Cells and Development最新文献_第2页

The significance of Ethel Browne's research on Hydra for the organizer concept 埃塞尔-布朗关于九头蛇的研究对组织者概念的意义。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203907

{"title":"The significance of Ethel Browne's research on Hydra for the organizer concept","authors":"","doi":"10.1016/j.cdev.2024.203907","DOIUrl":"10.1016/j.cdev.2024.203907","url":null,"abstract":"<div><p><span>This article focuses on the roots of the organizer concept, which was developed by Hans Spemann during his studies of early embryonic development in amphibians. The fundamental properties of this axis-inducing signaling center have been elucidated through pioneering molecular research by Eddy De Robertis' laboratory and other researchers. Evolutionary comparisons have disclosed the presence of this signaling center, involving the interaction of Wnt and TGF-beta signaling pathways, existed not only in vertebrates but also in basal Metazoa such as Cnidaria. – Notably, even prior to the groundbreaking experiments conducted by Hilde Mangold and Hans Spemann, Ethel Browne conducted similar transplantation experiments on </span><em>Hydra</em><span> polyps. They were performed under the guidance of Thomas H Morgan and in the laboratory of Edmund B Wilson. Howard Lenhoff was the first to draw connections between Ethel Browne's transplantation experiments and those of Spemann and Mangold, igniting a vivid debate on the precedence of the organizer concept and its recognition in Nobel Prize considerations. This review critically compares the experiments conducted by Spemann and Mangold with those preceding their seminal work, concluding that the organizer concept clearly builds upon earlier research aimed at understanding developmental gradients, such as in the simple model </span><em>Hydra</em>. However, these approaches were not pursued further by Morgan, who shifted his focus towards unraveling the genetic control of development in flies, an approach that ultimately revealed the molecular identity of the Spemann organizer in vertebrates.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Never-ending story of Brachyury: From short-tailed mice to tailless primates 腕足动物的故事永无止境：从短尾鼠到无尾灵长类动物

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2023.203896

{"title":"Never-ending story of Brachyury: From short-tailed mice to tailless primates","authors":"","doi":"10.1016/j.cdev.2023.203896","DOIUrl":"10.1016/j.cdev.2023.203896","url":null,"abstract":"<div><p>The history of developmental biology starts from the almost simultaneous discoveries of the Organizer of axial structures in amphibians by Spemann and Mangold in Freiburg and of the Brachyury mutant in mammals by the Dobrovolskaya-Zavadskaya laboratory at the Curie Institute and its follow-up studies in the Leslie Dunn laboratory at Columbia University. Following the Organizer's discovery, the inductive activity of several other embryonic tissues was found, including that of the ear primordium by Boris Balinsky in Kiev. Initially, the experimental embryological and genetic lines of research existed independently of each other, but after they met at the bench of Salome Gluecksohn, they strengthened and cross-fertilized each other, eventually leading to developmental genetics, which later became known as developmental biology. It appears that the regulatory activities of Brachyury and related T-box proteins in general are at the heart of the development of all vertebrates. These activities are fundamental and have been discovered in several model organisms subjected to mutagenesis, exemplified by the story of George Streisinger's discovery of the <em>no tail</em> mutant in zebrafish. This essay describes the history of Brachyury studies, their connection to an idea of embryonic induction by Organizer, and an impact of Brachyury and related genes on various fields of research from embryology and cell biology to medical genetics and evolutionary theory.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667290123000724/pdfft?md5=c0e9d0cc5d7d0ab3680c47888fcbe3d1&pid=1-s2.0-S2667290123000724-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Spemann-Mangold organizer discovery and society 斯佩曼-曼戈尔德组织者的发现与社会

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203906

{"title":"The Spemann-Mangold organizer discovery and society","authors":"","doi":"10.1016/j.cdev.2024.203906","DOIUrl":"10.1016/j.cdev.2024.203906","url":null,"abstract":"<div><p>This paper analyzes the influence of Hans Spemann and Hilde Mangold's discovery of the embryonic organizer on society outside the narrower confines of embryology. It begins by overviewing how in the 1920s–1930s, the organizer discovery fit well into the agenda of both right-wing and left-wing political camps, as it supported holistic theories of biological development that aligned with their ideological views. The paper then explores the organizer's influence on the formation and interdisciplinary discussions of the 1930s Cambridge Theoretical Biology Club. Club member C.H. Waddington's concept of the epigenetic landscape, inspired in part by Spemann and Mangold's work, went on to impact diverse fields including mathematics, psychology, anthropology, architecture, and art. Examples include mathematician René Thom's catastrophe landscapes and the field of ekistics (the science of human settlements). Spemann and Mangold's creation of an embryo chimera by combining tissues from different newt species also helped shape philosophers' and artists' understanding of the relationship between nature and technology as an integrated whole rather than separate entities. Additionally, Spemann's embryonic field concept helped influence field theories in other areas of science, and thinkers have pointed out metaphorical similarities between the organizer experiment and philosophical dialectics, film editing, or historical events. However, several factors likely limited the long-term societal impact of Spemann's holistic perspective, notably the rise of molecular biology and DNA-centric reductionist views of biology in the mid-late 20th century. While such reductionism still dominates public perceptions of biology, there seems to be a renewed openness to holistic perspectives reminiscent of Spemann's views.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266729012400007X/pdfft?md5=041baec31ebd47b7a2938c41d23e9bea&pid=1-s2.0-S266729012400007X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments 希尔德-曼戈尔德原始显微镜幻灯片和胃组织器实验记录。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203909

{"title":"Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments","authors":"","doi":"10.1016/j.cdev.2024.203909","DOIUrl":"10.1016/j.cdev.2024.203909","url":null,"abstract":"<div><p>The discovery of the amphibian gastrula organizer and its publication by Hans Spemann and Hilde Mangold in 1924 is a foundation of experimental embryology, and has shaped our understanding of embryonic induction and pattern formation in vertebrates until today. The original publication is a piece of scientific art, characterized by the meticulous hand drawings by Hilde Mangold, as well as the text that develops mechanistic concepts of modern embryology. While historic microphotographs of specimens got lost, the original microscope slides and Hilde Mangold's laboratory notebook have been secured in embryological collections until today. Here, we make the original data of the six embryonic specimens reported in 1924, as well as the laboratory notebook, available in an accessible digital format. Together, these data shed light on the scientific process that led to the discovery, and should help to make the experiments on the most important signalling center in early vertebrate development transparent for generations of embryologists to come.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266729012400010X/pdfft?md5=771a9b7e2f733db1ce54953764d6ae46&pid=1-s2.0-S266729012400010X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprint of: Cells & Development: Moving forward and upward 重印本：细胞与发育》：向前，向上。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203938

引用次数: 0

Celebrating the centennial of the most famous experiment in embryology: Hilde Mangold, Hans Spemann and the organizer 庆祝最著名的胚胎学实验一百周年：希尔德-曼戈尔德（Hilde Mangold）、汉斯-斯佩曼（Hans Spemann）和组织者。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203921

引用次数: 0

Reprint of: Prelude to molecularization: The double gradient model of Sulo Toivonen and Lauri Saxén 重印本：分子化的前奏：Sulo Toivonen 和 Lauri Saxén 的双梯度模型。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203919

引用次数: 0

Reprint of: Moving forward 重印：向前迈进。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203937

引用次数: 0

Spemann-Mangold organizer and mesoderm induction Spemann-Mangold组织器和中胚层诱导。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203903

{"title":"Spemann-Mangold organizer and mesoderm induction","authors":"","doi":"10.1016/j.cdev.2024.203903","DOIUrl":"10.1016/j.cdev.2024.203903","url":null,"abstract":"<div><p>The discovery of the Spemann-Mangold organizer strongly influenced subsequent research on embryonic induction, with research aiming to elucidate the molecular characteristics of organizer activity being currently underway. Herein, we review the history of research on embryonic induction, and describe how the mechanisms of induction phenomena and developmental processes have been investigated. Classical experiments investigating the differentiation capacity and inductive activity of various embryonic regions were conducted by many researchers, and important theories of region-specific induction and the concept for chain of induction were proposed. The transition from experimental embryology to developmental biology has enabled us to understand the mechanisms of embryonic induction at the molecular level. Consequently, many inducing substances and molecules such as transcriptional factors and peptide growth factors involved in the organizer formation were identified. One of peptide growth factors, activin, acts as a mesoderm- and endoderm-inducing substance. Activin induces several tissues and organs from the undifferentiated cell mass of amphibian embryos in a concentration-dependent manner. We review the extent to which we can control in vitro organogenesis from undifferentiated cells, and discuss the application to stem cell-based regenerative medicine based on insights gained from animal experiments, such as in amphibians.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667290124000044/pdfft?md5=cda513f7ca0e360ad917b82dfd7ff2b0&pid=1-s2.0-S2667290124000044-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“And it was the worst possible result, because it actually worked:” An interview with Richard Harland "理查德-哈兰德接受采访时说："这是最糟糕的结果，因为它真的起作用了。

IF 3.9 4区生物学

Cells and Development Pub Date : 2024-06-01 DOI: 10.1016/j.cdev.2024.203910

引用次数: 0