{"title":"[Current status of strictureplasty surgery for Crohn's disease].","authors":"Yuki Horio, Hiroki Ikeuchi, Motoi Uchino","doi":"10.11405/nisshoshi.123.173","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.173","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 3","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Emphysematous pancreatitis improved by conservative treatment: a case report].","authors":"Soshi Oyama, Hidekazu Horiuchi, Shotaro Akiba, Kazuo Okumoto, Shigemi Hachinohe","doi":"10.11405/nisshoshi.123.66","DOIUrl":"10.11405/nisshoshi.123.66","url":null,"abstract":"<p><p>A 74-year-old male patient with upper abdominal pain visited the outpatient clinic. A computed tomography scan revealed pancreatic enlargement, increased density of the surrounding fatty tissue, and retroperitoneal emphysema, which collectively indicated to emphysematous pancreatitis. Upper gastrointestinal endoscopy revealed no gastrointestinal perforation. His treatment regimen included fasting, fluid replacement, antibiotics, and total parenteral nutrition. Temporary encapsulation was observed, but eventually improved. A common bile duct stone was later discovered, and thus endoscopic lithotripsy was performed. Acute pancreatitis-induced retroperitoneal emphysema is referred to as emphysematous pancreatitis and is considered a subtype of necrotizing pancreatitis. Emphysematous pancreatitis is a rare disease with a poor prognosis;nonetheless, early diagnosis including confirmation of gastrointestinal perforation, and antibiotic administration along with drainage are required.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Unresectable advanced gastric cancer in which tumor shrinkage persisted for a long period even after the discontinuation of nivolumab third-line treatment due to immune-related adverse events:a case report].","authors":"Soichiro Torizawa, Takayuki Nakanishi, Hiroshi Araki, Makoto Kamei, Hiroyuki Makino, Ryotaro Nagao, Fumiya Kataoka, Takayuki Asano, Atsushi Tagami, Hisataka Moriwaki","doi":"10.11405/nisshoshi.123.291","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.291","url":null,"abstract":"<p><p>A 77-year-old man with unresectable advanced gastric cancer, complicated by multiple liver and distant lymph node metastases, began drug therapy. As a third-line treatment, nivolumab was administered for two courses;however, the patient developed destructive thyroiditis. Treatment with nivolumab was resumed after clinical improvement, but the patient developed interstitial pneumonia following a total of four courses, leading to discontinuation of treatment. Although nivolumab was discontinued and no further drug therapy was initiated, tumor shrinkage persisted for 15 months. Notably, the metastatic lesions remained stable and the tumor markers had not increased even 29 months later. The patient's clinical course differed from that typically observed in patients treated with conventional cytotoxic agents, as tumor shrinkage continued long after the discontinuation of nivolumab.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 4","pages":"291-299"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Recent advances in systemic therapy for unresectable biliary tract cancer: development of immunotherapy and personalized medicine].","authors":"Hiroshi Imaoka, Tomoyuki Satake, Masafumi Ikeda","doi":"10.11405/nisshoshi.123.255","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.255","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 4","pages":"255-267"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Infliximab-induced autoimmune-like hepatitis developed during treatment for Crohn's disease:a case report].","authors":"Shinichi Iwamura, Kunihisa Uchita, Yuriko Shigehisa, Michiyo Okazaki, Kenji Yorita","doi":"10.11405/nisshoshi.123.207","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.207","url":null,"abstract":"<p><p>A female patient in her 20s with abdominal pain, diarrhea, fever, and arthralgia was referred to our hospital. Colonoscopy revealed multiple ulcers in the right colon, and biopsy demonstrated non-caseating granulomas, leading to a Crohn's disease diagnosis. She initially received adalimumab, but secondary loss of response occurred after 5 years. Her treatment was then switched to infliximab (IFX), which induced remission. Liver dysfunction was noted at 9 months after IFX initiation. Laboratory tests revealed positive antinuclear antibody (ANA), and liver biopsy demonstrated lymphoplasmacytic infiltration in the portal areas with interface hepatitis, indicating autoimmune hepatitis (AIH). After IFX discontinuation and ustekinumab initiation, alanine aminotransferase levels normalized within 4 months, whereas ANA status turned negative by 9 months. IFX has been implicated in drug-induced autoimmune-like hepatitis, which typically resolves with drug withdrawal alone and rarely relapses upon discontinuing the immunosuppressive treatment. This case highlights the importance of distinguishing IFX-induced hepatitis from classical AIH to prevent unnecessary long-term immunosuppression.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 3","pages":"207-213"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Current status and challenges of minimally invasive surgery for ulcerative colitis].","authors":"Shinichi Yamauchi, Hiroyasu Kagawa, Yusuke Kinugasa","doi":"10.11405/nisshoshi.123.185","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.185","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 3","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Acute cholecystitis associated with IgG4-related sclerosing cholangitis: a case report].","authors":"Shoichiro Yoneyama, Ichitaro Horiuchi, Nobukazu Sasaki, Masafumi Minamisawa, Shohei Kondo, Takumi Yanagisawa, Masato Kamakura, Yasuhiro Kuraishi, Akira Nakamura","doi":"10.11405/nisshoshi.123.57","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.57","url":null,"abstract":"<p><p>A 72-year-old male patient with jaundice and hilar bile duct stenosis, initially suspected to have cholangiocarcinoma, was referred to our hospital. Subsequent cholangiography revealed bile duct stenosis improvement, and intraductal ultrasonography demonstrated homogeneous bile duct wall thickening. The increased serum immunoglobulin G4 (IgG4) levels and the presence of other organ lesions possibly indicated to IgG4-related sclerosing cholangitis (IgG4-SC). After 2 months, the patient developed acute cholecystitis. Endoscopic ultrasonography revealed circumferential wall thickening that extended from the common bile duct to the cystic duct. Cholangiography demonstrated cholecystic duct stenosis. The cholecystitis might have originated from bile stasis caused by cystic duct stenosis associated with IgG4-SC. Consequently, both IgG4-SC and the cholecystitis improved with steroid treatment.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Current situation of endoscopic biliary drainage for bile tract cancer].","authors":"Takuji Iwashita, Noriaki Yamashita, Shuhei Shintani","doi":"10.11405/nisshoshi.123.239","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.239","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 4","pages":"239-245"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}