{"title":"[Advances and future prospects in chemotherapy for gastrointestinal and pancreatic neuroendocrine tumors].","authors":"Masafumi Ikeda, Hiroshi Imaoka, Shuichi Mitsunaga","doi":"10.11405/nisshoshi.122.541","DOIUrl":"10.11405/nisshoshi.122.541","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 8","pages":"541-549"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Difficulty factors related to self-expandable metallic stent placement for malignant colonic obstruction].","authors":"Kazuki Boda, Hideharu Okanobu, Tomohiko Kohno, Toshitsune Ikeda, Takuya Okamoto, Kaho Fukuda, Eisuke Miyaki, Ryo Yuge, Tomoyuki Minami, Yoshinari Furukawa","doi":"10.11405/nisshoshi.122.278","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.278","url":null,"abstract":"<p><p>Recently, the endoscopic placement of self-expandable metallic stents (SEMS) for malignant colorectal obstruction has been increasing, but the longer procedure time may cause serious complications. This study aimed to confirm the efficacy and factors that prolong the procedure time for SEMS placement. This study enrolled 92 patients who required SEMS placement for malignant colonic obstruction at the Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital from June 2015 to July 2024. The technical success rate was 95.7% and the clinical success rate was 92.4%. The total median procedure time was 37 min and the median procedure time for SEMS placement was 23 min. The major adverse events included perforation (3.3%), stent migration (4.3%), and stent occlusion (4.3%). Deaths related to SEMS placement were not reported. Multivariate analyses revealed significant associations between technically difficult placement and stricture length of ≥5cm (odds ratio [OR]:6.34;p=0.022) as well as lesions invisible from the front (OR:34.30;p<0.001). Endoscopic placement of SEMS for malignant colorectal obstruction is an effective treatment with a high success rate but requires careful attention for lesions that are invisible from the front.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 4","pages":"278-287"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Evidence based medical care of MASLD/MASH -Future perspective of Japanese guideline].","authors":"Norio Akuta","doi":"10.11405/nisshoshi.122.319","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.319","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 5","pages":"319-322"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The current status of simultaneous liver kidney transplantation in Japan].","authors":"Ryugen Takahashi, Nobuhisa Akamatsu, Kiyoshi Hasegawa","doi":"10.11405/nisshoshi.122.624","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.624","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 9","pages":"624-629"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shohei Hirano, Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tomohiko Ikehara, Yudai Kuroiwa, Kenya Nakamura, Yuji Soejima
{"title":"[Neuroendocrine carcinoma of the extrahepatic bile duct:a case report].","authors":"Shohei Hirano, Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tomohiko Ikehara, Yudai Kuroiwa, Kenya Nakamura, Yuji Soejima","doi":"10.11405/nisshoshi.122.59","DOIUrl":"10.11405/nisshoshi.122.59","url":null,"abstract":"<p><p>A 78-year-old male patient came to our hospital with a chief complaint of fever. Computed tomography revealed an indistinct tumor in the pancreatic head, along with dilatation of the bile duct and main pancreatic duct. An endoscopic transpapillary biopsy demonstrated adenocarcinoma in the glandular epithelium and a dense formation of quasi-round cells. Pathology results indicated positive CK AE1/AE3 and INSM-1, negative CD45, and a Ki67 index of about 80%, leading to a diagnosis of neuroendocrine carcinoma (NEC) Grade 3 of the pancreatic head. Consequently, a pancreatoduodenectomy was performed. Postoperative pathology revealed small cell NEC (SCNEC) at the pancreatic head, with infiltrative growth of atypical gland ducts around the bile ducts, indicating the presence of a well-differentiated adenocarcinoma. The adenocarcinoma contained in situ lesions and biliary intraepithelial neoplasia (BilIN), with SCNEC being contiguous. Therefore, the diagnosis was NEC originating from the extrahepatic bile duct, which invaded the pancreatic head. NEC of the extrahepatic bile duct is rare, accounting for approximately 0.2-2% of gastrointestinal neuroendocrine tumors, and it has a poor prognosis, similar to other gastrointestinal NECs, even when surgical treatment is performed. The patient remained an outpatient without recurrence 17 months postoperatively.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Spontaneous reactivation of hepatitis B virus in an elderly patient: a case report and review of the literature].","authors":"Haruo Nakayama, Satoshi Takai, Masanori Tosa, Toshiyuki Ikeda, Seiichi Takahashi, Shinichi Ikeya","doi":"10.11405/nisshoshi.122.121","DOIUrl":"10.11405/nisshoshi.122.121","url":null,"abstract":"<p><p>Reactivation of resolved hepatitis B virus (HBV) infection without any immunosuppressants has rarely been reported. Here, we describe the spontaneous HBV reactivation in a 78-year-old male patient with resolved HBV infection. Twenty-five years ago, he received interferon treatment for chronic hepatitis C. Concurrently, he was negative for HBsAg and positive for anti-HBcAb, and he achieved a sustained virological response (SVR). He developed hepatitis B infection without any cause at the age of 78 years. His serum was positive for HBsAg, HBeAg, and HBV DNA (4.9logIU/ml;genotype B), but negative for anti-HBc IgM and HCV RNA. A liver biopsy revealed A2F1. His serum HBsAg and HBV DNA levels became negative 2 months and 6 months after entecavir treatment, respectively. HBcrAg, the last remaining HBV marker, became negative after 2 years, and ETV treatment was completed after 27 months. No HBV reactivation was observed 4 years after the end of treatment. Full-genome HBV sequence analysis indicated that the patient was infected with HBV of subgenotype B1 and had no mutations in the S, the core promoter, and pre-core regions. This case developed de novo hepatitis B without any immunosuppressants, indicating that aging may have been responsible for the spontaneous HBV reactivation. Additionally, in this report, we summarized the reported cases of reactivation of resolved hepatitis B in elderly patients with no previous triggers.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 2","pages":"121-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Anal high grade dysplasia associated with Crohn's disease:a case report].","authors":"Yuka Inaba, Kenji Tatsumi, Hirosuke Kuroki, Nao Obara, Akira Sugita, Hiroyuki Imaeda, Kazutaka Koganei","doi":"10.11405/nisshoshi.122.564","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.564","url":null,"abstract":"<p><p>A 47-year-old male patient with anal pain underwent a colonoscopy 12 years after Crohn's disease diagnosis. A biopsy from the protuberance of the anal canal revealed a well-differentiated adenocarcinoma. A reexamination of the histopathological specimen at our hospital revealed anal high grade dysplasia (HGD), thereby changing the initial diagnosis. A distal colon resection and rectal amputation were performed, and the final diagnosis of the resected specimen was anal canal HGD. While HGD associated with Crohn's disease is rare in Japan, this case suggests the importance of endoscopic examination, which might help in early detection of HGD.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 8","pages":"564-572"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}