中华病理学杂志最新文献

{"title":"[Progress on the genetic mechanisms and research models of neuroblastoma in children].","authors":"Y N Bi, Y Q Liu","doi":"10.3760/cma.j.cn112151-20241129-00799","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241129-00799","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"675-678"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combined detection of p16 and Rb with high-risk human papilloma virus infection in non-oropharyngeal squamous cell carcinoma of the head and neck].","authors":"S S Liu, H Zhang, D L Ma, H F Wan, Y H Li, R Li, H G Liu, Y S Piao","doi":"10.3760/cma.j.cn112151-20250121-00043","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250121-00043","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlation of combined detection of p16 and Rb with high-risk human papilloma virus (HR-HPV) infection in non-oropharyngeal squamous cell carcinoma (NOPSCC) of the head and neck. <b>Methods:</b> A total of 68 NOPSCC cases of the head and neck (23 cases of the nasal cavity and paranasal sinuses and 45 cases of larynx) with complete clinical and pathological data, diagnosed at the Beijing Tongren Hospital, Capital Medical University, Beijing, China from November 2013 to December 2023, were collected. The expression of p16 and Rb was detected using immunohistochemistry of the EnVision two-step method, while the HR-HPV mRNA expression was detected using in situ hybridization. The concordance, sensitivity, and specificity of p16 alone and the combined detection of p16 and Rb for detecting HR-HPV infection were analyzed. <b>Results:</b> Among the 68 patients with NOPSCC, 53 were male and 15 were female, with a median age of 63.5 (range, 57.3 to 66.8) years. 41 patients had a smoking history and 27 did not. 33 patients had an early T stage (T1/T2) and 35 had advanced T stage (T3/T4). 14 patients had lymph node metastasis and 2 had distant metastasis. Histological types included 62 cases of keratinized squamous cell carcinoma, 5 cases of non-keratinized squamous cell carcinoma, and 1 case of basal-like squamous cell carcinoma. 25 cases were positive for p16. Among the 25 cases, 16 cases were positive for Rb, and 6 cases were positive for HR-HPV mRNA. 43 cases were negative for p16, including 38 cases positive for Rb and no cases positive for HR-HPV mRNA. The concordance between p16 and HR-HPV mRNA expression was poor (<i>Kappa</i>=0.285, <i>P</i>=0.001), with a sensitivity of 100.0% and specificity of 69.4%. In contrast, the combined detection of p16+/Rb- showed high concordance with HR-HPV mRNA expression (<i>Kappa</i>=0.719, <i>P</i><0.001), with a sensitivity of 100.0% and specificity of 95.2%. <b>Conclusions:</b> In NOPSCC of the head and neck, the combined detection of p16 and Rb may be used as a marker for assessing HR-HPV infection. Recognizing the p16+/Rb- expression pattern in NOPSCC can improve the specificity of HR-HPV detection.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"612-617"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the study of cell lineage classification and characteristics within the tumor microenvironment based on single cell RNA sequencing technique].","authors":"A L Ma, L Y Xiang, J P Yuan, H L Yan","doi":"10.3760/cma.j.cn112151-20241009-00663","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241009-00663","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"669-674"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clear cell renal cell carcinoma complicated with Langerhans cell histiocytosis: report of a case].","authors":"Z Zheng, F Peng, W W Wang, X J Wang, J G Wei","doi":"10.3760/cma.j.cn112151-20241113-00756","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241113-00756","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"658-660"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathological classification of arteriovenous malformations based on morphological characteristics].","authors":"M Li, K Wang, Z S Wang, Y Z Ding, M H Zheng, S S Cheng, L Xiao, C Lu, Q Y Liu","doi":"10.3760/cma.j.cn112151-20240928-00646","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240928-00646","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"646-648"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[PRRX1-rearranged fibroblastic tumor: report of a case].","authors":"T T Zhang, B Y Liu, Z Y Wang, X Q Sun, Y B Su, Y Ding","doi":"10.3760/cma.j.cn112151-20240917-00614","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240917-00614","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"652-654"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chinese expert consensus for molecular pathological diagnosis of gliomas (2025 version)].","authors":"","doi":"10.3760/cma.j.cn112151-20250212-00090","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250212-00090","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"580-592"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic characteristics of gastric and duodenal eosinophilic gastroenteritis].","authors":"X Y Li, X X Mao, K W Li, J Li, W X Zhou","doi":"10.3760/cma.j.cn112151-20250207-00078","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250207-00078","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the diagnostic features of eosinophilic gastroenteritis (EGE) of the stomach and duodenum. <b>Methods:</b> A case-control study was conducted to retrospectively analyze 238 biopsy specimens of gastric and duodenal EGE (75 cases) and 133 biopsy specimens of chronic active gastroenteritis (97 cases) in Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China from 2012 to 2023. The eosinophil count, infiltration site and other pathological features (e.g., infiltration of neutrophils into the epithelium, edema, and increase of background lymphocytes and plasma cells) were examined under a microscope. Chi-square test, chi-square multiple comparison (<i>Bonferroni</i> method) and modified <i>Poisson</i> regression were used to analyze the data. <b>Results:</b> The results showed that there were significant differences in eosinophil count (<i>χ</i>²=43.926, <i>P</i><0.01), location (<i>χ</i>²=31.391, <i>P</i><0.01), neutrophilic infiltration of the epithelium (<i>χ</i>²=5.199, <i>P</i>=0.023), edema (<i>χ</i>²=3.934, <i>P</i>=0.047), and lymphoplasmacytosis (<i>χ</i>²=36.813, <i>P</i><0.01) between the EGE and control cases. The results of Chi-square multiple comparisons showed that eosinophils distributed in clusters or sheets (versus other grades of eosinophil presence) were statistically associated with EGE. When eosinophils infiltrated the epithelium (versus eosinophils in other locations of the mucosa), there was a statistically significant association with EGE. Modified <i>Poisson</i> regression also showed that EGE was more likely to have eosinophilic infiltration of epithelium [<i>RR</i>=1.661,<i>P</i>=0.001,95%<i>CI</i> (1.397,1.973)] and that of muscularis mucosa [<i>RR</i>=1.818,<i>P</i><0.01,95%<i>CI</i> (1.491,2.216)]. <b>Conclusions:</b> The important pathological features for diagnosing EGE of the stomach and duodenum are that eosinophils are clustered or distributed in sheets with epithelial infiltration. However, epithelial infiltration by neutrophils, edema and background lymphoplasmacytosis are relatively rare.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"640-645"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Update of molecular pathology in cartilage tumors].","authors":"Y L Luo, L K Zhang, Z Y Liu","doi":"10.3760/cma.j.cn112151-20250205-00071","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250205-00071","url":null,"abstract":"<p><p>Cartilage tumors are a group of mesenchymal neoplasms characterized by tumor cells that produce cartilage matrix.The molecular pathology of cartilage tumors, as outlined in the 5th edition WHO classification, has been significantly updated.Key updates include: isocitrate dehydrogenase 1/2 mutations in enchondoma and chondrosarcoma, H3F3B mutations in chondroblastoma, NCOA2 rearrangements in mesenchymal chondrosarcoma, and GRM1 gene fusion and promoter replacement are associated with chondromyxoid fibroma, etc.Since these molecular abnormalities serve as specific diagnostic and differential diagnostic markers, this article focuses on recent advances in the molecular characterization of cartilage tumors.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"562-567"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[ELOC-mutated renal cell carcinoma: from tumor genesis to clinical implications].","authors":"Y K Wu, Y Liu, X Q Yang, C F Wang","doi":"10.3760/cma.j.cn112151-20241011-00667","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241011-00667","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 6","pages":"664-668"},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}