{"title":"[Pathogenesis and treatment of primary sclerosing cholangitis -Role of the gut microbiota].","authors":"Haruka Okada, Takanori Kanai, Nobuhiro Nakamoto","doi":"10.11405/nisshoshi.122.235","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.235","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 4","pages":"235-247"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Drug-induced liver injury due to asymptomatically discovered Saire-to: a case report].","authors":"Soshi Oyama, Kazuo Okumoto, Shotaro Akiba, Hidekazu Horiuchi, Shigemi Hachinohe","doi":"10.11405/nisshoshi.122.216","DOIUrl":"10.11405/nisshoshi.122.216","url":null,"abstract":"<p><p>A 59-year-old female patient was prescribed Saire-to for dizziness. She demonstrated no symptoms, but a blood test conducted after 5 months revealed liver dysfunction, and thus she was referred to and admitted to our hospital. Her condition rapidly improved after drug discontinuation, and a liver biopsy test confirmed drug-induced liver injury, with a positive drug-induced lymphocyte stimulation test. Herbal medicine-induced liver damage has been increasing in recent years, many of which contain Ougon. Herbal medicines that contain Ougon pose a risk of liver damage;thus, regular blood tests are required even in the absence of symptoms.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 3","pages":"216-220"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Liver transplantation for primary sclerosing cholangitis:current status and challenges].","authors":"Shintaro Yagi, Hironori Haga, Hiroyuki Isayama","doi":"10.11405/nisshoshi.122.269","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.269","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 4","pages":"269-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A case of rectal varices with recurrent hepatic encephalopathy successfully treated with percutaneous embolization].","authors":"Shohei Amioka, Kohei Fukumoto, Yasuhide Mitsumoto, Keiichiro Okuda, Kei Terasaki, Hirohisa Oya, Takayuki Katayama, Chiemi Mizuno, Toshihide Shima, Takeshi Okanoue","doi":"10.11405/nisshoshi.122.368","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.368","url":null,"abstract":"<p><p>We report the case of an 81-year-old woman with a history of primary biliary cholangitis who had been hospitalized multiple times for hepatic encephalopathy. She presented with fresh bloody stools, and contrast-enhanced abdominal computed tomography (CT) revealed a dilated inferior mesenteric vein and varices protruding into the rectal lumen. A colonoscopy confirmed the presence of rectal varices (Rb), leading to a diagnosis of rectal variceal bleeding as the source of the hematochezia. Given her history of recurrent hepatic encephalopathy, percutaneous embolization was performed via a direct approach to the superior rectal vein to occlude the rectal varices and their feeding vessels. A follow-up colonoscopy performed 2 days after embolization showed that the rectal varices had decreased in size and had changed in color from red to blue. Contrast-enhanced CT conducted 5 days post-treatment demonstrated the disappearance of contrast enhancement in the rectal varices and thrombus formation leading to cessation of blood flow in the inferior mesenteric vein. The patient was subsequently discharged without further episodes of rectal variceal bleeding or recurrence of hepatic encephalopathy.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 5","pages":"368-374"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[BRAF V600E-positive intrahepatic cholangiocarcinoma with suspected malignant transformation of the bile duct adenoma:a case report].","authors":"Masayuki Miyazaki, Keisuke Sakaguchi, Yuichi Tachibana, Akihiro Ueda, Seiya Kato, Osamu Nakashima, Tetsuro Akashi","doi":"10.11405/nisshoshi.122.288","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.288","url":null,"abstract":"<p><p>A 69-year-old woman was diagnosed with extrahepatic portal vein occlusion and liver cirrhosis. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a ring-enhanced liver tumor. A liver tumor biopsy detected small bile duct proliferation without atypia and a map-like pattern on immunostaining for glutamine synthetase, resulting in a focal nodular hyperplasia diagnosis. CT after 4 years revealed the increased liver tumor. The patient was suspected of intrahepatic cholangiocarcinoma based on MRI findings. A liver tumor biopsy was re-conducted, and the patient was diagnosed with intrahepatic cholangiocarcinoma (small duct type), which was positive for BRAF V600E on immunostaining. We re-investigated the initial liver tumor biopsy tissue and diagnosed the BRAF V600E-positive bile duct adenoma, indicating a malignant transformation of the bile duct adenoma to an intrahepatic cholangiocarcinoma.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 4","pages":"288-296"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Crohn's disease complicated with squamous cell carcinoma originating from an enterocutaneous fistula:a case report].","authors":"Ayako Komatsu, Kazutaka Koganei, Kenji Tatsumi, Hirosuke Kuroki, Nao Obara, Sayumi Saito, Akira Sugita, Hiroyuki Hayashi","doi":"10.11405/nisshoshi.122.51","DOIUrl":"10.11405/nisshoshi.122.51","url":null,"abstract":"<p><p>This case report describes Crohn's disease complicated by squamous cell carcinoma in an enterocutaneous fistula. A 48-year-old male patient was diagnosed with Crohn's disease 24 years ago and has undergone five surgical operations. An enterocutaneous fistula originated from the midline abdominal wound 11 years after the onset. Azathioprine was initiated instead of surgery due to frequent recurrence of the fistula and his short residual small intestine (approximately 170cm). We followed him every 3 months and continued prescribing azathioprine as his fistula secretions decreased and became manageable. He noticed a mass at the same site 13 years after the appearance of the enterocutaneous fistula which was diagnosed as squamous cell carcinoma through biopsy. The tumor was markedly reduced after preoperative chemoradiotherapy. We resected the affected intestinal tract and abdominal wall associated with the enterocutaneous fistula, and he acheived a pathological complete response. Squamous cell carcinoma originating from an enterocutaneous fistula in Crohn's disease is rare;however, long-standing inflammatory lesions should be carefully monitored for carcinogenesis.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 1","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Current status of intestinal transplantation].","authors":"Takehisa Ueno","doi":"10.11405/nisshoshi.122.189","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.189","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 3","pages":"189-195"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}