中华病理学杂志 Pub Date : 2024-10-08 DOI: 10.3760/cma.j.cn112151-20240223-00114

D W Jin, S Zhang, L Y Qian, J L Yang, N W Lin

引用次数: 0

[HER2 amplification and PD-L1 expression in invasive stratified mucin-producing carcinoma of the cervix: a clinicopathological analysis of eighteen cases]. [宫颈浸润性分层粘液分泌癌中的 HER2 扩增和 PD-L1 表达：对 18 例病例的临床病理分析]。

中华病理学杂志 Pub Date : 2024-10-08 DOI: 10.3760/cma.j.cn112151-20240301-00144

D Tang, P Fu, L H Zhao

{"title":"[HER2 amplification and PD-L1 expression in invasive stratified mucin-producing carcinoma of the cervix: a clinicopathological analysis of eighteen cases].","authors":"D Tang, P Fu, L H Zhao","doi":"10.3760/cma.j.cn112151-20240301-00144","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240301-00144","url":null,"abstract":"Objective: To investigate the clinicopathological features, prognosis and the expression of HER2 and PD-L1 in invasive stratified mucin-producing carcinoma of the cervix (ISMC). Methods: The clinicopathological data of 18 ISMC cases with radical resection of the cervix diagnosed in the Daping Hospital, Army Medical University from January 2018 to December 2023 were collected and retrospectively analyzed. PD-L1 and HER2 immunohistochemical staining and HER2 FISH were conducted. Results: The patient ages ranged from 31 to 72 years, with an average of 45 years. Approximately 8% of cervical adenocarcinoma cases in our hospital during the same period. Eleven cases were pure ISMC, and 7 cases were mixed-type ISMC, with the component of squamous cell carcinoma or usual-type adenocarcinoma. One case showed concurrent small cell neuroendocrine carcinoma (SCNEC). Three cases were diagnosed through biopsy (3/18). Five cases were of Silva pattern B and 13 cases of Silva pattern C. Three cases showed regional lymph node metastasis. Thirteen patients were disease-free at the end of the follow-up, while the ISMC patient with concurrent SCNEC developed distant metastasis. Fifteen cases (15/18) had PD-L1 expression with CPS≥1, and 7 cases (7/18) had PD-L1 TPS≥1%. One case of HER2 3+ and one case of HER2 2+ were both positive for FISH amplification; two cases HER2 1+, 14 cases HER2 0. Conclusions: Cervical ISMC is rare, has a wide spectrum of morphology, and can coexist with other types of cervical cancer. PD-L1 is positive in most of the ISMC cases, while HER2 is amplified or lowly expressed in a small portion of them. Thus, it is possible to treat ISMC patients with therapies targeting PD-L1 and therapy targeting HER2.","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bronchiolar adenoma with atypical and malignant components: clinicopathological analysis of 4 cases]. [具有非典型和恶性成分的支气管腺瘤：4 个病例的临床病理分析]。

中华病理学杂志 Pub Date : 2024-10-08 DOI: 10.3760/cma.j.cn112151-20240311-00159

J Zhao, J W Zhang, T Jiang, S J Yu, D T Xiong, Y F Lu, W J Gan

引用次数: 0

[A new substrate Magenta suitable for immunohistochemical staining and its application]. [适用于免疫组化染色的新底物品红及其应用]。

中华病理学杂志 Pub Date : 2024-10-08 DOI: 10.3760/cma.j.cn112151-20240418-00257

C S Wang, C B Chu, X D Wang, J Shi, F Q Meng, H Y Wu

引用次数: 0

[Extramedullary plasmacytoma of the liver: report of a case]. [肝髓外浆细胞瘤：一例报告]。

中华病理学杂志 Pub Date : 2024-10-08 DOI: 10.3760/cma.j.cn112151-20240615-00389

H Wang, S Y Yin, W M Cong, H Dong