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Japanese Journal of Gastroenterology最新文献

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[Treatment selection for ulcerative colitis from the perspective of cytokine patterns: a stratification strategy based on inflammatory structure and cytokine profiles]. [从细胞因子模式的角度选择溃疡性结肠炎的治疗方法：基于炎症结构和细胞因子谱的分层策略]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.466
Ken Sugimoto
{"title":"[Treatment selection for ulcerative colitis from the perspective of cytokine patterns: a stratification strategy based on inflammatory structure and cytokine profiles].","authors":"Ken Sugimoto","doi":"10.11405/nisshoshi.123.466","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.466","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 7","pages":"466-471"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Infliximab-induced autoimmune-like hepatitis developed during treatment for Crohn's disease:a case report]. [英夫利昔单抗治疗克罗恩病期间发生的自身免疫性肝炎1例报告]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.207
Shinichi Iwamura, Kunihisa Uchita, Yuriko Shigehisa, Michiyo Okazaki, Kenji Yorita
{"title":"[Infliximab-induced autoimmune-like hepatitis developed during treatment for Crohn's disease:a case report].","authors":"Shinichi Iwamura, Kunihisa Uchita, Yuriko Shigehisa, Michiyo Okazaki, Kenji Yorita","doi":"10.11405/nisshoshi.123.207","DOIUrl":"10.11405/nisshoshi.123.207","url":null,"abstract":"<p><p>A female patient in her 20s with abdominal pain, diarrhea, fever, and arthralgia was referred to our hospital. Colonoscopy revealed multiple ulcers in the right colon, and biopsy demonstrated non-caseating granulomas, leading to a Crohn's disease diagnosis. She initially received adalimumab, but secondary loss of response occurred after 5 years. Her treatment was then switched to infliximab (IFX), which induced remission. Liver dysfunction was noted at 9 months after IFX initiation. Laboratory tests revealed positive antinuclear antibody (ANA), and liver biopsy demonstrated lymphoplasmacytic infiltration in the portal areas with interface hepatitis, indicating autoimmune hepatitis (AIH). After IFX discontinuation and ustekinumab initiation, alanine aminotransferase levels normalized within 4 months, whereas ANA status turned negative by 9 months. IFX has been implicated in drug-induced autoimmune-like hepatitis, which typically resolves with drug withdrawal alone and rarely relapses upon discontinuing the immunosuppressive treatment. This case highlights the importance of distinguishing IFX-induced hepatitis from classical AIH to prevent unnecessary long-term immunosuppression.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 3","pages":"207-213"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of primary biliary cholangitis whose pathology changed during autoimmune hepatitis]. 【自身免疫性肝炎病理改变的原发性胆管炎1例】。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.428
Takumi Hanatani, Shotaro Akiba, Hidekazu Horiuchi, Kazuo Okumoto, Shigemi Hachinohe
{"title":"[A case of primary biliary cholangitis whose pathology changed during autoimmune hepatitis].","authors":"Takumi Hanatani, Shotaro Akiba, Hidekazu Horiuchi, Kazuo Okumoto, Shigemi Hachinohe","doi":"10.11405/nisshoshi.123.428","DOIUrl":"10.11405/nisshoshi.123.428","url":null,"abstract":"<p><p>A 70-year-old female patient was diagnosed with autoimmune hepatitis (AIH) at the age of 58 years based on antinuclear antibodies (1:1280) and liver biopsy findings. She received prednisolone (PSL). Over time, elevated levels of liver enzymes and alkaline phosphatase were observed, and 12 years later, a repeat liver biopsy revealed no signs of AIH but showed characteristics of primary biliary cholangitis (PBC). After reducing the PSL dose and starting ursodeoxycholic acid and pemafibrate, the blood test results improved. A liver biopsy is useful if a change in the condition is suspected, even in a patient undergoing follow-up for AIH or PBC.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 6","pages":"428-434"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute cholecystitis associated with IgG4-related sclerosing cholangitis: a case report]. [急性胆囊炎合并igg4相关性硬化性胆管炎1例]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.57
Shoichiro Yoneyama, Ichitaro Horiuchi, Nobukazu Sasaki, Masafumi Minamisawa, Shohei Kondo, Takumi Yanagisawa, Masato Kamakura, Yasuhiro Kuraishi, Akira Nakamura
{"title":"[Acute cholecystitis associated with IgG4-related sclerosing cholangitis: a case report].","authors":"Shoichiro Yoneyama, Ichitaro Horiuchi, Nobukazu Sasaki, Masafumi Minamisawa, Shohei Kondo, Takumi Yanagisawa, Masato Kamakura, Yasuhiro Kuraishi, Akira Nakamura","doi":"10.11405/nisshoshi.123.57","DOIUrl":"10.11405/nisshoshi.123.57","url":null,"abstract":"<p><p>A 72-year-old male patient with jaundice and hilar bile duct stenosis, initially suspected to have cholangiocarcinoma, was referred to our hospital. Subsequent cholangiography revealed bile duct stenosis improvement, and intraductal ultrasonography demonstrated homogeneous bile duct wall thickening. The increased serum immunoglobulin G4 (IgG4) levels and the presence of other organ lesions possibly indicated to IgG4-related sclerosing cholangitis (IgG4-SC). After 2 months, the patient developed acute cholecystitis. Endoscopic ultrasonography revealed circumferential wall thickening that extended from the common bile duct to the cystic duct. Cholangiography demonstrated cholecystic duct stenosis. The cholecystitis might have originated from bile stasis caused by cystic duct stenosis associated with IgG4-SC. Consequently, both IgG4-SC and the cholecystitis improved with steroid treatment.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A challenging diagnostic case of hepatic mass]. [一个具有挑战性的肝脏肿块诊断病例]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.214
Sotaro Yamamoto, Shigeyuki Suenaga, Takushi Morishige, Hiroo Kawano, Yoshinobu Hoshii, Taro Takami
{"title":"[A challenging diagnostic case of hepatic mass].","authors":"Sotaro Yamamoto, Shigeyuki Suenaga, Takushi Morishige, Hiroo Kawano, Yoshinobu Hoshii, Taro Takami","doi":"10.11405/nisshoshi.123.214","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.214","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 3","pages":"214-219"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current situation of endoscopic biliary drainage for bile tract cancer]. 【胆道癌内镜下胆道引流的现状】。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.239
Takuji Iwashita, Noriaki Yamashita, Shuhei Shintani
{"title":"[Current situation of endoscopic biliary drainage for bile tract cancer].","authors":"Takuji Iwashita, Noriaki Yamashita, Shuhei Shintani","doi":"10.11405/nisshoshi.123.239","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.239","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 4","pages":"239-245"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Complete response to durvalumab+tremelimumab as second-line therapy after atezolizumab+bevacizumab in peritoneal recurrence after liver resection: a case report]. [阿特唑单抗+贝伐单抗治疗肝切除术后腹膜复发，durvalumab+tremelimumab作为二线治疗完全缓解：1例报告]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.421
Shu Inagaki, Yukiyasu Okamura, Hayato Abe, Osamu Aramaki
{"title":"[Complete response to durvalumab+tremelimumab as second-line therapy after atezolizumab+bevacizumab in peritoneal recurrence after liver resection: a case report].","authors":"Shu Inagaki, Yukiyasu Okamura, Hayato Abe, Osamu Aramaki","doi":"10.11405/nisshoshi.123.421","DOIUrl":"10.11405/nisshoshi.123.421","url":null,"abstract":"<p><p>A male patient in his 70s experienced peritoneal dissemination recurrence after resection for hepatocellular carcinoma. The disease progressed despite initial atezolizumab+bevacizumab combination therapy. Consequently, durvalumab+tremelimumab combination therapy was initiated. After one treatment course, the peritoneal disseminated lesions reduced in size, and the protein induced by vitamin K absence or antagonist-II (PIVKA-II) values remarkably decreased. After seven chemotherapy courses, the peritoneal disseminated lesions disappeared, and the PIVKA-II values decreased to normal levels. Peritoneal recurrence after liver resection is generally considered to have a poor prognosis. This case report describes the remarkable efficacy of a combination therapy with durvalumab+tremelimumab after atezolizumab+bevacizumab in advanced hepatocellular carcinoma.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 6","pages":"421-427"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Kyoto international consensus on the issues of gastroesophageal junction and future perspectives of the consensus]. [京都国际共识关于胃食管交界处的问题和未来的共识展望]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.384
Kentaro Sugano
{"title":"[Kyoto international consensus on the issues of gastroesophageal junction and future perspectives of the consensus].","authors":"Kentaro Sugano","doi":"10.11405/nisshoshi.123.384","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.384","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 6","pages":"384-391"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Emerging trends in acute-on-chronic liver failure]. [急性-慢性肝衰竭的新趋势]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.332
Yoshihito Uchida
{"title":"[Emerging trends in acute-on-chronic liver failure].","authors":"Yoshihito Uchida","doi":"10.11405/nisshoshi.123.332","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.332","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 5","pages":"332-337"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changing and unchanging aspects of liver cirrhosis management]. [改变与不变的肝硬化管理方面]。
Japanese Journal of Gastroenterology Pub Date : 2026-01-01 DOI: 10.11405/nisshoshi.123.307
Atsunori Tsuchiya
{"title":"[Changing and unchanging aspects of liver cirrhosis management].","authors":"Atsunori Tsuchiya","doi":"10.11405/nisshoshi.123.307","DOIUrl":"https://doi.org/10.11405/nisshoshi.123.307","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"123 5","pages":"307-311"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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