{"title":"Triggers of Anaphylaxis in Mastocytosis Patients: Evidence of the Current Drug-Avoidance Recommendation","authors":"Tiago Azenha Rama, Mariana Castells","doi":"10.1007/s40521-023-00349-2","DOIUrl":"https://doi.org/10.1007/s40521-023-00349-2","url":null,"abstract":"Opinion statement Mastocytosis is associated with a high risk of anaphylaxis, in part due to drug hypersensitivity reactions (DHR). Drugs associated with mast cell activation include nonsteroidal anti-inflammatory drugs (NSAIDs), drugs used in the perioperative setting, including general anesthetics, neuromuscular blocking agents (NMBAs) and opiates/opioids, radiocontrast media (RCM), vaccines, and antibiotics such as quinolones and vancomycin. To protect patients against DHR and anaphylaxis, general avoidance of potential drug triggers is common practice, which often deprives patients of important drugs at times of need and limits their options. We aimed to critically review current evidence on the indications to avoid drugs in children and adults with mastocytosis. Recent data shows that general avoidance of drugs with potential mast cell activation action is not indicated in all patients with mastocytosis, but guidelines are lacking. Drugs tolerated before and after the onset of mastocytosis should not be avoided and a personalized approach is recommended to address drugs inducing mast cell activation. Pre-medication (RCM, local and general anesthetics, vaccines), use of safer alternatives (opioids, NBMAs, NSAIDs in selected cases), and drug challenges (NSAIDs in most cases) are recommended to increase the safety of patients with mastocytosis when introduced to new drugs.","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136306959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Respiratory Exposure Tests in Aspirin Exacerbated Respiratory Disease","authors":"I. Bobolea, N. Rubira, J. Mullol","doi":"10.1007/s40521-023-00346-5","DOIUrl":"https://doi.org/10.1007/s40521-023-00346-5","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45999214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimising the Utility of In Vitro Tests for the Diagnosis of Drug Allergy: Insights from a Clinical Perspective","authors":"Marina Sabaté-Brescó, P. Quan, M. J. Goikoetxea","doi":"10.1007/s40521-023-00345-6","DOIUrl":"https://doi.org/10.1007/s40521-023-00345-6","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43020634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. García-Abujeta, P. Iriarte, M. A. Gonzalo-Garijo, L. de las Vecillas, Marta Bernaola
{"title":"Use of Epicutaneous Tests in the Study of Drug Allergy","authors":"J. García-Abujeta, P. Iriarte, M. A. Gonzalo-Garijo, L. de las Vecillas, Marta Bernaola","doi":"10.1007/s40521-023-00347-4","DOIUrl":"https://doi.org/10.1007/s40521-023-00347-4","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43521440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Updates in the Role of Biologics in Asthma","authors":"A. Sutherland, K. Keniston, V. Wang, J. Yusin","doi":"10.1007/s40521-023-00344-7","DOIUrl":"https://doi.org/10.1007/s40521-023-00344-7","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52820015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevention and Treatment of COVID-19-Associated Mucormycosis","authors":"Kevin T. Grafmiller, Jivianne T. Lee","doi":"10.1007/s40521-023-00339-4","DOIUrl":"https://doi.org/10.1007/s40521-023-00339-4","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"10 1","pages":"83 - 92"},"PeriodicalIF":1.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41896149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Salman, Nasser Mohammad Porras, A. Gimenez-Arnau
{"title":"Acute and Chronic Urticaria Diagnosis and Management Taking into Account Their Differences","authors":"A. Salman, Nasser Mohammad Porras, A. Gimenez-Arnau","doi":"10.1007/s40521-023-00333-w","DOIUrl":"https://doi.org/10.1007/s40521-023-00333-w","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"10 1","pages":"130 - 147"},"PeriodicalIF":1.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45524453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashna Mehra, R. Grohman, Sohini S. Shah, A. Nowak‐Wegrzyn
{"title":"Food Allergy: Emerging Therapies","authors":"Ashna Mehra, R. Grohman, Sohini S. Shah, A. Nowak‐Wegrzyn","doi":"10.1007/s40521-023-00343-8","DOIUrl":"https://doi.org/10.1007/s40521-023-00343-8","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47636020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Innate Immune Cells in Allergen Immunotherapy","authors":"Jin Liu, Wen-jing Li, R. Zhu","doi":"10.1007/s40521-023-00337-6","DOIUrl":"https://doi.org/10.1007/s40521-023-00337-6","url":null,"abstract":"","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"10 1","pages":"148 - 165"},"PeriodicalIF":1.1,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46831148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula Ollo-Morales, Marta Gutierrez-Niso, Elena De-la-Viuda-Camino, Marina Ruiz-de-Galarreta-Beristain, Ixone Osaba-Ruiz-de-Alegria, Carlota Martel-Martin
{"title":"Drug-Induced Kounis Syndrome: Latest Novelties.","authors":"Paula Ollo-Morales, Marta Gutierrez-Niso, Elena De-la-Viuda-Camino, Marina Ruiz-de-Galarreta-Beristain, Ixone Osaba-Ruiz-de-Alegria, Carlota Martel-Martin","doi":"10.1007/s40521-023-00342-9","DOIUrl":"10.1007/s40521-023-00342-9","url":null,"abstract":"<p><p>Kounis syndrome (KS) is defined by an acute coronary syndrome associated with hypersensitivity reactions, an under-diagnosed life-threatening medical emergency. Although multiple causes have been described, drugs constitute the most frequent cause. The purpose of this review is to update knowledge about drug-induced KS, to give guidelines on the correct diagnosis and treatment. This article reviews the literature on drug-induced KS from the last 5 years. Antibiotics and NSAIDs are the most frequently implicated drugs. In addition, data on pathophysiology, clinical presentation, diagnosis, and management are reviewed in detail. Highlight that there is a great deal of variability in the diagnosis and especially in the treatment of KS. This review provides a valuable selection of practical resources for all stakeholders to support effective care for KS, from a cardiologic and allergologic point of view. Future research should focus on developing validated, evidence-based, and patient-centered tools to improve the management of KS.</p>","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":" ","pages":"1-18"},"PeriodicalIF":1.1,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10647398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}