Sally Yang , Wei Zhou PhD , Evdokia Dimitriadis PhD , Ellen Menkhorst PhD
{"title":"Maternal blood lipoprotein cholesterol prior to and at the time of diagnosis of preeclampsia: a systematic review","authors":"Sally Yang , Wei Zhou PhD , Evdokia Dimitriadis PhD , Ellen Menkhorst PhD","doi":"10.1016/j.ajogmf.2025.101654","DOIUrl":"10.1016/j.ajogmf.2025.101654","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>Wide-spread endothelial dysfunction is thought to underlie the maternal symptoms of preeclampsia. Endothelial dysfunction is strongly associated with abnormal circulating lipoprotein cholesterol levels. This systematic review aimed to assess whether maternal circulating high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol levels were altered before or at the time of preeclampsia diagnosis. This may provide an understanding of the pathogenesis of preeclampsia and the predictive and diagnostic utility of lipoprotein cholesterol levels in distinguishing pregnancies complicated by preeclampsia from normal pregnancies.</div></div><div><h3>DATA SOURCES</h3><div>Literature searches were conducted in Ovid MEDLINE, Embase, Cumulative Index of Nursing and Allied Health Literature, and Google Scholar from inception to April 2024 for studies reporting high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein levels in normal pregnancies and pregnancies complicated by preeclampsia.</div></div><div><h3>STUDY ELIGIBILITY CRITERIA</h3><div>The selected studies included the following: population of pregnant women, exposure to preeclampsia, blood samples collected during a specific trimester of pregnancy, and at least 1 primary outcome (high-density lipoprotein, low-density lipoprotein, or very-low-density lipoprotein). Of note, 2 reviewers were involved in the study selection. The excluded studies included pregnancies complicated by other risk factors for preeclampsia (eg, preexisting hypertension, diabetes mellitus, and obesity) and other pregnancy-related hypertensive disorders (pregnancy-induced hypertension, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count).</div></div><div><h3>METHODS</h3><div>The quality of the included studies was evaluated using the Newcastle-Ottawa Scale for case-control, cohort, and cross-sectional studies.</div></div><div><h3>RESULTS</h3><div>A total of 41 studies were included. The quality of the studies was generally good. However, 59% of the studies did not control for the gestational age at which the blood samples were collected. No consistent change in high-density lipoprotein or low-density lipoprotein levels was found before preeclampsia diagnosis in the first, second, or third trimesters of pregnancy. Very-low-density lipoprotein was significantly elevated in 2 of 2 studies that reported levels before preeclampsia diagnosis in the late second (>23 weeks of gestation) or third trimester of pregnancy. After preeclampsia diagnosis in the third trimester of pregnancy, very-low-density lipoprotein levels were significantly elevated in 9 of 11 studies, and high-density lipoprotein levels were significantly decreased in 15 of 19 studies.</div></div><div><h3>CONCLUSION</h3><div>Very-low-density lipoprotein is highly atherogenic, and its elevation before and at the time of preeclampsia diagn","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 5","pages":"Article 101654"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association between perinatal depressive symptoms and child neurodevelopment: a response.","authors":"Emily S Miller, Lisa Mele, Maged M Costantine","doi":"10.1016/j.ajogmf.2025.101642","DOIUrl":"10.1016/j.ajogmf.2025.101642","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101642"},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathanael N. Hoskins DO, Elisabeth L. Stark MD, Fabrizio Zullo MD, Moeun Son MD, MSCI, Vincenzo Berghella MD
{"title":"The impact of inpatient nipple stimulation on labor duration: a systematic review and meta-analysis","authors":"Nathanael N. Hoskins DO, Elisabeth L. Stark MD, Fabrizio Zullo MD, Moeun Son MD, MSCI, Vincenzo Berghella MD","doi":"10.1016/j.ajogmf.2025.101650","DOIUrl":"10.1016/j.ajogmf.2025.101650","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 4","pages":"Article 101650"},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obstetrics and gynecology: a beautiful paradox.","authors":"Sara Sereno","doi":"10.1016/j.ajogmf.2025.101651","DOIUrl":"10.1016/j.ajogmf.2025.101651","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101651"},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor regarding \"Propranolol to decrease time to delivery: a meta-analysis of randomized controlled trials\".","authors":"Ben W Mol","doi":"10.1016/j.ajogmf.2025.101633","DOIUrl":"10.1016/j.ajogmf.2025.101633","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101633"},"PeriodicalIF":3.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oxytocin regimens used for induction of labor.","authors":"Uma M Reddy, Grecio J Sandoval, William A Grobman","doi":"10.1016/j.ajogmf.2025.101646","DOIUrl":"10.1016/j.ajogmf.2025.101646","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101646"},"PeriodicalIF":3.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is it not time to propose a maternal-fetal definition of fetal growth restriction specifically linked to maternal vascular malperfusion of the placenta?","authors":"Lionel Carbillon","doi":"10.1016/j.ajogmf.2025.101629","DOIUrl":"10.1016/j.ajogmf.2025.101629","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101629"},"PeriodicalIF":3.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neha Agarwal MD, Edgar Hernandez-Andrade MD, PhD, Baha M. Sibai MD, Farah H. Amro MD, Jennie O. Coselli MD, Michal F. Bartal MD, Dejian Lai PhD, Eleazar E. Soto Torres MD, Sami Backley MD, Anthony Johnson DO, Jimmy Espinoza MD, MSc, Eric P. Bergh MD, Sen Zhu MD, PhD, Ashley Salazar DNP, Sean C. Blackwell MD, Ramesha Papanna MD, MPH
{"title":"Reply to letter to editor regarding “Quantifying placenta accreta spectrum severity and its associated blood loss: a novel transvaginal ultrasound scoring system”","authors":"Neha Agarwal MD, Edgar Hernandez-Andrade MD, PhD, Baha M. Sibai MD, Farah H. Amro MD, Jennie O. Coselli MD, Michal F. Bartal MD, Dejian Lai PhD, Eleazar E. Soto Torres MD, Sami Backley MD, Anthony Johnson DO, Jimmy Espinoza MD, MSc, Eric P. Bergh MD, Sen Zhu MD, PhD, Ashley Salazar DNP, Sean C. Blackwell MD, Ramesha Papanna MD, MPH","doi":"10.1016/j.ajogmf.2025.101644","DOIUrl":"10.1016/j.ajogmf.2025.101644","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 4","pages":"Article 101644"},"PeriodicalIF":3.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor regarding ‘role of prophylactic intravenous calcium in prevention of postspinal hypotension among women with preeclampsia undergoing caesarean delivery: a placebo controlled randomized clinical trial: randomized clinical trial of calcium vs placebo for prevention of postspinal hypotension’: addressing dose and monitoring gaps in calcium infusion protocols","authors":"Binglin Li MD, Yueqi Feng MD, Ruijuan Chen MD","doi":"10.1016/j.ajogmf.2025.101647","DOIUrl":"10.1016/j.ajogmf.2025.101647","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 4","pages":"Article 101647"},"PeriodicalIF":3.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}