goldaracena","doi":"10.1007/s40472-022-00386-x","DOIUrl":"https://doi.org/10.1007/s40472-022-00386-x","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"240 - 249"},"PeriodicalIF":2.1,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43945415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic Technology for Evaluating and Preserving Islet Function for Islet Transplant in Type 1 Diabetes","authors":"Y. Xing, Love Li, Xiaoyu Yu, E. Fox, Yong Wang, J. Oberholzer","doi":"10.1007/s40472-022-00377-y","DOIUrl":"https://doi.org/10.1007/s40472-022-00377-y","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 1","pages":"287 - 296"},"PeriodicalIF":2.1,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41439563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.","authors":"Brittany Koons,&nbsp;Michaela R Anderson,&nbsp;Patrick J Smith,&nbsp;John R Greenland,&nbsp;Jonathan P Singer","doi":"10.1007/s40472-022-00365-2","DOIUrl":"https://doi.org/10.1007/s40472-022-00365-2","url":null,"abstract":"<p><strong>Purpose: </strong>Older adults (age ≥ 65 years) are the fastest growing age group undergoing lung transplantation. Further, international consensus document for the selection of lung transplant candidates no longer suggest a fixed upper age limit. Although carefully selected older adults can derive great benefit, understanding which older adults will do well after transplant with improved survival and health-related qualiy of life is key to informed decision-making. Herein, we review the epidemiology of aging in lung transplantation and its impact on outcomes, highlight selected physiological measures that may be informative when evaluating and managing older lung transplant patients, and identify directions for future research.</p><p><strong>Recent findings: </strong>In general, listing and transplanting older, sicker patients has contributed to worse clinical outcomes and greater healthcare use. Emerging evidence suggest that measures of physiological age, such as frailty, body composition, and neurocognitive and psychosocial function, may better identify risk for poor transplant outcomes than chronlogical age.</p><p><strong>Summary: </strong>The evidence base to inform transplant decision-making and improvements in care for older adults is small but growing. Multipronged efforts at the intersection of aging and lung transplantation are needed to improve the clinical and patient centered outcomes for this large and growing cohort of patients. Future research should focus on identifying novel and ideally modifiable risk factors for poor outcomes specific to older adults, better approaches to measuring physiological aging (e.g., frailty, body composition, neurocognitive and psychosocial function), and the underlying mechanisms of physiological aging. Finally, interventions that can improve clinical and patient centered outcomes for older adults are needed.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"9 3","pages":"149-159"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632682/pdf/nihms-1806931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}