American Journal of Obstetrics & Gynecology Mfm最新文献

{"title":"Polyhydramnios definitions should be outcome-dependent","authors":"Matthew J Blitz MD, MBA","doi":"10.1016/j.ajogmf.2026.102075","DOIUrl":"10.1016/j.ajogmf.2026.102075","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 9","pages":"Article 102075"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography angiography as preferred imaging modality for pulmonary embolism in pregnancy: an update on diagnostic imaging rates","authors":"Ade Herdian Putra MEd, Zadrian Ardi PhD, Evi Afiati PhD","doi":"10.1016/j.ajogmf.2026.102039","DOIUrl":"10.1016/j.ajogmf.2026.102039","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 9","pages":"Article 102039"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTA as preferred imaging modality for pulmonary embolism in pregnancy: an update on diagnostic imaging rates (Reply)","authors":"Suzanne O’Nan MD, Julia Burd MD, Jeannie C. Kelly MD, MS","doi":"10.1016/j.ajogmf.2026.102040","DOIUrl":"10.1016/j.ajogmf.2026.102040","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 9","pages":"Article 102040"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the article “Severe Maternal Morbidity and Hypertensive Disorders of Pregnancy Among Women with Intellectual Disabilities: Identifying Potential Intervention Targets” by Ryu, Rita, et al.","authors":"Beulah Joy K. Damasco RN, MAN, PhD, Dr. Lharra Mae C. Postrano (Doctor of Philosophy in Nursing), Hazel Ann J. Olvida RN, MSN, Reyvie Jade L. Urbiztondo MN, RN, BSN, Angelie Chariz E. Eduave RN, MN, Maribeth A. Pagas RN, MN","doi":"10.1016/j.ajogmf.2026.102071","DOIUrl":"10.1016/j.ajogmf.2026.102071","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 9","pages":"Article 102071"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental yield of genome sequencing after exome sequencing for nonimmune hydrops fetalis spectrum.","authors":"Rozlyn C T Boutin, Billie R Lianoglou, Nuriye N Sahin Hodoglugil, Katie Tick, Carmen M A Santoli, Ugur Hodoglugil, Pierre Martin, Jessica Van Ziffle, Patrick Devine, Neil Risch, Mary E Norton, Teresa N Sparks","doi":"10.1016/j.ajogmf.2026.102067","DOIUrl":"10.1016/j.ajogmf.2026.102067","url":null,"abstract":"<p><strong>Objective: </strong>Exome sequencing (ES) detects a monogenic disorder in approximately 30% of pregnancies with unexplained nonimmune hydrops fetalis spectrum (NIHFS), defined as the presence of one or more pathologic fetal fluid collection. Since genome sequencing (GS) can identify additional genetic variants not detectable by ES, we sought to determine the proportion of cases with new reportable findings on GS following nondiagnostic standard of care testing, including ES, for NIHFS.</p><p><strong>Study design: </strong>Cohort study of pregnancies with NIHFS that had nondiagnostic results of karyotype and/or chromosomal microarray analysis (CMA) and ES. Eligible fetal fluid collections included at least one of: ascites, pleural or pericardial effusions, skin edema, cystic hygroma, and/or nuchal translucency ≥3.5 mm. Pregnancies with NIHFS that did not receive a clear diagnosis with prior testing underwent additional testing with GS. ES and GS were performed in a Clinical Laboratory Improvement Amendments-approved laboratory, and genetic variants were classified according to the American College of Medical Genetics and Genomics guidelines. Primary outcome was the proportion of new reportable pathogenic or likely pathogenic (P/LP) variants identified on GS and resulting in a new diagnosis. Secondary outcome was the incremental yield of GS for detecting new secondary findings and variants of uncertain significance (VUSs).</p><p><strong>Results: </strong>Overall, 118 fetal samples underwent GS following negative (n=102) or inconclusive (n=16) ES. GS identified four P/LP copy number variants previously not detected by karyotype, CMA, or ES that led to a new genetic diagnosis in three pregnancies, providing a new positive finding yield of 2.5% (3/118). Additionally, one secondary finding and four VUSs were identified by GS in four different pregnancies. In contrast to the primary outcome, these additional findings were largely the result of updated analytical tools and literature rather than GS-specific technology.</p><p><strong>Conclusion: </strong>GS has a small but clinically relevant increased diagnostic yield over chromosome studies and ES for NIHFS, particularly for identifying copy number variants. As interpretation of noncoding regions and complex genomic variations improves, the incremental positive finding yield of GS is expected to further increase.</p>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"102067"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding “Time of day of induction impacts the total duration of labor”","authors":"Haicun Huang BS,&nbsp;Fei Wang PhD,&nbsp;Liehong Wang MD","doi":"10.1016/j.ajogmf.2026.102024","DOIUrl":"10.1016/j.ajogmf.2026.102024","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 8","pages":"Article 102024"},"PeriodicalIF":3.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: First trimester risk stratification algorithm for placenta accreta spectrum—defining the real-world clinical performance of the two-step screening strategy in the overall population with prior cesarean delivery","authors":"Run He MD,&nbsp;Yu Long MD,&nbsp;Jingrong Li MD","doi":"10.1016/j.ajogmf.2026.101991","DOIUrl":"10.1016/j.ajogmf.2026.101991","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 8","pages":"Article 101991"},"PeriodicalIF":3.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for placenta accreta spectrum in the first trimester","authors":"Alesha White MD,&nbsp;Jessica E. Pruszynski PhD,&nbsp;Catherine Y. Spong MD,&nbsp;Christina L. Herrera MD, MSCI","doi":"10.1016/j.ajogmf.2026.101992","DOIUrl":"10.1016/j.ajogmf.2026.101992","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 8","pages":"Article 101992"},"PeriodicalIF":3.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with failed induction of labor after cesarean delivery with an unfavorable cervix at term","authors":"Hannah S. Foster MD, MA,&nbsp;Holly W. Cummings MD,&nbsp;Lisa D. Levine MD, MSCE","doi":"10.1016/j.ajogmf.2026.101977","DOIUrl":"10.1016/j.ajogmf.2026.101977","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>With increasing rates of induction of labor and trial of labor after cesarean, induction of labor after cesarean is becoming more common. However, the predictors of success among patients undergoing induction of labor after cesarean, particularly those with an unfavorable cervix, remain unclear.</div></div><div><h3>OBJECTIVE</h3><div>This study aimed to identify risk factors associated with failed induction of labor after cesarean in patients with unfavorable Bishop scores.</div></div><div><h3>STUDY DESIGN</h3><div>This retrospective cohort study of patients at 2 academic hospitals who underwent induction of labor after cesarean in 2024 included full-term patients with 1 previous cesarean delivery and an unfavorable Bishop score (&lt;8) at the time of induction of labor. The primary outcome was failed induction of labor after cesarean, defined as repeat cesarean delivery. Associations between delivery mode and clinical characteristics were evaluated using univariate analyses and multivariate stepwise regression analyses.</div></div><div><h3>RESULTS</h3><div>The cohort included 201 patients, with an overall vaginal birth after cesarean rate of 66.2%. Successful induction of labor after cesarean was more likely among patients with a previous vaginal delivery before cesarean (<em>P</em>=.015) or previous vaginal birth after cesarean (<em>P</em>&lt;.001) and among those with higher Bishop scores (<em>P</em>&lt;.001). Previous cesarean delivery for failed induction of labor and arrested labor were associated with a 56.0% (relative risk, 1.56 [95% confidence interval, 1.01–2.39]) and 90.0% (relative risk, 1.90 [95% confidence interval, 1.24–2.91]) increased risk of repeat cesarean delivery, respectively (relative risk, 1.56 [95% confidence interval, 1.01–2.39]). Cesarean delivery for malpresentation was associated with a lower risk of repeat cesarean delivery (relative risk, 0.51 [95% confidence interval, 0.27–0.89]).</div></div><div><h3>CONCLUSION</h3><div>Previous vaginal birth after cesarean and higher Bishop score predict the success of induction of labor after cesarean, whereas previous cesarean delivery for labor arrest or failed induction of labor increases the risk of repeat cesarean delivery in patients with unfavorable cervices. These findings may guide counseling and future research.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 7","pages":"Article 101977"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consideration of social and environmental determinants of maternal and perinatal health in the geographic information systems era: a primer","authors":"Heather H. Burris MD, MPH,&nbsp;Kristin P. Tully PhD,&nbsp;Elizabeth A. Howell MD, MPP,&nbsp;Scott A. Lorch MD, MSCE","doi":"10.1016/j.ajogmf.2026.101985","DOIUrl":"10.1016/j.ajogmf.2026.101985","url":null,"abstract":"<div><div>Social and environmental exposures influence health outcomes across the lifespan, including during the perinatal period. Negative exposures such as neighborhood deprivation, air pollution, and violence, as well as positive exposures such as greenspace, neighborhood cohesion, and walkability, interact to affect many complex health outcomes. Understanding the impact of neighborhood environmental exposures on health is required to design effective interventions to improve health impacts of the places shaping people’s daily lives. In the era of geographic information systems (GIS), analyses delineating relationships between area-level exposures and health outcomes have become technically feasible for many public health researchers. In this primer, with a focus on maternal and perinatal health as members of the Pregnancy, Postpartum, and Postnatal Health Enhancing Quality and Access to Achieve Equitable Maternal and Infant Health (P³EQUATE) Health Equity Research Network (HERN) Social Determinants of Health Working Core, we put forth a stepwise approach to performing analyses of area-level exposures and health outcomes with considerations to promote scientific rigor.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 7","pages":"Article 101985"},"PeriodicalIF":3.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}