中华病理学杂志最新文献

{"title":"[Thyroid follicular origin carcinoma with PPP1R21::ALK gene fusion: report of a case].","authors":"F Liu, Q L Ao","doi":"10.3760/cma.j.cn112151-20240821-00562","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240821-00562","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"530-532"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary breast glomus tumor with uncertain malignant potential: report of a case].","authors":"Z Z Gao, M W Xu, J Y Liang, Z Y Ke, Z Wang, S P Guo","doi":"10.3760/cma.j.cn112151-20241203-00810","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241203-00810","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"539-541"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological features and prognostic value of CD30 expression in EBV-positive diffuse large B cell lymphoma].","authors":"Y X Gong, S N Sun, Y F Yang, G Chen, Z H Zhang","doi":"10.3760/cma.j.cn112151-20240910-00603","DOIUrl":"10.3760/cma.j.cn112151-20240910-00603","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical and pathological features of EBV-positive diffuse large B cell lymphoma (EBV⁺DLBCL) and to analyze the prognostic significance of CD30 expression in this entity. <b>Methods:</b> A retrospective analysis was conducted from 34 cases of EBV⁺DLBCL and 198 cases of EBV^-DLBCL diagnosed and treated at the First Affiliated Hospital of Nanjing Medical University, from January 2017 to June 2023. Based on CD30 expression, 34 patients with EBV⁺DLBCL were categorized into CD30-positive and CD30-negative groups. Fisher exact test and Kaplan-Meier survival curves were employed to analyze the relationship between CD30 expression and clinicopathological parameters as well as its prognostic implications. Chi-square tests were used to compare the clinicopathological features between EBV⁺DLBCL and EBV^-DLBCL. <b>Results:</b> There were 19 males and 15 females with a median age of 69.5 (15-83) years in the EBV⁺DLBCL group. Compared with EBV^-DLBCL, EBV⁺DLBCL was more likely to present with clinical features such as B symptoms (<i>χ</i>²=23.818,<i>P</i><0.001), Ann Arbor stage Ⅲ-Ⅳ (<i>χ</i>²=8.540,<i>P</i>=0.003), ECOG (Eastern Cooperative Oncology Group Performance Status) score 2-4 (<i>χ</i>²=6.722,<i>P</i>=0.010), IPI score 3-5 (<i>χ</i>²=9.953,<i>P</i>=0.002), and involvement of more than one extranodal site (<i>χ</i>²=6.825,<i>P</i>=0.009). Additionally, EBV⁺DLBCL exhibited higher frequencies of elevated LDH (<i>χ</i>²=4.307,<i>P</i>=0.038), CRP (<i>χ</i>²=5.596,<i>P</i>=0.018), and β2-MG (<i>χ</i>²=7.008,<i>P</i>=0.008) levels. Histopathologically, EBV⁺DLBCL was more commonly of the non-GCB subtype (<i>χ</i>²=12.421,<i>P</i><0.001), with higher frequencies of CD30-positive (<i>χ</i>²=62.706,<i>P</i><0.001),CD10-negative (<i>χ</i>²=8.687,<i>P</i>=0.003),bcl-6-negative (<i>χ</i>²=11.123,<i>P</i><0.001), and bcl-2-negative (<i>χ</i>²=22.779,<i>P</i>=0.003) expression. Using 20% as the positive threshold for CD30, the CD30-positive group had a higher proliferation index (<i>P</i>=0.045). No significant differences were observed in overall survival between the two groups. <b>Conclusions:</b> EBV⁺DLBCL is more prevalent in the elderly and often exhibits aggressive clinical features. The expression of CD30 is not associated with the overall prognosis of EBV⁺DLBCL.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"354-360"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Composite diffuse large B-cell lymphoma and CD5-negative mantle cell lymphoma: report of a case].","authors":"X J Li, L B Tang, Y Y Liu, X J Wang, Y P Chen","doi":"10.3760/cma.j.cn112151-20240901-00585","DOIUrl":"10.3760/cma.j.cn112151-20240901-00585","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"397-399"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metastatic type A thymoma of the kidney tumor as the initial symptom: report of a case].","authors":"J Liu, X S Fan, R Q Wang","doi":"10.3760/cma.j.cn112151-20241029-00711","DOIUrl":"10.3760/cma.j.cn112151-20241029-00711","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"409-411"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reunderstanding \"intramuscular hemangioma\"].","authors":"Q Y Liu, C X Li","doi":"10.3760/cma.j.cn112151-20250122-00048","DOIUrl":"10.3760/cma.j.cn112151-20250122-00048","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"415-418"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and molecular characteristics of bronchial adenoma: an analysis of 88 cases].","authors":"Q X Xu, T T Ma, L Q Xiang, Y Y Hou, S H Lu, W Yuan","doi":"10.3760/cma.j.cn112151-20240729-00480","DOIUrl":"10.3760/cma.j.cn112151-20240729-00480","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the clinicopathological features, gene mutations, and distribution of bronchial adenoma (BA). &lt;b&gt;Methods:&lt;/b&gt; Eighty-eight cases of BA diagnosed via routine section diagnosis between May 2015 and February 2024 were collected at the Pathology Departments of Zhongshan Hospital Affiliated to Fudan University (71 cases), Shanghai, China and Jining No.1 People's Hospital (17 cases), Jining, China. Clinical data, image features, histopathological sections, immunohistochemical stains, and genetic testing results were reviewed. &lt;b&gt;Results:&lt;/b&gt; Among the 88 patients with BA, there were 36 males and 52 females. The incidence of proximal-type BA was the same in both genders (50%, 28/56), while distal-type BA was more commonly found in females (75%, 24/32, &lt;i&gt;P=&lt;/i&gt;0.022). BA predominantly affected middle-aged and elderly adults, with an age range of 30-78 years (median, 61 years). Clinically, BA generally presented without obvious symptoms. Radiologically it mainly manifested as peripheral lung ground-glass nodules, mixed ground-glass nodules, or solid nodules, primarily located in the lower lobes of the lungs (72.7%, 64/88). Proximal-type BA was characterized by solid nodules (53.6%, 30/56), while distal-type BA by ground-glass nodules (56.3%, 18/32), with a statistically significant difference between the two types (&lt;i&gt;P&lt;&lt;/i&gt;0.01). The tumor was non-encapsulated, with a gray-white cut surface, and some areas were gray-brown. In 18.2% (16/88) of cases, the cut surface was slippery, with soft to medium-firm consistency and poorly defined margins. The smooth texture was predominantly found in proximal-type BA (14/16), whose tumor diameters ranged from 0.2 to 4.6 cm. Microscopically, the lesions exhibited glandular, papillary, or relatively flat patterns, with the main cellular components consisting of basal cells, ciliated columnar cells, mucinous cells, and alveolar epithelial cells in various proportions. Proximal-type BA resembled the morphology of proximal bronchioles and commonly contained mucinous and ciliated cells, while distal-type BA typically lacked mucinous and ciliated cells. The frequency of ciliated cell micropapillae in proximal-type BA (64.3%, 36/56) was significantly higher than that in distal-type BA (31.3%, 10/32, &lt;i&gt;P=&lt;/i&gt;0.003). The morphological manifestation of glandular duct dilation was more commonly noted in proximal-type BA (98.2%, 55/56) than that in distal-type BA (81.25%, 26/32, &lt;i&gt;P=&lt;/i&gt;0.009). Overall, the disagreement rate between frozen-section and routine diagnoses was 19.5% (17/87). Immunohistochemistry for cytokeratin 5/6 (CK5/6) and p40 showed that basal cell continuity in proximal-type BA (82.1%, 46/56) was significantly higher than that in distal-type BA (56.2%, 18/32, &lt;i&gt;P&lt;/i&gt;=0.009). Molecular testing showed an accumulative gene mutation rate of 60.5% (23/38) in BA, including mutations in BRAF V600E (34.2%, 13/38), KRAS (18.4%, 7/38), ALK (5.3%, 2/38), and EGFR (2.6%, 1/38). Pr","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"368-374"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in cytopathology in China over the past ten years: retrospect and prospect].","authors":"G P Wu, D G Liu, M L Jin","doi":"10.3760/cma.j.cn112151-20241126-00786","DOIUrl":"10.3760/cma.j.cn112151-20241126-00786","url":null,"abstract":"<p><p>For over a decade, Chinese cytopathologist has participated in the compilation of international reporting systems and subsequently promoted them widely in China; The clinical diagnostic level has significantly increased and has been widely recognized by clinical doctors in the industry; Dozens of clinical research papers have been published in international SCIE journals, among which the unique arrangement of cancer cell escape patterns was first discovered by Chinese cytology experts; Molecular detection methods are widely used in cytological specimens, and the differentiation between transient and persistent cervical HPV infection has achieved ideal results in the laboratory; The urgent need for standardized standards in clinical diagnosis has been resolved through expert consensus; Artificial intelligence assisted cervical cytology diagnosis has been applied in the screening of cervical cancer in a few hospitals and local areas.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"341-347"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary alveolar soft part sarcoma of the rectum with lymph node metastasis: report of a case].","authors":"S Liu, J Wu, H H He, H L Yan, L Xu","doi":"10.3760/cma.j.cn112151-20241105-00730","DOIUrl":"10.3760/cma.j.cn112151-20241105-00730","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"406-408"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Soft tissue aneurysm bone cysts: a clinicopathological analysis of two cases].","authors":"Y Zhang, L H Gong, W H Li, L N Gao, J L Mu, C Y Guo","doi":"10.3760/cma.j.cn112151-20240722-00468","DOIUrl":"10.3760/cma.j.cn112151-20240722-00468","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"394-396"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}