中华病理学杂志最新文献

{"title":"[Aggressive B-cell lymphomas with MYC gene cluster amplification: a clinicopathological analysis of eight cases].","authors":"Z H Wang, X D Teng, M C Zeng, H Cao, B Wang","doi":"10.3760/cma.j.cn112151-20260129-00097","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20260129-00097","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinicopathological characteristics, molecular genetics, treatments and prognosis of aggressive B-cell lymphomas (ABCL) with MYC gene cluster amplification. <b>Methods:</b> Eight cases of ABCL with MYC gene cluster amplification were collected, including 6 cases from the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China and 2 consultation cases from outside hospitals. The histomorphology, immunohistochemical profiles, and molecular genetic characteristics were analyzed. Clinical follow-up and literature review were also conducted. <b>Results:</b> Among the eight patients, six were male and two were female, with an age 71.5 (61.7, 74.2) years. All six in-house patients presented with abdominal pain at onset, without B symptoms. Most cases were classified as Ann Arbor stage Ⅲ-Ⅳ. Extranodal involvement occurred in 5 of the 6 in-house cases, primarily affecting the gastrointestinal tract (4/5). All initial bone marrow biopsies showed no evidence of lymphoma. One patient had a history of immunosuppression following renal transplantation. Two cases exhibited diffuse large B-cell lymphoma (DLBCL) morphology. The other six showed high-grade features, while three of them showed Burkitt lymphoma-like morphology. Except for one case of blastoid variant mantle cell lymphoma, the remaining six cases (6/7) displayed a germinal center B-cell phenotype. None of the in-house cases harbored bcl-2 or bcl-6 rearrangements as shown by fluorescence in situ hybridization. 11q alterations were identified in all but one consultation case, including gain/loss type in five cases and 11q gain in two. 11q telomere loss of heterozygosity by chromosomal microarray analysis was not detected in one of the two cases with 11q gain that was subject to the test. The duration of follow-up ranged from 5.9 to 55.5 months, with 5 patients alive at the end of the study. <b>Conclusions:</b> ABCL with MYC gene cluster amplification often presents high-grade morphology and gastrointestinal involvement, which strongly suggests the alteration of 11q. It seems to have a favorable prognosis.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 9","pages":"839-846"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cutaneous inflammatory myofibroblastic tumor with CARS::ALK fusion: report of a case].","authors":"Z Q Meng, X Y Zhao, X Liu, M L Yang, W H Liu, Z H Zhao","doi":"10.3760/cma.j.cn112151-20260126-00078","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20260126-00078","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 9","pages":"879-882"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Zuska's disease of the breast: a clinicopathological analysis of 315 cases].","authors":"J Cheng, Y H Chen, Y Du, R An, H Y Zhu, H Y Ding","doi":"10.3760/cma.j.cn112151-20260128-00091","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20260128-00091","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinicopathological characteristics of Zuska's disease of the breast. <b>Methods:</b> A total of 315 cases of breast Zuska's disease diagnosed from December 2018 to December 2025 were collected from the Seventh Medical Center of the People's Liberation Army General Hospital, Dongzhimen Hospital of Beijing University of Chinese Medicine, and the First Affiliated Laohekou Hospital of Hubei University of Arts and Science. HE staining was performed for the specimens, and the clinicopathological characteristics of these cases were analyzed and summarized. <b>Results:</b> Among the 315 patients, 306 were female and 9 were male, with an age of 31.0 (23.4,38.7) years. Clinically, viscous nipple discharge was often the initial symptom. Gross examination of the resected specimens of the breast lesion showed ulceration of skin. The cut surface of the lesion revealed significantly ductal dilatation, with secretions inside the ducts. Histologically, lactiferous ducts showed cystic dilatation with squamous metaplasia and hyperplasia. The lumens contained abundant acute, chronic inflammatory cells and keratin debris. There were extensive mixed inflammatory cell infiltration and fibrosis around the ducts. In later stages, the lactiferous duct centrically, subareolar abscess was developed. <b>Conclusions:</b> Mammary Zuska's disease is histopathologically characterized by squamous metaplasia of the lactiferous ducts, intraductal keratin accumulation, and periductal suppurative inflammation. A small subgroup of cases may be complicated by squamous cell carcinoma.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 9","pages":"854-859"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Precision medicine era: a molecular pathological diagnostic pathway for B-cell lymphomas].","authors":"M Yan, H Ni, Z Wang, L C Guo","doi":"10.3760/cma.j.cn112151-20260526-00409","DOIUrl":"10.3760/cma.j.cn112151-20260526-00409","url":null,"abstract":"<p><p>The pathological diagnosis of B-cell lymphomas is transitioning from traditional morphologic assessment to a multidimensional model that integrates histomorphology, immunophenotype, and genetic alterations. Establishing a standardized, stepwise clinical diagnostic pathway has become an urgent priority in precision medicine. This article systematically delineates a \"four-step\" integrated diagnostic pathway​ for B-cell lymphomas: step 1: initial screening and phenotyping, utilizing immunohistochemistry and flow cytometry to determine lineage and establish a preliminary classification; step 2: definitive diagnosis and differential diagnosis, employing gene rearrangement assays and in situ hybridization to verify clonality and identify characteristic genetic abnormalities; step 3: precision diagnostics, applying high-throughput sequencing for molecular subtyping, prognostic stratification, and targeted therapy guidance; and step 4: frontier exploration, leveraging single-cell and spatial multi-omics technologies along with artificial intelligence to address complex diagnostic challenges. It aims to help pathologists develop hierarchically structured and logically consistent​ molecular diagnostic approaches, promoting the translation of integrated lymphoma diagnosis from theory into clinical practice.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 9","pages":"795-802"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological analysis of nodal follicular helper T-cell lymphomas, angioimmunoblastic-type with EBV-positive neoplastic cells].","authors":"S S Lu, G N Wang, D D Zhang, W G Zhao, Y P Zhang, W C Li","doi":"10.3760/cma.j.cn112151-20260103-00002","DOIUrl":"10.3760/cma.j.cn112151-20260103-00002","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"752-755"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mixed germ cell-sex cord stromal tumour of the testis: report of a case].","authors":"H X Zou, H Y He","doi":"10.3760/cma.j.cn112151-20260121-00060","DOIUrl":"10.3760/cma.j.cn112151-20260121-00060","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"768-770"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Extraosseous adamantinoma-like Ewing sarcoma: a clinicopathological analysis of two cases].","authors":"L N Zhao, H H He, J P Yuan, D Yan, L Li","doi":"10.3760/cma.j.cn112151-20251116-00755","DOIUrl":"10.3760/cma.j.cn112151-20251116-00755","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"760-763"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on pathological image annotation for primary bronchial and lung cancer].","authors":"","doi":"10.3760/cma.j.cn112151-20251229-00857","DOIUrl":"10.3760/cma.j.cn112151-20251229-00857","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"703-710"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sweat gland carcinoma with neuroendocrine differentiation: a clinicopathological analysis of three cases].","authors":"W Y Pan, M Y Deng, L J Luan, W Zhou, Y Y Hou, C Xu","doi":"10.3760/cma.j.cn112151-20260119-00054","DOIUrl":"10.3760/cma.j.cn112151-20260119-00054","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinicopathological features, immunophenotype, and molecular characteristics of sweat gland carcinoma with neuroendocrine differentiation (SCAND). <b>Methods:</b> Three cases of SCAND diagnosed at the Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China from June 2022 to June 2025 were collected. Hematoxylin-eosin (HE) staining and immunohistochemistry (EnVision method) were performed to characterize morphologic and immunophenotypic features. Next-generation sequencing (NGS) was utilized to explore their molecular pathological characteristics. <b>Results:</b> All three patients were male, aged 67, 63, and 48 years, respectively. The primary tumors presented as solitary nodules or masses located in the lower abdomen, anterior chest wall, or inguinal region, with a maximum diameter of 2.0, 1.3, and 1.8 cm, respectively. Histologically, the tumors were situated primarily within the dermis, invading the epidermis and subcutaneous tissue, with focal mucin production. The tumor cells were arranged in nests, cords, and sieve-like patterns, exhibiting mild to moderate atypia. The nuclei were round to oval with coarsely granular chromatin and relatively inconspicuous nucleoli, accompanied by eosinophilic cytoplasm. Mitotic figures were scarce. All cases were positive for CK7, GATA3, TRPS1, Ber-EP4, epithelial membrane antigen, estrogen receptor, progesterone receptor, and the neuroendocrine markers of synaptophysin and chromogranin A. The tumors were negative for p40 and HER2. The Ki-67 proliferation index ranged from 2% to 30%. Multiple class Ⅲ and Ⅳ variants were identified by NGS analysis in cases 1 and 2. In case 3, a class Ⅱ variant, specifically an SF3B1 missense mutation, was identified along with multiple class Ⅲ and Ⅳ variants. Additionally, multiple germline variants were detected in all three cases, while none of them were classified as pathogenic or likely pathogenic. The patients were followed up for 13, 37 and 155 months, respectively. Metastases were detected 6, 36, and 96 months after diagnosis. Case 2 showed local metastasis, while cases 1 and 3 developed multiple nodal and bone metastases. <b>Conclusions:</b> SCAND is a rare cutaneous adnexal neoplasm characterized by co-expression of sweat gland and neuroendocrine markers. Despite low-grade morphology, it follows a non-indolent clinical course warranting close clinical attention.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"711-717"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological analysis of pulmonary composite gangliocytoma/neuroma and neuroendocrine tumors].","authors":"J J Zhang, Y Y Qiao, M Y Li, E H Kang, J Y Sun, F Hou","doi":"10.3760/cma.j.cn112151-20251218-00834","DOIUrl":"10.3760/cma.j.cn112151-20251218-00834","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 8","pages":"756-759"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}