Liaquat National Journal of Cancer Care最新文献_第2页

The Significance of Androgen Receptor in Oncogenesis and Cancer Treatment: Emphasis on Oral Squamous Cell Carcinoma 雄激素受体在肿瘤发生和肿瘤治疗中的意义:以口腔鳞状细胞癌为例

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.3.2

引用次数: 0

Duodenal Adenocarcinoma – A Rare Encounter and Management in a Young Male 十二指肠腺癌——一例罕见的年轻男性病例及治疗

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.8

{"title":"Duodenal Adenocarcinoma – A Rare Encounter and Management in a Young Male","authors":"","doi":"10.37184/lnjcc.2789-0112.4.8","DOIUrl":"https://doi.org/10.37184/lnjcc.2789-0112.4.8","url":null,"abstract":"Duodenal Adenocarcinoma (DA) is a rarely encountered tumor. It usually resides in the elderly, diagnosed at an average age of 60 years. The malignancy has a poor outcome with 5-year survival at 30%. DA along with peritoneal dissemination in a subset of the younger population has not been well reported in the literature review so we intend to report this case. \u0000\u0000We report a case of a patient with Duodenal Adenocarcinoma (DA). The carcinoma was diagnosed in the third segment of the duodenum with associated peritoneal carcinomatosis. The patient presented with abdominal pain, nausea, weight loss, and other symptoms with a history of cholecystectomy for his prior abdominal complaints. A large obstructive ulcerated mass in the third segment of the duodenum (D3) confirmed the presence of a DA. A palliative gastrojejunostomy was performed with a subsequent Whipple procedure ahead concomitantly with hyperthermic intraperitoneal chemotherapy (HIPEC). \u0000\u0000After surgery, the patient presented with post-operative complications including pelvic and abdominal ascites with perforation of the sigmoid colon. On subsequent follow-ups, he did well but with a recurrence in the form of lung nodules a year after the Whipple’s procedure. \u0000 \u0000DA is one of the rarest malignancies ever encountered and is significantly scarce in the younger subset. The key to a successful outcome involves an aggressive approach with an early diagnosis. Lymph node assessment has been pivotal as an important prognostic factor. No positive correlation has been established between adjuvant chemotherapy and survival rates. Peritoneal dissemination from DA appears to be sparse. HIPEC, although a reasonable therapeutic strategy for disseminated peritoneal carcinomatosis, resulted in sigmoid perforation.","PeriodicalId":363682,"journal":{"name":"Liaquat National Journal of Cancer Care","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122481599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Finding of Bladder Carcinoma during Stone Removal: A Rare Correlation and Upcoming Physician Challenge 在结石移除术中偶然发现膀胱癌:罕见的相关性和即将到来的医师挑战

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.10

{"title":"Incidental Finding of Bladder Carcinoma during Stone Removal: A Rare Correlation and Upcoming Physician Challenge","authors":"","doi":"10.37184/lnjcc.2789-0112.4.10","DOIUrl":"https://doi.org/10.37184/lnjcc.2789-0112.4.10","url":null,"abstract":"Vesical calculi and bladder carcinomas have rarely been correlated and addressed in the literature. Recent publications have noted an association between the two as an upcoming physician challenge. Vesical calculi are now categorized as an etiological factor in bladder carcinogenesis. Chronic bladder stones appear to play a pivotal role in the disruption of the bladder mucosal epithelium. Bladder carcinomas' findings tend to be incidental during stone removal; multiple large-scale studies are needed to identify dysplastic changes at an earlier stage. \u0000\u0000Screening biopsies and cystoscopies aid in the preliminary diagnosis of bladder tumors. Despite vesical calculi comprising 5% of the cases of urinary tract stones, no effective rationale has been developed to prevent this lethal complication of prolonged stone disease. The size and weight of calculi have been identified as determinants of neoplastic changes. Urinary tract infections have been strongly correlated with the concomitant occurrence of bladder stones. Repeated UTIs may warrant the need to diagnose the presence of calculus and initiate therapeutic intervention. Active surveillance will likely be beneficial for patients with a chronic history of frequent UTIs and bladder stone disease.","PeriodicalId":363682,"journal":{"name":"Liaquat National Journal of Cancer Care","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116850035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contemporary Literature Review of Clinical Characteristics and Management of Merkel Cell Carcinoma 梅克尔细胞癌临床特点及治疗的当代文献综述

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.12

引用次数: 0

Spontaneous Tumor Lysis Syndrome in a Patient with Mantle Zone Cell Lymphoma 套带细胞淋巴瘤患者的自发性肿瘤溶解综合征

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.6

引用次数: 0

Areca Nut and its Products: A Culprit for Many Cancers 槟榔果及其制品:许多癌症的罪魁祸首

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.3.1

Altaf Khan Pathan, Aftab Hussain Pathan, G. Phull, Mehtab Hussain Pathan

{"title":"Areca Nut and its Products: A Culprit for Many Cancers","authors":"Altaf Khan Pathan, Aftab Hussain Pathan, G. Phull, Mehtab Hussain Pathan","doi":"10.37184/lnjcc.2789-0112.3.1","DOIUrl":"https://doi.org/10.37184/lnjcc.2789-0112.3.1","url":null,"abstract":"This article is to give a comprehensive review about the areca nut, different products made from it, and the important cancers associated with the use of different products of areca nut. Areca nut is a chewing substance consumed by a large population around the globe including our country Pakistan. Areca nut is a constituent of many products like supari, pan, gutkha and mawa, which are frequently used in Pakistan especially in urban areas. Areca nut is very dangerous for human health as it is associated with a large number of benign and malignant diseases. Different products of the areca nut are associated with very common cancers like mouth cancer, cancer of oesophagus, salivary gland cancer, hepatocellular cancer and different other head and neck cancer. To answer the research question “Areca nut and its products: A Culprit for many cancers” the literature review was done using Pubmed, google scholar and Medline using keywords “areca nut, paan, gutkha and cancers” and relevant articles from the year 2000 to the year 2020 were searched and relevant articles were selected in this review. The cancers of the oral cavity, oesophagus and liver develop in habitual chewers of areca nut due to the presence of some dangerous chemicals present in areca nut like arecoline which is an alkaloid. Arecoline and some other alkaloids cause cancer of the human body by inhibiting the tumor suppressor gene. Areca nut and its products should be strictly banned in Pakistan to decrease the burden of these cancers.","PeriodicalId":363682,"journal":{"name":"Liaquat National Journal of Cancer Care","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127789171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ways of Managing Palliative Care Needs of Adult Cancer Patients at Home in the Context of Pakistan: A Qualitative Approach 在巴基斯坦的背景下管理成年癌症患者在家的姑息治疗需求的方法:定性方法

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.3.10

引用次数: 0

Ileocolic Anastomotic Site Recurrence 回肠结肠吻合口复发

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.3.4

引用次数: 0

The Pivotal Role of Anti-Hypertensives in the Pre-operative Management of Pheochromocytoma 抗高血压在嗜铬细胞瘤术前治疗中的关键作用

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.7

引用次数: 0

Influence of Prognostic Group Classification of Advanced Male Germ Cell Tumor on Treatment Outcomes 晚期男性生殖细胞瘤预后分组分类对治疗结果的影响

Liaquat National Journal of Cancer Care Pub Date : 1900-01-01 DOI: 10.37184/lnjcc.2789-0112.4.2

{"title":"Influence of Prognostic Group Classification of Advanced Male Germ Cell Tumor on Treatment Outcomes","authors":"","doi":"10.37184/lnjcc.2789-0112.4.2","DOIUrl":"https://doi.org/10.37184/lnjcc.2789-0112.4.2","url":null,"abstract":"Background: Male germ cell tumor is a rare disease, associated with high rates of cure, including in the advanced setting. This disease mostly affects young males aged 15-34 years. The rising incidence trends of germ cell tumors in the last two decades have defined a new priority area of oncology. \u0000\u0000Objective: To investigate the influence of prognostic group classification and histology on treatment outcomes in men treated in a single institution in Pakistan. \u0000\u0000Methods: We developed an observational study on fifty male patients diagnosed with advanced germ cell cancer completing first-line treatment, between 2011-2014. Patients with a follow-up time of at least 5 years post-treatment were included. Patients were classified into good, intermediate, and poor prognostic groups, according to the International Germ Cell Cancer Collaborative Group classification (IGCCCG). The outcomes of all three prognostic groups were measured including response to first-line treatment according to Memorial Sloan-Kettering Cancer Center criteria and five years OS. Survival rates were calculated using Kaplan and Meier method. The level of significance was set at P < 0.05.\u0000\u0000Results: Overall 50 patients were included in the study. The mean age of patients was 30.6 years + 9.49 years. The most common primary site of involvement was the right testicle i.e.56.0%. Complete responses (CR) were observed in 23 (46.0%) patients. The patients classified into the good prognostic group (n=29) had significantly superior (p=0.002) five years OS (86.2%, n= 25) than intermediate and poor groups. Additionally, CR was higher for seminoma-type cancer i.e. 12 (63.15%) while it was limited to 11(35.48%) in non-seminoma; however, the inferior response rate in NSGCT did not translate into statistical significance in 5 years OS.\u0000\u0000Conclusion: The IGCCCG prognostic grouping system is an effective tool for predicting treatment outcomes in terms of 5-year overall survival in our local population based in a low-middle income setting.","PeriodicalId":363682,"journal":{"name":"Liaquat National Journal of Cancer Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122041171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0