Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru最新文献_第2页

[Microbiome-Gut-Brain Axis in Irritable Bowel Syndrome: Pathophysiology and Therapeutic Approaches]. [肠易激综合征的微生物-肠-脑轴：病理生理学和治疗方法]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Wilfor Diaz Fernandez, Vanessa Pamela Salolin Vargas, Huber Said Padilla-Zambrano, Maria Susana Cerino-Penaloza, Mauricio Alejandro Saldaña Ruiz, Cadman Leggett

{"title":"[Microbiome-Gut-Brain Axis in Irritable Bowel Syndrome: Pathophysiology and Therapeutic Approaches].","authors":"Wilfor Diaz Fernandez, Vanessa Pamela Salolin Vargas, Huber Said Padilla-Zambrano, Maria Susana Cerino-Penaloza, Mauricio Alejandro Saldaña Ruiz, Cadman Leggett","doi":"","DOIUrl":"","url":null,"abstract":"Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder characterized by chronic abdominal pain, bloating, and altered bowel habits, with a substantial impact on quality of life and healthcare systems. In recent years, the gut microbiota has emerged as a central component in its pathophysiology. Patients with IBS exhibit alterations in microbial diversity and composition -known as dysbiosis- that vary according to clinical subtype: diarrhea-predominant, constipation-predominant, or mixed. These alterations are associated with intestinal epithelial barrier dysfunction, low-grade inflammation mediated by mast cells and proinflammatory cytokines, disturbances in fermentation and gas production, and dysregulation of the microbiota-gut-brain axis, a multidirectional communication system integrating the central nervous system, the enteric nervous system, and the gut microbiota. Microbial metabolites -including short-chain fatty acids, serotonin, tryptamine, and histamine- actively participate in the modulation of motility, visceral sensitivity, and neuroimmunoendocrine responses. In this context, microbiota-targeted therapeutic strategies have emerged, including probiotics, prebiotics, synbiotics, a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet, rifaximin, and fecal microbiota transplantation, showing promising but heterogeneous results. Emerging therapies such as postbiotics and phage therapy open new perspectives. This review analyzes the pathophysiological mechanisms linking dysbiosis to IBS and evaluates the main microbiota-directed therapeutic interventions.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 2","pages":"175-187"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C among people experiencing homelessness in Chile: prevalence and associated factors. 智利无家可归者中的丙型肝炎：患病率及相关因素

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Francisco Idalsoaga, Luis Antonio Diaz, Hanna Blaney, Camila Picchio, Fernanda Contreras, Barbara Ricouz, David Salinas, Valentina Espinoza, Pía Venegas, Miguel Harfagar, Ingrid Santander, María Paz Medel, Carolina Ramirez-Cadiz, Marco Arrese, Alejandro Soza, Abe Oudshoorn, Juan Pablo Arab

{"title":"Hepatitis C among people experiencing homelessness in Chile: prevalence and associated factors.","authors":"Francisco Idalsoaga, Luis Antonio Diaz, Hanna Blaney, Camila Picchio, Fernanda Contreras, Barbara Ricouz, David Salinas, Valentina Espinoza, Pía Venegas, Miguel Harfagar, Ingrid Santander, María Paz Medel, Carolina Ramirez-Cadiz, Marco Arrese, Alejandro Soza, Abe Oudshoorn, Juan Pablo Arab","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Hepatitis C virus (HCV) infection remains an important public health concern among people experiencing homelessness (PEH), yet data from Latin America are limited. We aimed to estimate HCV prevalence and describe associated risk factors and linkage to care in this population.Materials and methods: We conducted a retrospective study of 800 PEH in Santiago, Chile. Participants underwent rapid HCV antibody screening followed by confirmatory RNA testing. Standardized data on sociodemographic characteristics and potential risk factors were collected.Results: Four participants tested positive for HCV, corresponding to a prevalence of 0.5%. Reported exposures among HCV-positive individuals included tattoos, high-risk sexual behaviors, previous blood transfusion, and cocaine use; none reported intravenous drug use. Linkage to care was limited, with only one individual (25%) initiating direct-acting antiviral therapy. Barriers included lack of health insurance coverage, administrative obstacles, unstable living conditions, and loss to follow-up.Conclusions: HCV prevalence in this cohort was low. However, distinct risk profiles and important gaps in treatment access were identified. These findings support the need for targeted microelimination strategies and strengthened linkage-to-care pathways for PEH in Latin America.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 2","pages":"138-143"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rome V Criteria: a new era for disorders of gut-brain interaction]. [罗马V标准：肠脑相互作用紊乱的新时代]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Hugo Guillermo Cedrón Cheng

引用次数: 0

[Delayed post-ERCP complication: an unusual case of biliary stent migration]. [迟发性ercp术后并发症：胆道支架移位1例]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Lázaro Antonio Arango Molano, Andrés Sánchez Gil, Adhara Marina Estrada Torres, Javier Gregorio Liévano-Barreto, Karla Patricia Gutiérrez-de la Peña

引用次数: 0

[Irritable bowel syndrome: an organic disease]. 肠易激综合征：一种器质性疾病。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Jose Augusto Urrego, Hernando Marulanda, Juan Sebastián Frías, Hugo Cedrón, Jorge Espinoza-Ríos, Lina Otero, William Otero

{"title":"[Irritable bowel syndrome: an organic disease].","authors":"Jose Augusto Urrego, Hernando Marulanda, Juan Sebastián Frías, Hugo Cedrón, Jorge Espinoza-Ríos, Lina Otero, William Otero","doi":"","DOIUrl":"","url":null,"abstract":"Irritable bowel syndrome (IBS) is a disorder of gut-brain axis interaction characterized by abdominal pain and alterations in stool form and/or frequency. The previous concept of a \"functional disorder\" has often been misinterpreted as \"the opposite of organic\" or \"purely psychological,\" leading to stigmatization and even delegitimization of this condition. However, evidence supports that IBS has an underlying organic basis mediated by the complex interaction of multiple measurable and quantifiable pathophysiological alterations. These alterations include genetic predisposition, changes in the intestinal microbiota, visceral hypersensitivity, abnormalities in central pain processing, gastrointestinal motility disturbances, impaired intestinal barrier function, and environmental influences. Together, these elements are integrated through the gut-brain axis model, in which they form multiple positive feedback loops that initiate, exacerbate, and perpetuate IBS manifestations. In this review, we discuss in depth the underlying pathophysiological alterations of IBS to remind and raise awareness among healthcare professionals about the organic nature of this syndrome. Additionally, we summarize modern therapeutic approaches and their limitations in light of these organic alterations.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 2","pages":"159-174"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prevalence and associated factors of Helicobacter pylori in pediatric patients at a high-complexity institution in Medellín]. [一所高复杂性医院儿科患者幽门螺杆菌患病率及相关因素[Medellín]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-04-01

Daniela Londoño-Cañas, Paola Acero-Portilla, Catalina Ortiz-Piedrahita, Daniela Vélez-Henao, Carolina Buitrago-Salazar

{"title":"[Prevalence and associated factors of Helicobacter pylori in pediatric patients at a high-complexity institution in Medellín].","authors":"Daniela Londoño-Cañas, Paola Acero-Portilla, Catalina Ortiz-Piedrahita, Daniela Vélez-Henao, Carolina Buitrago-Salazar","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To provide information on the sociodemographic, environmental, and clinical characteristics associated with Helicobacter pylori (H. pylori) infection in children.Methods: A total of 183 children aged 4 to 17 years who underwent upper gastrointestinal endoscopy with biopsies at a high-complexity hospital in Medellín, Colombia, between April 2022 and March 2024 were included. Socioeconomic data, gastrointestinal symptoms, endoscopic, and histological findings were analyzed. The prevalence of H. pylori and its association with sociodemographic, clinical, and environmental factors were calculated.Results: The prevalence of H. pylori infection was 23%. There was no association between infection and sociodemographic variables or symptoms. Infected patients more frequently presented with active chronic inflammation (97.6% vs. 13.5%, p<0.001), antral nodularity (50% vs. 7.1%, p<0.001), pangastric erythema (33.3% vs. 14.2%, p=0.005), a personal history of H. pylori infection (4.8% vs. 2,1%, p=0.009) was significantly more frequent in the infected group. A family history of gastric cancer was found in 2 patients in the infected group (4,8%).Conclusions: A similar prevalence to that reported in other Latin American studies was observed. The importance of integrating endoscopic and histological assessment with relevant sociodemographic and clinical factors is highlighted to enable a more rational identification of H. pylori, and to lay the groundwork for future research in our population.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 2","pages":"131-137"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Welcome the partnership between the Pan American Organization for Crohn's and Ulcerative Colitis and the Revista de Gastroenterología del Perú]. [欢迎泛美克罗恩病和溃疡性结肠炎组织与Gastroenterología del Perú杂志之间的伙伴关系]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-01-01

Fabián Juliao-Baños

引用次数: 0

[Lymphocytic esophagitis as a cause of dysphagia: a case report and brief literature review]. [淋巴细胞性食管炎引起吞咽困难：1例报告及简要文献复习]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-01-01

Javier Perez-Valenzuela, Manuel Barrera, María Francisca Vergara, Javier Chahuán

{"title":"[Lymphocytic esophagitis as a cause of dysphagia: a case report and brief literature review].","authors":"Javier Perez-Valenzuela, Manuel Barrera, María Francisca Vergara, Javier Chahuán","doi":"","DOIUrl":"","url":null,"abstract":"Lymphocytic esophagitis (LyE) is a chronic inflammatory condition of the esophagus with a prevalence of ~0.1% among esophageal biopsies. The main clinical manifestations are dysphagia, heartburn, and chest pain; some endoscopic findings includes rings, strictures, and furrows. We present the case of a patient with diagnosis of LyE. A 63-year-old woman with Sjögren syndrome and treated hypothyroidism presented with a 1-year history of progressive solid-food dysphagia and 4-kg weight loss. Endoscopy and a barium esophagogram revealed a proximal esophageal web, which was treated with endoscopic dilation. A follow-up esophagogastroduodenoscopy showed esophageal rings and luminal narrowing. Biopsies confirmed LyE. She was treated with esomeprazole with good clinical response. LyE is a recently described entity in which clinicopathologic correlations are not always straightforward. Given overlap in symptoms and endoscopic features, eosinophilic esophagitis is the principal differential diagnosis. Management options include proton-pump inhibitors, swallowed topical corticosteroids, and esophageal dilation for fixed strictures. Clear, evidence-based clinical guidelines are still lacking.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 1","pages":"74-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment patterns in inflammatory bowel disease in Panama: experience from a specialized center]. [巴拿马炎症性肠病的治疗模式：来自一个专业中心的经验]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-01-01

Carlos Rettally, Valeria Orillac

{"title":"[Treatment patterns in inflammatory bowel disease in Panama: experience from a specialized center].","authors":"Carlos Rettally, Valeria Orillac","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Inflammatory bowel disease has shown a sustained increase in incidence in developing countries. In Panama, there are no previous reports describing treatment patterns or the use of biologic therapies. The objective is to describe the therapeutic patterns in patients with ulcerative colitis and Crohn's disease, including the use of conventional and advanced therapies, as well as prior exposure to biologic agents in real-world clinical practice.Materials and methods: This was an observational, descriptive, and retrospective study of adult patients with Crohn's disease or ulcerative colitis treated between 2009 and 2024 at a gastroenterology clinic in Panama City.Results: 140 patients were included, with the majority (65%) diagnosed within the last decade. At the time of the last evaluation, 35% were receiving immunomodulators, 33.6% aminosalicylates, 21.4% turmeric and Qing Dai, 7.9% corticosteroids, and 40.7% biologic therapies; 12.1% were not on active treatment. Among patients on biologic therapy, 63.2% were using anti-TNF agents, and 45.6% had received at least one previous biologic. Intestinal surgery was documented in 17.9% of the cohort.Conclusions: High penetration of biological therapies was observed, with significant use of non-anti-TNF agents and the need for multiple lines of treatment in refractory cases. The limited use of aminosalicylates and the pioneering incorporation of turmeric-Qing Dai differentiate this cohort from other Latin American cohorts and reflect the specific characteristics of a specialized private center.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Exocrine pancreatic insufficiency and hyperoxaluria: a preventable renal complication from gastroenterology]. [外分泌胰功能不全和高血氧症：一种可预防的胃肠病学肾脏并发症]。

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2026-01-01

Ernesto Hornung, Ignacio Moratorio, Serena Amor, Mariana Seija, Adrián Canavesi

{"title":"[Exocrine pancreatic insufficiency and hyperoxaluria: a preventable renal complication from gastroenterology].","authors":"Ernesto Hornung, Ignacio Moratorio, Serena Amor, Mariana Seija, Adrián Canavesi","doi":"","DOIUrl":"","url":null,"abstract":"Exocrine pancreatic insufficiency (EPI) is the inability of the pancreas to produce essential digestive enzymes for fat metabolism, leading to systemic and nutritional repercussions. Although its manifestations are typically digestive, systemic complications such as enteric hyperoxaluria can occur. We present a 68-year-old man with insulin-dependent diabetes mellitus, who developed steatorrheic diarrhea and significant weight loss. Computed tomography revealed an atrophic pancreas with diffuse calcifications. Based on a diagnosis of chronic pancreatitis, pancreatic enzyme replacement therapy (PERT) was initiated empirically with clinical improvement. Three years later, while asymptomatic from a gastrointestinal perspective, he developed bilateral calcium oxalate nephrolithiasis progressing to end-stage renal disease, requiring hemodialysis. This was interpreted as oxalate nephropathy secondary to enteric hyperoxaluria, favored by suboptimal PERT dosing and poor follow-up adherence. PERT was optimized to 40,000 units per meal with good nutritional and digestive outcomes. The etiological study for EPI showed no obstructive or systemic causes. This case highlights the importance of suspecting EPI when systemic complications like secondary hyperoxaluria appear. Early diagnosis remains challenging and requires close monitoring, as specific guidelines to prevent irreversible renal damage are lacking; early recognition can significantly improve prognosis and quality of life.","PeriodicalId":35807,"journal":{"name":"Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru","volume":"46 1","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0