{"title":"Innovations and Emerging Therapies in Atopic Dermatitis Part 1.","authors":"Robyn Okereke, Eric Simpson","doi":"10.1007/s40521-025-00390-3","DOIUrl":"10.1007/s40521-025-00390-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to discuss the innovative aspects of present and newer therapies used for the treatment of AD, as well as to highlight the characteristics of emerging treatments. We also compare alternative systemic therapies. The novelties surrounding systemic therapies will be highlighted in this first review (part 1), while innovations in topical therapies will be discussed in a subsequent review (part 2).</p><p><strong>Recent findings: </strong>The treatment landscape of atopic dermatitis has been quickly evolving in recent history. The treatment framework of AD is shifting from broad suppression of the inflammatory response to targeted molecular therapy.</p><p><strong>Summary: </strong>Overall, this therapeutic shift does appear to correlate with a superior efficacy and safety profile, though we also highlight encountered shortcomings when assessing long-term and real-world data of systemic therapies. Despite significant recent advances, future studies are needed to optimize formulations and performance of systemic therapies for AD.</p>","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"12 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovations and Emerging Therapies in Atopic Dermatitis Part 2.","authors":"Robyn Okereke, Eric Simpson","doi":"10.1007/s40521-025-00389-w","DOIUrl":"10.1007/s40521-025-00389-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to discuss the novel aspects of topical therapies used for the treatment of AD. We also discuss the lapses observed when comparing topical therapies. After the innovations regarding systemic therapies in AD were highlighted in a first review (part 1), this second component (part 2) will perceive the advances in topical therapies for AD.</p><p><strong>Recent findings: </strong>Recent history has realized a prompt evolution in the options for topical therapy in AD. Novel, molecularly targeted topical therapies appear to address the drawbacks of traditional topical medicines.</p><p><strong>Summary: </strong>The transformation towards targeted AD therapies is associated with increased efficacy and safety profiles, as well as patient compliance. We also evaluate available real-world and long-term data. Future studies should focus on optimizing topical therapies by increasing the duration of available long-term data.</p>","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"12 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian Vigand Svendsen, Kristian F. Mose, C. Mortz
{"title":"Allergic Contact Dermatitis in Children: Clinical Management and Emerging Allergens","authors":"Sebastian Vigand Svendsen, Kristian F. Mose, C. Mortz","doi":"10.1007/s40521-023-00357-2","DOIUrl":"https://doi.org/10.1007/s40521-023-00357-2","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"77 14","pages":"1-15"},"PeriodicalIF":1.1,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Zubeldia-Varela, Andrea Macías-Camero, M. Pérez-Gordo
{"title":"From Bacteria to Host: Deciphering the Impact of Sphingolipid Metabolism on Food Allergic Reactions","authors":"E. Zubeldia-Varela, Andrea Macías-Camero, M. Pérez-Gordo","doi":"10.1007/s40521-023-00356-3","DOIUrl":"https://doi.org/10.1007/s40521-023-00356-3","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"33 2","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What is New in Alpha-Gal Syndrome?","authors":"Teresa Peralta, Gigia Roizen, Natalia Crisóstomo, Raquel Aguilera-Insunza","doi":"10.1007/s40521-023-00353-6","DOIUrl":"https://doi.org/10.1007/s40521-023-00353-6","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"5 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Quan, Sergio Sánchez-Fernández, Lucía Parrado Gil, Alfonso Calvo Alonso, José Miguel Bodero Sánchez, Ana Ortega Eslava, Marta Luri, Gabriel Gastaminza Lasarte
{"title":"Usefulness of Drug Allergy Alert Systems: Present and Future","authors":"P. Quan, Sergio Sánchez-Fernández, Lucía Parrado Gil, Alfonso Calvo Alonso, José Miguel Bodero Sánchez, Ana Ortega Eslava, Marta Luri, Gabriel Gastaminza Lasarte","doi":"10.1007/s40521-023-00351-8","DOIUrl":"https://doi.org/10.1007/s40521-023-00351-8","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"57 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139261694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cesar Fireth Pozo-Beltran, Barbara Elizondo-Villarreal, Fernando Morett-Vera, Victor Gonzalez-Uribe, Roxana Minerva Rodriguez-Romo, Elsy Maureen Navarrete-Rodriguez, Jorge Andres Paniagua-Santos, Jesus Fernando Ledezma-Ortega, Adriana Virginia Briceño-Gamboa
{"title":"Severe Asthma Patients: Can We Really Wean Them off of Oral Corticosteroids","authors":"Cesar Fireth Pozo-Beltran, Barbara Elizondo-Villarreal, Fernando Morett-Vera, Victor Gonzalez-Uribe, Roxana Minerva Rodriguez-Romo, Elsy Maureen Navarrete-Rodriguez, Jorge Andres Paniagua-Santos, Jesus Fernando Ledezma-Ortega, Adriana Virginia Briceño-Gamboa","doi":"10.1007/s40521-023-00340-x","DOIUrl":"https://doi.org/10.1007/s40521-023-00340-x","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136209281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina Gomez-Casado, Zsofia Unger, Peter Olah, Bernhard Homey
{"title":"Microbiome in Atopic Dermatitis: Is It All About Staphylococcus aureus?","authors":"Cristina Gomez-Casado, Zsofia Unger, Peter Olah, Bernhard Homey","doi":"10.1007/s40521-023-00350-9","DOIUrl":"https://doi.org/10.1007/s40521-023-00350-9","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Roots and Growth of Allergen Immunotherapy","authors":"Ira Finegold","doi":"10.1007/s40521-023-00348-3","DOIUrl":"https://doi.org/10.1007/s40521-023-00348-3","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}