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Neuroprotective effect of Dark Chocolate on ketamine-induced animal model of psychosis through the reversal of behavioral, biochemical and histopathological changes 黑巧克力通过逆转行为、生化和组织病理学变化对氯胺酮诱导的精神病动物模型具有神经保护作用
Journal of Advanced Zoology Pub Date : 2024-02-08 DOI: 10.53555/jaz.v45i2.3447
Monu Yadav, M. Parle, Deepak Lamba, Sumit Kumar, Mini Dahiya, Kajal Joshi
{"title":"Neuroprotective effect of Dark Chocolate on ketamine-induced animal model of psychosis through the reversal of behavioral, biochemical and histopathological changes","authors":"Monu Yadav, M. Parle, Deepak Lamba, Sumit Kumar, Mini Dahiya, Kajal Joshi","doi":"10.53555/jaz.v45i2.3447","DOIUrl":"https://doi.org/10.53555/jaz.v45i2.3447","url":null,"abstract":"The present study was designed to evaluate the antipsychotic-like activity of dark chocolate against Ketamine-induced psychosis in animals and to explore the possible underlying mechanisms for this activity. Dark chocolate (200, 400 mg/kg, along with diet), haloperidol (1mg/kg, i.p.), and olanzapine (5mg/kg, i.p) were administered daily to different groups of mice and rats; after 30 min Ketamine was injected for 21 successive days. The antipsychotic- like activity was assessed using an actophotometer, stereotypic behaviors, forced swim test (FST), and passive avoidance test. Dark Chocolate (DC) and olanzapine remarkably decreased the immobility period of Ketamine-treated mice in FST, indicating the beneficial effect of DC against depressive or negative symptoms of psychosis. There was no significant effect on the locomotor activity of the mice with the administration of DC, while it showed a reducing impact against stereotypic behaviors. Furthermore, DC significantly reduced the time taken by the rats to climb the pole, showing the effect of DC on cognition. In addition, acetylcholinesterase (AChE) activity, malondialdehyde (MDA), and tissue necrosis factor (TNF-α) levels were markedly decreased and increased GABA and enhanced reduced glutathione (GSH) levels with the treatment of DC. Furthermore, DC was also effective in reducing the ketamine induced hyperchromatic nuclei, perinuclear vacuolization, and dilated vascular channels in the cortex part of the brain. Behavioral, biochemical, and histopathological studies suggest the protective effect of DC against Ketamine induced psychosis.","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effect of Dark Chocolate on ketamine-induced animal model of psychosis through the reversal of behavioral, biochemical and histopathological changes 黑巧克力通过逆转行为、生化和组织病理学变化对氯胺酮诱导的精神病动物模型具有神经保护作用
Journal of Advanced Zoology Pub Date : 2024-02-08 DOI: 10.53555/jaz.v45i2.3447
Monu Yadav, M. Parle, Deepak Lamba, Sumit Kumar, Mini Dahiya, Kajal Joshi
{"title":"Neuroprotective effect of Dark Chocolate on ketamine-induced animal model of psychosis through the reversal of behavioral, biochemical and histopathological changes","authors":"Monu Yadav, M. Parle, Deepak Lamba, Sumit Kumar, Mini Dahiya, Kajal Joshi","doi":"10.53555/jaz.v45i2.3447","DOIUrl":"https://doi.org/10.53555/jaz.v45i2.3447","url":null,"abstract":"The present study was designed to evaluate the antipsychotic-like activity of dark chocolate against Ketamine-induced psychosis in animals and to explore the possible underlying mechanisms for this activity. Dark chocolate (200, 400 mg/kg, along with diet), haloperidol (1mg/kg, i.p.), and olanzapine (5mg/kg, i.p) were administered daily to different groups of mice and rats; after 30 min Ketamine was injected for 21 successive days. The antipsychotic- like activity was assessed using an actophotometer, stereotypic behaviors, forced swim test (FST), and passive avoidance test. Dark Chocolate (DC) and olanzapine remarkably decreased the immobility period of Ketamine-treated mice in FST, indicating the beneficial effect of DC against depressive or negative symptoms of psychosis. There was no significant effect on the locomotor activity of the mice with the administration of DC, while it showed a reducing impact against stereotypic behaviors. Furthermore, DC significantly reduced the time taken by the rats to climb the pole, showing the effect of DC on cognition. In addition, acetylcholinesterase (AChE) activity, malondialdehyde (MDA), and tissue necrosis factor (TNF-α) levels were markedly decreased and increased GABA and enhanced reduced glutathione (GSH) levels with the treatment of DC. Furthermore, DC was also effective in reducing the ketamine induced hyperchromatic nuclei, perinuclear vacuolization, and dilated vascular channels in the cortex part of the brain. Behavioral, biochemical, and histopathological studies suggest the protective effect of DC against Ketamine induced psychosis.","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"36 S158","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARATIVE ANALYSIS OF SENSILLA ON ANTENNAE AND MOUTHPARTS OF LARVAE IN TWO SPECIES OF DITRYSIAN MOTHS (LEPIDOPTERA) 两种双翅目蛾类（鳞翅目）幼虫触角和口器上感觉器的比较分析
Journal of Advanced Zoology Pub Date : 2024-02-05 DOI: 10.53555/jaz.v45i1.2915
A. S. Kaleka, Harsimrat Kaur Dulai
{"title":"COMPARATIVE ANALYSIS OF SENSILLA ON ANTENNAE AND MOUTHPARTS OF LARVAE IN TWO SPECIES OF DITRYSIAN MOTHS (LEPIDOPTERA)","authors":"A. S. Kaleka, Harsimrat Kaur Dulai","doi":"10.53555/jaz.v45i1.2915","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.2915","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139864750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARATIVE ANALYSIS OF SENSILLA ON ANTENNAE AND MOUTHPARTS OF LARVAE IN TWO SPECIES OF DITRYSIAN MOTHS (LEPIDOPTERA) 两种双翅目蛾类（鳞翅目）幼虫触角和口器上感觉器的比较分析
Journal of Advanced Zoology Pub Date : 2024-02-05 DOI: 10.53555/jaz.v45i1.2915
A. S. Kaleka, Harsimrat Kaur Dulai
{"title":"COMPARATIVE ANALYSIS OF SENSILLA ON ANTENNAE AND MOUTHPARTS OF LARVAE IN TWO SPECIES OF DITRYSIAN MOTHS (LEPIDOPTERA)","authors":"A. S. Kaleka, Harsimrat Kaur Dulai","doi":"10.53555/jaz.v45i1.2915","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.2915","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacognostical Exploration And Pharmacological Potential Of Solanum Indicum Berries Belongs To The Family Solanaceae 茄科植物茄属浆果的药理探索和药理潜力
Journal of Advanced Zoology Pub Date : 2024-01-16 DOI: 10.53555/jaz.v45i1.3371
Mr. Sandip Chatterjee, Mr. Sourav Khawas, Dr. Sabita Kumari, Kiran Raj Satpathy
{"title":"Pharmacognostical Exploration And Pharmacological Potential Of Solanum Indicum Berries Belongs To The Family Solanaceae","authors":"Mr. Sandip Chatterjee, Mr. Sourav Khawas, Dr. Sabita Kumari, Kiran Raj Satpathy","doi":"10.53555/jaz.v45i1.3371","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.3371","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"36 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139528450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing Drug Delivery: The Role of Nanofibers - A Review 给药革命：纳米纤维的作用 - 综述
Journal of Advanced Zoology Pub Date : 2024-01-12 DOI: 10.53555/jaz.v45i1.3347
Niyati Shah, Ritu Sapra, Mamta Kumari, Piyushkumar Sadhu, Chitrali R. Talele
{"title":"Revolutionizing Drug Delivery: The Role of Nanofibers - A Review","authors":"Niyati Shah, Ritu Sapra, Mamta Kumari, Piyushkumar Sadhu, Chitrali R. Talele","doi":"10.53555/jaz.v45i1.3347","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.3347","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation And Evaluation Of Mouth Dissolving Tablets Of Amoxapine 阿莫沙平口腔溶解片的配制与评估
Journal of Advanced Zoology Pub Date : 2024-01-10 DOI: 10.53555/jaz.v45is1.3380
G. B. Buela, Shaheen, S. Suguna, N. M, Voleti Vijaya Kumar
{"title":"Formulation And Evaluation Of Mouth Dissolving Tablets Of Amoxapine","authors":"G. B. Buela, Shaheen, S. Suguna, N. M, Voleti Vijaya Kumar","doi":"10.53555/jaz.v45is1.3380","DOIUrl":"https://doi.org/10.53555/jaz.v45is1.3380","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"65 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Nano-Herbal Innovations: Precision In Therapeutic Delivery” "纳米草药创新：精准治疗"
Journal of Advanced Zoology Pub Date : 2024-01-10 DOI: 10.53555/jaz.v45i1.3392
Niyati Shah, Mamta Kumari, Piyushkumar Sadhu, Chitrali R. Talele, Hemraj Singh Rajput, Ritu Sapra
{"title":"“Nano-Herbal Innovations: Precision In Therapeutic Delivery”","authors":"Niyati Shah, Mamta Kumari, Piyushkumar Sadhu, Chitrali R. Talele, Hemraj Singh Rajput, Ritu Sapra","doi":"10.53555/jaz.v45i1.3392","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.3392","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of habit behaviours in severity of Oral lichen planus, Oral submucous fibrosis and Leukoplakia: A cross sectional study 习惯行为对口腔扁平苔藓、口腔黏膜下纤维化和白斑病严重程度的影响：横断面研究
Journal of Advanced Zoology Pub Date : 2024-01-10 DOI: 10.53555/jaz.v45i1.3453
Saba Khan, D. N. Mehta
{"title":"Role of habit behaviours in severity of Oral lichen planus, Oral submucous fibrosis and Leukoplakia: A cross sectional study","authors":"Saba Khan, D. N. Mehta","doi":"10.53555/jaz.v45i1.3453","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.3453","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"66 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Overview Of Sickle Cell Disease: Global Impact, Management Strategies, And Future Directions 镰状细胞病综述：全球影响、管理策略和未来方向
Journal of Advanced Zoology Pub Date : 2024-01-10 DOI: 10.53555/jaz.v45i1.3390
H. Rajput, Mamta Kumari, Chitrali R. Talele, Cyril Sajan, Varunsingh Saggu, Rajesh Hadia
{"title":"Comprehensive Overview Of Sickle Cell Disease: Global Impact, Management Strategies, And Future Directions","authors":"H. Rajput, Mamta Kumari, Chitrali R. Talele, Cyril Sajan, Varunsingh Saggu, Rajesh Hadia","doi":"10.53555/jaz.v45i1.3390","DOIUrl":"https://doi.org/10.53555/jaz.v45i1.3390","url":null,"abstract":"","PeriodicalId":35945,"journal":{"name":"Journal of Advanced Zoology","volume":"67 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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