Journal of Fluorine Chemistry最新文献_第4页

Fluorine in Pharmaceuticals and Synthetic Strategies for Fluorine-Containing Molecules in Anticancer Drug Discovery: A Review 药物中的氟及抗癌药物中含氟分子的合成策略综述

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-02-01 Epub Date: 2026-01-07 DOI: 10.1016/j.jfluchem.2026.110527

Vivek Kumar , Meenu , M. Shaquiquzzaman, M. Mumtaz Alam, Mymoona Akhter, Darakhshan Parveen, Mohammad Kaleem, Shyama Charan, Md. Khalid Saifullah, Sharba Tasneem

{"title":"Fluorine in Pharmaceuticals and Synthetic Strategies for Fluorine-Containing Molecules in Anticancer Drug Discovery: A Review","authors":"Vivek Kumar , Meenu , M. Shaquiquzzaman, M. Mumtaz Alam, Mymoona Akhter, Darakhshan Parveen, Mohammad Kaleem, Shyama Charan, Md. Khalid Saifullah, Sharba Tasneem","doi":"10.1016/j.jfluchem.2026.110527","DOIUrl":"10.1016/j.jfluchem.2026.110527","url":null,"abstract":"<div><div>Fluorine has emerged as a key element in modern drug discovery. It influences the pharmacokinetic and pharmacodynamic properties of the drug substance, affecting the overall pharmacological profile. Its impact is reflected in the growing number of FDA-approved fluorine-containing drugs across diverse disease areas, particularly in oncology. This review provides a comprehensive account of FDA-approved fluorine-containing drugs, highlighting their clinical applications in various diseases. Special emphasis is placed on fluorine-containing anticancer agents, tracing their synthetic evolution from 1955 to 2024 as reported in the literature. By integrating structural, mechanistic, and synthetic perspectives, this work emphasises the critical role of fluorination in shaping drug design strategies and therapeutic innovation. Furthermore, a target-oriented classification and SAR evaluation of fluorinated drugs are presented to elucidate how specific fluorine substitutions shape potency, selectivity, and overall therapeutic performance. To support these analyses, a comparative SAR table is included, detailing fluorine positions, their impact on potency and pharmacokinetics, and the mechanistic rationale underlying these effects. The insights presented herein aim to guide future medicinal chemistry efforts toward the rational development of next-generation fluorinated drugs with enhanced efficacy and safety profiles.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"290 ","pages":"Article 110527"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Organophotocatalytic defluorinative γ-substitution towards monofluoroalkenes 有机光催化对单氟烯烃的脱氟γ-取代

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jfluchem.2026.110540

Taylor Semeniuk, Dennis D. Toporkov, Tyler de Goede, Jean-Denys Hamel

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Corrigendum to “Paramagnetic centers in ion bombarded polyvinylidenefluoride” [Journal of Fluorine Chemistry, 2026, 289, 110526] “离子轰击聚偏偏氟乙烯的顺磁中心”的勘误表[氟化学杂志，2026,289,110526]

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-02-01 Epub Date: 2026-02-20 DOI: 10.1016/j.jfluchem.2026.110541

Aleksandr V. Akimov , Alexandr S. Shmakov , Rostislav V. Pisarev , Sadulla R. Allayarov , Anna V. Pisareva , Uliana V. Pinaeva , Georgy A. Khromov , Andrey А. Tyutyunov , Alexander N. Nechaev , Pavel Yu. Apel , Yury A. Dobrovolsky , Sergei V. Tokarev , Matthew P. Confer , David A. Dixon

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Thermal decomposition behavior of branched and linear perfluoropolyether lubricants 支链和线性全氟聚醚润滑剂的热分解行为

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-02-01 Epub Date: 2026-02-21 DOI: 10.1016/j.jfluchem.2026.110548

Shizhao Yang , Jun Ma , Xin Xu , Jianqiang Hu , Li Guo , Jingpei Cao , Teng Chen

{"title":"Thermal decomposition behavior of branched and linear perfluoropolyether lubricants","authors":"Shizhao Yang , Jun Ma , Xin Xu , Jianqiang Hu , Li Guo , Jingpei Cao , Teng Chen","doi":"10.1016/j.jfluchem.2026.110548","DOIUrl":"10.1016/j.jfluchem.2026.110548","url":null,"abstract":"<div><div>Perfluoropolyether (PFPE) lubricants play a significant role in the aerospace industry due to their outstanding chemical stability, thermal stability and anti-wear properties, however, their decomposition behavior has not been revealed fully. Herein, the decomposition mechanism and performance characteristics of four types of PFPE lubricants are investigated thoroughly by means of <em>in situ</em> heating fourier-transform infrared spectroscopy (<em>in situ</em> FTIR) and pyrolysis-gas chromatography/mass spectrometry (Py-GCMS). The results show that the specific sequence of antioxidant ability of PFPE is Fomblin Z03>Fomblin LC80>Fomblin M03≈Fomblin Y04. Moreover, metals can accelerate the oxidation of PFPE lubricants, generating acids, esters and anhydrides, resulting in an increase of acid value from 0.0025 mg KOH/g to 0.0109 mg KOH/g and 7.7 per cent increase in kinematic viscosity for Fomblin M03 after oxidation in 260 °C for 72 h. This work provides a technical scheme for the safe use of perfluoroalkylpolyether lubricants and promotes the research and application of new-generation ultra-high-temperature aviation engine lubricants.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"290 ","pages":"Article 110548"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Paramagnetic centers in ion bombarded poly(vinylidene fluoride) 离子轰击聚偏氟乙烯的顺磁中心

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-12-27 DOI: 10.1016/j.jfluchem.2025.110526

Aleksandr V. Akimov , Alexandr S. Shmakov , Rostislav V. Pisarev , Sadulla R. Allayarov , Anna V. Pisareva , Uliana V. Pinaeva , Georgy A. Khromov , Andrey А. Tyutyunov , Alexander N. Nechaev , Pavel Yu. Apel , Yury A. Dobrovolsky , Sergei V. Tokarev , Matthew P. Confer , David A. Dixon

{"title":"Paramagnetic centers in ion bombarded poly(vinylidene fluoride)","authors":"Aleksandr V. Akimov , Alexandr S. Shmakov , Rostislav V. Pisarev , Sadulla R. Allayarov , Anna V. Pisareva , Uliana V. Pinaeva , Georgy A. Khromov , Andrey А. Tyutyunov , Alexander N. Nechaev , Pavel Yu. Apel , Yury A. Dobrovolsky , Sergei V. Tokarev , Matthew P. Confer , David A. Dixon","doi":"10.1016/j.jfluchem.2025.110526","DOIUrl":"10.1016/j.jfluchem.2025.110526","url":null,"abstract":"<div><div>Stabilized radicals formed by irradiation of thin poly(vinylidene fluoride) films with high-energy accelerated <sup>22</sup>Ne<sup>+4</sup>, <sup>132</sup>Xe<sup>+26</sup> and <sup>209</sup>Bi<sup>+51</sup> ions with respective energies of 24, 158 and 670 MeV were studied by EPR, Fourier transform infrared, and UV-visible spectroscopies. The bombarding ions cause significant excitation and ionization along the ion tracks throughout the thickness of the film. The reduction of crystallinity and the formation of unsaturated bonds in the irradiated polymer were explored spectroscopically The presence of alkyl, peroxide, and polyenyl radicals were identified in the spectra of the irradiated polymer; mechanisms for radical formation are proposed. Preliminary freezing of the irradiated films to dry ice temperature and subsequent study after storage at room temperature led to quantitative estimates of the loss of radicals during storage. Computational chemistry was used to predict the thermodynamics of the degradation processes and resulting peroxide radical reactions. Localized energy due to the ion bombardment enabled thermodynamically unfavorable reactions to proceed. The results of the study should be useful for optimization of processes for creating PVDF-based membranes for various applications.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"289 ","pages":"Article 110526"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparative evaluation of quantifiable PFAS generated as byproducts from polytetrafluoroethylene (PTFE) incineration 聚四氟乙烯（PTFE）焚烧副产物产生的可量化PFAS的比较评价

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI: 10.1016/j.jfluchem.2025.110523

Takashi Fujimori , Ayame Saido , Taichi Murakami , Takaki Mine , Hidekazu Okamoto

{"title":"Comparative evaluation of quantifiable PFAS generated as byproducts from polytetrafluoroethylene (PTFE) incineration","authors":"Takashi Fujimori , Ayame Saido , Taichi Murakami , Takaki Mine , Hidekazu Okamoto","doi":"10.1016/j.jfluchem.2025.110523","DOIUrl":"10.1016/j.jfluchem.2025.110523","url":null,"abstract":"<div><div>There is a need for quantitative data on generation of per- and polyfluoroalkyl substances (PFAS) during incineration of polytetrafluoroethylene (PTFE) at the end of the lifecycle of PTFE products. This study quantified the temperature-dependent generation of PFAS byproducts that were formed during the thermal decomposition of PTFE in an oxidizing atmosphere. The PFAS analyzed were C<sub>4</sub> to C<sub>18</sub> perfluoroalkyl carboxylic acids (PFCAs) and four compounds of perfluoroalkyl ether carboxylic acids (PFECAs). As a result of the blank tests, trace amounts of PFAS were detected. Therefore, the results for byproduct PFAS were discussed after subtracting the blank values. After incineration, total PFAS byproducts formed at a maximum of 0.028 % (700 °C) and a minimum of 6.9 × 10⁻⁶ % (950 °C) relative to the PTFE input. Comparative evaluation of total PFAS byproducts generated during PTFE incineration showed that the changes observed were comparable to or were one order of magnitude lower than those observed for PFAS byproducts generated during the thermal decomposition of perfluorooctanoic acid (PFOA) and perfluorooctadecanoic acid (PFOcDA). Analysis of individual PFAS data revealed relatively high levels of short-chain PFCAs as byproducts, high-temperature suppression of long-chain PFCAs, characteristic generation patterns of PFECAs, and trace residues of PFOA at elevated temperatures. Based on the distribution behavior of individual PFAS by medium, we found that in addition to adsorption by resins, capture using solutions such as toluene or NaOH is necessary depending on the carbon number. This report demonstrated that decomposition of PTFE at temperatures above 850 °C can suppress the generation of PFAS byproducts to the levels equivalent to or lower than those produced during decomposition of regulated PFAS.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"289 ","pages":"Article 110523"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Multigram Synthesis and Physicochemical Characterization of cis-β-CHF2- and cis-β-CF3-α-Proline 顺式β- chf2 -和顺式β- cf3 -α-脯氨酸的多元谱合成及理化性质研究

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.jfluchem.2025.110524

Mykhailo O. Redka , Olga A. Sherstiuk , Anastasia Hurieva , Ivan S. Kondratov , Oleksandr Liashuk , Oleksandr O. Grygorenko

引用次数: 0

The structure and performance of polyvinylidene fluoride membranes by using water-soluble polyester as an additive via immersion precipitation phase inversion 以水溶性聚酯为添加剂，通过浸渍沉淀法对聚偏氟乙烯膜的结构和性能进行了研究

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-11-18 DOI: 10.1016/j.jfluchem.2025.110507

Jiaxin He , Shuo Sun , Hongjun Li , Wei Du , Hongwei Zhang , Danying Zuo

{"title":"The structure and performance of polyvinylidene fluoride membranes by using water-soluble polyester as an additive via immersion precipitation phase inversion","authors":"Jiaxin He , Shuo Sun , Hongjun Li , Wei Du , Hongwei Zhang , Danying Zuo","doi":"10.1016/j.jfluchem.2025.110507","DOIUrl":"10.1016/j.jfluchem.2025.110507","url":null,"abstract":"<div><div>Flat porous membranes of polyvinylidene fluoride (PVDF) were synthesized utilizing a water-soluble polyester (WSPET) as a pore-forming agent through immersion precipitation phase inversion. The influence of different WSPET contents on the thermodynamic stability of the casting solution, membrane structure, and performance was investigated. The findings indicated that the incorporation of WSPET diminished the thermodynamic stability of the casting solution, thereby increasing its susceptibility to immediate liquid-liquid phase separation. The mobility of the chain segments was hindered and the crystallinity of the membranes decreased with the α-crystal content decreasing and the β-crystal content increasing. With increasing WSPET content, the porosity, mean pore size and water fluxes of the membranes increased and the contact angle on the surface decreased. The top surface of the membranes with added WSPET exhibited a porous structure and a finger-like macroporous structure in the membrane. Dynamic cyclic filtration experiments showed that with WSPET content increasing, the rejection rate of the PVDF membranes decreased, the flux recovery rates of the PVDF membranes exceeded those of the blank membrane, while both the reversible and irreversible fouling rates of the membranes were lower in comparison to the blank membrane. These results indicate that using WSPET as a pore-forming agent improved PVDF membrane hydrophilicity and enhanced the water flux and antifouling properties.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"289 ","pages":"Article 110507"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Palladium catalyst synthesis, computational chemical study and molecular docking of a new series of (aryl)-2-(trifluoromethyl) tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one derivatives 钯催化剂合成、计算化学研究及新系列（芳基）-2-（三氟甲基）四氢苯并[4,5]噻吩[2,3-d]嘧啶-4(3H)- 1衍生物的分子对接

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/j.jfluchem.2025.110510

Razieh Masoomifard , Ali Darehkordi , Marziyeh Mohammadi , Mohammad Salarvand

{"title":"Palladium catalyst synthesis, computational chemical study and molecular docking of a new series of (aryl)-2-(trifluoromethyl) tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one derivatives","authors":"Razieh Masoomifard , Ali Darehkordi , Marziyeh Mohammadi , Mohammad Salarvand","doi":"10.1016/j.jfluchem.2025.110510","DOIUrl":"10.1016/j.jfluchem.2025.110510","url":null,"abstract":"<div><div>As part of this study, we successfully synthesized trifluoromethylated thieno[3,2-d]pyrimidin-4(3H)-one derivatives, which have the potential to be biologically active. These derivatives were produced through a condensation-cyclization reaction between 3-aminothiophene-2-carboxamide derivatives and 2,2,2-trifluoroacetimidoyl chlorides. The reaction took place in the presence of a palladium catalyst. In the course of this research, good yields of 3-aminothiophene-2-carboxamide intermediates were achieved by utilizing morpholine as a catalyst in the condensation of a cyclic ketone, cyanoacetamide, and sulfur. Based on the results of molecular docking tests conducted with cyclic nucleotide phosphodiesterases (PDEs) receptors, it was discovered that the dimethoxyphenyl derivative 6a exhibited the lowest binding energy, with a value of -1453.42 kJ/mol. Furthermore, a theoretical investigation was carried out by employing density functional theory (DFT) with the 6–311++<em>G</em>(d, p) basis set in order to analyze the electronic structures, geometries, and reactivity features of molecular compounds. The findings showed that compounds (5a-5d) have a better level of stability in comparison to compounds (6a-6f), with compound 5d displaying noteworthy reactivity as a result of its reduced energy gap (7.957 eV) and higher electrophilicity (2.327).</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"289 ","pages":"Article 110510"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Temperature-induced modulation and adsorption mechanism: Its effect on deep defluoridation by Mg-Al-LDO 温度诱导调制及其吸附机理：对Mg-Al-LDO深度除氟的影响

IF 1.9 4区化学

Journal of Fluorine Chemistry Pub Date : 2026-01-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jfluchem.2025.110518

Jiale Zou, Qing Wang, Peien Huang, Shixun Chen, Yongzhi Tu, Ziming Zhang, Jianxin Chen, Zhifei Ma

{"title":"Temperature-induced modulation and adsorption mechanism: Its effect on deep defluoridation by Mg-Al-LDO","authors":"Jiale Zou, Qing Wang, Peien Huang, Shixun Chen, Yongzhi Tu, Ziming Zhang, Jianxin Chen, Zhifei Ma","doi":"10.1016/j.jfluchem.2025.110518","DOIUrl":"10.1016/j.jfluchem.2025.110518","url":null,"abstract":"<div><div>The issue of fluoride pollution is posing significant threats to the global ecological environment. Layered Double Hydroxides (LDHs) have attracted widespread attention from researchers due to their high adsorption capacity, strong adaptability, and excellent selectivity. In this study, the Mg/Al-CO₃ LDHs material was synthesized using the co-precipitation method, and the corresponding Layered Double Oxides (LDOs) were further obtained through pyrolysis at various temperatures. The results indicate that as the calcination temperature increases, the maximum adsorption capacity of the material gradually improves, with Mg/Al-LDO-1000 achieving an adsorption capacity of 84.01 mg/g. Notably, these materials maintain stable adsorption performance and good environmental adaptability over a wide pH range of 3 to 11. The structural properties of the materials were further characterized using SEM, XRD, FT-IR, and BET analyses to elucidate the influence of pyrolysis temperature on their adsorption performance. Within the pyrolysis temperature range of 400–600 °C, ion exchange was identified as the dominant adsorption mechanism. However, when the pyrolysis temperature exceeded 800 °C, the mechanism gradually shifted toward chemical adsorption, involving the interaction between F<sup>−</sup> and Mg<sup>2+</sup> on the material surface. This work expands the traditional LDHs research, further clarifies the influence of pyrolysis temperature on adsorption performance, and provides new ideas for the development of efficient fluoride removal agents.</div></div>","PeriodicalId":357,"journal":{"name":"Journal of Fluorine Chemistry","volume":"289 ","pages":"Article 110518"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0