Japanese Journal of Gastroenterology最新文献_第2页

[Short bowel syndrome in adults].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.169

Kazuhiro Watanabe, Shinobu Ohnuma, Michiaki Unno

引用次数: 0

[Spontaneous reactivation of hepatitis B virus in an elderly patient: a case report and review of the literature].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.121

Haruo Nakayama, Satoshi Takai, Masanori Tosa, Toshiyuki Ikeda, Seiichi Takahashi, Shinichi Ikeya

{"title":"[Spontaneous reactivation of hepatitis B virus in an elderly patient: a case report and review of the literature].","authors":"Haruo Nakayama, Satoshi Takai, Masanori Tosa, Toshiyuki Ikeda, Seiichi Takahashi, Shinichi Ikeya","doi":"10.11405/nisshoshi.122.121","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.121","url":null,"abstract":"Reactivation of resolved hepatitis B virus (HBV) infection without any immunosuppressants has rarely been reported. Here, we describe the spontaneous HBV reactivation in a 78-year-old male patient with resolved HBV infection. Twenty-five years ago, he received interferon treatment for chronic hepatitis C. Concurrently, he was negative for HBsAg and positive for anti-HBcAb, and he achieved a sustained virological response (SVR). He developed hepatitis B infection without any cause at the age of 78 years. His serum was positive for HBsAg, HBeAg, and HBV DNA (4.9logIU/ml;genotype B), but negative for anti-HBc IgM and HCV RNA. A liver biopsy revealed A2F1. His serum HBsAg and HBV DNA levels became negative 2 months and 6 months after entecavir treatment, respectively. HBcrAg, the last remaining HBV marker, became negative after 2 years, and ETV treatment was completed after 27 months. No HBV reactivation was observed 4 years after the end of treatment. Full-genome HBV sequence analysis indicated that the patient was infected with HBV of subgenotype B1 and had no mutations in the S, the core promoter, and pre-core regions. This case developed de novo hepatitis B without any immunosuppressants, indicating that aging may have been responsible for the spontaneous HBV reactivation. Additionally, in this report, we summarized the reported cases of reactivation of resolved hepatitis B in elderly patients with no previous triggers.","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 2","pages":"121-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.39

引用次数: 0

[Neuroendocrine carcinoma of the extrahepatic bile duct:a case report]. 肝外胆管神经内分泌癌1例。

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.59

Shohei Hirano, Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tomohiko Ikehara, Yudai Kuroiwa, Kenya Nakamura, Yuji Soejima

{"title":"[Neuroendocrine carcinoma of the extrahepatic bile duct:a case report].","authors":"Shohei Hirano, Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tomohiko Ikehara, Yudai Kuroiwa, Kenya Nakamura, Yuji Soejima","doi":"10.11405/nisshoshi.122.59","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.59","url":null,"abstract":"A 78-year-old male patient came to our hospital with a chief complaint of fever. Computed tomography revealed an indistinct tumor in the pancreatic head, along with dilatation of the bile duct and main pancreatic duct. An endoscopic transpapillary biopsy demonstrated adenocarcinoma in the glandular epithelium and a dense formation of quasi-round cells. Pathology results indicated positive CK AE1/AE3 and INSM-1, negative CD45, and a Ki67 index of about 80%, leading to a diagnosis of neuroendocrine carcinoma (NEC) Grade 3 of the pancreatic head. Consequently, a pancreatoduodenectomy was performed. Postoperative pathology revealed small cell NEC (SCNEC) at the pancreatic head, with infiltrative growth of atypical gland ducts around the bile ducts, indicating the presence of a well-differentiated adenocarcinoma. The adenocarcinoma contained in situ lesions and biliary intraepithelial neoplasia (BilIN), with SCNEC being contiguous. Therefore, the diagnosis was NEC originating from the extrahepatic bile duct, which invaded the pancreatic head. NEC of the extrahepatic bile duct is rare, accounting for approximately 0.2-2% of gastrointestinal neuroendocrine tumors, and it has a poor prognosis, similar to other gastrointestinal NECs, even when surgical treatment is performed. The patient remained an outpatient without recurrence 17 months postoperatively.","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Current status and prospects of image enhanced endoscopy in the upper gastrointestinal tract].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.78

Mitsuru Kaise, Katsuhiko Iwakiri

引用次数: 0

[Imaging diagnosis of IPMN]. 【IPMN影像学诊断】。

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.9

Eizaburo Ohno, Yoshiki Hirooka

引用次数: 0

[Hemosuccus pancreaticus caused by pancreatic cancer treated with radiation therapy for hemostasis].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.130

Hirofumi Harima, Harumi Suehiro, Michitaka Kawano, Tadasuke Hanazono, Kenji Mori, Yasuyo Chochi, Taro Takami

{"title":"[Hemosuccus pancreaticus caused by pancreatic cancer treated with radiation therapy for hemostasis].","authors":"Hirofumi Harima, Harumi Suehiro, Michitaka Kawano, Tadasuke Hanazono, Kenji Mori, Yasuyo Chochi, Taro Takami","doi":"10.11405/nisshoshi.122.130","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.130","url":null,"abstract":"A 67-year-old female patient, with a chief complaint of melena, was referred to our hospital because of a pancreatic tumor. A blood assessment revealed anemia with a hemoglobin (Hb) level of 7.7g/dL. Contrast-enhanced computed tomography (CT) detected a large pancreatic tail tumor and liver metastasis. Upper endoscopy demonstrated bile juice containing a blood-like red in the duodenum. We confirmed the pancreatic cancer diagnosis via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). CT after the procedure indicated a hematoma in the pancreatic tumor. The patient required frequent blood transfusions due to severe anemia. The second upper endoscopy demonstrated bleeding from the papilla of Vater. We diagnosed the patient with hemosuccus pancreaticus (HP). Pancreatic cancer, not hematoma, was considered to cause HP because we detected blood, such as red bile juice, before EUS-FNA. Her Hb levels decreased although she underwent coil embolization of the left gastric artery and splenic artery branches. We considered surgical treatment to stop the bleeding, but we abandoned surgery because of the pancreatic cancer invasion of the surrounding organs. We then attempted radiation therapy. Her Hb level stopped decreasing following treatment. She did not need frequent blood transfusions until she received radiation therapy and died 3 months later. The autopsy revealed a final diagnosis of anaplastic carcinoma. HP is an uncommon disease caused by bleeding from the papilla of Vater. HP is frequently caused by chronic pancreatitis, but it is also induced by a pancreatic tumor. Most HP cases received interventional radiology and surgical treatment. Here, we describe a case of HP caused by pancreatic cancer in which radiation therapy was effective for hemostasis.","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 2","pages":"130-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Image-enhanced endoscopy and AI in upper gastrointestinal screening].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.112

Toshiaki Hirasawa, Sho Suzuki, Tomohiro Tada

引用次数: 0

[Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.196

Yusuke Ozeki, Jun Kato, Yuki Ohta, Takashi Taida, Ryosuke Horio, Michiko Sonoda, Tatsuya Kaneko, Kenichiro Okimoto, Keiko Saito, Tomoaki Matsumura, Naoya Kato

{"title":"[Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease].","authors":"Yusuke Ozeki, Jun Kato, Yuki Ohta, Takashi Taida, Ryosuke Horio, Michiko Sonoda, Tatsuya Kaneko, Kenichiro Okimoto, Keiko Saito, Tomoaki Matsumura, Naoya Kato","doi":"10.11405/nisshoshi.122.196","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.196","url":null,"abstract":"Iron deficiency anemia (IDA) is a prevalent complication in patients with inflammatory bowel disease (IBD). Ferric carboxymaltose (FCM) is a new intravenous iron formation that has been available for IDA in Japan since 2020. The present study aimed to investigate the efficacy and safety of FCM in patients with IBD and IDA. This single-center retrospective study included 41 patients with IBD treated with FCM at our hospital from September 2020 to June 2023. The FCM administered dose was 500mg in 28 patients, 1000mg in 7 patients, and >1500mg in 6 patients. The median hemoglobin level improved from 9.8g/dL to 11.8g/dL at 16 weeks after the first FCM administration during the study period. Median change in hemoglobin levels 16 weeks after the first FCM dose did not significantly differ between patients with low C-reactive protein (CRP) levels (CRP ≤0.5mg/dL;n=31) and those with high CRP levels (CRP >0.5mg/dL;n=10) (2.2g/dL vs. 1.7g/dL, p=0.94). Adverse events were observed in 6 patients, including hypophosphatemia in 2 (4.9%) and osteomalacia in 1 (2.4%). FCM administration in patients with IBD is expected to improve anemia even with fewer administrations.","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 3","pages":"196-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Efforts to reduce parenteral support in short bowel syndrome].

Japanese Journal of Gastroenterology Pub Date : 2025-01-01 DOI: 10.11405/nisshoshi.122.178

Toshiyuki Sato, Yuki Horio, Shinichiro Shinzaki

引用次数: 0